Genetic Models of Serotonin (5‐HT) Depletion: What do They Tell Us About the Developmental Role of 5‐HT?

The developmental role of serotonin: news from mouse molecular genetics

Gaspar, P., Cases, O., & Maroteaux, L. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1256 · Cited by 1,297 · see citing works

Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA

Cases, O., Seif, I., Grimsby, J. S., Gaspar, P., Chen, K., Vandormael‐Pournin, S., Müller, U., Aguet, M., Babinet, C., Shih, J. C., et al. (1995) · Science · doi:10.1126/science.7792602 · Cited by 1,225 · see citing works

Long story short: the serotonin transporter in emotion regulation and social cognition

Canli, T., & Lesch, K.-P. (2007) · Nature Neuroscience · doi:10.1038/nn1964 · Cited by 1,034 · see citing works

Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult

Gross, C. T., Zhuang, X., Stark, K. L., Ramboz, S., Oosting, R. S., Kirby, L. G., Santarelli, L., Beck, S. G., & Hen, R. (2002) · Nature · doi:10.1038/416396a · Cited by 906 · see citing works

Early-Life Blockade of the 5-HT Transporter Alters Emotional Behavior in Adult Mice

Ansorge, M. S., Zhou, M., Lira, A., Hen, R., & Gingrich, J. A. (2004) · Science · doi:10.1126/science.1101678 · Cited by 817 · see citing works

Platelet-Derived Serotonin Mediates Liver Regeneration

Lesurtel, M., Graf, R., Aleil, B., Walther, D. J., Tian, Y., Jochum, W., Gachet, C., Bäder, M., & Clavien, P. (2006) · Science · doi:10.1126/science.1123842 · Cited by 783 · see citing works

A unique central tryptophan hydroxylase isoform

Walther, D. J., & Bäder, M. (2003) · Biochemical Pharmacology · doi:10.1016/s0006-2952(03)00556-2 · Cited by 752 · see citing works

A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure

Yadav, V. K., Oury, F., Suda, N., Liu, Z.-W., Gao, X.-B., Confavreux, C., Klemenhagen, K. C., Tanaka, K. F., Gingrich, J. A., Guo, X. E., et al. (2009) · Cell · doi:10.1016/j.cell.2009.06.051 · Cited by 661 · see citing works

Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal liver haematopoiesis

Pandolfi, P. P., Roth, M. E., Karis, A., Leonard, M. W., Dzierzak, E. A., Grosveld, F. G., Engel, J. D., & Lindenbaum, M. (1995) · Nature Genetics · doi:10.1038/ng0995-40 · Cited by 630 · see citing works

Limb and kidney defects in Lmx1b mutant mice suggest an involvement of LMX1B in human nail patella syndrome

Chen, H., Lun, Y., Ovchinnikov, D. A., Kokubo, H., Oberg, K. C., Pepicelli, C. V., Can, L., Lee, B., & Johnson, R. L. (1998) · Nature Genetics · doi:10.1038/ng0598-51 · Cited by 562 · see citing works

Lack of Barrels in the Somatosensory Cortex of Monoamine Oxidase A–Deficient Mice: Role of a Serotonin Excess during the Critical Period

Cases, O., Vitalis, T., Seif, I., Maeyer, E. D., Sotelo, C., & Gaspar, P. (1996) · Neuron · doi:10.1016/s0896-6273(00)80048-3 · Cited by 514 · see citing works

Serotonin and brain development: role in human developmental diseases

Whitaker-Azmitia, P. M. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00615-3 · Cited by 506 · see citing works

Modern views on an ancient chemical: serotonin effects on cell proliferation, maturation, and apoptosis

Azmitia, E. C. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00614-1 · Cited by 497 · see citing works

Pet-1 ETS gene plays a critical role in 5-HT neuron development and is required for normal anxiety-like and aggressive behavior.

