Remarkable Suppression of Vibrational Relaxation in Organic Semiconducting Polymers by Introducing a Weak Electron Donor for Improved NIR‐II Phototheranostics
Abstract
Exploration of high‐efficiency agents for near‐infrared‐II fluorescence imaging (NIR‐II FI) promotes the development of NIR‐II FI in life science. Despite the extensive use of organic semiconducting nanomaterials for NIR‐II FI, the fluorescence efficiency is barely satisfying, and the molecular guideline to improve the imaging quality has not been clarified yet. This contribution designs self‐brightened organic semiconducting polymers (OSPs) for improved NIR‐II phototheranostics of cancer. The amplification of NIR‐II brightness is realized by incorporating a weak electron‐donating unit (5,5′‐dibromo‐4,4′‐didodecyl‐2,2′‐bithiophene, DDB) into the semiconducting backbone with strong electron donor–acceptor alternated structure, which exhibits 6.3‐fold and 25‐fold fluorescence enhancement compared with the counterpart OSP at the same optical concentration and mass concentration, respectively. The broadband femtosecond transient absorption spectra experimentally elucidate the DDB doping‐induced suppression of vibrational relaxation as the underlying reason for the NIR‐II fluorescence amplification. Biocompatible nanoparticles fabricated from the optimal OSP 12 exhibit excellent NIR‐II phototheranostic performance both in vitro and in vivo. Our research not only reveals the mechanistic insights for fluorescence enhancement of the designed OSPs from the essential view but also highlights an effective molecular methodology to guide the rational design of imaging agents with enhanced NIR‐II brightness for improved phototheranostics in living subjects.
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DDB doping induced a 6.3- to 25-fold fluorescence enhancement compared to the undoped counterpart OSP10.
“The DDB doping induced a 6.3- to 25-fold fluorescence enhancement compared to the undoped counterpart (OSP10).”
From The Pursuit of Shortwave Infrared-Emitting Nanoparticles with Bright Fluorescence through Molecular Design and Excited-State Engineering of Molecular Aggregates (2022) · cites this paper as [180]
Femtosecond transient absorption spectroscopy revealed that DDB doping-induced suppression of vibrational relaxation is the major mechanism underlying the observed amplifications of SWIR fluorescence.
“A femtosecond transient absorption spectroscopy revealed that the DDB doping-induced suppression of vibrational relaxation is the major mechanism underlying the observed amplifications of the SWIR fluorescence.”
From The Pursuit of Shortwave Infrared-Emitting Nanoparticles with Bright Fluorescence through Molecular Design and Excited-State Engineering of Molecular Aggregates (2022) · cites this paper as [180]
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- Authors
- Yin, C., Zhang, H., Sun, B., Chen, S., Jiang, X., Miao, X., Sun, P., Hu, W., Fan, Q., & Huang, W.
- Affiliations
- Nanjing University of Posts and Telecommunications (CN)
- Northwestern Polytechnical University (CN)
- Corresponding author
- Sun, Pengfei
- Hu, Wenbo
- Fan, Quli
- Venue
- Advanced Functional Materials
- Publisher
- Wiley
- Published
- 2021-08-25
- Volume
- 31
- Issue
- 47
- ISSN
- 1616-301X (ISSN-L)
- 1616-3028
- OpenAlex
- W3193407034
- Cited by
- 48
- References
- 46
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 9 · 2023: 8 · 2022: 13 · 2021: 1
- FWCI
- 2.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Functional Materials (publishedVersion)
- Funders
- National Natural Science Foundation of China (62005127, 21674048, 21604042, 61805118)
- Natural Science Foundation of Jiangsu Province (BK20200751, BK20201380)
- Fundamental Research Funds for the Central Universities
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Organic Electronics and Photovoltaics
- Keywords
- NIR-II fluorescence imaging, organic semiconducting polymers, fluorescence enhancement, phototheranostics, tumor imaging, bithiophene, femtosecond transient absorption, biocompatible nanoparticles
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