Counterion‐Paired Bright Heptamethine Fluorophores with NIR‐II Excitation and Emission Enable Multiplexed Biomedical Imaging

In vivo three-photon microscopy of subcortical structures within an intact mouse brain

Horton, N. G., Wang, K., Kobat, D., Clark, C. G., Wise, F. W., Schaffer, C. B., & Xu, C. (2013) · Nature Photonics · doi:10.1038/nphoton.2012.336 · Cited by 1,505 · see citing works

A route to brightly fluorescent carbon nanotubes for near-infrared imaging in mice

Welsher, K., Liu, Z., Sherlock, S. P., Robinson, J. T., Chen, Z., Daranciang, D., & Dai, H. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.294 · Cited by 1,287 · see citing works

Molecular Engineering of NIR‐II Fluorophores for Improved Biomedical Detection

Lei, Z., & Zhang, F. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202007040 · Cited by 689 · see citing works

Next-generation in vivo optical imaging with short-wave infrared quantum dots

Bruns, O. T., Bischof, T. S., Harris, D. K., Franke, D., Shi, Y., Riedemann, L., Bartelt, A., Jaworski, F. B., Carr, J. A., Rowlands, C. J., et al. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-017-0056 · Cited by 686 · see citing works

An Efficient 1064 nm NIR‐II Excitation Fluorescent Molecular Dye for Deep‐Tissue High‐Resolution Dynamic Bioimaging

Li, B., Lu, L., Zhao, M., Lei, Z., & Zhang, F. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201801226 · Cited by 658 · see citing works

A high quantum yield molecule-protein complex fluorophore for near-infrared II imaging

Antaris, A. L., Chen, H., Diao, S., Ma, Z., Zhang, Z., Zhu, S., Wang, J., Lozano, A. X., Fan, Q., Chew, L., et al. (2017) · Nature Communications · doi:10.1038/ncomms15269 · Cited by 623 · see citing works

In vivo molecular imaging for immunotherapy using ultra-bright near-infrared-IIb rare-earth nanoparticles

Zhong, Y., Ma, Z., Wang, F., Wang, X., Yang, Y., Liu, Y., Zhao, X., Li, J., Du, H., Zhang, M., et al. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0262-4 · Cited by 575 · see citing works

Anti-quenching NIR-II molecular fluorophores for in vivo high-contrast imaging and pH sensing

Wang, S., Fan, Y., Li, D., Sun, C., Lei, Z., Lu, L., Wang, T., & Zhang, F. (2019) · Nature Communications · doi:10.1038/s41467-019-09043-x · Cited by 510 · see citing works

Rational Design of Molecular Fluorophores for Biological Imaging in the NIR‐II Window

Yang, Q., Ma, Z., Wang, H., Zhou, B., Zhu, S., Zhong, Y., Wang, J., Wan, H., Antaris, A., Ma, R., et al. (2017) · Advanced Materials · doi:10.1002/adma.201605497 · Cited by 467 · see citing works

Flavylium Polymethine Fluorophores for Near‐ and Shortwave Infrared Imaging

Cosco, E. D., Caram, J. R., Bruns, O. T., Franke, D., Day, R. A., Farr, E. P., Bawendi, M. G., & Sletten, E. M. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201706974 · Cited by 415 · see citing works

Organic NIR-II molecule with long blood half-life for in vivo dynamic vascular imaging

Li, B., Zhao, M., Feng, L., Dou, C., Ding, S., Zhou, G., Lu, L., Zhang, H., Chen, F., Li, X., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16924-z · Cited by 374 · see citing works

Shortwave infrared polymethine fluorophores matched to excitation lasers enable non-invasive, multicolour in vivo imaging in real time

Cosco, E. D., Spearman, A. L., Ramakrishnan, S., Lingg, J. G. P., Saccomano, M., Pengshung, M., Arús, B. A., Wong, K. C. Y., Glasl, S., Ntziachristos, V., et al. (2020) · Nature Chemistry · doi:10.1038/s41557-020-00554-5 · Cited by 343 · see citing works

Biological Imaging Using Nanoparticles of Small Organic Molecules with Fluorescence Emission at Wavelengths Longer than 1000 nm

Tao, Z., Hong, G., Shinji, C., Chen, C., Diao, S., Antaris, A. L., Zhang, B., Zou, Y., & Dai, H. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201307346 · Cited by 330 · see citing works

