Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives

Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review

Maeda, H., Wu, J., Sawa, T., Matsumura, Y., & Hori, K. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00248-5 · Cited by 6,565

Recent advances with liposomes as pharmaceutical carriers

Torchilin, V. P. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1632 · Cited by 5,282

Drug Delivery Systems: Entering the Mainstream

Allen, T. M., & Cullis, P. R. (2004) · Science · doi:10.1126/science.1095833 · Cited by 4,552

Long-Circulating and Target-Specific Nanoparticles: Theory to Practice

Moghimi, S. M., Hunter, A. C., & Murray, J. C. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01494-7 · Cited by 3,521

Thermo- and pH-responsive polymers in drug delivery☆

SCHMALJOHANN, D. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.09.020 · Cited by 3,023

Biodegradable Long-Circulating Polymeric Nanospheres

Gref, R., Minamitake, Y., Peracchia, M. T., Trubetskoy, V. S., Torchilin, V. P., & Langer, R. (1994) · Science · doi:10.1126/science.8128245 · Cited by 2,951

Synthetic biodegradable polymers as orthopedic devices

Middleton, J. C., & Tipton, A. J. (2000) · Biomaterials · doi:10.1016/s0142-9612(00)00101-0 · Cited by 2,741

PEGylation, successful approach to drug delivery

Veronese, F. M., & Pasut, G. (2005) · Drug Discovery Today · doi:10.1016/s1359-6446(05)03575-0 · Cited by 2,344

Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes

Klibanov, A. L., Maruyama, K., Torchilin, V. P., & Huang, L. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)81016-h · Cited by 2,030

Polymer conjugates as anticancer nanomedicines

Duncan, R. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1958 · Cited by 1,956

Polymer-lipid hybrid systems: merging the benefits of polymeric and lipid-based nanocarriers to improve oral drug delivery

Rao, S., & Prestidge, C. A. (2016) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2016.1151872 · Cited by 121

Efficient, pH‐Triggered Drug Delivery Using a pH‐Responsive DNA‐Conjugated Gold Nanoparticle

Song, L., Ho, V. H. B., Chen, C., Yang, Z., Liu, D., Chen, R., & Zhou, D. (2012) · Advanced Healthcare Materials · doi:10.1002/adhm.201200112 · Cited by 125

Designed guanidinium-rich amphipathic oligocarbonate molecular transporters complex, deliver and release siRNA in cells

Stanzl, E. G., Cooley, C. B., Simon, J., Kiesewetter, M. K., Edward, J. A., Hickerson, R. P., Kaspar, R. L., Hedrick, J. L., Waymouth, R. M., & Wender, P. A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1211361109 · Cited by 120

Ginsenosides emerging as both bifunctional drugs and nanocarriers for enhanced antitumor therapies

Wang, H., Zheng, Y., Sun, Q., Zhang, Z., Zhao, M., Peng, C. Y., & Shi, S. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-01062-5 · Cited by 120

Delivery of Cancer Therapeutics Using Nanotechnology

Lim, E., Jang, E., Lee, K., Haam, S., & Huh, Y. (2013) · Pharmaceutics · doi:10.3390/pharmaceutics5020294 · Cited by 120

Prodrugs of triterpenoids and their derivatives

Zhou, M., Zhang, R., Wang, M., Xu, G., & Liao, S. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.03.005 · Cited by 120

Contribution of Kupffer cells to liposome accumulation in the liver

Samuelsson, E., Shen, H., Blanco, E., Mauro Ferrari, B., & Wolfram, J. (2017) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2017.07.014 · Cited by 123

Bioinspired Shielding Strategies for Nanoparticle Drug Delivery Applications

Gulati, N. M., Stewart, P. L., & Steinmetz, N. F. (2018) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b00292 · Cited by 119

Hydrophilicity Regulates the Stealth Properties of Polyphosphoester‐Coated Nanocarriers

Simon, J., Wolf, T., Klein, K., Landfester, K., Wurm, F. R., & Mailänder, V. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201800272 · Cited by 119

