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Responsive Exosome Nano-bioconjugates for Synergistic Cancer Therapy
Abstract
Exosomes hold great potential in therapeutic development. However, native exosomes usually induce insufficient effects in vivo and simply act as drug delivery vehicles. Herein, we synthesize responsive exosome nano-bioconjugates for cancer therapy. Azide-modified exosomes derived from M1 macrophages are conjugated with dibenzocyclooctyne-modified antibodies of CD47 and SIRPα (aCD47 and aSIRPα) through pH-sensitive linkers. After systemic administration, the nano-bioconjugates can actively target tumors through the specific recognition between aCD47 and CD47 on the tumor cell surface. In the acidic tumor microenvironment, the benzoic-imine bonds of the nano-bioconjugates are cleaved to release aSIRPα and aCD47 that can, respectively, block SIRPα on macrophages and CD47, leading to abolished "don't eat me" signaling and improved phagocytosis of macrophages. Meanwhile, the native M1 exosomes effectively reprogram the macrophages from pro-tumoral M2 to anti-tumoral M1.
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“Meanwhile, native M1 exosomes efficiently reprogram macrophages from pro-tumor M2 to anti-tumor M1 [44].”
From The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System (2022) · cites this paper as [44]
In the citing paper
“Their result showed that the nano-bioconjugates could specifically bind with cancer by recognition of CD47.”
From The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System (2022) · cites this paper as [44]
Citations
Cites
Extracellular vesicles: Exosomes, microvesicles, and friends
Raposo, G., & Stoorvogel, W. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201211138 · Cited by 8,099
The chemokine system in diverse forms of macrophage activation and polarization
MANTOVANI, A., SICA, A., SOZZANI, S., ALLAVENA, P., VECCHI, A., & LOCATI, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.09.015 · Cited by 6,534
Protective and pathogenic functions of macrophage subsets
Murray, P. J., & Wynn, T. A. (2011) · Nature Reviews Immunology · doi:10.1038/nri3073 · Cited by 5,269
Shared Principles in NF-κB Signaling
Hayden, M. S., & Ghosh, S. (2008) · Cell · doi:10.1016/j.cell.2008.01.020 · Cited by 4,954
Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
Biswas, S. K., & Mantovani, A. (2010) · Nature Immunology · doi:10.1038/ni.1937 · Cited by 3,840
Schreck, R., RIEBER, P., & Baeuerle, P. A. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07761.x · Cited by 3,793
The NF- B Family of Transcription Factors and Its RegulationPreprint
Oeckinghaus, A., & Ghosh, S. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000034 · Cited by 2,944
Crosstalk in NF-κB Signaling Pathways
Oeckinghaus, A., Hayden, M. S., & Ghosh, S. (2011) · Nature Immunology · doi:10.1038/ni.2065 · Cited by 1,942
NF-κB activation by reactive oxygen species: Fifteen years later
Gloire, G., Legrand-Poels, S., & Piette, J. G. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.04.011 · Cited by 1,561
Lin, L., Song, J., Song, L., Ke, K., Liu, Y., Zhou, Z., Shen, Z., Li, J., Yáng, Z., Tang, W., et al. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201712027 · Cited by 1,474
