Responsive Exosome Nano-bioconjugates for Synergistic Cancer Therapy

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Simultaneous Fenton‐like Ion Delivery and Glutathione Depletion by MnO 2 ‐Based Nanoagent to Enhance Chemodynamic Therapy

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Harnessing Engineered Immune Cells and Bacteria as Drug Carriers for Cancer Immunotherapy

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Macrophages, as a Promising Strategy to Targeted Treatment for Colorectal Cancer Metastasis in Tumor Immune Microenvironment

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Exosomes for angiogenesis induction in ischemic disorders

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Engineering exosomes to reshape the immune microenvironment in breast cancer: Molecular insights and therapeutic opportunities

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Biomaterials‐Based Delivery of Therapeutic Antibodies for Cancer Therapy

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Recent progresses of exosome–liposome fusions in drug delivery

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Orchestrating NK and T cells via tri-specific nano-antibodies for synergistic antitumor immunity

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Tumor-associated macrophages in nanomaterial-based anti-tumor therapy: as target spots or delivery platforms

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Enhancing the Efficacy of Active Pharmaceutical Ingredients in Medicinal Plants through Nanoformulations: A Promising Field

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Extracellular Vesicles for Drug Delivery and Theranostics In Vivo

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Anti-Tumor Strategies by Harnessing the Phagocytosis of Macrophages

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Tumor Microenvironment-Derived Exosomes: A Double-Edged Sword for Advanced T Cell-Based Immunotherapy

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Peak force tapping atomic force microscopy for advancing cell and molecular biology

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Exosomes as drug delivery systems in glioma immunotherapy

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Synergistic ferroptosis and macrophage re-polarization using engineering exosome-mimic M1 nanovesicles for cancer metastasis suppression

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The Immuno-Modulation Effect of Macrophage-Derived Extracellular Vesicles in Chronic Inflammatory Diseases

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Engineered extracellular vesicles: A new approach for targeted therapy of tumors and overcoming drug resistance

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Therapeutic exosomal vaccine for enhanced cancer immunotherapy by mediating tumor microenvironment

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Exosome-based drug delivery systems in cancer therapy

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Defining tropism and activity of natural and engineered extracellular vesicles

Choi, W., Park, D. J., & Eliceiri, B. P. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1363185 · Cited by 51

Nanomedicine enables spatiotemporally regulating macrophage-based cancer immunotherapy

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Recent Advances of Tumor Therapy Based on the CD47-SIRPα Axis

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Cellular nanovesicles for therapeutic immunomodulation: A perspective on engineering strategies and new advances

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Nanotechnology-Boosted Biomaterials for Osteoarthritis Treatment: Current Status and Future Perspectives

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Immune cell-derived exosomes as promising tools for cancer therapy

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Immune Cycle‐Based Strategies for Cancer Immunotherapy

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Hydrophobic mismatch drives self-organization of designer proteins into synthetic membranes

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Reprogramming exosomes for immunity-remodeled photodynamic therapy against non-small cell lung cancer

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Biomimetic nanocarriers in cancer therapy: based on intercellular and cell-tumor microenvironment communication

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Inhibition of SerpinB9 to enhance granzyme B-based tumor therapy by using a modified biomimetic nanoplatform with a cascade strategy

Han, R., Yu, L., Zhao, C., Li, Y., Ma, Y., Zhai, Y., Qian, Z., Gu, Y., & Li, S. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121723 · Cited by 39

Versatile biomimetic nanomedicine for treating cancer and inflammation disease

Zhao, Z., Wang, D., & Li, Y. (2023) · Medical Review · doi:10.1515/mr-2022-0046 · Cited by 40

Engineered Cell Membrane-Camouflaged Nanomaterials for Biomedical Applications

Guan, X.-J., Xing, S., & Liu, Y. (2024) · Nanomaterials · doi:10.3390/nano14050413 · Cited by 41

Synergistic Potential of Nanomedicine in Prostate Cancer Immunotherapy: Breakthroughs and Prospects

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Nanomaterials targeting macrophages in sepsis: A promising approach for sepsis management