Hendricks, T. J., Fyodorov, D., Wegman, L. J., Lelutiu, N. B., Pehek, E. A., Yamamoto, B., Silver, J., Weeber, E., Sweatt, J., & Deneris, E. S. (2003) · Neuron · doi:10.1016/s0896-6273(02)01167-4 · Cited by 486 · see citing works

Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function

Côté, F., Thévenot, E., Fligny, C., Fromes, Y., Darmon, M. C., Ripoche, M., Bayard, E., Hanoun, N., Saurini, F., Lechat, P. P., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2233056100 · Cited by 483 · see citing works

Targeting the murine serotonin transporter: insights into human neurobiology

Murphy, D. L., & Lesch, K.-P. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2284 · Cited by 478 · see citing works

Serotonylation of small GTPases is a signal transduction pathway that triggers platelet α-granule release

Walther, D. J., Peter, J.-U., Winter, S., Höltje, M., Paulmann, N., Grohmann, M., Vowinckel, J., Alamo-Bethencourt, V., Wilhelm, C. S., Ahnert-Hilger, G., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)01014-6 · Cited by 475 · see citing works

GATA-3 Is Involved in the Development of Serotonergic Neurons in the Caudal Raphe Nuclei

van Doorninck, J. H., van der Wees, J., Karis, A., Sabel-Goedknegt, E., Coesmans, M., Rutteman, M., Grosveld, F. G., & Zeeuw, C. I. D. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-12-j0002.1999 · Cited by 416 · see citing works

Intracellular Serotonin Modulates Insulin Secretion from Pancreatic β-Cells by Protein Serotonylation

Paulmann, N., Grohmann, M., Voigt, J.-P., Bert, B., Vowinckel, J., Bader, M., Skelin, M., Jevšek, M., Fink, H., Rupnik, M., et al. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000229 · Cited by 404 · see citing works

Altered depression-related behaviors and functional changes in the dorsal raphe nucleus of serotonin transporter-deficient mice

Lira, A., Zhou, M., Castanon, N., Ansorge, M. S., Gordon, J. A., Francis, J. H., Bradley-Moore, M., Lira, J., Underwood, M. D., Arango, V., et al. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00696-6 · Cited by 385 · see citing works

Serotonin 2B receptor is required for heart development

Nebigil, C. G., Choi, D., Dierich, A., Hickel, P., LeMeur, M., Messaddeq, N., Launay, J., & Maroteaux, L. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.17.9508 · Cited by 382 · see citing works

Maternal serotonin is crucial for murine embryonic development

Côté, F., Fligny, C., Bayard, E., Launay, J.-M., Gershon, M. D., Mallet, J., & Vodjdani, G. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606722104 · Cited by 381 · see citing works

Knockout of the Vesicular Monoamine Transporter 2 Gene Results in Neonatal Death and Supersensitivity to Cocaine and Amphetamine

Wang, Y.-M., Gainetdinov, R. R., Fumagalli, F., Xu, F., Jones, S. R., Bock, C. B., Miller, G. W., Wightman, R. M., & Caron, M. G. (1997) · Neuron · doi:10.1016/s0896-6273(00)80419-5 · Cited by 376 · see citing works

Role of GSK3β in behavioral abnormalities induced by serotonin deficiency

Beaulieu, J.-M., Zhang, X., Rodriguiz, R. M., Sotnikova, T. D., Cools, M. J., Wetsel, W. C., Gainetdinov, R. R., & Caron, M. G. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711496105 · Cited by 368 · see citing works

Growth retardation and altered autonomic control in mice lacking brain serotonin

Alenina, N. V., Kikic, D., Todiraş, M., Mosienko, V., Qadri, F., Plehm, R., Boyé, P., Vilianovich, L., Sohr, R., Tenner, K., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810793106 · Cited by 349 · see citing works

Vesicular Transport Regulates Monoamine Storage and Release but Is Not Essential for Amphetamine Action

Fon, E. A., Pothos, E. N., Sun, B.-C., Killeen, N. P., Sulzer, D. L., & Edwards, R. H. (1997) · Neuron · doi:10.1016/s0896-6273(00)80418-3 · Cited by 337 · see citing works