A hybrid erbium(III)–bacteriochlorin near-infrared probe for multiplexed biomedical imaging

Wang, T., Wang, S., Liu, Z., He, Z., Yu, P., Zhao, M., Zhang, H., Lu, L., Wang, Z., Wang, Z., et al. (2021) · Nature Materials · doi:10.1038/s41563-021-01063-7 · Cited by 308 · see citing works

Upconversion NIR-II fluorophores for mitochondria-targeted cancer imaging and photothermal therapy

Zhou, H., Zeng, X., Li, A., Zhou, W., Tang, L., Hu, W., Fan, Q., Meng, X., Deng, H., Duan, L., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19945-w · Cited by 289 · see citing works

NIR-II bioluminescence for in vivo high contrast imaging and in situ ATP-mediated metastases tracing

Lu, L., Li, B., Ding, S., Fan, Y., Wang, S., Sun, C., Zhao, M., Zhao, C.-X., & Zhang, F. (2020) · Nature Communications · doi:10.1038/s41467-020-18051-1 · Cited by 274 · see citing works

A General Strategy for Development of Activatable NIR‐II Fluorescent Probes for In Vivo High‐Contrast Bioimaging

Ren, T., Wang, Z., Xiang, Z., Lu, P., Lai, H., Yuan, L., Zhang, X., & Tan, W. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202009986 · Cited by 273 · see citing works

Molecular Fluorophores for Deep-Tissue Bioimaging

Wang, S., Li, B., & Zhang, F. (2020) · ACS Central Science · doi:10.1021/acscentsci.0c00544 · Cited by 268 · see citing works

Constitutional Isomerization Enables Bright NIR‐II AIEgen for Brain‐Inflammation Imaging

Liu, S., Chen, C., Li, Y., Zhang, H., Liu, J., Wang, R., Wong, S. T. H., Lam, J. W. Y., Ding, D., & Tang, B. Z. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201908125 · Cited by 266 · see citing works

Biological Imaging Using Nanoparticles of Small Organic Molecules with Fluorescence Emission at Wavelengths Longer than 1000 nm

Tao, Z., Hong, G., Shinji, C., Chen, C., Diao, S., Antaris, A. L., Zhang, B., Zou, Y., & Dai, H. (2013) · Angewandte Chemie · doi:10.1002/ange.201307346 · Cited by 239 · see citing works

Light-sheet microscopy in the near-infrared II window

Wang, F., Wan, H., Ma, Z., Zhong, Y., Sun, Q., Tian, Y., Qu, L., Du, H., Zhang, M., Li, L., et al. (2019) · Nature Methods · doi:10.1038/s41592-019-0398-7 · Cited by 237 · see citing works

Hypoxia-triggered single molecule probe for high-contrast NIR II/PA tumor imaging and robust photothermal therapy

Meng, X., Zhang, J., Sun, Z., Zhou, L., Deng, G., Li, S., Li, W., Gong, P., & Cai, L. (2018) · Theranostics · doi:10.7150/thno.26607 · Cited by 231 · see citing works

Collective fluorescence switching of counterion-assembled dyes in polymer nanoparticles

Reisch, A., Didier, P., Richert, L., Oncul, S., Arntz, Y., Mély, Y., & Klymchenko, A. S. (2014) · Nature Communications · doi:10.1038/ncomms5089 · Cited by 226 · see citing works

Design, Synthesis, and Application of a Small Molecular NIR-II Fluorophore with Maximal Emission beyond 1200 nm

Fang, Y., Shang, J., Liu, D., Shi, W., Li, X., & Ma, H. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.0c08187 · Cited by 223 · see citing works

Xanthene-Based NIR-II Dyes for <i>In Vivo</i> Dynamic Imaging of Blood Circulation

Liu, D., He, Z., Zhao, Y., Yang, Y., Shi, W., Li, X., & Ma, H. (2021) · Journal of the American Chemical Society · doi:10.1021/jacs.1c07711 · Cited by 217 · see citing works

Polymethine Thiopyrylium Fluorophores with Absorption beyond 1000 nm for Biological Imaging in the Second Near-Infrared Subwindow

Ding, B., Xiao, Y., Zhou, H., Zhang, X., Qu, C., Xu, F., Deng, Z., Cheng, Z., & Hong, X. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b01682 · Cited by 215 · see citing works

Continuous Symmetry Breaking Induced by Ion Pairing Effect in Heptamethine Cyanine Dyes: Beyond the Cyanine Limit

