The DOI matches its Crossref record; 219 of the 219 references it cites were found in a registry or an index.
Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives
Abstract
Poly(ethylene glycol) (PEG) is the most used polymer and also the gold standard for stealth polymers in the emerging field of polymer‐based drug delivery. The properties that account for the overwhelming use of PEG in biomedical applications are outlined in this Review. The first approved PEGylated products have already been on the market for 20 years. A vast amount of clinical experience has since been gained with this polymer—not only benefits, but possible side effects and complications have also been found. The areas that might need consideration and more intensive and careful examination can be divided into the following categories: hypersensitivity, unexpected changes in pharmacokinetic behavior, toxic side products, and an antagonism arising from the easy degradation of the polymer under mechanical stress as a result of its ether structure and its non‐biodegradability, as well as the resulting possible accumulation in the body. These possible side effects will be discussed in this Review and alternative polymers will be evaluated.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“However, immunogenicity of PEG depends on the degree of PEGylation to which molecule it is coupled with and have been shown to induce unpredictable complement activation.[ 204 ]”
From Unraveling and Harnessing the Immune Response at the Cell–Biomaterial Interface for Tissue Engineering Purposes (2024) · cites this paper as [204]
In the citing paper
“Incorporating PEG-lipids further decreases recognition by the MPS and clearance by renal filtration17,127.”
From Lipid nanoparticles for mRNA delivery (2021) · cites this paper as [127]
In the citing paper
“Moreover, anti-PEG antibodies could result in fast systemic clearance of subsequently administered PEGylated nanoparticles by accelerated blood clearance127,169.”
From Lipid nanoparticles for mRNA delivery (2021) · cites this paper as [127]
In the citing paper
“The accelerated blood clearance phenomenon may change the bioavailability and biodistribution of the drug encapsulated in PEGylated nanoparticles and, thus, cause side effects127,169.”
From Lipid nanoparticles for mRNA delivery (2021) · cites this paper as [127]
In the citing paper
“To ameliorate safety concerns, numerous natural and synthetic polymers have been investigated as alternatives to PEG, of which several are under evaluation in clinical trials127,169.”
From Lipid nanoparticles for mRNA delivery (2021) · cites this paper as [127]
In the citing paper
“Lipid components may activate host immune responses following systemic or local administration; for example, PEG-lipids could induce hypersensitivity reactions by stimulating the complement system127,169.”
From Lipid nanoparticles for mRNA delivery (2021) · cites this paper as [127]
In the citing paper
“Lipid components may activate host immune responses following systemic or local administration; for example, PEG-lipids could induce hypersensitivity reactions by stimulating the complement system127,169.”
From Lipid nanoparticles for mRNA delivery (2021) · cites this paper as [127]
Citations
Cites
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review
Maeda, H., Wu, J., Sawa, T., Matsumura, Y., & Hori, K. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00248-5 · Cited by 6,565
Recent advances with liposomes as pharmaceutical carriers
Torchilin, V. P. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1632 · Cited by 5,282
Drug Delivery Systems: Entering the Mainstream
Allen, T. M., & Cullis, P. R. (2004) · Science · doi:10.1126/science.1095833 · Cited by 4,552
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
Moghimi, S. M., Hunter, A. C., & Murray, J. C. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01494-7 · Cited by 3,521
Thermo- and pH-responsive polymers in drug delivery☆
SCHMALJOHANN, D. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.09.020 · Cited by 3,023
Biodegradable Long-Circulating Polymeric Nanospheres
Gref, R., Minamitake, Y., Peracchia, M. T., Trubetskoy, V. S., Torchilin, V. P., & Langer, R. (1994) · Science · doi:10.1126/science.8128245 · Cited by 2,951
Synthetic biodegradable polymers as orthopedic devices
Middleton, J. C., & Tipton, A. J. (2000) · Biomaterials · doi:10.1016/s0142-9612(00)00101-0 · Cited by 2,741
PEGylation, successful approach to drug delivery
Veronese, F. M., & Pasut, G. (2005) · Drug Discovery Today · doi:10.1016/s1359-6446(05)03575-0 · Cited by 2,344
Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes
Klibanov, A. L., Maruyama, K., Torchilin, V. P., & Huang, L. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)81016-h · Cited by 2,030
Polymer conjugates as anticancer nanomedicines
Duncan, R. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1958 · Cited by 1,956
Research works printed but not linked: 13
- Bhadra D., 2002, Pharmazie, 57, 5
- Woodle M. C., 1990, Proc. Int. Symp. Controlled Release Bioact. Mater., 17, 77
- 2007, Encyclopedia of Polymer Science and Technology
- Kwon O. H., 2003, J. Ind. Eng. Chem., 9, 138
- Le Coz C.‐J., 2001, Contact Dermatitis, 44, 308
- J. M. Metselaar Dissertation Dept. Pharmaceutics Utrecht Institute for Pharmaceutical Sciences Utrecht University The Netherlands 2006.