The ETS Domain Factor Pet-1 Is an Early and Precise Marker of Central Serotonin Neurons and Interacts with a Conserved Element in Serotonergic Genes

Hendricks, T. J., Francis, N. J., Fyodorov, D. V., & Deneris, E. S. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-23-10348.1999 · Cited by 300 · see citing works

Serotonin and serotonin-like substances as regulators of early embryogenesis and morphogenesis

Buznikov, G. A., Lambert, H. W., & Lauder, J. M. (2001) · Cell and Tissue Research · doi:10.1007/s004410100408 · Cited by 274 · see citing works

New perspectives on the neurodevelopmental effects of SSRIs

Homberg, J. R., Schubert, D., & Gaspar, P. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.11.003 · Cited by 266 · see citing works

Excessive Activation of Serotonin (5-HT) 1B Receptors Disrupts the Formation of Sensory Maps in Monoamine Oxidase A and 5-HT Transporter Knock-Out Mice

Salichon, N., Gaspar, P., Upton, A. L., Picaud, S., Hanoun, N., Hamon, M., Maeyer, E. D., Murphy, D. L., Mößner, R., Lesch, K., et al. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-03-00884.2001 · Cited by 265 · see citing works

Genetic Disruption of Both Tryptophan Hydroxylase Genes Dramatically Reduces Serotonin and Affects Behavior in Models Sensitive to Antidepressants

Savelieva, K. V., Zhao, S., Pogorelov, V. M., Rajan, I., Yang, Q., Cullinan, E. B., & Lanthorn, T. H. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003301 · Cited by 265 · see citing works

Lmx1b is essential for the development of serotonergic neurons

Ding, Y.-Q., Marklund, U., Yuan, W., Yin, J., Wegman, L., Ericson, J., Deneris, E., Johnson, R. L., & Chen, Z.-F. (2003) · Nature Neuroscience · doi:10.1038/nn1104 · Cited by 262 · see citing works

Serotonin Regulates Mammary Gland Development via an Autocrine-Paracrine Loop

Matsuda, M., Imaoka, T., Vomachka, A. J., Gudelsky, G. A., Hou, Z., Mistry, M. J., Bailey, J. P., Nieport, K. M., Walther, D. J., Bäder, M., et al. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00022-x · Cited by 250 · see citing works

Barrel Pattern Formation Requires Serotonin Uptake by Thalamocortical Afferents, and Not Vesicular Monoamine Release

Persico, A. M., Mengual, E., Moessner, R., Hall, F. S., Revay, R. S., Sora, I., Arellano, J. I., DeFelipe, J., Giménez‐Amaya, J. M., Conciatori, M., et al. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-17-06862.2001 · Cited by 213 · see citing works

Lmx1bIs Required for Maintenance of Central Serotonergic Neurons and Mice Lacking Central Serotonergic System Exhibit Normal Locomotor Activity

Zhao, Z.-Q., Scott, M. M., Chiechio, S., Wang, J.-S., Renner, K. J., Gereau, R. W., Johnson, R. L., Deneris, E. S., & Chen, Z. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4143-06.2006 · Cited by 204 · see citing works

Ascl1/Mash1 is required for the development of central serotonergic neurons

Pattyn, A., Simplicio, N., van Doorninck, J. H., Goridis, C., Guillemot, F., & Brunet, J. (2004) · Nature Neuroscience · doi:10.1038/nn1247 · Cited by 198 · see citing works

Excess of serotonin (5-HT) alters the segregation of ispilateral and contralateral retinal projections in monoamine oxidase A knock-out mice: possible role of 5-HT uptake in retinal ganglion cells during development

Upton, A. L., Salichon, N., Lebrand, C., Ravary, A., Blakely, R., Seif, I., & Gaspar, P. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-16-07007.1999 · Cited by 173 · see citing works

Deficiency of brain 5-HT synthesis but serotonergic neuron formation in Tph2 knockout mice

