Cited by 176Cerebrospinal fluid and hydrocephalusBarrier Structure and Function StudiesIon Transport and Channel Regulation

The Choroid Plexus in Healthy and Diseased Brain

Kaur, Charanjit, Rathnasamy, Gurugirijha, Ling, Eng-Ang·2016·Journal of Neuropathology & Experimental Neurology

Abstract

The choroid plexus is composed of epithelial cells resting on a basal lamina. These cells produce the cerebrospinal fluid (CSF), which has many functions including rendering mechanical support, providing a route for some nutrients, removing by-products of metabolism and synaptic activity, and playing a role in hormonal signaling. The choroid plexus synthesizes many growth factors, including insulin-like, fibroblast, and platelet-derived growth factors. The tight junctions located between the apical parts of the choroid plexus epithelial cells form the blood-CSF barrier (BCSFB), which is crucial for the homeostatic regulation of the brain microenvironment along with the blood-brain barrier (BBB). Morphological changes such as atrophy of the epithelial cells and thickening of the basement membrane suggest altered CSF production occurs in aging and in Alzheimer disease. In brain injuries and infections, leukocytes accumulate in the CSF by passing through the choroid plexus. In inflammatory CNS diseases (eg, multiple sclerosis), pathogenic autoreactive T lymphocytes may migrate through the BBB and BCSFB into the CNS. The development of therapeutic strategies to mitigate disruption of the BCSFB may be helpful to curtail the entry of inflammatory cells into the CSF and hence reduce inflammation, thereby overcoming choroid plexus dysfunction in senescence and in various diseases of the CNS.

Integrity signals

Registry

Crossref · 10.1093/jnen/nlv030

Cites

267 of 267 references verified0 citation errors · 0 not checkable

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  • This molecularly driven invasion allows GBS to cross the BBB directly, preceding the development of a massive inflammatory infiltrate that would be reflected as pleocytosis in the CSF.

    “This molecularly driven invasion allows GBS to cross the BBB directly, again preceding the development of a massive inflammatory infiltrate that would be reflected as pleocytosis in the CSF (18).”
  • Blood vessels within the choroid plexus and circumventricular organs have endothelia that lack tight junctions and are open to peripheral circulation.

    “Blood vessels within these two structures have endothelia that lack tight junctions and are open to peripheral circulation (25, 26).”

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Authors
Kaur, C., Rathnasamy, G., & Ling, E.-A.
Affiliations
National University of Singapore (SG)
Venue
Journal of Neuropathology & Experimental Neurology
Published
2016-02-17
Volume
75
Issue
3
Pages
198-213
ISSN
  • 0022-3069 (ISSN-L)
  • 1554-6578
OpenAlex
W2281330516
Cited by
176
References
267
Citations by year
2026: 16 · 2025: 22 · 2024: 21 · 2023: 14 · 2022: 21 · 2021: 27 · 2020: 14 · 2019: 22 · 2018: 5 · 2017: 11 · 2016: 3
FWCI
1.50
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neuropathology & Experimental Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
Keywords
choroid plexus, cerebrospinal fluid production, blood-CSF barrier, choroid plexus epithelial cells, tight junctions, growth factors, aging, Alzheimer's disease, brain injury, central nervous system infection, multiple sclerosis, autoreactive T cells, leukocyte transmigration, blood-brain barrier
MeSH terms
Animals, Blood-Brain Barrier, Brain Diseases, Choroid Plexus, Humans, Tight Junctions

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