Responsive Exosome Nano-bioconjugates for Synergistic Cancer Therapy

Extracellular vesicles: Exosomes, microvesicles, and friends

Raposo, G., & Stoorvogel, W. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201211138 · Cited by 8,099

The chemokine system in diverse forms of macrophage activation and polarization

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Protective and pathogenic functions of macrophage subsets

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Shared Principles in NF-κB Signaling

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Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

Biswas, S. K., & Mantovani, A. (2010) · Nature Immunology · doi:10.1038/ni.1937 · Cited by 3,840

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF‐kappa B transcription factor and HIV‐1.

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The NF- B Family of Transcription Factors and Its RegulationPreprint

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Crosstalk in NF-κB Signaling Pathways

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NF-κB activation by reactive oxygen species: Fifteen years later

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Simultaneous Fenton‐like Ion Delivery and Glutathione Depletion by MnO 2 ‐Based Nanoagent to Enhance Chemodynamic Therapy

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Biomimetic Exosome‐Camouflaged pH‐Responsive Dendrimer Nanogels as a Therapeutic Vaccine Against Pancreatic Cancer Through Reprogramming of Multiple Cell Types

Li, Y., Wang, Z., Gao, Y., Li, Z., Li, J., Zhang, C., He, M., Wang, H., Shi, X., & Shen, M. (2026) · Advanced Functional Materials · doi:10.1002/adfm.202526444 · Cited by 4

Advances of M1 macrophages-derived extracellular vesicles in tumor therapy

Liu, H., Ouyang, Z., & Li, S. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117735 · Cited by 6

A game of hide-and-seek: how extracellular vesicles evade the immune system

Ghoshal, B., & Jhunjhunwala, S. (2025) · Drug Delivery and Translational Research · doi:10.1007/s13346-025-01789-w · Cited by 4

Extracellular Vesicle‐Based Antitumor Nanomedicines

Li, M., Liu, Y., Liu, F., Chen, Q., Xu, L., Cheng, Z., Tan, Y., & Liu, Z. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202403903 · Cited by 5

Enhancing Chemotherapy‐Related Immune Responses via Bioorthogonal Metabolic Engineering‐Driven Tumor Exosomes Elimination

Zhang, W., Yang, T., Jin, T., Zhu, T., Fang, H., Fan, M., & Zhang, Y. (2025) · Advanced Science · doi:10.1002/advs.202506409 · Cited by 4

Extracellular vesicles in cancer: biogenesis, oncogenic mechanisms, biomarker potential, and therapeutic applications

Aditi, Khajuria, A., Garima, Kaur, G., Singh, S. K., Dhanawat, M., & Mittal, N. (2025) · Medical Oncology · doi:10.1007/s12032-025-03145-x · Cited by 4

Mitochondria-targeted nanocarriers for smart response delivery of natural products: a review

Cao, J., Lu, W., Lv, Y. L., Li, M., Tang, Y. H., & Feng, Y. (2026) · Journal of drug targeting · doi:10.1080/1061186x.2025.2611940 · Cited by 4

Leveraging macrophage plasticity for precision-targeted tumor immunotherapy

Li, S., Wang, X., Li, L., Chen, L., & Sun, Z.-J. (2026) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2026.168176 · Cited by 5

Exosomes in renal cell carcinoma: challenges and opportunities

Mohammadi, M., Mansouri, K., Mohammadi, P., Pournazari, M., & Najafi, H. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09384-x · Cited by 4

Mild Magnetothermal Immunotherapy for Malignant Pleural Effusion

Min, T., Yang, C., Zhang, M., Hu, P., & Shi, J. (2024) · Small · doi:10.1002/smll.202407734 · Cited by 4

Nanotechnology empowering biomedical therapy: new treatment perspectives for sarcopenia and degenerative muscle atrophy

Liu, L., Cai, Y., Liu, D., Fang, R., Huang, H., Zou, M., Chen, B., Peng, J., & Hao, L. (2026) · Biomaterials Science · doi:10.1039/d5bm01061f · Cited by 4

