Cited by 211Photodynamic Therapy Research StudiesLuminescence and Fluorescent MaterialsNanoplatforms for cancer theranostics

Time‐Dependent Photodynamic Therapy for Multiple Targets: A Highly Efficient AIE‐Active Photosensitizer for Selective Bacterial Elimination and Cancer Cell Ablation

Li, Qiyao, Li, Ying, Min, Tianliang, Gong, Junyi, Du, Lili, Phillips, David Lee, Liu, Junkai, Lam, Jacky W. Y. +7 more·2020·Angewandte Chemie International Edition

Abstract

Pathogen infections and cancer are two major human health problems. Herein, we report the synthesis of an organic salt photosensitizer (PS), called 4TPA‐BQ, by a one‐step reaction. 4TPA‐BQ presents aggregation‐induced emission features. Owing to the aggregation‐induced reactive oxygen species generated and a sufficiently small Δ EST, 4TPA‐BQ shows a satisfactorily high 1 O 2 generation efficiency of 97.8 %. In vitro and in vivo experiments confirmed that 4TPA‐BQ exhibited potent photodynamic antibacterial performance against ampicillin‐resistant Escherichia coli with good biocompatibility in a short time (15 minutes). When the incubation duration persisted long enough (12 hours), cancer cells were ablated efficiently, leaving normal cells essentially unaffected. This is the first reported time‐dependent fluorescence‐guided photodynamic therapy in one individual PS, which achieves ordered and multiple targeting simply by varying the external conditions. 4TPA‐BQ reveals new design principles for the implementation of efficient PSs in clinical applications.

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Crossref · 10.1002/anie.201909706

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Authors
Li, Q., Li, Y., Min, T., Gong, J., Du, L., Phillips, D. L., Liu, J., Lam, J. W. Y., Sung, H. H. Y., Williams, I. D., Kwok, R. T. K., Ho, C. L., Li, K., Wang, J., & Tang, B. Z.
Affiliations
  • Hong Kong University of Science and Technology (HK)
  • Shenzhen University (CN)
  • Southern University of Science and Technology (CN)
  • University of Hong Kong (HK)
  • Inner Mongolia University (CN)
Corresponding author
  • Wang, Jianguo
  • Tang, Ben Zhong
Venue
Angewandte Chemie International Edition
Publisher
Wiley
Published
2019-10-22
Volume
59
Issue
24
Pages
9470-9477
ISSN
  • 1433-7851 (ISSN-L)
  • 1521-3773
OpenAlex
W2976022258
Cited by
211
References
58
Citations by year
2026: 13 · 2025: 22 · 2024: 27 · 2023: 27 · 2022: 60 · 2021: 33 · 2020: 29
FWCI
22.41
Type
journal article
Language
en
Open access
closed
Locations
  • Angewandte Chemie International Edition (publishedVersion)
  • PubMed (publishedVersion)
  • Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
  • Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Keywords
aggregation-induced emission, photosensitizers, photodynamic therapy, singlet oxygen generation, antibacterial activity, ampicillin-resistant Escherichia coli, cancer cell ablation, reactive oxygen species
MeSH terms
A549 Cells, Animals, Chlorocebus aethiops, Escherichia coli, Humans, Photochemotherapy, Photosensitizing Agents, COS Cells, Ablation Techniques, Molecular Targeted Therapy

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