Gutknecht, L., Waider, J., Kraft, S., Kriegebaum, C., Holtmann, B., Reif, A., Schmitt, A., & Lesch, K.-P. (2008) · Journal of Neural Transmission · doi:10.1007/s00702-008-0096-6 · Cited by 173 · see citing works

Transgenic mice lacking serotonin neurons have severe apnea and high mortality during development

Hodges, M. R., Wehner, M., Aungst, J., Smith, J. C., & Richerson, G. B. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.1963-09.2009 · Cited by 173 · see citing works

Spatio-temporal expression of tryptophan hydroxylase isoforms in murine and human brain: Convergent data from Tph2 knockout mice

Gutknecht, L., Kriegebaum, C., Waider, J., Schmitt, A. G., & Lesch, K. (2009) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2008.12.005 · Cited by 170 · see citing works

Serotonin as a regulator of craniofacial morphogenesis: Site specific malformations following exposure to serotonin uptake inhibitors

Shuey, D. L., Sadler, T. W., & Lauder, J. M. (1992) · Teratology · doi:10.1002/tera.1420460407 · Cited by 166 · see citing works

Development of the blood‐brain barrier: A historical point of view

Ribatti, D., Nico, B., Enrico Crivellato, B., & Artico, M. (2006) · The Anatomical Record Part B The New Anatomist · doi:10.1002/ar.b.20087 · Cited by 157 · see citing works

Increased Expression of the 5-HT Transporter Confers a Low- Anxiety Phenotype Linked to Decreased 5-HT Transmission

Jennings, K. A., Loder, M. K., Sheward, W. J., Pei, Q., Deacon, R. M. J., Benson, M. A., Olverman, H. J., Hastie, N. D., Harmar, A. J., Shen, S., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5356-05.2006 · Cited by 153 · see citing works

Axonal projections originating from raphe serotonergic neurons in the developing and adult zebrafish,Danio rerio, using transgenics to visualize raphe‐specificpet1expression

Lillesaar, C., Stigloher, C., Tannhäuser, B., Wullimann, M. F., & Bally‐Cuif, L. (2008) · The Journal of Comparative Neurology · doi:10.1002/cne.21887 · Cited by 151 · see citing works

Gata2 specifies serotonergic neurons downstream of sonic hedgehog

Craven, S. E., Lim, K.-C., Ye, W., Engel, J. D., de Sauvage, F. J., & Rosenthal, A. (2004) · Development · doi:10.1242/dev.01024 · Cited by 149 · see citing works

Neurochemical differentiation of human bulbospinal monoaminergic neurons during the first trimester

Sundström, E., Kölare, S., Souverbic, F., Samuelsson, E., Pschera, H., Lunell, N., & Seiger, Å. (1993) · Developmental Brain Research · doi:10.1016/0165-3806(93)90059-j · Cited by 149 · see citing works

Serotonin transporter transgenic (SERTcre) mouse line reveals developmental targets of serotonin specific reuptake inhibitors (SSRIs)

Narboux-Nême, N., Pavone, L. M., Avallone, L., Zhuang, X., & Gaspar, P. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.08.020 · Cited by 148 · see citing works

Enhanced contextual fear memory in central serotonin-deficient mice

Dai, J., Han, H., Tian, M., Cao, J., Xiu, J., Song, N., Huang, Y., Xu, T., Ding, Y., & Xu, L. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801329105 · Cited by 133 · see citing works

Early Life Blockade of 5-Hydroxytryptamine 1A Receptors Normalizes Sleep and Depression-Like Behavior in Adult Knock-Out Mice Lacking the Serotonin Transporter

Alexandre, C., Popa, D., Fabre, V., Bouali, S., Venault, P., Lesch, K., Hamon, M., & Adrien, J. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5156-05.2006 · Cited by 123 · see citing works

Late Developmental Stage-Specific Role of Tryptophan Hydroxylase 1 in Brain Serotonin Levels