Enhanced Permeability and Retention-like Extravasation of Nanoparticles from the Vasculature into Tuberculosis Granulomas in Zebrafish and Mouse Models

Fenaroli, F., Repnik, U., Xu, Y., Johann, K., Herck, S. V., Dey, P., Skjeldal, F. M., Frei, D. M., Bagherifam, S., Kocere, A., et al. (2018) · ACS Nano · doi:10.1021/acsnano.8b04433 · Cited by 121

Effects of pharmaceutical PEGylation on drug metabolism and its clinical concerns

Zhang, X., Wang, H., Ma, Z., & Wu, B. (2014) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2014.967679 · Cited by 117

Upconversion processes: versatile biological applications and biosafety

Gulzar, A., Xu, J., Yang, P., He, F., & Xu, L. (2017) · Nanoscale · doi:10.1039/c7nr01836c · Cited by 121

Controlling cell adhesion using layer-by-layer approaches for biomedical applications

Guo, S., Zhu, X., & Loh, X. J. (2016) · Materials Science and Engineering C · doi:10.1016/j.msec.2016.03.074 · Cited by 116

Cancer‐Targeted Nanomedicine: Overcoming the Barrier of the Protein Corona

Barui, A. K., Oh, J. Y., Jana, B., Kim, C., & Ryu, J. (2019) · Advanced Therapeutics · doi:10.1002/adtp.201900124 · Cited by 117

mRNA delivery systems for cancer immunotherapy: Lipid nanoparticles and beyond

Sentí, M. E., del Valle, L. G., & Schiffelers, R. M. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115190 · Cited by 124

Redox‐Responsive Nanoparticle‐Mediated Systemic RNAi for Effective Cancer Therapy

Xu, X., Wu, J., Liu, S., Saw, P. E., Tao, W., Li, Y., Krygsman, L., Yegnasubramanian, S., Marzo, A. M. D., Shi, J., et al. (2018) · Small · doi:10.1002/smll.201802565 · Cited by 115

Functional Polylactide-g-Paclitaxel–Poly(ethylene glycol) by Azide–Alkyne Click Chemistry

Yu, Y., Zou, J., Yu, L., Ji, W., Li, Y., Law, W., & Cheng, C. (2011) · Macromolecules · doi:10.1021/ma2005102 · Cited by 120

Nanomaterials engineering for drug delivery: a hybridization approach

Mohammadi, M. R., Nojoomi, A., Mozafari, M., Dubņika, A., Inayathullah, M., & Rajadas, J. (2017) · Journal of Materials Chemistry B · doi:10.1039/c6tb03247h · Cited by 113

Targeted Delivery to Tumors: Multidirectional Strategies to Improve Treatment Efficiency

Kutova, O. M., Guryev, E. L., Соколова, Е. А., Alzeibak, R., & Balalaeva, I. V. (2019) · Cancers · doi:10.3390/cancers11010068 · Cited by 115

Challenges and Opportunities in the Delivery of Cancer Therapeutics: Update on Recent Progress

Lorscheider, M., Gaudin, A., Nakhlé, J., Veiman, K.-L., Richard, J., & Chassaing, C. (2020) · Therapeutic Delivery · doi:10.4155/tde-2020-0079 · Cited by 113

Drug-encapsulated blend of PLGA-PEG microspheres: in vitro and in vivo study of the effects of localized/targeted drug delivery on the treatment of triple-negative breast cancer

Jusu, S. M., Obayemi, J. D., Salifu, A. A., Nwazojie, C. C., Uzonwanne, V., Odusanya, O. S., & Soboyejo, W. O. (2020) · Scientific Reports · doi:10.1038/s41598-020-71129-0 · Cited by 112

The Tumor Proteolytic Landscape: A Challenging Frontier in Cancer Diagnosis and Therapy

Vizovišek, M., Ristanovic, D., Menghini, S., Christiansen, M. G., & Schuerle, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052514 · Cited by 118