Song, C., Xu, J., Gao, C., Zhang, W., Fang, X., & Shang, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1026173 · Cited by 38

Current and prospective strategies for advancing the targeted delivery of CRISPR/Cas system via extracellular vesicles

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Strategies for targeted gene delivery using lipid nanoparticles and cell-derived nanovesicles

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Synergistic vesicle-vector systems for targeted delivery

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Circular RNAs in human diseases

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Exosome-like systems: Nanotechnology to overcome challenges for targeted cancer therapies

García-Fernández, J., & Freire, M. D. L. F. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216151 · Cited by 37

Orthogonally Engineered Albumin with Attenuated Macrophage Phagocytosis for the Targeted Visualization and Phototherapy of Liver Cancer

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Cancer Extracellular Vesicles: Next-Generation Diagnostic and Drug Delivery Nanotools

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Supramolecular Polymer‐Nanomedicine Hydrogel Loaded with Tumor Associated Macrophage‐Reprogramming polyTLR7/8a Nanoregulator for Enhanced Anti‐Angiogenesis Therapy of Orthotopic Hepatocellular Carcinoma

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New hope for tumor immunotherapy: the macrophage-related “do not eat me” signaling pathway

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Exosomes: a double‐edged sword in cancer immunotherapy

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Revisiting the advances and challenges in the clinical applications of extracellular vesicles in cancer

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Exosome‐Mimetic Supramolecular Vesicles with Reversible and Controllable Fusion and Fission**

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Emerging Nanoparticle Strategies for Modulating Tumor-Associated Macrophage Polarization

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Progress in nanoparticle-based regulation of immune cells

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A Gene‐Editable Palladium‐Based Bioorthogonal Nanoplatform Facilitates Macrophage Phagocytosis for Tumor Therapy

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Investigating the proliferative inhibition of HepG2 cells by exosome-like nanovesicles derived from Centella asiatica extract through metabolomics

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Emerging chemical engineering of exosomes as “bioscaffolds” in diagnostics and therapeutics

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Mutual regulation of PD-L1 immunosuppression between tumor-associated macrophages and tumor cells: a critical role for exosomes

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Biofunctional Peptide-Modified Extracellular Vesicles Enable Effective Intracellular Delivery via the Induction of Macropinocytosis

Nakase, I. (2021) · Processes · doi:10.3390/pr9020224 · Cited by 31

Polyvalent spherical aptamer engineered macrophages: X-ray-actuated phenotypic transformation for tumor immunotherapy

Chen, Y., Gao, P., Pan, W., Shi, M., Liu, S., Li, N., & Tang, B. (2021) · Chemical Science · doi:10.1039/d1sc03997k · Cited by 32

Phase-transition nanodroplets with immunomodulatory capabilities for potentiating mild magnetic hyperthermia to inhibit tumour proliferation and metastasis

Qin, Q., Zhou, Y., Li, P., Liu, Y., Deng, R., Tang, R., Wu, N., Wan, L., Ye, M., Zhou, H., et al. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-01885-4 · Cited by 32

Engineering prodrug nanomicelles as pyroptosis inducer for codelivery of PI3K/mTOR and CDK inhibitors to enhance antitumor immunity

Yang, Q., Ma, X., Xiao, Y., Zhang, T., Yang, L., Yang, S., Liang, M., Wang, S., Wu, Z., Xu, Z., et al. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.02.024 · Cited by 31

A review on exosome-based cancer therapy

Schulze, A. T. V., & Deng, F. (2020) · Journal of Cancer Metastasis and Treatment · doi:10.20517/2394-4722.2020.79 · Cited by 30

Transformable vesicles for cancer immunotherapy

Wang, S., Hu, X., Wei, W., & Ma, G. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113905 · Cited by 31

Bacterial outer membrane vesicles-clothed nanoparticles delivered by live macrophages for potentiating antitumor photoimmunotherapy

Fu, C., Tang, L., Cao, Y., Yin, Y., Liu, H., Feng, J., Gao, J., Li, J., & Wang, W. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.156420 · Cited by 29