Bouit, P., Aronica, C., Toupet, L., et al. (2010) · Journal of the American Chemical Society · doi:10.1021/ja9100886 · Cited by 208 · see citing works

Polypeptide-Conjugated Second Near-Infrared Organic Fluorophore for Image-Guided Photothermal Therapy

Li, T., Li, C., Ruan, Z., Xu, P., Yang, X., Yuan, P., Wang, Q., & Yan, L. (2019) · ACS Nano · doi:10.1021/acsnano.9b00452 · Cited by 202 · see citing works

Beyond the Cyanine Limit: Peierls Distortion and Symmetry Collapse in a Polymethine Dye

Tolbert, L. M., & Zhao, X. (1997) · Journal of the American Chemical Society · doi:10.1021/ja9626953 · Cited by 191 · see citing works

Bright Chromenylium Polymethine Dyes Enable Fast, Four-Color <i>In Vivo</i> Imaging with Shortwave Infrared Detection

Cosco, E. D., Arús, B. A., Spearman, A. L., Atallah, T. L., Lim, I., Leland, O. S., Caram, J. R., Bischof, T. S., Bruns, O. T., & Sletten, E. M. (2021) · Journal of the American Chemical Society · doi:10.1021/jacs.0c11599 · Cited by 183 · see citing works

ROS/RNS and Base Dual Activatable Merocyanine‐Based NIR‐II Fluorescent Molecular Probe for in vivo Biosensing

Zhang, X., Chen, Y., He, H., Wang, S., Lei, Z., & Zhang, F. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202109728 · Cited by 176 · see citing works

Fluorination Enhances NIR‐II Fluorescence of Polymer Dots for Quantitative Brain Tumor Imaging

Liu, Y., Liu, J., Chen, D., Wang, X., Zhang, Z., Yang, Y., Jiang, L., Qi, W., Ye, Z., He, S., et al. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202007886 · Cited by 173 · see citing works

Tumor Microenvironment‐Activated NIR‐II Nanotheranostic System for Precise Diagnosis and Treatment of Peritoneal Metastasis

Ling, S., Yang, X., Li, C., Zhang, Y., Yang, H., Chen, G., & Wang, Q. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202000947 · Cited by 156 · see citing works

An Efficient 1064 nm NIR‐II Excitation Fluorescent Molecular Dye for Deep‐Tissue High‐Resolution Dynamic Bioimaging

Li, B., Lu, L., Zhao, M., Lei, Z., & Zhang, F. (2018) · Angewandte Chemie · doi:10.1002/ange.201801226 · Cited by 137 · see citing works

Polymethine‐Based Semiconducting Polymer Dots with Narrow‐Band Emission and Absorption/Emission Maxima at NIR‐II for Bioimaging

Liu, M., Zhang, Z., Yang, Y., & Chan, Y. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202011914 · Cited by 134 · see citing works

Deciphering the Structure–Property Relations in Substituted Heptamethine Cyanines

Štacková, L., Muchová, E., Russo, M., Slavı́ček, P., Štacko, P., & Petr Klán, A. (2020) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.0c01104 · Cited by 105 · see citing works

Counterion-Mediated Crossing of the Cyanine Limit in Crystals and Fluid Solution: Bond Length Alternation and Spectral Broadening Unveiled by Quantum Chemistry

Eskandari, M., Roldao, J. C., Cerezo, J., Milián‐Medina, B., & Gierschner, J. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.9b10686 · Cited by 89 · see citing works

NIR-II fluorescence in vivo confocal microscopy with aggregation-induced emission dots

Yu, W., Guo, B., Zhang, H., Zhou, J., Yu, X., Zhu, L. J., Xue, D., Liu, W., Sun, X., & Qian, J. (2019) · 中国科学通报：英文版 · doi:10.1016/j.scib.2019.02.019 · Cited by 85 · see citing works

In vivo NIR-II structured-illumination light-sheet microscopy

Wang, F., Ma, Z., Zhong, Y., Salazar, F., Xu, C., Ren, F., Qu, L., Wu, A. M., & Dai, H. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2023888118 · Cited by 85 · see citing works

Short-Wave Infrared Confocal Fluorescence Imaging of Deep Mouse Brain with a Superconducting Nanowire Single-Photon Detector