Combining Stem Cells and Biomaterial Scaffolds for Constructing Tissues and Cell Delivery

Willerth, S. M., & Sakiyama‐Elbert, S. E. (2019) · StemJournal · doi:10.3233/stj-180001 · Cited by 114

Glycans as Biofunctional Ligands for Gold Nanorods: Stability and Targeting in Protein-Rich Media

Garcı́a, I., Sánchez‐Iglesias, A., Henriksen‐Lacey, M., Grzelczak, M., Penadés, S., & Liz‐Marzán, L. M. (2015) · Journal of the American Chemical Society · doi:10.1021/jacs.5b01001 · Cited by 112

Pre-existing anti-polyethylene glycol antibody reduces the therapeutic efficacy and pharmacokinetics of PEGylated liposomes

Hsieh, Y.-C., Wang, H.-E., Lin, W.-W., Roffler, S. R., Cheng, T.-C., Su, Y.-C., Li, J.-J., Chen, C., Huang, C.-H., Chen, B., et al. (2018) · Theranostics · doi:10.7150/thno.22164 · Cited by 111

Protein PEPylation: A New Paradigm of Protein–Polymer Conjugation

Hou, Y., & Lu, H. (2019) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.9b00236 · Cited by 112

Poly(2‐oxazoline)‐ and Poly(2‐oxazine)‐Based Self‐Assemblies, Polyplexes, and Drug Nanoformulations—An Update

Zahoranová, A., & Luxenhofer, R. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202001382 · Cited by 115

Functionalization of Strongly Interacting Magnetic Nanocubes with (Thermo)Responsive Coating and Their Application in Hyperthermia and Heat-Triggered Drug Delivery

Kakwere, H., Leal, M. P., Materia, M. E., Curcio, A., Guardia, P., Niculaes, D., Marotta, R., Falqui, A., & Pellegrino, T. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/am5088117 · Cited by 112

25th Anniversary Article: Interfacing Nanoparticles and Biology: New Strategies for Biomedicine

Tonga, G. Y., Saha, K., & Rotello, V. M. (2013) · Advanced Materials · doi:10.1002/adma.201303001 · Cited by 112

Poly(2-oxazoline)-based stimulus-responsive (Co)polymers: An overview of their design, solution properties, surface-chemistries and applications

Jana, S., & Uchman, M. (2020) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2020.101252 · Cited by 112

Partial Hydrolysis of Poly(2‐ethyl‐2‐oxazoline) and Potential Implications for Biomedical Applications?

van Kuringen, H. P. C., Lenoir, J., Adriaens, E., Bender, J. C. M. E., Geest, B. G. D., & Hoogenboom, R. (2012) · Macromolecular Bioscience · doi:10.1002/mabi.201200080 · Cited by 110

Recent advances in biocompatible nanocarriers for delivery of chemotherapeutic cargoes towards cancer therapy

Ang, C. Y., Tan, S. Y., & Zhao, Y. (2014) · Organic & Biomolecular Chemistry · doi:10.1039/c4ob00164h · Cited by 111

Degradable and Comb-Like PEG-Based Copolymers by Nitroxide-Mediated Radical Ring-Opening Polymerization

Delplace, V., Tardy, A., Harrisson, S., Mura, S., Gigmès, D., Guillaneuf, Y., & Nicolas, J. (2013) · Biomacromolecules · doi:10.1021/bm401157g · Cited by 109

Topology Effects on the Structural and Physicochemical Properties of Polymer Brushes

Divandari, M., Morgese, G., Trachsel, L., Romio, M., Dehghani, E. S., Rosenboom, J., Paradisi, C., Zenobi‐Wong, M., Ramakrishna, S. N., & Benetti, E. M. (2017) · Macromolecules · doi:10.1021/acs.macromol.7b01720 · Cited by 109

Cancer cell membrane-coated rare earth doped nanoparticles for tumor surgery navigation in NIR-II imaging window