Advanced extracellular vesicle immunotherapy

Zhang, J., Mu, Y., Ji, X., Jiang, X., Wang, R., Ding, X., & Wang, L. (2026) · FlexMat. · doi:10.1002/flm2.70030 · Cited by 4

The potential of biomimetic nanoparticles for macrophage repolarisation and phagocytosis in tumour immunotherapy

Sun, Z., Zhou, R., Liu, J., Zhao, Q., Sun, C., & Sun, Y. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.154506 · Cited by 3

“A perfect pair”: extracellular vesicle-based novel strategies for precise cancer diagnosis and effective treatment

Zhao, H., Du, F., Guo, R., & Qiu, L. (2025) · Journal of Materials Chemistry B · doi:10.1039/d5tb01154j · Cited by 3

EGFR-targeted extracellular vesicles loaded with doxorubicin for enhanced chemotherapy in non-small cell lung cancer via bioorthogonal click chemistry

Li, X., Zeng, X., & Hu, X. (2025) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2025.130419 · Cited by 3

Nano‐Engineering Strategies for Tumor‐Specific Therapy

Li, Z., Xie, H., & Nie, W. (2024) · ChemMedChem · doi:10.1002/cmdc.202300647 · Cited by 3

Engineered macrophages as versatile platforms for targeted cancer immunotherapy

Mujahid, K., Aslam, M. A., Nam, J., & Choi, J. U. (2025) · Journal of Pharmaceutical Investigation · doi:10.1007/s40005-025-00754-6 · Cited by 2

Recombinant PD1 liposome loading nintedanib for pulmonary fibrosis therapy in mice

Luo, Q., Xie, Y., Xu, J., Ren, Y., Xiong, S., Zhang, H., Chen, Y., Chen, H., Wang, J., Huang, P., et al. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.169905 · Cited by 2

Co-delivery of panobinostat and siSTAT3 using engineered M1 exosomes to establish a one-two punch therapeutic strategy for glioblastoma recurrence

Liu, X., Hu, Y., Zhang, Y., Liu, C. X., Wu, J., Zhao, R., Xue, Z., Zhou, W., Liu, X., Miletić, H., et al. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102680 · Cited by 2

Preparation of hyaluronic acid nanospheres with synergistic charge reversal and active targeting for enhanced selective anticancer drug delivery

Zhao, X., Feng, Y., Ke, Y., & Yang, W. (2026) · New Journal of Chemistry · doi:10.1039/d5nj04505c · Cited by 2

Extracellular Vesicles in Ophthalmology: From Natural Nanocarriers to Engineered Therapeutics

Flores, C., Mastantuono, F., Huang, L. J., McKay, T. B., Coyne, G., Hefley, B. S., Vasini, B., Karamichos, D., & Yang, M. (2026) · Bioengineering · doi:10.3390/bioengineering13030275 · Cited by 3

Engineered Extracellular Vesicles: Advancing Cancer Therapy Through Precision Nanomedicine

Ma, S., Niu, Y., Sui, S., Xu, W., Kong, L., Wu, X., Wu, J., Gao, Y., & Yan, T. (2026) · BIO Integration · doi:10.15212/bioi-2025-0208 · Cited by 2

A Gene‐Editable Palladium‐Based Bioorthogonal Nanoplatform Facilitates Macrophage Phagocytosis for Tumor Therapy

Feng, S., Zhang, Y. X., Gao, Y., Liu, Y., Wang, Y., Han, X., Zhang, T., & Song, Y. (2023) · Angewandte Chemie · doi:10.1002/ange.202313968 · Cited by 2

Advances of extracellular vesicles in oral diseases: Summary of research progress, clinical implications and future directions

Li, W., Yu, Z., Wu, Z., Jia, J., & Chen, G. (2024) · Translational dental research. · doi:10.1016/j.tdr.2024.100004 · Cited by 2