Bioengineered hybrid dual-targeting nanoparticles reprogram the tumour microenvironment for deep glioblastoma photodynamic therapy

Zhao, R., Hou, Y., Li, B., Pan, Z., Qiu, J., Wang, Q., Qi, Y., Han, Z. W., Zhao, H., Liu, H., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-63081-2 · Cited by 40

Mesenchymal Stem Cell-Derived Antimicrobial Peptides as Potential Anti-Neoplastic Agents: New Insight into Anticancer Mechanisms of Stem Cells and Exosomes

Moeinabadi‐Bidgoli, K., Rezaee, M., Rismanchi, H., Mohammadi, M. M., & Babajani, A. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.900418 · Cited by 33

Fighting hypoxia to improve photodynamic therapy-driven immunotherapy: Alleviating, exploiting and disregarding

Jia, L., Hong, Y., He, X., Zhou, Y., Ren, L., Du, H., Zhao, B., Qin, B., Yang, Z., & Gao, D. (2024) · Chinese Chemical Letters · doi:10.1016/j.cclet.2024.109957 · Cited by 29

Emerging Strategies for Cargo Loading and Engineering of Extracellular Vesicles for Breast Cancer Treatment

Mediratta, K., Diab, M. D., Han, P., Hu, H., & Wang, L. (2025) · Nanomaterials · doi:10.3390/nano15181418 · Cited by 29

Mimovirus Vesicle‐Based Biological Orthogonal Reaction for Cancer Diagnosis

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Engineering Macrophages via Nanotechnology and Genetic Manipulation for Cancer Therapy

Ding, X., Sun, X., Cai, H., Wu, L., Liu, Y., Zhao, Y., Zhou, D., Yu, G., & Zhou, X. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2021.786913 · Cited by 28

Origin and Composition of Exosomes as Crucial Factors in Designing Drug Delivery Systems

Rech, J., Getinger-Panek, A., Gałka, S., & Bednarek, I. A. (2022) · Applied Sciences · doi:10.3390/app122312259 · Cited by 29

Hypoxia alleviating platinum(IV)/chlorin e6-based combination chemotherapeutic-photodynamic nanomedicine for oropharyngeal carcinoma

Paul, M., Itoo, A. M., Ghosh, B., & Biswas, S. (2022) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2022.112627 · Cited by 27

Challenges for the Development of Extracellular Vesicle-Based Nucleic Acid Medicines

Kuriyama, N., Yoshioka, Y., Kikuchi, S., Okamura, A., Azuma, N., & Ochiya, T. (2021) · Cancers · doi:10.3390/cancers13236137 · Cited by 27

An acceptor-shielding strategy of photosensitizers for enhancing the generation efficiency of type I reactive oxygen species and the related photodynamic immunotherapy

Qu, J., Zhang, Y., Cai, Z., Tong, B., Xie, H., Dong, Y., & Shi, J. (2022) · Nanoscale · doi:10.1039/d2nr02273g · Cited by 26

Nanoparticle-enabled concurrent modulation of phagocytosis and repolarization of macrophages for enhanced cancer immunotherapy

Zhang, J., Chen, F., Liu, R., Luo, J., Huang, Y., Shu, N., Zheng, S.-J., Shao, D., Leong, K. W., & Du, J. (2022) · Nano Today · doi:10.1016/j.nantod.2022.101651 · Cited by 26

Bio‐Orthogonal Chemistry in Cell Engineering

Wang, Y., & Hu, Q. (2022) · Advanced NanoBiomed Research · doi:10.1002/anbr.202200128 · Cited by 26

Injectable Scaffolds for In Vivo Programmed Macrophages Manufacture and Postoperative Cancer Immunotherapy

Wu, X., Zhong, Z., Li, Y., Wang, Y., Tian, Y., Liu, X., Zhang, X., Tao, W., Wang, J., Du, Y., et al. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202300058 · Cited by 26

Intracellular Magnetic Hyperthermia Enables Concurrent Down-Regulation of CD47 and SIRPα To Potentiate Antitumor Immunity

