Responsive Exosome Nano-bioconjugates for Synergistic Cancer Therapy

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Crosstalk in NF-κB Signaling Pathways

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Simultaneous Fenton‐like Ion Delivery and Glutathione Depletion by MnO 2 ‐Based Nanoagent to Enhance Chemodynamic Therapy

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Theranostic nanoparticles ZIF-8@ICG for pH/NIR-responsive drug-release and NIR-guided chemo-phototherapy against non-small-cell lung cancer

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Promising alternatives of CD47 monoclonal antibody: an injectable degradable hydrogel loaded with PQ912 for postoperative immunotherapy effectively blocks CD47-SIRPα signal

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Natural killer cell-derived extracellular vesicle significantly enhanced adoptive T cell therapy against solid tumors via versatilely immunomodulatory coordination

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An efficient photochemotherapy nanoplatform based on the endogenous biosynthesis of photosensitizer in macrophage-derived extracellular vesicles

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Hierarchically Injectable Hydrogel Sequentially Delivers AntagomiR‐467a‐3p‐Loaded and AntagomiR‐874‐5p‐Loaded Satellite‐Cell‐Targeting Bioengineered Extracellular Vesicles Attenuating Sarcopenia

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Targeting Macrophages for Tumor Therapy

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Nanocarrier-based targeting of metabolic pathways for endometrial cancer: Status and future perspectives

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Exosomes as a drug delivery tool for cancer therapy: a new era for existing drugs and oncolytic viruses

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The role of exosomes in cancer‐related programmed cell death

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Manganese-Doped Potassium Chloride Nanoelectrodes to Potentiate Electrochemical Immunotherapy

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Exosomes as a Therapeutic Strategy in Cancer: Potential Roles as Drug Carriers and Immune Modulators

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Biofunctional Janus particles promote phagocytosis of tumor cells by macrophages

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Role of CD47-SIRPα Checkpoint in Nanomedicine-Based Anti-Cancer Treatment

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Phytochemical natural killer cells reprogram tumor microenvironment for potent immunotherapy of solid tumors

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Physio-chemical Modifications to Re-engineer Small Extracellular Vesicles for Targeted Anticancer Therapeutics Delivery and Imaging

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Ir(III)‐Based Photosensitizer‐Loaded M1 Macrophage Exosomes for Synergistic Photodynamic Therapy

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Prospect of extracellular vesicles in tumor immunotherapy

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Novel Strategy for Optimized Nanocatalytic Tumor Therapy: From an Updated View

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Protective role of engineered extracellular vesicles loaded quercetin nanoparticles as anti-viral therapy against SARS-CoV-2 infection: A prospective review

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Aptamer-functionalized mesenchymal stem cells-derived exosomes for targeted delivery of SN38 to colon cancer cells.

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Targeting the lipid metabolic reprogramming of tumor-associated macrophages: A novel insight into cancer immunotherapy

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An Activatable Dual Polymer Nanosystem for Photoimmunotherapy and Metabolic Modulation of Deep‐Seated Tumors

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Unveiling Invisible Extracellular Vesicles: Cutting‐Edge Technologies for Their in Vivo Visualization

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Cellular transformers for targeted therapy

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Tumor-Derived Membrane Vesicles: A Promising Tool for Personalized Immunotherapy

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Genetically engineered cell-derived nanovesicles for cancer immunotherapy

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Recent advances in stimuli-responsive hyaluronic acid-based nanodelivery systems for cancer treatment: A review

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Strategies, Challenges and Application Prospects for Exosome Engineering Modifications in Tumor Targeted Therapeutics

Ge, X., Shan, S., Lu, H., Wang, W., Gao, C., & Fu, S. (2026) · International Journal of Nanomedicine · doi:10.2147/ijn.s572435 · Cited by 15

pH-Responsive Materials for Therapy and Precision Biomedical Imaging

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Bioorthogonal chemistry mediated cell engineering for advanced cell and cell-derived vesicle therapies: Principles, progresses, and remaining challenges

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Tiny Actors in the Big Cellular World: Extracellular Vesicles Playing Critical Roles in Cancer