Nakamura, K., Sugawara, Y., Sawabe, K., Ohashi, A., Tsurui, H., Xiu, Y., Ohtsuji, M., Lin, Q. S., Nishimura, H., Hasegawa, H., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1835-05.2006 · Cited by 122 · see citing works

Changing distribution of monoaminergic markers in the developing human cerebral cortex with special emphasis on the serotonin transporter

Verney, C., Lebrand, C., & Gaspar, P. (2002) · The Anatomical Record · doi:10.1002/ar.10089 · Cited by 119 · see citing works

Serotonin uptake in the ectoplacental cone and placenta of the mouse

Yavarone, M., Shuey, D. L., Sadler, T. W., & Lauder, J. M. (1993) · Placenta · doi:10.1016/s0143-4004(05)80257-7 · Cited by 107 · see citing works

Serotonergic transcriptional programming determines maternal behavior and offspring survival

Lerch, J. K., Frierson, D. M. W., Crawford, L. K., Beck, S. G., & Deneris, E. S. (2008) · Nature Neuroscience · doi:10.1038/nn.2176 · Cited by 107 · see citing works

Local serotonergic signaling in mammalian follicles, oocytes and early embryos

Dubé, F., & Amireault, P. (2007) · Life Sciences · doi:10.1016/j.lfs.2007.09.034 · Cited by 104 · see citing works

Gata2is a tissue-specific post-mitotic selector gene for midbrain GABAergic neurons

Achim, K., Haugas, M., Lilleväli, K., Guimerá, J., Wurst, W., Salminen, M., & Partanen, J. M. (2008) · Development · doi:10.1242/dev.029900 · Cited by 101 · see citing works

Arrest of 5HT neuron differentiation delays respiratory maturation and impairs neonatal homeostatic responses to environmental challenges

Erickson, J. T., Shafer, G. O., Rossetti, M. D., Wilson, C. G., & Deneris, E. S. (2007) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2007.06.002 · Cited by 97 · see citing works

Transcriptional repression coordinates the temporal switch from motor to serotonergic neurogenesis

Jacob, J., Ferri, L., Milton, C. I., Prin, F., Pla, P., Lin, W., Gavalas, A., Ang, S., & Briscoe, J. (2007) · Nature Neuroscience · doi:10.1038/nn1985 · Cited by 90 · see citing works

Serotonin transporter messenger RNA expression in neural crest-derived structures and sensory pathways of the developing rat embryo

Hansson, S. R., Mezey, É., & Hoffman, B. J. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00281-4 · Cited by 80 · see citing works

Monoamine oxidase inhibition during brain development induces pathological aggressive behavior in mice

Mejia, J. M., Ervin, F. R., Baker, G. B., & Palmour, R. M. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01418-x · Cited by 70 · see citing works

Molecular genetics of the early development of hindbrain serotonergic neurons

Cordes, S. P. (2005) · Clinical Genetics · doi:10.1111/j.1399-0004.2005.00534.x · Cited by 66 · see citing works

Lack of 5-HT1B receptor and of serotonin transporter have different effects on the segregation of retinal axons in the lateral geniculate nucleus compared to the superior colliculus

Upton, A. L., Ravary, A., Salichon, N., Moessner, R., Lesch, K., Hen, R., Seif, I., & Gaspar, P. (2002) · Neuroscience · doi:10.1016/s0306-4522(01)00602-9 · Cited by 60 · see citing works

Insm1 (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the vertebrate hindbrain

Jacob, J., Storm, R., Castro, D. S., Milton, C. I., Pla, P., Guillemot, F., Birchmeier, C., & Briscoe, J. (2009) · Development · doi:10.1242/dev.034546 · Cited by 54 · see citing works

Sites of serotonin uptake in epithelia of the developing mouse palate, oral cavity, and face: possible role in morphogenesis.