- de Groot M. C. H., 2004, Ned. Tijdschr. Geneeskd., 148, 1887
- Hinds K. D., 2005, Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids
- 10.1021/ie070287 · DOI
- Li C., 1999, Clin. Cancer Res., 5, 891
- Li C., 1998, Cancer Res., 58, 2404
- You E. S., 2007, J. Ind. Eng. Chem., 13, 219
- 10.1021/ma052593 · DOI
Cited by
Sorted by citations
Items 501–600 of 1,003
O’Shea, T. M., Aimetti, A. A., Kim, E., Yesilyurt, V., & Langer, R. (2014) · Advanced Materials · doi:10.1002/adma.201403724 · Cited by 95
Drug Delivery and Imaging with Polydiacetylene Micelles
Gravel, E., Ogier, J. R., Arnauld, T., Mackiewicz, N., Ducongè, F., & Doris, E. (2011) · Chemistry - A European Journal · doi:10.1002/chem.201102769 · Cited by 104
Effect of gold nanoparticle shapes for phototherapy and drug delivery
Adnan, N. N. M., Cheng, Y., Ong, N. M. N., Kamaruddin, T. T., Rozlan, E., Schmidt, T. W., Duong, H. T. T., & Boyer, C. A. (2016) · Polymer Chemistry · doi:10.1039/c6py00465b · Cited by 95
Wong, Y. S., Salvekar, A. V., Zhuang, K. D., Liu, H., Birch, W. R., Tay, K. H., Huang, W., & Venkatraman, S. S. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.06.014 · Cited by 95
Andishmand, H., Tabibiazar, M., Mohammadifar, M. A., & Hamishehkar, H. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2016.12.087 · Cited by 94
A critical review on properties and applications of microbial l -asparaginases
Krishnapura, P. R., Belur, P. D., & Subramanya, S. B. (2015) · Critical Reviews in Microbiology · doi:10.3109/1040841x.2015.1022505 · Cited by 94
Self-Assembly of Temperature-Responsive Protein–Polymer Bioconjugates
Moatsou, D., Li, J., Ranji, A., Pitto‐Barry, A., Ntai, I., Jewett, M. C., & O’Reilly, R. K. (2015) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.5b00264 · Cited by 94
Polymer architectures via mass spectrometry and hyphenated techniques: A review
Crotty, S., Gerişlioğlu, S., Endres, K. J., Wesdemiotis, C., & Schubert, U. S. (2016) · Analytica Chimica Acta · doi:10.1016/j.aca.2016.05.024 · Cited by 94
Self-citationHedayatnasab, Z., Dabbagh, A., Abnisa, F., & Daud, W. M. A. W. (2020) · European Polymer Journal · doi:10.1016/j.eurpolymj.2020.109789 · Cited by 94
Caballero, M. L., Krantz, M. S., Quirce, S., Phillips, E. J., & Stone, C. A. (2021) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2021.03.002 · Cited by 94
Pinto, M., Silva, V., Barreiro, S., Silva, R. V. D. S., Remião, F., Borges, F., & Fernandes, C. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101658 · Cited by 97
Reifarth, M., Hoeppener, S., & Schubert, U. S. (2018) · Advanced Materials · doi:10.1002/adma.201703704 · Cited by 94
Self-citationPoly(2-oxazoline) Hydrogels for Controlled Fibroblast Attachment
Farrugia, B. L., Kempe, K., Schubert, U. S., Hoogenboom, R., & Dargaville, T. R. (2013) · Biomacromolecules · doi:10.1021/bm400518h · Cited by 97
Self-citationSequence-defined multifunctional polyethers via liquid-phase synthesis with molecular sieving
Dong, R., Liu, R., Gaffney, P. R. J., Schaepertoens, M., Marchetti, P., Williams, C. M., Chen, R., & Livingston, A. G. (2018) · Nature Chemistry · doi:10.1038/s41557-018-0169-6 · Cited by 93
Luo, D., Wang, X., Zeng, S., Ramamurthy, G., Burda, C., & Basilion, J. P. (2019) · Chemical Science · doi:10.1039/c9sc02290b · Cited by 93