Xia, F., Gevers, M., Fognini, A., Mok, A. T. Y., Li, B., Akbari, N., Zadeh, I. E., Qin-Dregely, J., & Xu, C. (2021) · ACS Photonics · doi:10.1021/acsphotonics.1c01018 · Cited by 68 · see citing works

Ultrabright NIR‐II Emissive Polymer Dots for Metastatic Ovarian Cancer Detection

Zhou, X., Liu, Q., Yuan, W., Li, Z., Xu, Y., Feng, W., Xu, C., & Li, F. (2020) · Advanced Science · doi:10.1002/advs.202000441 · Cited by 67 · see citing works

Flavylium Polymethine Fluorophores for Near‐ and Shortwave Infrared Imaging

Cosco, E. D., Caram, J. R., Bruns†, O. T., Franke, D., Day, R. A., Farr, E. P., Bawendi, M. G., & Sletten, E. M. (2017) · Angewandte Chemie · doi:10.1002/ange.201706974 · Cited by 65 · see citing works

Molecular Engineering of NIR‐II Fluorophores for Improved Biomedical Detection

Lei, Z., & Zhang, F. (2020) · Angewandte Chemie · doi:10.1002/ange.202007040 · Cited by 63 · see citing works

Antiquenching Macromolecular NIR‐II Probes with High‐Contrast Brightness for Imaging‐Guided Photothermal Therapy under 1064 nm Irradiation

Cheng, Q., Tian, Y., Dang, H., Teng, C., Xie, K., Yin, D., & Yan, L. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202101697 · Cited by 54 · see citing works

A General Strategy for Development of Activatable NIR‐II Fluorescent Probes for In Vivo High‐Contrast Bioimaging

Ren, T., Wang, Z., Xiang, Z., Peng, L. J., Lai, H., Yuan, L., Zhang, X., & Tan, W. (2020) · Angewandte Chemie · doi:10.1002/ange.202009986 · Cited by 47 · see citing works

Photophysical Tuning of Shortwave Infrared Flavylium Heptamethine Dyes via Substituent Placement

Pengshung, M., Li, J., Mukadum, F., Lopez, S. A., & Sletten, E. M. (2020) · Organic Letters · doi:10.1021/acs.orglett.0c02213 · Cited by 42 · see citing works

A thiopyrylium salt for PET/NIR‐II tumor imaging and image‐guided surgery

Zhang, X., Ding, B., Qu, C., Li, H., Sun, Y., Gai, Y., Chen, H., Fang, H., Qian, K., Zhang, Y., et al. (2020) · Molecular Oncology · doi:10.1002/1878-0261.12674 · Cited by 33 · see citing works

ROS/RNS and Base Dual Activatable Merocyanine‐Based NIR‐II Fluorescent Molecular Probe for in vivo Biosensing

Zhang, X., Chen, Y., He, H., Wang, S., Lei, Z., & Zhang, F. (2021) · Angewandte Chemie · doi:10.1002/ange.202109728 · Cited by 25 · see citing works

Fluorination Enhances NIR‐II Fluorescence of Polymer Dots for Quantitative Brain Tumor Imaging

Liu, Y., Liu, J., Chen, D., Wang, X., Zhang, Z., Yang, Y., Jiang, L., Qi, W., Ye, Z., He, S., et al. (2020) · Angewandte Chemie · doi:10.1002/ange.202007886 · Cited by 22 · see citing works

Tumor Microenvironment‐Activated NIR‐II Nanotheranostic System for Precise Diagnosis and Treatment of Peritoneal Metastasis

Ling, S., Yang, X., Li, C., Zhang, Y., Yang, H., Chen, G., & Wang, Q. (2020) · Angewandte Chemie · doi:10.1002/ange.202000947 · Cited by 15 · see citing works

Polymethine‐Based Semiconducting Polymer Dots with Narrow‐Band Emission and Absorption/Emission Maxima at NIR‐II for Bioimaging

Liu, M.-H., Zhang, Z., Yang, Y., & Chan, Y. (2020) · Angewandte Chemie · doi:10.1002/ange.202011914 · Cited by 10 · see citing works

Molecular engineering of AIE luminogens for NIR-II/IIb bioimaging and surgical navigation of lymph nodes

Song, S., Wang, Y., Zhao, Y., Huang, W., Zhang, F., Zhu, S., Wu, Q., Fu, S., Tang, B. Z., & Wang, D. (2022) · Matter · doi:10.1016/j.matt.2022.06.030 · Cited by 133 · see citing works