Zhang, X., He, S., Ding, B., Qu, C., Zhang, Q., Chen, H., Sun, Y., Fang, H., Long, Y., Zhang, R., et al. (2019) · Chemical Engineering Journal · doi:10.1016/j.cej.2019.123959 · Cited by 110

Biomimetic Nano-Drug Delivery System: An Emerging Platform for Promoting Tumor Treatment

Han, X., Gong, C., Yang, Q., Zheng, K., Wang, Z., & Zhang, W. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s442877 · Cited by 116

pH and reduction dual responsive polyurethane triblock copolymers for efficient intracellular drug delivery

Yu, S., He, C., Ding, J., Cheng, Y., Song, W., Zhuang, X., & Chen, X. (2013) · Soft Matter · doi:10.1039/c2sm27616j · Cited by 108

Water‐Dispersible Fullerene Aggregates as a Targeted Anticancer Prodrug with both Chemo‐ and Photodynamic Therapeutic Actions

Fan, J., Fang, G., Zeng, F., Wang, X., & Wu, S. (2012) · Small · doi:10.1002/smll.201201456 · Cited by 108

Poly(ethylene glycol-co-allyl glycidyl ether)s: A PEG-Based Modular Synthetic Platform for Multiple Bioconjugation

Obermeier, B., & Frey, H. (2011) · Bioconjugate Chemistry · doi:10.1021/bc1004747 · Cited by 108

The architecture and biological performance of drug-loaded LbL nanoparticles

Morton, S. W., Poon, Z., & Hammond, P. T. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.03.059 · Cited by 108

Targeted cancer drug delivery with aptamer-functionalized polymeric nanoparticles

Vahed, S. Z., Fathi, N., Samiei, M., Dizaj, S. M., & Sharifi, S. (2018) · Journal of drug targeting · doi:10.1080/1061186x.2018.1491978 · Cited by 108

PEG-Detachable Polymeric Micelles Self-Assembled from Amphiphilic Copolymers for Tumor-Acidity-Triggered Drug Delivery and Controlled Release

Xu, M., Zhang, C. Y., Wu, J., Zhou, H., Bai, R., Shen, Z., Deng, F., Liu, Y., & Liu, J. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b13059 · Cited by 109

Sub‐50 nm Nanoparticles with Biomimetic Surfaces to Sequentially Overcome the Mucosal Diffusion Barrier and the Epithelial Absorption Barrier

Zhu, X. D., Wu, J., Shan, W., Zhou, Z., Liu, M., & Huang, Y. (2016) · Advanced Functional Materials · doi:10.1002/adfm.201505000 · Cited by 107

High-performance porous PLLA-based scaffolds for bone tissue engineering: Preparation, characterization, and in vitro and in vivo evaluation

Ju, J., Peng, X., Huang, K., Li, L., Liu, X., Chitrakar, C., Chang, L., Gu, Z., & Kuang, T. (2019) · Polymer · doi:10.1016/j.polymer.2019.121707 · Cited by 107

Solid lipid-based nanocarriers as efficient targeted drug and gene delivery systems

Dolatabadi, J. E. N., & Omidi, Y. (2016) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2015.12.016 · Cited by 106

Tumor acidity-sensitive linkage-bridged block copolymer for therapeutic siRNA delivery

Xu, C., Zhang, H., Sun, C., Liu, Y., Shen, S., Yang, X., Zhu, Y., & Wang, J. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.02.031 · Cited by 106

Nanosized Delivery Systems for Therapeutic Proteins: Clinically Validated Technologies and Advanced Development Strategies

Moncalvo, F., Espinoza, M. I. M., & Cellesi, F. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00089 · Cited by 106

Polyoxazoline: A review article from polymerization to smart behaviors and biomedical applications

Mahand, S. N., Aliakbarzadeh, S., Moghaddam, A., Moghaddam, A. S., Kruppke, B., Nasrollahzadeh, M., & Khonakdar, H. A. (2022) · European Polymer Journal · doi:10.1016/j.eurpolymj.2022.111484 · Cited by 106