Wang, S., Chen, D., Hong, Q., Gui, Y., Cao, Y., Ren, G., & Liang, Z. (2023) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2023.122821 · Cited by 93
Smith, A. E., Sizovs, A., Grandinetti, G., Xue, L., & Reineke, T. M. (2011) · Biomacromolecules · doi:10.1021/bm200643c · Cited by 93
Red Blood Cells for Drug Delivery
Yan, J., Yu, J., Wang, C., & Gu, Z. (2017) · Small Methods · doi:10.1002/smtd.201700270 · Cited by 93
Banskota, S., Yousefpour, P., Kirmani, N., Li, X., & Chilkoti, A. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.11.012 · Cited by 93
Liu, L., Xiang, Y., Wang, Z., Yang, X., Yu, X., Lü, Y., Deng, L., & Cui, W. (2019) · NPG Asia Materials · doi:10.1038/s41427-019-0185-z · Cited by 92
Pelosi, C., Tinè, M. R., & Wurm, F. R. (2020) · European Polymer Journal · doi:10.1016/j.eurpolymj.2020.110079 · Cited by 93
Khodabandehlou, K., Masehi-Lano, J. J., Poon, C., Wang, J., & Chung, E. J. (2017) · Experimental Biology and Medicine · doi:10.1177/1535370217693116 · Cited by 91
Supramolecular polymeric chemotherapy based on cucurbit[7]uril-PEG copolymer
Chen, H., Chen, Y., Wu, H., Xu, J., Sun, Z., & Zhang, X. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.02.051 · Cited by 91
Chen, H., Sha, H., Zhang, L., Qian, H., Chen, F., Ding, N., Ji, L., Zhu, A., Xu, Q., Meng, F., et al. (2018) · International Journal of Nanomedicine · doi:10.2147/ijn.s165109 · Cited by 91
Biomaterials as vectors for the delivery of CRISPR–Cas9
Eoh, J. H., & Gu, L. (2019) · Biomaterials Science · doi:10.1039/c8bm01310a · Cited by 92
Yi, S., Lu, Z., Zhang, J. C., Wang, J., Xie, Z., & Hou, L. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b01205 · Cited by 91
Polymer-tetrodotoxin conjugates to induce prolonged duration local anesthesia with minimal toxicity
Zhao, C., Liu, A., Santamaria, C. M., Shomorony, A., Ji, T., Wei, T., Gordon, A. G. R., Elofsson, H., Mehta, M. N., Yang, R., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10296-9 · Cited by 91
Piloni, A., Wong, C. K., Chen, F., Lord, M. S., Walther, A., & Stenzel, M. H. (2019) · Nanoscale · doi:10.1039/c9nr06835j · Cited by 91
Mallakpour, S. E., Azadi, E., & Hussain, C. M. (2020) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2020.213378 · Cited by 91
Yang, X., Ye, W., Qi, Y., Yin, Y., & Xia, Z. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.696514 · Cited by 93
Soroudi, S., Jaafari, M. R., & Arabi, L. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.06.023 · Cited by 96
Dynamics of Poly(ethylene oxide) around Its Melting Temperature
Money, B. K., & Swenson, J. (2013) · Macromolecules · doi:10.1021/ma4003598 · Cited by 91
Minicircle DNA vectors for gene therapy: advances and applications
Gaspar, V. M., de Melo‐Diogo, D., Costa, E. C., Moreira, A. F., Queiroz, J. A., Pichon, C., Correia, I. J., & de Sousa, F. P. (2014) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2015.996544 · Cited by 97
Liang, S., Liu, Y., Jin, X., Liu, G., Wen, J., Zhang, L., Li, J., Yuan, X., Chen, I. S. Y., Chen, W., et al. (2016) · Nano Research · doi:10.1007/s12274-016-0991-3 · Cited by 91
Ekanem, E. E., Nabavi, S. A., Vladisavljević, G. T., & Gu, S. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b06943 · Cited by 90
Zhang, J., Lin, Y., Zhou, H., He, H., Ma, J., Luo, M., Zhang, Z., & Pang, D. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201900341 · Cited by 90
