Cited by 134Luminescence and Fluorescent MaterialsQuantum Dots Synthesis And PropertiesOptical Imaging and Spectroscopy Techniques

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Polymethine‐Based Semiconducting Polymer Dots with Narrow‐Band Emission and Absorption/Emission Maxima at NIR‐II for Bioimaging

Liu, Ming‐Ho, Zhang, Zhe, Yang, Yu‐Chi, Chan, Yang‐Hsiang·2021·Angewandte Chemie International Edition

DOI 10.1002/anie.202011914

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Abstract

Deep‐penetration fluorescence imaging in the second near‐infrared (NIR‐II) window heralds a new era of clinical surgery, in which high‐resolution vascular/lymphatic anatomy and detailed cancerous tissues can be visualized in real time. Described here is a series of polymethine‐based semiconducting polymers with intrinsic emission maxima in the NIR‐IIa (1300–1400 nm) window and absorption maxima ranging from 1082 to 1290 nm. These polymers were prepared as semiconducting polymer dots (Pdots) in aqueous solutions with fluorescence quantum yields of 0.05–0.18 %, and they demonstrate promising applications in noninvasive through‐skull brain imaging in live mice with remarkable spatial resolution as well as signal‐to‐background contrast. This study offers a platform for future design of NIR‐IIa or even NIR‐IIb emitting Pdots.

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Authors: Liu, M., Zhang, Z., Yang, Y., & Chan, Y.
Affiliations: National Yang Ming Chiao Tung University (TW)
Southern University of Science and Technology (CN)
Corresponding author: Chan, Yang‐Hsiang
ORCID: Zhang, Zhe
Yang, Yu‐Chi
Chan, Yang‐Hsiang
Venue: Angewandte Chemie International Edition
Publisher: Wiley
Published: 2020-11-10
Volume: 60
Issue: 2
Pages: 983-989
ISSN: 1433-7851 (ISSN-L)
1521-3773
DOI: 10.1002/anie.202011914
OpenAlex: W3089389187
Cited by: 134
References: 65
Citations by year: 2026: 18 · 2025: 12 · 2024: 39 · 2023: 21 · 2022: 29 · 2021: 14 · 2020: 1
FWCI: 6.33
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Angewandte Chemie International Edition (publishedVersion)
PubMed (publishedVersion)
Funders: Ministry of Science and Technology, Taiwan (105-2113-M-110-012-MY3)
Topics: Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
Physical Sciences › Materials Science › Materials Chemistry › Quantum Dots Synthesis And Properties
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
Keywords: polymethine dyes, semiconducting polymer dots, NIR-II fluorescence imaging, bioimaging, vascular imaging, lymphatic imaging, fluorescence quantum yield
MeSH terms: Density Functional Theory, Animals, Brain, Contrast Media, Fluorescent Dyes, Indoles, Infrared Rays, Medulloblastoma, Mice, Inbred C57BL, Semiconductors, Spectroscopy, Near-Infrared, Quantum Dots, Mice, Optical Imaging

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Polymethine‐Based Semiconducting Polymer Dots with Narrow‐Band Emission and Absorption/Emission Maxima at NIR‐II for Bioimaging

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