Self-citationLi, J., & Pu, K. (2018) · Chemical Society Reviews · doi:10.1039/c8cs00001h · Cited by 1,169
Self-citationIn situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment
Chen, Q., Wang, C., Zhang, X., Chen, G., Hu, Q., Li, H., Wang, J., Wen, D., Zhang, Y., Lü, Y., et al. (2018) · Nature Nanotechnology · doi:10.1038/s41565-018-0319-4 · Cited by 1,029
Self-citationMolecular afterglow imaging with bright, biodegradable polymer nanoparticles
Miao, Q., Xie, C., Xu, Z. J., Lyu, Y., Duan, H., Liu, X., Jokerst, J. V., & Pu, K. (2017) · Nature Biotechnology · doi:10.1038/nbt.3987 · Cited by 980
Self-citationTumor exosome-based nanoparticles are efficient drug carriers for chemotherapy
Yong, T., Zhang, X., Bie, N., Zhang, H., Zhang, X., Li, F., Hakeem, A., Hu, J., Gan, L., Santos, H. A., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11718-4 · Cited by 806
Exosomes: Vehicles of Intercellular Signaling, Biomarkers, and Vectors of Cell Therapy
Kourembanas, S. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021014-071641 · Cited by 761
Molecular optical imaging probes for early diagnosis of drug-induced acute kidney injury
Huang, J., Li, J., Lyu, Y., Miao, Q., & Pu, K. (2019) · Nature Materials · doi:10.1038/s41563-019-0378-4 · Cited by 729
Self-citationJohnsen, K. B., Gudbergsson, J. M., Skov, M. N., Pilgaard, L., Moos, T., & Duroux, M. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.04.005 · Cited by 704
The CD47–SIRPα pathway in cancer immune evasion and potential therapeutic implications
Chao, M. P., Weissman, I. L., & Majeti, R. (2012) · Current Opinion in Immunology · doi:10.1016/j.coi.2012.01.010 · Cited by 667
Dendritic cell-derived exosomes for cancer therapy.
Pitt, J. M., André, F., Amigorena, S., Soria, J.-C., Eggermont, A., Kroemer, G., & Zitvogel, L. (2016) · Journal of Clinical Investigation · doi:10.1172/jci81137 · Cited by 636
Exosomes and their roles in immune regulation and cancer
Greening, D. W., Gopal, S. K., Xu, R., Simpson, R. J., & Chen, W. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.02.009 · Cited by 627
Zhou, F., Feng, B., Yu, H., Wang, D., Wang, T., Ma, Y., Wang, S., & Li, Y. (2019) · Advanced Materials · doi:10.1002/adma.201805888 · Cited by 503
Exosomes: The next generation of endogenous nanomaterials for advanced drug delivery and therapy
Liao, W., Du, Y., Zhang, C., Pan, F., Yao, Y., Zhang, T., & Peng, Q. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.12.045 · Cited by 418
Lu, Z., Zuo, B., Jing, R., Gao, X., Rao, Q., Liu, Z., Qi, H., Guo, H., & Yin, H. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.05.019 · Cited by 361
Molecular Repolarisation of Tumour-Associated Macrophages
van Dalen, F. J., van Stevendaal, M. H. M. E., Fennemann, F. L., Verdoes, M., & Ilina, O. (2018) · Molecules · doi:10.3390/molecules24010009 · Cited by 309
Organic Semiconducting Pro‐nanostimulants for Near‐Infrared Photoactivatable Cancer Immunotherapy
Li, J., Cui, D. M., Huang, J., He, S., Yang, Z., Zhang, Y., Luo, Y., & Pu, K. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201906288 · Cited by 304
Self-citationMiao, Q., Lyu, Y., Ding, D., & Pu, K. (2016) · Advanced Materials · doi:10.1002/adma.201505681 · Cited by 270
Self-citationLin, L., Song, J., Song, L., Ke, K., Liu, Y., Zhou, Z., Shen, Z., Li, J., Yáng, Z., Tang, W., et al. (2018) · Angewandte Chemie · doi:10.1002/ange.201712027 · Cited by 261