Onugwu, A. L., Attama, A. A., Nnamani, P. O., Onugwu, S. O., Onuigbo, E. B., & Khutoryanskiy, V. V. (2022) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2022.103527 · Cited by 92
Delivering metal ions by nanomaterials: Turning metal ions into drug-like cancer theranostic agents
Liu, C., Guo, L., Wang, Y., Zhang, J., & Fu, C. (2023) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2023.215332 · Cited by 90
Hagedorn, L., Jürgens, D. C., Merkel, O. M., & Winkeljann, B. (2024) · Extracellular Vesicles and Circulating Nucleic Acids · doi:10.20517/evcna.2024.19 · Cited by 93
Poly(2‐oxazoline) Hydrogel Monoliths via Thiol‐ene Coupling
Dargaville, T. R., Forster, R. A., Farrugia, B. L., Kempe, K., Voorhaar, L., Schubert, U. S., & Hoogenboom, R. (2012) · Macromolecular Rapid Communications · doi:10.1002/marc.201200249 · Cited by 90
Self-citationBiomimetic stem cell membrane-camouflaged iron oxide nanoparticles for theranostic applications
Lai, P.-Y., Huang, R.-Y., Lin, S.-Y., Lin, Y.-H., & Chang, C. (2015) · RSC Advances · doi:10.1039/c5ra17447c · Cited by 90
A Library of Well-Defined and Water-Soluble Poly(alkyl phosphonate)s with Adjustable Hydrolysis
Wolf, T., Steinbach, T., & Wurm, F. R. (2015) · Macromolecules · doi:10.1021/acs.macromol.5b00897 · Cited by 89
Hou, Y., Yuan, J., Zhou, Y. J., Yu, J. Z., & Lu, H. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b05413 · Cited by 89
Nanomaterials for cancer therapies
Zhou, Q., Zhang, L., & Wu, H. Y. (2017) · Nanotechnology Reviews · doi:10.1515/ntrev-2016-0102 · Cited by 89
Gao, Y., Zheng, Q., Xu, S., Yuan, Y., Cheng, X. C., Jiang, S., Kenry, K., Yu, Q., Song, Z., Liu, B., et al. (2019) · Theranostics · doi:10.7150/thno.29101 · Cited by 91
Zheng, D., Yu, P., Wei, Z., Zhong, C., Wu, M., & Liu, X. (2020) · Nano-Micro Letters · doi:10.1007/s40820-020-00429-x · Cited by 89
Reversible-deactivation radical polymerization of cyclic ketene acetals
Jackson, A. W. (2020) · Polymer Chemistry · doi:10.1039/d0py00446d · Cited by 89
Oh, J. Y., Yang, G., Choi, E., & Ryu, J. (2022) · Biomaterials Science · doi:10.1039/d2bm00010e · Cited by 90
Zhao, M., Cheng, X., Shao, P., Yao, D., Wu, Y., Xiao, L., Cui, Z., Sun, X., Gao, C., Chen, J., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-44941-9 · Cited by 92
Biosynthetic Polymers as Functional Materials
Carlini, A. S., Adamiak, L., & Gianneschi, N. C. (2016) · Macromolecules · doi:10.1021/acs.macromol.6b00439 · Cited by 92
IR780-loaded TPGS-TOS micelles for breast cancer photodynamic therapy
Pais‐Silva, C., de Melo‐Diogo, D., & Correia, I. J. (2017) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2017.01.002 · Cited by 88
Sputtering onto a liquid: interesting physical preparation method for multi-metallic nanoparticles
Nguyen, M. T., & Yonezawa, T. (2018) · Science and Technology of Advanced Materials · doi:10.1080/14686996.2018.1542926 · Cited by 90
Poly(Sarcosine) Surface Modification Imparts Stealth‐Like Properties to Liposomes
Bleher, S., Buck, J., Muhl, C., Sieber, S., Barnert, S., Witzigmann, D., Huwyler, J., Barz, M., & Süss, R. (2019) · Small · doi:10.1002/smll.201904716 · Cited by 91
Saha, S., Banskota, S., Roberts, S., Kirmani, N., & Chilkoti, A. (2020) · Advanced Therapeutics · doi:10.1002/adtp.201900164 · Cited by 88