Lauder, J. M., & Zimmerman, E. F. (1988) · PubMed · Cited by 49 · see citing works

Effects of genetic depletion of monoamines on somatosensory cortical development

Alvarez, C., Vitalis, T., Fon, E. A., Hanoun, N., Hamon, M., Seif, I., Edwards, R. H., Gaspar, P., & Cases, O. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00484-0 · Cited by 48 · see citing works

Modulation of serotonin uptake kinetics by ions and ion gradients in human placental brush-border membrane vesicles

Cool, D. R., Leibach, F. H., & Ganapathy, V. (1990) · Biochemistry · doi:10.1021/bi00459a022 · Cited by 42 · see citing works

Developmental Cell Death Is Enhanced in the Cerebral Cortex of Mice Lacking the Brain Vesicular Monoamine Transporter

Stankovski, L., Alvarez, C., Ouimet, T., Vitalis, T., Hachimi, K. H. E., Price, D. J., Deneris, E. S., Gaspar, P., & Cases, O. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4395-06.2007 · Cited by 42 · see citing works

Expression and purification of human tryptophan hydroxylase from Escherichia coli and Pichia pastoris

McKinney, J. A., Knappskog, P. M., Pereira, J., Ekern, T., Toska, K., Kuitert, B. B., Levine, D., Gronenborn, A. M., Martı́nez, A., & Haavik, J. (2003) · Protein Expression and Purification · doi:10.1016/j.pep.2003.09.014 · Cited by 41 · see citing works

Serotonergic Transcription of HumanFEVReveals Direct GATA Factor Interactions and Fate ofPet-1-Deficient Serotonin Neuron Precursors

Krueger, K. C., & Deneris, E. S. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4349-08.2008 · Cited by 41 · see citing works

Sudden Infant Death Syndrome: Rare Mutation in the Serotonin System FEV Gene

Rand, C. M., Berry‐Kravis, E., Zhou, L., Fan, W., & Weese‐Mayer, D. E. (2007) · Pediatric Research · doi:10.1203/pdr.0b013e3180a725a0 · Cited by 40 · see citing works

The Ets transcription factor Fev is specifically expressed in the human central serotonergic neurons

Maurer, P., Rorive, S., d’Exaerde, A. D. K., Schiffmann, S. N., Salmon, I. J., & de Launoit, Y. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2003.12.086 · Cited by 36 · see citing works

Maternal serotonin influences cardiac function in adult offspring

Fiigny, C., Fromes, Y., Bonnin, P., Darmon, M. C., Bayard, E., Launay, J., Côté, F., Mallet, J. J., & Vodjdani, G. (2008) · The FASEB Journal · doi:10.1096/fj.07-100743 · Cited by 34 · see citing works

5-HT2A receptors are concentrated in regions of the human infant medulla involved in respiratory and autonomic control

Paterson, D. S., & Darnall, R. (2009) · Autonomic Neuroscience · doi:10.1016/j.autneu.2009.01.004 · Cited by 25 · see citing works

Heart valve cardiomyocytes of mouse embryos express the serotonin transporter SERT

Pavone, L. M., Spina, A., Muto, R. L., Santoro, D., Mastellone, V., & Avallone, L. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.09.152 · Cited by 23 · see citing works

The ETS oncogene family transcription factor FEV identifies serotonin-producing cells in normal and neoplastic small intestine

Wang, Y.-C., Zuraek, M. B., Kosaka, Y., Ota, Y., German, M. S., Deneris, E. S., Bergsland, E. K., Donner, D. B., Warren, R. S., & Nakakura, E. K. (2010) · Endocrine Related Cancer · doi:10.1677/erc-09-0243 · Cited by 21 · see citing works

Using biosensors to detect the release of serotonin from taste buds during taste stimulation.