The future of poly(2-oxazoline)s

Hoogenboom, R. (2022) · European Polymer Journal · doi:10.1016/j.eurpolymj.2022.111521 · Cited by 106

Anti-PEG Antibodies and Their Biological Impact on PEGylated Drugs: Challenges and Strategies for Optimization

Fu, S., Zhu, X., Fanghua, H., & Chen, X. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17081074 · Cited by 106

Application of Isothermal Titration Calorimetry for Characterizing Thermodynamic Parameters of Biomolecular Interactions: Peptide Self-Assembly and Protein Adsorption Case Studies

Kabiri, M., & Unsworth, L. D. (2014) · Biomacromolecules · doi:10.1021/bm5004515 · Cited by 111

Fluorescence imaging of cancer tissue based on metal-free polymeric nanoparticles – a review

Vollrath, A., Schubert, S., & Schubert, U. S. (2013) · Journal of Materials Chemistry B · doi:10.1039/c3tb20089b · Cited by 105

The role of polymer size and hydrophobic end-group in PEG–protein interaction

Bekale, L. A., Agudelo, D., & Tajmir‐Riahi, H. A. (2015) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2015.03.045 · Cited by 105

Upconversion nanophosphors for use in bioimaging, therapy, drug delivery and bioassays

Yang, Y. (2013) · Microchimica Acta · doi:10.1007/s00604-013-1139-8 · Cited by 104

Reversal of multidrug resistance by the inhibition of ATP-binding cassette pumps employing “Generally Recognized As Safe” (GRAS) nanopharmaceuticals: A review

Sosnik, A. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.09.002 · Cited by 106

Hydrogel biomaterials and their therapeutic potential for muscle injuries and muscular dystrophies

Lev, R., & Seliktar, D. (2018) · Journal of The Royal Society Interface · doi:10.1098/rsif.2017.0380 · Cited by 105

Rare Earth Metal-Mediated Precision Polymerization of Vinylphosphonates and Conjugated Nitrogen-Containing Vinyl Monomers

Soller, B. S., Salzinger, S., & Rieger, B. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00313 · Cited by 104

PLGA's Plight and the Role of Stealth Surface Modification Strategies in Its Use for Intravenous Particulate Drug Delivery

Sheffey, V. V., Siew, E. B., Tanner, E. E. L., & Eniola‐Adefeso, O. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202101536 · Cited by 103

Polymeric particle-based therapies for acute inflammatory diseases

Brannon, E. R., Guevara, M. V., Pacifici, N. J., Lee, J. K., Lewis, J. S., & Eniola‐Adefeso, O. (2022) · Nature Reviews Materials · doi:10.1038/s41578-022-00458-5 · Cited by 103

Nanoparticle technology for treatment of Parkinson’s disease: The role of surface phenomena in reaching the brain

Leyva-Gómez, G., Cortés, H., Magaña, J. J., Leyva-García, N., Quintanar-Guerrero, D., & Florán, B. (2015) · Drug Discovery Today · doi:10.1016/j.drudis.2015.02.009 · Cited by 102

Charge-conversional and reduction-sensitive poly(vinyl alcohol) nanogels for enhanced cell uptake and efficient intracellular doxorubicin release

Chen, W., Achazi, K., Schade, B., & Haag, R. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.11.012 · Cited by 102

Nanoparticles for Targeted and Temporally Controlled Drug Delivery

Swami, A., Shi, J., Gadde, S., Votruba, A. R., Kolishetti, N., & Farokhzad, O. C. (2012) · Nanostructure science and technology · doi:10.1007/978-1-4614-2305-8_2 · Cited by 108

Systematic investigation of functional ligands for colloidal stable upconversion nanoparticles

Duong, H. T. T., Chen, Y., Tawfik, S. A., Wen, S., Parviz, M., Ford, M. J., Shimoni, O., & Jin, D. (2018) · RSC Advances · doi:10.1039/c7ra13765f · Cited by 102

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Jin, H., Yang, L., Ahonen, M. J. R., & Schoenfisch, M. H. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b07661 · Cited by 103