Engineering Magnetic Micro/Nanorobots for Versatile Biomedical Applications
Wang, L., Meng, Z., Chen, Y., & Zheng, Y. (2021) · Advanced Intelligent Systems · doi:10.1002/aisy.202000267 · Cited by 88
Deliver the promise: RNAs as a new class of molecular entities for therapy and vaccination
Yu, A., & Tu, M. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107967 · Cited by 94
Biodegradable Small‐Scale Swimmers for Biomedical Applications
Llacer‐Wintle, J., Rivas‐Dapena, A., Chen, X., Pellicer, E., Nelson, B. J., Puigmartí‐Luis, J., & Pané, S. (2021) · Advanced Materials · doi:10.1002/adma.202102049 · Cited by 89
Nguyen, H. V. ‐., Jiang, Y., Mohapatra, S., Wang, W., Barnes, J. C., Oldenhuis, N. J., Chen, K. K., Axelrod, S., Huang, Z., Chen, Q., et al. (2021) · Nature Chemistry · doi:10.1038/s41557-021-00826-8 · Cited by 88
Switchable Lipids: Conformational Change for Fast pH‐Triggered Cytoplasmic Delivery
Viricel, W., Mbarek, A., & Chain, J. L. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201504661 · Cited by 95
Biomimetic non-fouling surfaces: extending the concepts
Pop‐Georgievski, O., Rodriguez‐Emmenegger, C., Pereira, A. D. L. S., Proks, V., Brynda, E., & Rypáček, F. (2013) · Journal of Materials Chemistry B · doi:10.1039/c3tb20346h · Cited by 89
Wei, J., Shuai, X., Wang, R., He, X., Li, Y., Ding, M., Li, J., Tan, H. S., & Fu, Q. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.08.005 · Cited by 90
Fluorescent Multiblock π‐Conjugated Polymer Nanoparticles for In Vivo Tumor Targeting
Ahmed, E., Morton, S. W., Hammond, P. T., & Swager, T. M. (2013) · Advanced Materials · doi:10.1002/adma.201301656 · Cited by 87
Xu, Z., Liu, S., Kang, Y., & Wang, M. (2015) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.5b00119 · Cited by 88
Triggers and Prodromal Symptoms of Angioedema Attacks in Patients With Hereditary Angioedema
for the IOS Study Group, Caballero, T., Maurer, M., Longhurst, H. J., Aberer, W., Bouillet, L., & Fabien, V. (2016) · Journal of Investigational Allergology and Clinical Immunology · doi:10.18176/jiaci.0102 · Cited by 87
Zwitterionic polymers in drug delivery: A review
Harijan, M., & Singh, M. (2021) · Journal of Molecular Recognition · doi:10.1002/jmr.2944 · Cited by 87
Nanostructured Lipid Carriers-Hydrogels System for Drug Delivery: Nanohybrid Technology Perspective
Azhar, S. N. A. S., Ashari, S. E., Zainuddin, N., & Hassan, M. (2022) · Molecules · doi:10.3390/molecules27010289 · Cited by 87
siRNA Functionalized Lipid Nanoparticles (LNPs) in Management of Diseases
Kalita, T., Dezfouli, S. A., Pandey, L. M., & Uludağ, H. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14112520 · Cited by 90
Porsio, B., Craparo, E. F., Mauro, N., Giammona, G., & Cavallaro, G. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b14992 · Cited by 87
Bruusgaard‐Mouritsen, M. A., Johansen, J. D., & Garvey, L. H. (2021) · Clinical & Experimental Allergy · doi:10.1111/cea.13822 · Cited by 86
PEGylated gold nanoparticles: Stability, cytotoxicity and antibacterial activity
Reznickova, A., Slavikova, N., Kolská, Z., Kolářová, K., Bělinová, T., Kalbáčová, M. H., Cieslar, M., & Švorčı́k, V. (2018) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2018.09.083 · Cited by 86