Self-citationImmune Cell-Derived Extracellular Vesicles – Functions and Therapeutic Applications
Veerman, R. E., Akpinar, G. G., Eldh, M., & Gabrielsson, S. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.02.003 · Cited by 251
Seo, N., Shirakura, Y., Tahara, Y., Momose, F., Harada, N., Ikeda, H., Akiyoshi, K., & Shiku, H. (2018) · Nature Communications · doi:10.1038/s41467-018-02865-1 · Cited by 243
Lyu, Y., Cui, D. M., Huang, J., Fan, W., Miao, Y., & Pu, K. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201900092 · Cited by 234
Self-citationThe softness of tumour-cell-derived microparticles regulates their drug-delivery efficiency
Liang, Q., Bie, N., Yong, T., Tang, K., Shi, X., Wei, Z., Jia, H., Zhang, X., Zhao, H. Y., Huang, W., et al. (2019) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0405-4 · Cited by 225
Li, C., Zhang, Y., Dong, X., Zhang, L., Liu, M., Ли, Б., Zhang, M., Feng, J. X., & Zhang, X. (2019) · Advanced Materials · doi:10.1002/adma.201807211 · Cited by 204
Self-citationInhibition of Pathogen Adhesion by Bacterial Outer Membrane‐Coated Nanoparticles
Zhang, Y., Chen, Y., Lo, C. Y. Z., Zhuang, J., Angsantikul, P., Zhang, Q., Wei, X., Zhou, Z., Obonyo, M., Fang, R. H., et al. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201906280 · Cited by 182
Self-citationExosomes as Drug Carriers for Cancer Therapy
Pullan, J. E., Confeld, M. I., Osborn, J., Kim, J., Sarkar, K., & Mallik, S. (2019) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.9b00104 · Cited by 179
Xie, C., Xu, Z. J., Lyu, Y., & Pu, K. (2017) · Advanced Materials · doi:10.1002/adma.201703693 · Cited by 169
Self-citationExosomes: Diagnostic Biomarkers and Therapeutic Delivery Vehicles for Cancer
Jiang, L., Gu, Y., Du, Y., & Liu, J. (2019) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.9b00409 · Cited by 159
Liu, H., Gao, W., Yuan, J., Wu, C., Yao, K., Zhang, L., Ma, L., Zhu, J., Zou, Y., & Ge, J. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.12.028 · Cited by 155
Diagnostic and Therapeutic Potential of Exosomes in Cancer: The Beginning of a New Tale?
Mirzaei, H., Sahebkar, A., Jaafari, M. R., Goodarzi, M., & Mirzaei, H. R. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25739 · Cited by 155
Roles of Exosomes Derived From Immune Cells in Cardiovascular Diseases
Wu, R., Gao, W., Kang, Y., & Ge, J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00648 · Cited by 134
Gehrmann, U., Hiltbrunner, S., Georgoudaki, A., Karlsson, M. C. I., Näslund, T. I., & Gabrielsson, S. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-3918 · Cited by 130
Bioresponsive Protein Complex of aPD1 and aCD47 Antibodies for Enhanced Immunotherapy
Chen, Q., Chen, G., Chen, J., Shen, J., Zhang, X., Wang, J., Chan, A., & Gu, Z. (2019) · Nano Letters · doi:10.1021/acs.nanolett.9b00584 · Cited by 122
Wang, C., & Steinmetz, N. F. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201801288 · Cited by 63
Organic Semiconducting Pro‐nanostimulants for Near‐Infrared Photoactivatable Cancer Immunotherapy
Li, J., Cui, D. M., Huang, J., He, S., Yang, Z., Zhang, Y., Luo, Y., & Pu, K. (2019) · Angewandte Chemie · doi:10.1002/ange.201906288 · Cited by 56
Self-citationRole of hydroxyl radical in silica-induced NF-kappa B activation in macrophages.