Liposomes, transfersomes and niosomes: production methods and their applications in the vaccinal field

Riccardi, D., Baldino, L., & Reverchon, E. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05160-4 · Cited by 102

Regulating the surface poly(ethylene glycol) density of polymeric nanoparticles and evaluating its role in drug delivery in vivo

Du, X., Wang, J., Liu, W.-W., Yang, J., Sun, C., Sun, R., Li, H.-J., Shen, S., Luo, Y., Xiao-dong, Y., et al. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.07.048 · Cited by 106

Is there a clinical future for polymeric nanoparticles as brain-targeting drug delivery agents?

Costantino, L., & Boraschi, D. (2011) · Drug Discovery Today · doi:10.1016/j.drudis.2011.10.028 · Cited by 103

Water-soluble and fluorescent dendritic perylene bisimides for live-cell imaging

Gao, B., Li, H., Liu, H., Zhang, L., Bai, Q., & Ba, X. (2011) · Chemical Communications · doi:10.1039/c1cc00058f · Cited by 101

Formation of Stable Nanocarriers by in Situ Ion Pairing during Block-Copolymer-Directed Rapid Precipitation

Pinkerton, N. M., Grandeury, A., Fisch, A., Brozio, J., Riebesehl, B. U., & Prud’homme, R. K. (2012) · Molecular Pharmaceutics · doi:10.1021/mp300452g · Cited by 101

Three-Fold Metal-Free Efficient (“Click”) Reactions onto a Multifunctional Poly(2-oxazoline) Designer Scaffold

Kempe, K., Hoogenboom, R., Jaeger, M., & Schubert, U. S. (2011) · Macromolecules · doi:10.1021/ma201385k · Cited by 106

Amphiphilic Polymer-Mediated Formation of Laponite-Based Nanohybrids with Robust Stability and pH Sensitivity for Anticancer Drug Delivery

Wang, G., Maciel, D., Wu, Y., Rodrigues, J., Shi, X., Yuan, Y., Liu, C., Tomás, H., & Li, Y. (2014) · ACS Applied Materials & Interfaces · doi:10.1021/am5032874 · Cited by 101

PEG as an alternative reaction medium in metal-mediated transformations

Colacino, E., Martínez, J., Lamaty, F., Patrikeeva, L. S., Khemchyan, L. L., Ananikov, V. P., & Beletskaya, I. P. (2012) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2012.05.027 · Cited by 100

Immunoliposomes in clinical oncology: State of the art and future perspectives

Merino, M., Zalba, S., & Garrido, M. J. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.02.015 · Cited by 100

Adaptive Polymersome Nanoreactors

Che, H., & van Hest, J. C. M. (2019) · ChemNanoMat · doi:10.1002/cnma.201900245 · Cited by 103

Branched PEG-modification: A new strategy for nanocarriers to evade of the accelerated blood clearance phenomenon and enhance anti-tumor efficacy

Liu, M., Li, J., Zhao, D., Yan, N. J., Zhang, H., Liu, M., Tang, X., Hu, Y., Ding, J., Zhang, N., et al. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121415 · Cited by 100

Drug conjugate-based anticancer therapy - Current status and perspectives

Yang, Y., Wang, S., Ma, P., Jiang, Y., Cheng, K., Yu, Y., Jiang, N., Miao, H., Tang, Q., Liu, F., et al. (2022) · Cancer Letters · doi:10.1016/j.canlet.2022.215969 · Cited by 101

Exploring the Application of Micellar Drug Delivery Systems in Cancer Nanomedicine

Wang, Q., Atluri, K., Tiwari, A. K., & Babu, R. J. (2023) · Pharmaceuticals · doi:10.3390/ph16030433 · Cited by 104

A Polymer Chemistry Point of View on Mucoadhesion and Mucopenetration

Schattling, P., Taipaleenmäki, E., Zhang, Y., & Städler, B. (2017) · Macromolecular Bioscience · doi:10.1002/mabi.201700060 · Cited by 100