Wang, T., Rong, F., Tang, Y., Li, M., Feng, T., Zhou, Q., Li, P., & Huang, W. (2021) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2021.101389 · Cited by 88
Sun, S.-C., Xu, Y. B., Wen, J., Yuan, T., & Sun, R. (2022) · Green Chemistry · doi:10.1039/d2gc01503j · Cited by 86
Liposomes-Based Drug Delivery Systems of Anti-Biofilm Agents to Combat Bacterial Biofilm Formation
Makhlouf, Z., Ali, A. A., & Al-Sayah, M. H. (2023) · Antibiotics · doi:10.3390/antibiotics12050875 · Cited by 89
Li, Y., Xu, B., Bai, T., & Liu, W. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.03.034 · Cited by 86
Mylonaki, I., Kaditi, E., Pispas, S., & Demetzos, C. (2011) · Journal of Polymer Science Part A Polymer Chemistry · doi:10.1002/pola.25888 · Cited by 87
Guan, M., Ge, J., Wu, J., Zhang, G., Chen, D., Zhang, W., Zhang, Y., Zou, T., Zhen, M., Wang, C., et al. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.06.023 · Cited by 87
Double Hydrophilic Block Copolymer Self‐Assembly in Aqueous Solution
Schmidt, B. V. K. J. (2018) · Macromolecular Chemistry and Physics · doi:10.1002/macp.201700494 · Cited by 88
Structure of a PEGylated protein reveals a highly porous double-helical assembly
Cattani, G., Vogeley, L., & Crowley, P. B. (2015) · Nature Chemistry · doi:10.1038/nchem.2342 · Cited by 85
Qiu, F., Wang, D., Zhu, Q., Zhu, L., Tong, G., Lu, Y., Yan, D., & Zhu, X. (2014) · Biomacromolecules · doi:10.1021/bm401891c · Cited by 85
In situ glyco-nanostructure formulation via photo-polymerization induced self-assembly
Ferji, K., Venturini, P., Cleymand, F., Chassenieux, C., & Six, J. (2018) · Polymer Chemistry · doi:10.1039/c8py00346g · Cited by 85
Hou, Y., Zhou, Y. J., Wang, H., Sun, J., Wang, R., Sheng, K., Yuan, J., Hu, Y., Chao, Y., Liu, Z., et al. (2019) · ACS Central Science · doi:10.1021/acscentsci.8b00548 · Cited by 85
Drug Delivery Systems for Wound Healing
Johnson, N., & Wang, Y. (2015) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201016666150206113720 · Cited by 85
Hydration Effects Turn a Highly Stretched Polymer from an Entropic into an Energetic Spring
Liese, S., Gensler, M., Krysiak, S., Schwarzl, R., Achazi, A. J., Paulus, B., Hugel, T., Rabe, J. P., & Netz, R. R. (2016) · ACS Nano · doi:10.1021/acsnano.6b07071 · Cited by 84
The Protein Corona as a Confounding Variable of Nanoparticle-Mediated Targeted Vaccine Delivery
Bros, M., Nuhn, L., Simon, J., Moll, L., Mailänder, V., Landfester, K., & Grabbe, S. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01760 · Cited by 86
Jia, Q., Li, Z., Guo, C., Huang, X., Kang, M., Song, Y., He, L., Zhou, N., Wang, M., Zhang, Z. H., et al. (2020) · Chemical Engineering Journal · doi:10.1016/j.cej.2020.124468 · Cited by 84
Recent advances of zwitterionic-based topological polymers for biomedical applications
Zhang, M., Yu, P., Xie, J., & Li, J. (2022) · Journal of Materials Chemistry B · doi:10.1039/d1tb02323c · Cited by 87
Silva, J. P., Dhall, S., Garcia, M., Chan, A., Costa, C., Gama, M., & Martins‐Green, M. M. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.07.043 · Cited by 86
Sun, H., Chang, M. Y. Z., Cheng, W.-I., Wang, Q., Commisso, A. J., Capeling, M. M., Wu, Y., & Cheng, C. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.10.016 · Cited by 84
Nanopharmaceuticals for wound healing – Lost in translation?
