Cited by 376Extracellular vesicles in diseaseNanoplatforms for cancer theranosticsPhagocytosis and Immune Regulation

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Responsive Exosome Nano-bioconjugates for Synergistic Cancer Therapy

Nie, Weidong, Wu, Guanghao, Zhang, Jinfeng, Huang, Li‐Li, Ding, Jingjing, Jiang, Anqi, Zhang, Yahui, Liu, Yanhong, Li, Jingchao, Pu, Kanyi, Xie, Hai‐Yan·2020·Angewandte Chemie International Edition

DOI 10.1002/anie.201912524

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Abstract

Exosomes hold great potential in therapeutic development. However, native exosomes usually induce insufficient effects in vivo and simply act as drug delivery vehicles. Herein, we synthesize responsive exosome nano-bioconjugates for cancer therapy. Azide-modified exosomes derived from M1 macrophages are conjugated with dibenzocyclooctyne-modified antibodies of CD47 and SIRPα (aCD47 and aSIRPα) through pH-sensitive linkers. After systemic administration, the nano-bioconjugates can actively target tumors through the specific recognition between aCD47 and CD47 on the tumor cell surface. In the acidic tumor microenvironment, the benzoic-imine bonds of the nano-bioconjugates are cleaved to release aSIRPα and aCD47 that can, respectively, block SIRPα on macrophages and CD47, leading to abolished "don't eat me" signaling and improved phagocytosis of macrophages. Meanwhile, the native M1 exosomes effectively reprogram the macrophages from pro-tumoral M2 to anti-tumoral M1.

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Authors: Nie, W., Wu, G., Zhang, J., Huang, L., Ding, J., Jiang, A., Zhang, Y., Liu, Y., Li, J., Pu, K., & Xie, H.
Affiliations: Beijing Institute of Technology (CN)
Chinese Academy of Sciences (CN)
School of Chemical and Biomedical Engineering Nanyang Technological University 70 Nanyang Drive Singapore 637457 Singapore
Nanyang Technological University (SG)
School of Life Science Beijing Institute of Technology Beijing 100081 P. R. China
Corresponding author: Pu, Kanyi
ORCID: Nie, Weidong
Wu, Guanghao
Zhang, Jinfeng
Ding, Jingjing
Jiang, Anqi
Zhang, Yahui
Liu, Yanhong
Pu, Kanyi
Venue: Angewandte Chemie International Edition
Publisher: Wiley
Published: 2019-12-18
Volume: 59
Issue: 5
Pages: 2018-2022
ISSN: 1433-7851 (ISSN-L)
1521-3773
DOI: 10.1002/anie.201912524
OpenAlex: W2991079475
Cited by: 376
References: 56
Citations by year: 2026: 39 · 2025: 52 · 2024: 69 · 2023: 71 · 2022: 65 · 2021: 52 · 2020: 28
FWCI: 11.99
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Angewandte Chemie International Edition (publishedVersion)
PubMed (publishedVersion)
DR-NTU (Nanyang Technological University) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Keywords: exosomes, cancer therapy, CD47, SIRPα, M1 macrophages, macrophage reprogramming, tumor microenvironment, tumor targeting, phagocytosis, macrophage polarization
MeSH terms: Humans, Immunotherapy, Neoplasms, Nanotechnology, Exosomes

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Responsive Exosome Nano-bioconjugates for Synergistic Cancer Therapy

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