Hydrogels for therapeutic cardiovascular angiogenesis

Rufaihah, A. J., & Seliktar, D. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.07.003 · Cited by 101

Glucagon-Like Peptide-1 Receptor Agonists and Strategies To Improve Their Efficiency

Alavi, S. E., Cabot, P. J., & Moyle, P. M. (2019) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.9b00308 · Cited by 100

Gold nanoparticles-mediated photothermal and photodynamic therapies for cancer

Koc, S. N. T., Benam, S. R., Aral, İ. P., Shahbazi, R., & Ulubayram, K. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124057 · Cited by 99

Morphology‐Tailoring of a Red AIEgen from Microsized Rods to Nanospheres for Tumor‐Targeted Bioimaging

Li, Y., Shao, A., Wang, Y., Mei, J., Niu, D., Gu, J., Shi, P., Zhu, W., Tian, H., & Shi, J. (2016) · Advanced Materials · doi:10.1002/adma.201504782 · Cited by 98

Evasion of the accelerated blood clearance phenomenon by polysarcosine coating of liposomes

Son, K., Ueda, M., Taguchi, K., Maruyama, T., Takeoka, S., & Ito, Y. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.03.022 · Cited by 98

Controllable C–H Alkylation of Polyethers via Iron Photocatalysis

Zhang, Z., Li, X., Zhou, D., Ding, S., Wang, M., & Zeng, R. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.3c01100 · Cited by 98

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Patel, D., Solanki, J. D., Kher, M. M., & Azagury, A. (2024) · Small · doi:10.1002/smll.202401990 · Cited by 98

Biodegradable Block Copolymer Micelles with Thiol-Responsive Sheddable Coronas

Khorsand, B., Cunningham, A. J., Zhang, Q., & Oh, J. K. (2011) · Biomacromolecules · doi:10.1021/bm2011032 · Cited by 97

μPET imaging of the pharmacokinetic behavior of medium and high molar mass 89Zr-labeled poly(2-ethyl-2-oxazoline) in comparison to poly(ethylene glycol)

Wyffels, L., Verbrugghen, T., Monnery, B. D., Glaßner, M., Stroobants, S. G., Hoogenboom, R., & Staelens, S. G. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.05.048 · Cited by 97

Tuning the Drug Loading and Release of DNA‐Assembled Gold‐Nanorod Superstructures

Raeesi, V., Chou, L. Y. T., & Chan, W. C. W. (2016) · Advanced Materials · doi:10.1002/adma.201600773 · Cited by 97

Polypeptides with High Zwitterion Density for Safe and Effective Therapeutics

Zhang, P., Jain, P. R., Tsao, C., Yuan, Z., Li, W., Li, B., Wu, K., Hung, H., Lin, X., & Jiang, S. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201802452 · Cited by 97

Metal‐Free Route to Precise Synthesis of Poly(propylene oxide) and Its Blocks with High Activity

Zhang, C., Duan, H., Hu, L., Zhang, C., & Zhang, X. (2018) · ChemSusChem · doi:10.1002/cssc.201802258 · Cited by 97

Polymeric siRNA gene delivery – transfection efficiency versus cytotoxicity

Kargaard, A., Sluijter, J. P. G., & Klumperman, B. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.10.046 · Cited by 100

Well-Defined Protein/Peptide–Polymer Conjugates by Aqueous Cu-LRP: Synthesis and Controlled Self-Assembly

Zhang, Q., Li, M., Zhu, C., Nurumbetov, G., Li, Z., Wilson, P., Kempe, K., & Haddleton, D. M. (2015) · Journal of the American Chemical Society · doi:10.1021/jacs.5b04139 · Cited by 97

Nanovaccines for malaria using Plasmodium falciparum antigen Pfs25 attached gold nanoparticles

Kumar, R., Ray, P. C., Datta, D., Bansal, G. P., Angov, E., & Kumar, N. (2015) · Vaccine · doi:10.1016/j.vaccine.2015.08.025 · Cited by 100