Huang, Y.-J., Maruyama, Y., Lu, K. S., Pereira, E., Plonsky, I., Baur, J. E., Wu, D. W., & Roper, S. D. (2005) · PubMed · Cited by 19 · see citing works

Serotonin-Related FEV Gene Variant in the Sudden Infant Death Syndrome Is a Common Polymorphism in the African-American Population

Broadbelt, K. G., Barger, M. A., Paterson, D. S., Holm, I. A., Haas, E. A., Krous, H. F., Kinney, H. C., Markianos, K., & Beggs, A. H. (2009) · Pediatric Research · doi:10.1203/pdr.0b013e3181bd5a31 · Cited by 18 · see citing works

Transport and Metabolism of Serotonin in the Human Placenta from Normal and Severely Pre-Eclamptic Pregnancies

Carrasco, G., Cruz, M. A., Gallardo, V., Miguel, P., Dominguez, A., & González, C. (2000) · Gynecologic and Obstetric Investigation · doi:10.1159/000010237 · Cited by 15 · see citing works

Development of prefrontal cortex

Kolk, S. M., & Rakic, P. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01137-9 · Cited by 378 · see citing works

The serotonergic system in fish.

Lillesaar, C. (2011) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2011.05.009 · Cited by 309 · see citing works

P5-HT1A receptors in mood and anxiety: recent insights into autoreceptor versus heteroreceptor function

Garcia‐García, Á. L., Newman‐Tancredi, A., & Leonardo, E. D. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3389-x · Cited by 250 · see citing works

Developmental origins of brain disorders: roles for dopamine

Money, K. M., & Stanwood, G. D. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00260 · Cited by 221 · see citing works

Probing the diversity of serotonin neurons

Gaspar, P., & Lillesaar, C. (2012) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2011.0378 · Cited by 196 · see citing works

Mitochondrial Impairment: A Common Motif in Neuropsychiatric Presentation? The Link to the Tryptophan–Kynurenine Metabolic System

Tanaka, M., Szabó, Á., Spekker, E., Polyák, H., Tóth, F., & Vécsei, L. (2022) · Cells · doi:10.3390/cells11162607 · Cited by 160 · see citing works

Important role of mucosal serotonin in colonic propulsion and peristaltic reflexes: <i>in vitro</i> analyses in mice lacking tryptophan hydroxylase 1

Heredia, D. J., Gershon, M. D., Koh, S. D., Corrigan, R. D., Okamoto, T., & Smith, T. K. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2013.256230 · Cited by 144 · see citing works

Genetic depletion of brain 5HT reveals a common molecular pathway mediating compulsivity and impulsivity

Angoa-Perez, M., Kane, M. J., Briggs, D. I., Sykes, C. E., Shah, M. M., Francescutti, D., Rosenberg, D. R., Thomas, D. M., & Kuhn, D. M. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2012.07739.x · Cited by 133 · see citing works

Rethinking 5-HT 1A Receptors: Emerging Modes of Inhibitory Feedback of Relevance to Emotion-Related Behavior

Altieri, S. C., Garcia‐García, Á. L., Leonardo, E. D., & Andrews, A. M. (2012) · ACS Chemical Neuroscience · doi:10.1021/cn3002174 · Cited by 111 · see citing works

Investigating anxiety and depressive-like phenotypes in genetic mouse models of serotonin depletion

Fernández, S. P., & Gaspar, P. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.08.049 · Cited by 108 · see citing works

Severe Serotonin Depletion after Conditional Deletion of the Vesicular Monoamine Transporter 2 Gene in Serotonin Neurons: Neural and Behavioral Consequences

Narboux‐Nême, N., Sagné, C., Doly, S., Diaz, S. L., Martin, C. B. P., Angenard, G., Martres, M., Bruno Giros, A., Hamon, M., Lanfumey, L., et al. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.142 · Cited by 83 · see citing works

Postnatal Growth Defects in Mice with Constitutive Depletion of Central Serotonin

Narboux‐Nême, N., Angenard, G., Mosienko, V., Klempin, F., Pitychoutis, P. M., Deneris, E. S., Bäder, M., Bruno Giros, A., Alenina, N. V., & Gaspar, P. (2012) · ACS Chemical Neuroscience · doi:10.1021/cn300165x · Cited by 80 · see citing works

Insights into the complex influence of 5‐HT signaling on thalamocortical axonal system development

van Kleef, E. S. B., Gaspar, P., & Bonnin, A. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.8096.x · Cited by 61 · see citing works