Recent advances in the design and applications of near-infrared II responsive small molecule phototherapeutic agents

Ma, D., Bian, H., Gu, M., Wang, L., Chen, X., & Peng, X. (2024) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2024.215677 · Cited by 124 · see citing works

Neutral Cyanine: Ultra‐Stable NIR‐II Merocyanines for Highly Efficient Bioimaging and Tumor‐Targeted Phototheranostics

Wan, Y., Chen, W., Liu, Y., Lee, K., Gao, Y., Zhang, D., Li, Y., Huang, Z., Luo, J., Lee, C., et al. (2024) · Advanced Materials · doi:10.1002/adma.202405966 · Cited by 90 · see citing works

“Dual‐Key‐and‐Lock” NIR‐II NSCyanines Enable High‐Contrast Activatable Phototheranostics in Extrahepatic Diseases

Tian, Y., Chen, Z., Liu, S., Wu, F., Cao, W., Pang, D., & Xiong, H. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202309768 · Cited by 57 · see citing works

Finely tunable NIR‐II organic scaffolds for fluorescence/photoacoustic duplex imaging–guided noninvasive photothermal therapy of glioblastoma

Song, Y., Tong, X., Han, Y., & Zhang, Q. (2025) · Aggregate · doi:10.1002/agt2.680 · Cited by 47 · see citing works

Aggregation‐Mediated Photoacoustic/NIR‐II and Photodynamic Properties of pH‐Reversible Thiopyrylium Agents: A Computational and Experimental Approach

Liu, Y., Zhang, Z., Hou, X., Ding, Q., Zeng, S., Shen, H., Gong, W., Ding, T., Mahmood, Z., Zeng, X., et al. (2025) · Advanced Materials · doi:10.1002/adma.202420006 · Cited by 30 · see citing works

Constructing Stable and Wavelength‐Extended Heptamethine Cyanines via Donor Ectopic Substitution for NIR‐IIa/b Bioimaging

Ou, Y., Xiang, H., Yang, X., Wang, R., Huan, S., Yuan, L., Ren, T., & Zhang, X. (2025) · Angewandte Chemie International Edition · doi:10.1002/anie.202423978 · Cited by 29 · see citing works

Organic NIR‐II Nanofluorophore with Ultrahigh Quantum Yield for Vessels Imaging and Fluorescence Image‐Guided Surgery

Zhang, X., Li, L., Ren, Y., Li, M., & Tang, Y. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202413341 · Cited by 26 · see citing works

Design, Synthesis, and <i>In Vivo</i> Imaging of a Stable Xanthene-Based Dye with NIR-II Emission up to 1450 nm

Gao, X., Wang, J.-Y., Qin, Y., Zhu, Y., Liu, Y.-J., Zhou, K., & Cui, M. (2025) · Analytical Chemistry · doi:10.1021/acs.analchem.4c05794 · Cited by 20 · see citing works

Organic small-molecule NIR-II fluorophores for tumor phototheranostics

Xiang, D., Wang, Z., Zheng, H., Tang, Y., & Li, Q. (2026) · Light: Science &amp; Applications · doi:10.1038/s41377-026-02212-w · Cited by 22 · see citing works

Imaging of Dihexadecylphosphate Vesicles by AFM and Counterion Effect on Their Size and Stability

Kardassi, D., Tsiourvas, D., & Paleos, C. M. (1997) · Journal of Colloid and Interface Science · doi:10.1006/jcis.1996.4560 · Cited by 12 · see citing works

An electron spin resonance investigation of the 4,5-methylenephenanthrene dianion radical

Casson, D., & Tabner, B. J. (1971) · Journal of the Chemical Society B Physical Organic · doi:10.1039/j29710000479 · Cited by 4 · see citing works

Stabilization of β-octamolybdate with large counterions

Kama, A. B., Dessapt, R., Serier‐Brault, H., et al. (2017) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2017.03.111 · Cited by 6 · see citing works

Counterion correlations and attractions in dense polyelectrolyte solutions

Liverpool, T. B., & Müller-Nedebock, K. K. (2006) · Journal of Physics Condensed Matter · doi:10.1088/0953-8984/18/10/l01 · Cited by 5 · see citing works

THE EFFECT OF COUNTERIONS ON THE J-AGGREGATION OF AN ANIONIC CYANINE DYE

Zhou, J. (1989) · Ganguang kexue yu guanghuaxue