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Nanoconjugates-Based Stem Cell Therapy for the Management of COVID-19

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Ferritin-armed extracellular vesicles with enhanced BBB penetration and tumor-targeting ability for synergistic therapy against glioblastoma

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Engineering polymeric micelles for targeted drug delivery: “click” chemistry enabled bioconjugation strategies and emerging applications

Civril, E., Sanyal, R., & Sanyal, A. (2025) · Journal of Materials Chemistry B · doi:10.1039/d5tb02193f · Cited by 14

Engineered small extracellular vesicles as bioactive materials: Integrating engineering strategies for cargo loading and targeted delivery systems

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Immunological gadolinium-doped mesoporous carbon nanoparticles for tumor-targeted MRI and photothermal-immune co-therapy

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Membrane vesicles nanotheranostic systems: sources, engineering methods, and challenges

Nie, W., Wu, G., Zhong, H., & Xie, H. (2020) · Biomedical Materials · doi:10.1088/1748-605x/abd2c8 · Cited by 14

Engineering M1-derived nanovesicles loading with docosahexaenoic acid synergizes ferroptosis and immune activation for treating hepatocellular carcinoma

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Potential of exosomes for targeted therapy in neuroinfectious disease management: crossing the blood–brain barrier

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Unlocking the potential of mesoporous silica nanoparticles: balancing biomedical applications and safety concerns

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Exosomes: Small Vesicles with Important Roles in the Development, Metastasis and Treatment of Breast Cancer

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Activation of RIG‐I/MDA5 Signaling and Inhibition of CD47‐SIRPα Checkpoint with a Dual siRNA‐Assembled Nanoadjuvant for Robust Cancer Immunotherapy

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Transforming native exosomes to engineered drug vehicles: A smart solution to modern cancer theranostics

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Applications of nanotechnology in remodeling the tumour microenvironment for glioblastoma treatment

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In situ reprogramming of tumor-associated macrophages enhances cancer immunotherapy

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Engineered macrophage-derived exosomes via click chemistry for the treatment of osteomyelitis

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Gut–Brain–Microbiome Axis in the Regulation of Cancer Immune Escape and Immunotherapy in Tumors

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CD47-SIRPα axis in cancer therapy: Precise delivery of CD47-targeted therapeutics and design of anti-phagocytic drug delivery systems

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A STING agonist-loaded bispecific nanobioconjugate modulates macrophage immune responses to enhance antitumor immunotherapy

Nie, C., Ma, T., Ye, J., He, M., Zhang, T., Wei, K., Jiang, J., & Chu, X. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.149901 · Cited by 11

The role of extracellular vesicles in immune cell exhaustion and resistance to immunotherapy

Aghakhani, A., Pezeshki, P. S., & Rezaei, N. (2024) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2024.2360209 · Cited by 11

Regulatory role of exosome-derived miRNAs and other contents in adipogenesis

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Overcoming drug resistance through extracellular vesicle-based drug delivery system in cancer treatment

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Inorganic nanoparticle-based nanogels and their biomedical applications

Sonkar, C., Ranjan, R., & Mukhopadhyay, S. (2025) · Dalton Transactions · doi:10.1039/d4dt02986k · Cited by 11

Small extracellular vesicles: crucial mediators for prostate cancer

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Preparation and evaluation of dabrafenib-loaded, CD47-conjugated human serum albumin-based nanoconstructs for chemoimmunomodulation

Pham, L. M., Poudel, K., Phung, C. D., Nguyen, T. T., Pandit, M., Nguyen, H. T., Chang, J., Jin, S. G., Jeong, J., Ku, S., et al. (2021) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2021.112093 · Cited by 11

Tumor‐Associated Macrophages as Therapeutic Targets: Deciphering Interaction Networks and Advancing Clinical Translation

Bao, W., Qu, X., Wang, Y., Huang, D., Zhang, H., Dong, M., Sun, H., Yang, Z., & Li, X. (2026) · MedComm · doi:10.1002/mco2.70599 · Cited by 13

Bioengineering extracellular vesicles for enhanced therapeutic functionality and clinical potential in the cardiovascular system