Ashtikar, M., & Wacker, M. G. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.03.005 · Cited by 84
Polyoxazoline biointerfaces by surface grafting
Morgese, G., & Benetti, E. M. (2016) · European Polymer Journal · doi:10.1016/j.eurpolymj.2016.11.003 · Cited by 87
Biomedical applications of gold nanomaterials: opportunities and challenges
Sasidharan, A., & Monteiro-Riviere, N. A. (2015) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1341 · Cited by 83
The influence of polymer architecture on in vitro pDNA transfection
Rinkenauer, A. C., Schubert, S., Traeger, A., & Schubert, U. S. (2015) · Journal of Materials Chemistry B · doi:10.1039/c5tb00782h · Cited by 88
Self-citationChoi, A. W., Louie, M., Li, S. P., Liu, H.-W., Chan, B. T.-N., Lam, T. C.-Y., Lin, A. C.-C., Cheng, S. H., & Lo, K. K. (2012) · Inorganic Chemistry · doi:10.1021/ic301948d · Cited by 83
Bunker, A. (2012) · Physics Procedia · doi:10.1016/j.phpro.2012.05.004 · Cited by 86
Enhanced Biostability of Nanoparticle-Based Drug Delivery Systems by Albumin Corona
Peng, Q., Wei, X., Yang, Q., Zhang, S., Zhang, T., Shao, X., Cai, X., Zhang, Z., & Lin, Y. (2015) · Nanomedicine · doi:10.2217/nnm.14.86 · Cited by 84
Shi, S., Huang, Y., Chen, X., Weng, J., & Zheng, N. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b03106 · Cited by 83
Gambogic acid-loaded biomimetic nanoparticles in colorectal cancer treatment
Zhang, Z., Qian, H., Yang, M., Li, R., Hu, J. Y., Li, L., Yu, L., Liu, B., & Qian, X. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s127256 · Cited by 83
Targeting neutrophils using novel drug delivery systems in chronic respiratory diseases
Chellappan, D. K., Yee, L. W., Xuan, K. Y., Kunalan, K., Rou, L. C., Jean, L. S., Ying, L. Y., Wie, L. X., Chellian, J., Mehta, M., et al. (2020) · Drug Development Research · doi:10.1002/ddr.21648 · Cited by 82
Nanomedicine: A Promising Way to Manage Alzheimer’s Disease
Khan, N. H., Mir, M., Ngowi, E. E., Zafar, U., Khakwani, M. M. A. K., Khattak, S., Zhai, Y., Jiang, E., Zheng, M., Duan, S., et al. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.630055 · Cited by 84
Yang, Z., Zhang, Z., Sun, Y., Lei, Z., Wang, D., Ma, H., & Tang, B. Z. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120934 · Cited by 84
Metadata
- Authors
- Knop, K., Hoogenboom, R., Fischer, D., & Schubert, U. S.
- Affiliations
- Dutch Polymer Institute (NL)
- Friedrich Schiller University Jena (DE)
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2010-07-20
- Volume
- 49
- Issue
- 36
- Pages
- 6288-6308
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2164841185
- Cited by
- 3,533
- References
- 219
- Citations by year
- 2026: 176 · 2025: 207 · 2024: 191 · 2023: 213 · 2022: 255 · 2021: 270 · 2020: 259 · 2019: 260 · 2018: 277 · 2017: 234 · 2016: 275 · 2015: 254 · 2014: 206 · 2013: 180 · 2012: 159
- FWCI
- 7.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Angewandte Chemie International Edition (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- DIAL (Catholic University of Leuven) (submittedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
- Keywords
- polyethylene glycol, PEGylation, stealth polymers, polymeric drug delivery, hypersensitivity, pharmacokinetics, polymer degradation
- MeSH terms
- Biocompatible Materials, Drug Carriers, Pharmaceutical Preparations, Polyethylene Glycols, Polymers
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