Poly(trehalose): Sugar-Coated Nanocomplexes Promote Stabilization and Effective Polyplex-Mediated siRNA Delivery

Sizovs, A., Xue, L., Tolstyka, Z. P., Ingle, N. P., Wu, Y., Cortez, M. A., & Reineke, T. M. (2013) · Journal of the American Chemical Society · doi:10.1021/ja404941p · Cited by 97

Post-fabrication modification of forward osmosis membranes with a poly(ethylene glycol) block copolymer for improved organic fouling resistance

Shaffer, D. L., Jaramillo, H., Castrillón, S. R.-V., Lu, X., & Elimelech, M. (2015) · Journal of Membrane Science · doi:10.1016/j.memsci.2015.04.060 · Cited by 96

Cell membrane–camouflaged liposomes for tumor cell–selective glycans engineering and imaging in vivo

Liu, Z., Wang, F., Liu, X., Sang, Y., Zhang, L., Ren, J., & Qu, X. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2022769118 · Cited by 96

Lipid nanoparticle-based mRNA delivery systems for cancer immunotherapy

Han, J., Lim, J., Wang, C. J., Han, J., Shin, H. E., Kim, S.-N., Jeong, D., Lee, S. H., Chun, B.-H., Park, C. G., et al. (2023) · Nano Convergence · doi:10.1186/s40580-023-00385-3 · Cited by 100

A degradable brush polymer–drug conjugate for pH-responsive release of doxorubicin

Yu, Y., Chen, C.-K., Law, W., Sun, H., Prasad, P. N., & Cheng, C. (2014) · Polymer Chemistry · doi:10.1039/c4py01194e · Cited by 95

Dual-pH Sensitive Charge-reversal Nanocomplex for Tumor-targeted Drug Delivery with Enhanced Anticancer Activity

Zhou, Q., Hou, Y., Zhang, L., Wang, J., Qiao, Y., Guo, S., Fan, L., Yang, T., Zhu, L., & Wu, H. (2017) · Theranostics · doi:10.7150/thno.18607 · Cited by 96

Silk‐Inspired β‐Peptide Materials Resist Fouling and the Foreign‐Body Response

Zhang, D., Chen, Q., Zhang, W., Liu, H., Wan, J., Qian, Y., Li, B., Tang, S., Liu, Y., Chen, S., et al. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202000416 · Cited by 95

Anwendung von Poly(ethylenglycol) beim Wirkstoff‐Transport: Vorteile, Nachteile und Alternativen

Knop, K., Hoogenboom, R., Fischer, D., & Schubert, U. S. (2010) · Angewandte Chemie · doi:10.1002/ange.200902672 · Cited by 121

Polyethylene glycol: Properties, applications, and challenges

Gaballa, S. A., Naguib, Y. W., Mady, F. M., & Khaled, K. (2023) · Journal of advanced Biomedical and Pharmaceutical Sciences · doi:10.21608/jabps.2023.241685.1205 · Cited by 52

From PEGylation to Next-Generation Polymers: Overcoming Biological Barriers—A Review

Iminova, R., Berganayeva, G., Shepilov, D., Almabekova, A., Zhurtbayeva, A., Abdurakhmanova, L., Vassilina, G., Nurmahanova, A., Kairalapova, G., & Dyusebaeva, M. A. (2026) · Molecules · doi:10.3390/molecules31040675 · Cited by 11

The Importance of Poly(ethylene glycol) Alternatives for Overcoming PEG Immunogenicity in Drug Delivery and Bioconjugation

Hoang Thi, T. T., Pilkington, E. H., Nguyen, D. H., Lee, J. S., Park, K. D., & Truong, N. P. (2020) · Polymers · doi:10.3390/polym12020298 · Cited by 668

ChemInform Abstract: Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives.

Knop, K., Hoogenboom, R., Fischer, D., & Schubert, U. S. (2010) · ChemInform · doi:10.1002/chin.201103264 · Cited by 3