Improved Targeting of Therapeutics by Nanocarrier-Based Delivery in Cancer Immunotherapy and Their Future Perspectives

Dhara, A., Majumder, S., Pahari, S., & Kar, D. (2023) · BioNanoScience · doi:10.1007/s12668-023-01065-6 · Cited by 2

Pharmaceutical Nanotechnology

Sun, T., Li, C., Li, X., Song, H., Su, B., You, H., Zhang, T., & Jiang, C. (2022) · Micro/Nano technologies · doi:10.1007/978-981-13-9374-7_10-1 · Cited by 1

Why Extracellular Vesicles Are Attractive Vehicles for RNA-Based Therapies?

Aqel, F., Schneider, K., Hartung, D., Schwarz, K., & Shatnyeva, O. (2024) · SynBio · doi:10.3390/synbio2040024 · Cited by 1

Exosome-Derived circ0009910 Promotes Pituitary Adenoma Cell Proliferation, Invasion, Migration, and EMT through the miR-106b-5p/STAT3 Axis

Yang, Z., Zhang, W., Wei, L. G., qu, Y., Jiazi, Y., & Liu, Q. (2025) · Journal of Neurological Surgery Part A Central European Neurosurgery · doi:10.1055/a-2599-4212 · Cited by 1

Microcurrent stimulation improved the skin penetration and wound healing effect of allantoic fluid-derived exosomes hybridized with tetrapeptide nanoparticles

Lee, P., Liao, M.-H., Birhan, Y. S., Syu, W.-J., Li, C.-Z., Peng, C., Hu, C.-C., & Lai, P. (2025) · Journal of Industrial and Engineering Chemistry · doi:10.1016/j.jiec.2025.09.046 · Cited by 1

Expression of porcine-derived IgA against PEDV and use of Alg-CS gel to protect the IgA from degradation in simulated gastric fluid

Zhang, J., Zhang, Y., Wu, H., Shi, S., Cao, S., Chen, H., & Song, Y. (2025) · Archives of Virology · doi:10.1007/s00705-025-06459-3 · Cited by 1

Nanomedicine-driven strategies for CD8+ T cell enhancement in Cancer immunotherapy

Gao, Z., Chen, C., Chen, X., Yao, P., Li, W., Fan, Y., Wang, S., Sun, M., Sun, K., & Zhang, J. (2025) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2025.217468 · Cited by 1

Controlled Assembly of Vesicle-Based Superstructures Using Megamolecules

Vu, T. Q., Sridhar, S., Shekour, B. G., Iyer, A., Cline, L., Kimmel, B. R., Modica, J. A., Mocan, L., Mrksich, M., & Kamat, N. P. (2026) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5c23536 · Cited by 1

Notch-1 in macrophages promoted the ischemia-reperfusion via modulating EZH2/HSF1/BRD4/SIRPα/SHP2 induced ROS and apoptosis in cardiomyocyte

Tong, C., Zhang, J., Yajing, Z., Yu, X., Zang, S., & Liu, S. (2026) · Scientific Reports · doi:10.1038/s41598-026-40683-4 · Cited by 1

Extracellular Vesicles‐Functionalized Biomaterials for Oral Disease Theragnostics

Zhao, Z., Zeng, Y., Liu, R., & Qiu, X. (2026) · MedComm – Biomaterials and Applications · doi:10.1002/mba2.70048 · Cited by 1

Targeted synergistic therapy for bone and brain disorders using hydrogel microneedles loaded with exosomes and drugs

Shi, H., Chen, Y., Huang, Z., Shen, C., Xiao, J., Zhao, H., Zou, Z., Zhang, W., Feng, K., Ou, Z., et al. (2026) · Microstructures · doi:10.20517/microstructures.2025.132 · Cited by 1

Smart exosomes: multimodal engineering strategies for logic-gated and stimuli-responsive precision theranostics