Chen, F., Lu, Y., Demers, L. M., Rojanasakul, Y., Shi, X., Vallyathan, V., & Castranova, V. (1998) · PubMed · Cited by 55
Lyu, Y., Cui, D. M., Huang, J., Fan, W., Miao, Y., & Pu, K. (2019) · Angewandte Chemie · doi:10.1002/ange.201900092 · Cited by 47
Self-citationHuang, L.-L., Lu, G., Hao, J., Wang, H., Yin, D., & Xie, H. (2013) · Analytical Chemistry · doi:10.1021/ac4008144 · Cited by 45
Self-citationImmature dendritic cell exosomes suppress experimental autoimmune myasthenia gravis
Bu, N., Wu, H., Zhang, G., Zhan, S., Zhang, R., Fan, Q., Li, Y.-L., Zhai, Y.-F., & Ren, H. (2015) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2015.04.009 · Cited by 42
Human Platelet Membrane Functionalized Microchips with Plasmonic Codes for Cancer Detection
Kumar, S., Han, J., Michael, I. J., Ki, D. Y., Sunkara, V., Park, J., Gautam, S., Ha, H. K., Zhang, L., & Cho, Y. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201902669 · Cited by 40
Progress on the labeling and single-particle tracking technologies of viruses
Huang, L.-L., & Xie, H. (2014) · The Analyst · doi:10.1039/c4an00038b · Cited by 28
Self-citationInhibition of Pathogen Adhesion by Bacterial Outer Membrane‐Coated Nanoparticles
Zhang, Y., Chen, Y., Lo, C. Y. Z., Zhuang, J., Angsantikul, P., Zhang, Q., Wei, X., Zhou, Z., Obonyo, M., Fang, R. H., et al. (2019) · Angewandte Chemie · doi:10.1002/ange.201906280 · Cited by 6
Self-citationDurand, J., Gauttier, V., Morello, A., Pengam, S., Vanhove, B., & Poirier, N. (2018) · Cancer Research · doi:10.1158/1538-7445.am2018-1753 · Cited by 5
Research works printed but not linked: 1
- Chen F., 1998, Ann. Clin. Lab. Sci., 28, 1
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Engineered exosomes from different sources for cancer-targeted therapy
Zhang, M. H., Hu, S., Liu, L., Dang, P., Liu, Y., Sun, Z., Qiao, B., & Wang, C. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01382-y · Cited by 493
Self-citationRecent Advances in Hyperthermia Therapy‐Based Synergistic Immunotherapy
Chang, M., Hou, Z., Wang, M., Li, C., & Lin, J. (2020) · Advanced Materials · doi:10.1002/adma.202004788 · Cited by 457
Cancer-Derived Exosomes: Their Role in Cancer Biology and Biomarker Development
Kok, V. C., & Yu, C. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s272378 · Cited by 409
Tumor-associated macrophages: potential therapeutic strategies and future prospects in cancer
Li, C., Xu, X., Wei, S., Jiang, P., Xue, L., & Wang, J. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-001341 · Cited by 360
Metadata
- Authors
- Nie, W., Wu, G., Zhang, J., Huang, L., Ding, J., Jiang, A., Zhang, Y., Liu, Y., Li, J., Pu, K., & Xie, H.
- Affiliations
- Beijing Institute of Technology (CN)
- Chinese Academy of Sciences (CN)
- School of Chemical and Biomedical Engineering Nanyang Technological University 70 Nanyang Drive Singapore 637457 Singapore
- Nanyang Technological University (SG)
- School of Life Science Beijing Institute of Technology Beijing 100081 P. R. China
- Corresponding author
- Pu, Kanyi
- ORCID
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2019-12-18
- Volume
- 59
- Issue
- 5
- Pages
- 2018-2022
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2991079475
- Cited by
- 376
- References
- 56
- Citations by year
- 2026: 39 · 2025: 52 · 2024: 69 · 2023: 71 · 2022: 65 · 2021: 52 · 2020: 28
- FWCI
- 11.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Angewandte Chemie International Edition (publishedVersion)
- PubMed (publishedVersion)
- DR-NTU (Nanyang Technological University) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Keywords
- exosomes, cancer therapy, CD47, SIRPα, M1 macrophages, macrophage reprogramming, tumor microenvironment, tumor targeting, phagocytosis, macrophage polarization
- MeSH terms
- Humans, Immunotherapy, Neoplasms, Nanotechnology, Exosomes
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