Wang, Y., Hu, M., Spanos, M., Xu, S., Song, J., Li, G., Crețoiu, D., & Xiao, J. (2026) · 中国科学通报：英文版 · doi:10.1016/j.scib.2026.01.067 · Cited by 10

Combinational antitumor strategies of exosomes as drug carriers: Mini review

Xiao, G., Xu, Z., & Luo, F. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1107329 · Cited by 11

Theoretical explore of bridge and donor engineering for novel naphthalimide based photosensitizers for two-photo photodynamic therapy

Cui, W.-B., Wei, X., Sun, F.-Y., Zou, L.-Y., Guo, J., Hao, X.-L., Li, H., Ren, A., & Wang, S. (2023) · Dyes and Pigments · doi:10.1016/j.dyepig.2023.111841 · Cited by 10

The role of tumor-derived exosomal LncRNA in tumor metastasis

Yu, Z., Fu, J., Mantareva, V. N., Blažević, I., Wu, Y., Wen, D., Battulga, T., Wang, Y.-Q., & Zhang, J. (2025) · Cancer Gene Therapy · doi:10.1038/s41417-024-00852-x · Cited by 10

Cancer vaccine from intracellularly gelated tumor cells functionalized with CD47 blockage and damage-associated molecular pattern exposure

Cheng, G., Luo, R., Kwong, C. H. T., Liu, J., Tang, M., Xie, B., Duan, T., & Wang, R. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.102092 · Cited by 10

Exploration of the Effect on Genome-Wide DNA Methylation by miR-143 Knock-Out in Mice Liver

Chen, X., Luo, J., Liu, J., Chen, T., Sun, J., Zhang, Y., & Xi, Q. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222313075 · Cited by 10

Abscopal Effect, Extracellular Vesicles and Their Immunotherapeutic Potential in Cancer Treatment

Salazar, A., Chavarria, V., Flores, I., Ruiz, S., de la Cruz, V. P., Sánchez‐García, F. J., & Pineda, B. (2023) · Molecules · doi:10.3390/molecules28093816 · Cited by 10

Polymers in Engineering Extracellular Vesicle Mimetics: Current Status and Prospective

Wei, X., Liu, S., Cao, Y., Wang, Z., & Chen, S. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15051496 · Cited by 10

Construction of a cascade nanosystem to implement indirect and direct cell modulation for tumor microenvironment immunostimulation

Wang, X., Han, X., Yan, J., Wang, Y., Song, P., Kang, Y., Zhang, X., Shi, X., Xue, G., Rauf, A., et al. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.150141 · Cited by 10

Micro/Nanomotors Actively Penetrate Physiological Barriers: Basic Nanoarchitectonics to Practical Application

Huang, S. Q., Liu, B., Peng, F., Wang, Y., Han, S., & Tu, Y. (2025) · Advanced Materials · doi:10.1002/adma.202508865 · Cited by 11

BSA–MnO 2 –SAL multifunctional nanoparticle-mediated M 1 macrophages polarization for glioblastoma therapy

Liang, F., Zhu, L., Wang, C., Yang, Y., & He, Z. (2021) · RSC Advances · doi:10.1039/d1ra06705b · Cited by 9

Emerging Roles of Using Small Extracellular Vesicles as an Anti-Cancer Drug

Joo, H. S., Suh, J. H., So, C. M., Jeon, H. J., Yoon, S. H., & Lee, J. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241814063 · Cited by 9

Active-Targeting Biomimetic Polymer Nanoparticles for NIR Fluorescence Imaging and Enhanced Chemo-Sonodynamic Therapy of Cancer

Jin, R., Zhang, G., Tang, L., Li, M., Yang, M., Li, J., Wang, Z., & Guan, F. (2024) · ACS Applied Nano Materials · doi:10.1021/acsanm.3c05575 · Cited by 9

Artificial Engineering of Immune Cells for Improved Immunotherapy

Li, C., Qi, Y., Zhang, Y. X., Chen, Y., Feng, J. X., & Zhang, X. (2021) · Advanced NanoBiomed Research · doi:10.1002/anbr.202000081 · Cited by 9

Targeted nanomedicine for reprogramming the tumor innate immune system: From bench to bedside