Hu, Y., Yang, X., Shu, F., Jin, L., Sarsaiya, S., Han, S., & Chen, J. (2026) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2026.126846 · Cited by 2

The Role of Extracellular Vesicles in Tumor Therapy and Imaging

Feng, T., Wan, Y., Cui, S., & Liu, Y. (2023) · Advanced Therapeutics · doi:10.1002/adtp.202300195 · Cited by 1

New Progress in the Treatment of Refractory Epilepsy

景, 世. (2023) · Advances in Clinical Medicine · doi:10.12677/acm.2023.13122627 · Cited by 1

Activation of RIG‐I/MDA5 Signaling and Inhibition of CD47‐SIRPα Checkpoint with a Dual siRNA‐Assembled Nanoadjuvant for Robust Cancer Immunotherapy

Xu, X., Li, S., Yu, W., Yao, S., Fan, H., & Guo, Z. (2024) · Angewandte Chemie · doi:10.1002/ange.202318544 · Cited by 1

Exosomes: Key Players for Treatment of Cancer and Their Future Perspectives

Gupta, R., Gupta, J., & Roy, S. (2024) · Assay and Drug Development Technologies · doi:10.1089/adt.2023.026 · Cited by 1

Exosomes as novel nanocarriers for cancer therapy

Li, J., Zan, J., Xu, Z., Yang, C., Han, X., Huang, S., Xu, H., & Zhen, Y. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.106262 · Cited by 2

Cell-derived nanoplatforms for cancer therapy

Lins, P. M. P. (2021) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.76.2021.tde-03092021-114705 · Cited by 1

NIR Light‐Activated Conversion Nanomaterials for Photothermal/Immunotherapy

Zhang, Y., & Hou, Z. (2025) · Wiley eBooks · doi:10.1002/9783527845347.ch12 · Cited by 1

Self-Assembled Tetrahedral Framework Nucleic Acid Mediated Tumor-Associated Macrophages Reprogramming and Enhancing Cancer ImmunotherapyPreprint

Qian, H., Fu, Y., Guo, M., Wu, Y. F., Zhang, D., Zhou, T., Fang, W., Yao, M., Shi, H., Chai, C., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-373672/v1

Engineered extracellular vesicles as drug delivery systems for the next generation of nanomedicine

Fan, Z., & Jiang, C. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91376-8.00010-0

Recent Progress of Nanomedicine and Targeted Drug Delivery for Cancer Treatment

Zhang, H. (2023) · MDPI eBooks · doi:10.3390/books978-3-0365-7040-2

The Effect of Engineering Methods on the Efficacy of Therapeutic Exosomes

Zhang, C. (2023) · Highlights in Science Engineering and Technology · doi:10.54097/hset.v65i.11230

Biomedical Applications of Extracellular Vesicles in Treatment of Disease

Wang, F., Ai, J., Zhang, Z., Li, Y., & Li, Z. (2023) · Wiley eBooks · doi:10.1002/9783527842155.ch4

Technologies for the Surface Functionalization of Extracellular Vesicles

Han, G., Geng, M., & Yin, H. (2024) · Springer eBooks · doi:10.1007/978-981-99-8365-0_11

Exploring the tumor microenvironment in head and neck squamous cell carcinoma through single-cell and multi-omics analysis to identify prognostic genes associated with M1/M2 macrophages

Zhu, J., Zhuang, L., & Yang, Y. (2025) · Noordanesh. · doi:10.61186/ijkd.9123

Rapid Detection of Plasma Exosomal Casc9 for Hcc Using Rt-Rpa-Crispr/Cas12a AssayPreprint

Wu, J., Li, X., Yin, X., Hu, J., Zhou, P., Zhong, X., & Wu, M. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5226218

Emerging applications of stimuli-responsive novel vesicular carriers: exosomes, supramolecular vesicles, and catanionic vesicles

Karmakar, S., Tadge, T. S., Devidas, S. G., & Raichur, A. M. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-29125-8.00012-0

