Cited by 147Luminescence and Fluorescent MaterialsNanoplatforms for cancer theranosticsMolecular Sensors and Ion Detection

In Situ Self‐Assembled Nanofibers Precisely Target Cancer‐Associated Fibroblasts for Improved Tumor Imaging

Zhao, Xiao‐Xiao, Li, Li‐Li, Zhao, Ying, An, Hong‐Wei, Cai, Qian, Lang, Jia‐Yan, Han, Xue‐Xiang, Peng, Bo +5 more·2019·Angewandte Chemie International Edition

Abstract

Tumor complexity makes the development of highly sensitive tumor imaging probes an arduous task. Here, we construct a peptide‐based near‐infrared probe that is responsive to fibroblast activation protein‐α (FAP‐α), and specifically forms nanofibers on the surface of cancer‐associated fibroblasts (CAFs) in situ. The assembly/aggregation‐induced retention (AIR) effect results in enhanced accumulation and retention of the probe around the tumor, resulting in a 5.5‐fold signal enhancement in the tumor 48 h after administration compared to that of a control molecule that does not aggregate. The probe provides a prolonged detectable window of 48 h for tumor diagnosis. The selective assembly of the probe results in a signal intensity over four‐ and fivefold higher in tumor than in the liver and kidney, respectively. With enhanced tumor imaging capability, this probe can visualize small tumors around 2 mm in diameter.

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Crossref · 10.1002/anie.201908185

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  • J-aggregate nanomedicines possessing in situ self-assembly capabilities hold the potential to redefine tumor targeting modalities through the assembly/aggregation-induced retention effect.

    “J-aggregate nanomedicines possessing in situ self-assembly capabilities hold the potential to redefine tumor targeting modalities through the assembly/aggregation-induced retention effect240.”

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Authors
Zhao, X., Li, L., Zhao, Y., An, H., Cai, Q., Lang, J., Han, X., Peng, B., Fei, Y., Liu, H., Qin, H., Nie, G., & Wang, H.
Affiliations
  • CAS Center for Excellence in Nanoscience CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology (NCNST) No. 11 Beiyitiao Zhongguancun Beijing 100190 China
  • Chinese Academy of Sciences (CN)
Corresponding author
  • Nie, Guangjun
  • Wang, Hao
Venue
Angewandte Chemie International Edition
Publisher
Wiley
Published
2019-09-12
Volume
58
Issue
43
Pages
15287-15294
ISSN
  • 1433-7851 (ISSN-L)
  • 1521-3773
OpenAlex
W2967302867
Cited by
147
References
69
Citations by year
2026: 10 · 2025: 15 · 2024: 16 · 2023: 33 · 2022: 31 · 2021: 22 · 2020: 20
FWCI
6.59
Type
journal article
Language
en
Open access
closed
Locations
  • Angewandte Chemie International Edition (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (31671028, 51873045, 51725302, 51573032 and 11621505)
  • Youth Innovation Promotion Association of the Chinese Academy of Sciences (2017053)
Topics
  • Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
  • Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
Keywords
cancer-associated fibroblasts, tumor imaging, fibroblast activation protein, peptide-based probe, self-assembled nanofibers, tumor targeting, small tumor detection, tumor microenvironment
MeSH terms
Cancer-Associated Fibroblasts, Fibroblast Activation Protein Alpha, Amino Acid Sequence, Animals, Fluorescent Dyes, Humans, Membrane Proteins, Mice, Nude, Microscopy, Electron, Scanning, Neoplasms, Endopeptidases, Peptides, Serine Endopeptidases, Tissue Distribution, Transplantation, Heterologous, Gelatinases, Coculture Techniques, Spectroscopy, Near-Infrared, Cell Line, Tumor, Mice, Nanofibers

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