Cited by 3,533Nanoparticle-Based Drug DeliveryAdvanced Drug Delivery SystemsDendrimers and Hyperbranched Polymers

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Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives

Knop, Katrin, Hoogenboom, Richard, Fischer, Dagmar, Schubert, Ulrich S.·2010·Angewandte Chemie International Edition

DOI 10.1002/anie.200902672

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Abstract

Poly(ethylene glycol) (PEG) is the most used polymer and also the gold standard for stealth polymers in the emerging field of polymer‐based drug delivery. The properties that account for the overwhelming use of PEG in biomedical applications are outlined in this Review. The first approved PEGylated products have already been on the market for 20 years. A vast amount of clinical experience has since been gained with this polymer—not only benefits, but possible side effects and complications have also been found. The areas that might need consideration and more intensive and careful examination can be divided into the following categories: hypersensitivity, unexpected changes in pharmacokinetic behavior, toxic side products, and an antagonism arising from the easy degradation of the polymer under mechanical stress as a result of its ether structure and its non‐biodegradability, as well as the resulting possible accumulation in the body. These possible side effects will be discussed in this Review and alternative polymers will be evaluated.

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Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review
Maeda, H., Wu, J., Sawa, T., Matsumura, Y., & Hori, K. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00248-5 · Cited by 6,565
Recent advances with liposomes as pharmaceutical carriers
Torchilin, V. P. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1632 · Cited by 5,282
Drug Delivery Systems: Entering the Mainstream
Allen, T. M., & Cullis, P. R. (2004) · Science · doi:10.1126/science.1095833 · Cited by 4,552
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
Moghimi, S. M., Hunter, A. C., & Murray, J. C. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01494-7 · Cited by 3,521
Thermo- and pH-responsive polymers in drug delivery☆
SCHMALJOHANN, D. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.09.020 · Cited by 3,023
Biodegradable Long-Circulating Polymeric Nanospheres
Gref, R., Minamitake, Y., Peracchia, M. T., Trubetskoy, V. S., Torchilin, V. P., & Langer, R. (1994) · Science · doi:10.1126/science.8128245 · Cited by 2,951
Synthetic biodegradable polymers as orthopedic devices
Middleton, J. C., & Tipton, A. J. (2000) · Biomaterials · doi:10.1016/s0142-9612(00)00101-0 · Cited by 2,741
PEGylation, successful approach to drug delivery
Veronese, F. M., & Pasut, G. (2005) · Drug Discovery Today · doi:10.1016/s1359-6446(05)03575-0 · Cited by 2,344
Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes
Klibanov, A. L., Maruyama, K., Torchilin, V. P., & Huang, L. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)81016-h · Cited by 2,030
Polymer conjugates as anticancer nanomedicines
Duncan, R. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1958 · Cited by 1,956

Show all 219 references

Research works printed but not linked: 13

Bhadra D., 2002, Pharmazie, 57, 5
Woodle M. C., 1990, Proc. Int. Symp. Controlled Release Bioact. Mater., 17, 77
2007, Encyclopedia of Polymer Science and Technology
Kwon O. H., 2003, J. Ind. Eng. Chem., 9, 138
Le Coz C.‐J., 2001, Contact Dermatitis, 44, 308
J. M. Metselaar Dissertation Dept. Pharmaceutics Utrecht Institute for Pharmaceutical Sciences Utrecht University The Netherlands 2006.
de Groot M. C. H., 2004, Ned. Tijdschr. Geneeskd., 148, 1887
Hinds K. D., 2005, Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids
10.1021/ie070287 · DOI
Li C., 1999, Clin. Cancer Res., 5, 891
Li C., 1998, Cancer Res., 58, 2404
You E. S., 2007, J. Ind. Eng. Chem., 13, 219
10.1021/ma052593 · DOI

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Authors: Knop, K., Hoogenboom, R., Fischer, D., & Schubert, U. S.
Affiliations: Dutch Polymer Institute (NL)
Friedrich Schiller University Jena (DE)
ORCID: Hoogenboom, Richard
Fischer, Dagmar
Schubert, Ulrich S.
Venue: Angewandte Chemie International Edition
Publisher: Wiley
Published: 2010-07-20
Volume: 49
Issue: 36
Pages: 6288-6308
ISSN: 1433-7851 (ISSN-L)
1521-3773
DOI: 10.1002/anie.200902672
OpenAlex: W2164841185
Cited by: 3,533
References: 219
Citations by year: 2026: 176 · 2025: 207 · 2024: 191 · 2023: 213 · 2022: 255 · 2021: 270 · 2020: 259 · 2019: 260 · 2018: 277 · 2017: 234 · 2016: 275 · 2015: 254 · 2014: 206 · 2013: 180 · 2012: 159
FWCI: 7.02
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Angewandte Chemie International Edition (publishedVersion)
PubMed (publishedVersion)
Ghent University Academic Bibliography (Ghent University) (submittedVersion)
DIAL (Catholic University of Leuven) (submittedVersion)
Topics: Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
Keywords: polyethylene glycol, PEGylation, stealth polymers, polymeric drug delivery, hypersensitivity, pharmacokinetics, polymer degradation
MeSH terms: Biocompatible Materials, Drug Carriers, Pharmaceutical Preparations, Polyethylene Glycols, Polymers

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Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives

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