Engineering Cell Membrane-Derived Nanovesicles for Advanced Biomedical Applications

Hussain, Z., Ahmed, W., Gao, T., Zhang, Y., & Pei, R. (2025) · Springer eBooks · doi:10.1007/978-3-031-93425-4_2

Biological Membrane Engineering for Unlocking Therapeutic Potential of Membrane-Based Platforms

Ahmed, W., Hussain, Z., & Pei, R. (2025) · Springer eBooks · doi:10.1007/978-3-031-93425-4_1

In Situ Monitoring of the Movement of a Single Nanovesicle: Toward Elucidating Their Biological Activities in Human Cells

Sun, H., Chu, Z., & Liang, Q. (2025) · Small · doi:10.1002/smll.202509696

Additional file 1 of Engineering M1-derived nanovesicles loading with docosahexaenoic acid synergizes ferroptosis and immune activation for treating hepatocellular carcinoma

Meng, M., Zhang, X., Li, Q., Han, J., Chen, Y., Qiao, H., Yang, Y., & Huang, X. (2024) · Figshare · doi:10.6084/m9.figshare.26573194

Extracellular Vesicles: Emerging Roles in the Diagnosis and Management of Pregnancy-Related Disorders

Li, Q., Lin, Q., Du, H., & Ou, Z. (2026) · Obstetrics and gynecology. · doi:10.5772/intechopen.1014084

Co-Extracellular Vesicles Delivery System Enhances Immunochemotherapy for Glioblastoma

Niu, W., Guan, R., Sun, L., Wang, M., Wang, X., Zhang, B., Hao, X., Wu, Q., Cheng, Z., Wei, J., et al. (2026) · Research · doi:10.34133/research.1219

The multifaceted mechanisms of Tanshinone IIA in doxorubicin-induced cardiotoxicity

Wang, Q., Zou, D., Chen, H., Cui, D., Huang, X., Chen, Y., Qi, Y., Nan, Z., Wang, X., & Shang, X. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1783433

Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles

Kemunto, G., & Dellinger, K. (2026) · Advanced NanoBiomed Research · doi:10.1002/anbr.202500173

Functionalization of extracellular vesicles for biomedical applications

Rani, S., Hussain, Z., & Pei, R. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-36641-3.00009-7

Emerging trends in implication of nanocarriers in repolarization of tumor associated macrophages for improved triple negative breast cancer therapy

Banjare, N., Singh, M., Kuiry, A., & Gupta, P. N. (2026) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2026.115798

A Genetically Engineered Macrophage-Derived Vesicular Nanodecoy Targeting the CD47/SIRPα Axis for Reinforced Tumor Radioimmunotherapy

Zhang, J., Tong, T., Cai, C., Cai, X., Sun, B., Wen, K., Qu, X., Fan, Q., & Dong, Z. (2026) · ACS Nano · doi:10.1021/acsnano.6c06363

The CircRNA/miRNA axis in breast cancer: From molecular mechanisms to clinical translation

Li, H., Lei, X., & Yang, X. (2026) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2026.109069

Extracellular vesicles in solid tumors: from tumor ecology to engineered therapeutics

Cai, W., Chen, Y., Dai, S., Cheng, C., & Chen, L. (2026) · Molecular Cancer · doi:10.1186/s12943-026-02705-7

Engineered Exosomes for Skin Antiaging: A New Frontier in Regenerative Medicine

Sun, Y. W., Guo, X., He, Z., Cui, Y., Wen, D., Xue, B., & Li, L. (2026) · The FASEB Journal · doi:10.1096/fj.202601698r

A dual-tumor-recognition trispecific T-cell nano-engager enhances effector–target conjugation and antitumor activity

Ma, Y.-J., Zhang, Z., Kang, J., Che, X.-H., Tian, J.-Y., Cai, Y.-Y., Shen, S., Zhao, D., & Zhu, L. (2026) · Biomaterials Science · doi:10.1039/d6bm00886k