Pednekar, K. P., Minnee, J., de Vries, I. J. M., & Prakash, J. (2024) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2024.114510 · Cited by 8

Engineering and Monitoring the Sustained Release of Extracellular Vesicles from Hydrogels for In Vivo Therapeutic Applications

Uman, S., Weingarten, N., Helmers, M. R., Iyengar, A., Xu, K. L., Worthington, K., Meldrum, D. E., Dominic, J., Guevara-Plunkett, S., Schiazza, A. R., et al. (2024) · Advanced NanoBiomed Research · doi:10.1002/anbr.202400073 · Cited by 8

Extracellular vesicles originating from the mechanical microenvironment in the pathogenesis and applications for cardiovascular diseases

Zeng, Y., Cui, X., Li, H., Wang, Y., Cheng, M., & Zhang, X. (2024) · Regenerative Therapy · doi:10.1016/j.reth.2024.10.012 · Cited by 8

Translational Potential of Surface Engineered Extracellular Vesicles as Theranostic Nanocarriers in Cancer Management: Recent Developments from Bench to Bedside

Vasave, R., Bhawale, R., Khan, O., Pardhi, E. R., Rajana, N., Kumari, N. U., Chary, P. S., & Mehra, N. K. (2025) · ACS Applied Bio Materials · doi:10.1021/acsabm.5c00955 · Cited by 9

Extracellular vesicles as the drug delivery vehicle for gene-based therapy

Aquino, A. D., Rubinstein, A., Кудрявцев, И. В., Yakovlev, A. A., & Головкин, А. С. (2025) · Applied Physics Reviews · doi:10.1063/5.0255519 · Cited by 9

Bionic lipoprotein loaded with chloroquine-mediated blocking immune escape improves antitumor immunotherapy

Dong, Q., Han, D., Li, B., Yang, Y., Ren, L., Xiao, T., Zhang, J., Li, Z., Yang, H., & Liu, H. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.124342 · Cited by 8

ICAM‐1‐Expressing Extracellular Vesicles Enable Sequential Delivery Barrier‐Breaking and Microenvironment Modulating for Glioblastoma Stem Cell Inhibition

Liang, F., You, Q., Wang, H., Liu, J., Yang, Q., Lu, D., Ma, X., Wang, C., He, Z., Yang, Y., et al. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202408006 · Cited by 8

Pharmaceutical Nanotechnology

Sun, T., Li, C., Li, X., Song, H., Su, B., You, H., Zhang, T., & Jiang, C. (2023) · Micro/Nano technologies · doi:10.1007/978-981-16-8984-0_10 · Cited by 8

Role of Exosomes in the Invasion and Metastasis of Ovarian Cancer and Application Potential of Clinical Diagnosis and Treatment

Zhu, Y., Wang, C., Ma, Z., Li, F., Xu, C., Pan, W., & Liu, A. (2023) · Journal of Cancer · doi:10.7150/jca.83663 · Cited by 9

Exosomes in oral squamous cell carcinoma: functions, challenges, and potential applications

Zhao, B., Li, Z., & Li, R. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2024.1502283 · Cited by 7

Nebulized Inhalation of Engineered Extracellular Vesicles to Destruct Pre-metastatic Niche and Inhibit Postoperative Lung Metastasis in a Mouse Model

Wang, X., Han, X., Yuan, H., Zhang, X., Kang, Y., Wang, Y., Song, P., Su, X., Chen, Z., Liang, H., et al. (2025) · ACS Nano · doi:10.1021/acsnano.5c12218 · Cited by 8

A Metabolism‐Oriented Strategy to Directly Generate Photosensitizer‐Engineered Extracellular Vesicles from Cancer Cells

Wang, D., Liu, X., Zhang, X., Pham, T. T., Zhuang, J., Li, B., Chong, K. C., Liu, C., Shan, Y., Wu, M., et al. (2025) · Advanced Materials · doi:10.1002/adma.202505726 · Cited by 7

Enzyme-Loaded Catalytic Macrophage Vesicles with Cascade Amplification of Tumor-Targeting for Oxygenated Photodynamic Therapy

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