Wang, S., Jiao, W., Yan, B., Liu, X., Tang, Q., Zhang, Y., Liang, C., Wang, X., Lyu, Y., Fan, H., et al. (2024) · Nano Letters · doi:10.1021/acs.nanolett.4c00003 · Cited by 26

Extracellular vesicle as a next-generation drug delivery platform for rheumatoid arthritis therapy

Jin, Y., Xu, C., Zhu, Y., & Gu, Z. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.113610 · Cited by 26

Dendritic cell-derived exosomes as anti-cancer cell-free agents: new insights into enhancing immunogenic effects

Redkin, T. S., & Turubanova, V. D. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1586892 · Cited by 26

Dynamic nanoassembly-based drug delivery system (DNDDS): Learning from nature

Hu, X., Li, F., Xia, F., Wang, Q., Lin, P., Wei, M., Gong, L., Low, L. E., Lee, J. Y., & Ling, D. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113830 · Cited by 25

Recent progress of macrophage vesicle-based drug delivery systems

Xu, W., Cai, J., Li, Y., Wu, J., & Xiang, D. (2022) · Drug Delivery and Translational Research · doi:10.1007/s13346-021-01110-5 · Cited by 27

Self-assembled tetrahedral framework nucleic acid mediates tumor-associated macrophage reprogramming and restores antitumor immunity

Qian, H., Zhou, T., Fu, Y., Guo, M., Wu, Y. F., Zhang, D., Fang, W., Yao, M., Shi, H., Chai, C., et al. (2022) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2021.12.036 · Cited by 25

Bioreactor: Intelligent platform for drug delivery

Yang, C., Kong, L., & Zhang, Z. (2022) · Nano Today · doi:10.1016/j.nantod.2022.101481 · Cited by 25

Extracellular vesicle-based macromolecule delivery systems in cancer immunotherapy

Chen, H., Sun, T., & Jiang, C. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.06.014 · Cited by 25

Therapeutic and diagnostic applications of exosomal circRNAs in breast cancer

Gopikrishnan, M., Hephzibah Cathryn, R., Ramanathan, G., Ashour, H. M., Pintus, G., Hammad, M., Kashyap, M. K., Doss, C. G. P., & Zayed, H. (2023) · Functional & Integrative Genomics · doi:10.1007/s10142-023-01083-3 · Cited by 27

Engineered exosomes as a natural nanoplatform for cancer targeted delivery of metal-based drugs

Feng, T., Karges, J., Liao, X., Ji, L., & Chao, H. (2021) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2021.214325 · Cited by 24

Multivalent Engineering of Exosomes with Activatable Aptamer Probes for Specific Regulation and Monitoring of Cell Targeting

Liu, W., Huang, Y., Li, Z., Li, L., Zhao, Y., & Li, M. (2022) · Analytical Chemistry · doi:10.1021/acs.analchem.1c04741 · Cited by 24

Engineered exosomes in emerging cell-free therapy

Si, C., Gao, J., & Ma, X. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1382398 · Cited by 26

Intratumoral antigen-presenting cell activation by a nanovesicle for the concurrent tertiary lymphoid structure de novo neogenesis

Cheng, R., Li, S., Ma, X., Zhuang, W., Lei, Y., He, J., Liang, C. L., Nie, W., & Xie, H.-Y. (2025) · Science Advances · doi:10.1126/sciadv.adr1299 · Cited by 23

Knowledge landscape of tumor-associated macrophage research: A bibliometric and visual analysis

Zhou, F., Liu, Y., Liu, C., Wang, F., Peng, J., Xie, Y., & Zhou, X. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1078705 · Cited by 23

Nature’s carriers: leveraging extracellular vesicles for targeted drug delivery

Chen, Q., Zheng, Y., Jiang, X., Wang, Y., Chen, Z., & Wu, D. (2024) · Drug Delivery · doi:10.1080/10717544.2024.2361165 · Cited by 25

The Advances in the Development of Epigenetic Modifications Therapeutic Drugs Delivery Systems

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