A genetically engineered biomimetic nanomedicine with radio-taxis and CD47 blockade for precision tumor radio-immunotherapy

Zhao, X., Hu, Z., Xu, Q., Zou, J., Huo, J., Yang, Y., Yang, J., & Zhang, M. (2026) · Chemical Engineering Journal · doi:10.1016/j.cej.2026.179697

Recent advances in stimulus-responsive nanomaterials for the treatment of inflammatory bowel disease

Zhang, Y., Zhao, Y., Xu, P., Zhang, C. L., Chen, X., Guo, J., He, B., & Liang, Y. (2026) · Nanoscale · doi:10.1039/d6nr01522k

A Chemical Framework for Engineering Extracellular Vesicles’ Biointerface to Advance Precision Therapeutics

Jahromi, L. P., Geng, F., Frenzke, J., & Fuhrmann, G. (2026) · Advanced Materials · doi:10.1002/adma.74203

Programmable nanomedicine via bioorthogonal molecular engineering

Im, S., Koo, S., & Kim, J. S. (2026) · Nano Convergence · doi:10.1186/s40580-026-00568-8 · Cited by 1

Engineering and Precision Delivery Strategies of Functionalized Extracellular Vesicles for Antitumor Therapy

Zhang, X., Zhou, X., Fu, S., Liu, X., Xie, Y., Zhang, Y., Fang, Y., & Yu, J. (2026) · Pharmaceutics · doi:10.3390/pharmaceutics18101215

Engineered exosomes for breast cancer immunotherapy: Emerging strategies and translational potential

Orooji, N., Ghasemian-Irani, M., Salari, N., Eskandari, T., Shams, M., Razavi, F. T., & Haghmorad, D. (2026) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2026.102822

Nanoparticle-Based Drug Delivery Systems for Anticancer Therapy: Microenvironment-Driven Strategies, Advances, and Challenges

Ban, M., Zhao, S., Liu, Z., & Zhao, L. (2026) · Pharmaceutics · doi:10.3390/pharmaceutics18101273

Intratumoral Fusogenic Outer Membrane Vesicles Enhance Antitumor Immunity Through Tumor MHC‐I Upregulation and Tumor Bacterization

Liu, X., Zhou, J., Lu, G., Zhao, C., Wang, W., Chen, J., Zhang, F., Zhang, F., Xie, H.-Y., & Nie, W. (2026) · Advanced Science · doi:10.1002/advs.78279

M1 Macrophage Derived Exosomes As Platform For CD47 Immune Checkpoint Blockade And Chemotherapy DeliveryPreprint

Bao, X., Feng, F. Y., Dong, C., Xu, M., & Jiang, G. (2026) · Research Square · doi:10.21203/rs.3.rs-10301984/v1

Exosome-SIRPα, a CD47 blockade increases cancer cell phagocytosis

Koh, E., Lee, E. J., Nam, G., Hong, Y., Cho, E., Yang, Y., & Kim, I. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.01.004 · Cited by 371

Macrophage-derived exosomes in cancer: a double-edged sword with therapeutic potential

Liu, L., Zhang, S., Ren, Y., Wang, R., Zhang, Y., Weng, S., Zhou, Z., Luo, P., Cheng, Q., Xu, H., et al. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03321-1 · Cited by 28

Construction of biomimetic hybrid nanovesicles based on M1 macrophage-derived exosomes for therapy of cancer

Li, Y., Cai, Z., Wang, Z., Zhu, S., Liu, W., & Wang, C. (2024) · Chinese Chemical Letters · doi:10.1016/j.cclet.2024.109942 · Cited by 12

Tumor Exosome-Mimicking Iron Oxide Nanoparticles for Near Infrared-Responsive Drug Delivery

Yuan, A., Ruan, L., Jia, R., Wang, X., Wu, L. H., Cao, J., Qi, X., Wei, Y., & Shen, S. (2021) · ACS Applied Nano Materials · doi:10.1021/acsanm.1c03643 · Cited by 16