Developmental exposure to the SSRI citalopram causes long-lasting behavioural effects in the three-spined stickleback (Gasterosteus aculeatus)

Kellner, M., Porseryd, T., Porsch-Hällström, I., Borg, B., Roufidou, C., & Olsén, K. H. (2017) · Ecotoxicology · doi:10.1007/s10646-017-1866-4 · Cited by 43 · see citing works

Paradoxical increase in survival of newborn neurons in the dentate gyrus of mice with constitutive depletion of serotonin

Diaz, S. L., Narboux‐Nême, N., Trowbridge, S., Scotto‐Lomassese, S., Kleine Borgmann, F. B., Jessberger, S., Giros, B., Maroteaux, L., Deneris, E., & Gaspar, P. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12297 · Cited by 41 · see citing works

The role of the serotonergic system in suicidal behavior

Samaan, Sadkowski, M., Clayden, R. C., Dennis, B. B., El-Sheikh, W., Rangarajan, S., & DeJesus, J. (2013) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s50300 · Cited by 40 · see citing works

Necdin shapes serotonergic development and SERT activity modulating breathing in a mouse model for Prader-Willi syndrome

Matarazzo, V. A., Prato, L. C. D., Schaller, F., Shvarev, Y., Kourdougli, N., Bertoni, A., Menuet, C., Voituron, N., Deneris, E. S., Gaspar, P., et al. (2017) · eLife · doi:10.7554/elife.32640 · Cited by 39 · see citing works

Perturbed Developmental Serotonin Signaling Affects Prefrontal Catecholaminergic Innervation and Cortical Integrity

Garcia, L. P., Witteveen, J. S., Middelman, A., van Hulten, J. A., Martens, G. J. M., Homberg, J. R., & Kolk, S. M. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1105-x · Cited by 28 · see citing works

Preclinical Testing in Translational Animal Models of Prader-Willi Syndrome: Overview and Gap Analysis

Carias, K. V., & Wevrick, R. (2019) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2019.03.001 · Cited by 26 · see citing works

Implication of 5-HT7 receptor in prefrontal circuit assembly and detrimental emotional effects of SSRIs during development

Olusakin, J., Moutkine, I., Dumas, S., Ponimaskin, E. G., Païzanis, E., Soiza‐Reilly, M., & Gaspar, P. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0775-z · Cited by 24 · see citing works

Mouse Models of the 5-HTTLPR × Stress Risk Factor for Depression

Carola, V., & Gross, C. T. (2011) · Current topics in behavioral neurosciences · doi:10.1007/7854_2011_190 · Cited by 23 · see citing works

Differences in serotoninergic metabolism possibly contribute to differences in breathing phenotype of FVB/N and C57BL/6J mice

Menuet, C., Kourdougli, N., Hilaire, G., & Voituron, N. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00117.2011 · Cited by 21 · see citing works

Beyond Gene Inactivation: Evolution of Tools for Analysis of Serotonergic Circuitry

Hainer, C., Mosienko, V., Koutsikou, S., Crook, J. J., Gloss, B. R., Kasparov, S., Lumb, B. M., & Alenina, N. V. (2015) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5b00045 · Cited by 18 · see citing works

Serotonergic Neurons in Vertebrate and Invertebrate Model Organisms (Rodents, Zebrafish, Drosophila melanogaster, Aplysia californica, Caenorhabditis elegans)

Lillesaar, C., & Gaspar, P. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-800050-2.00003-6 · Cited by 19 · see citing works

Adult Tph2 knockout mice without brain serotonin have moderately elevated spine trabecular bone but moderately low cortical bone thickness

Brommage, R., Liu, J., Doree, D. D., Yu, W., Powell, D. R., & Yang, Q. (2015) · BoneKEy Reports · doi:10.1038/bonekey.2015.87 · Cited by 18 · see citing works

Discovery of spirocyclic proline tryptophan hydroxylase-1 inhibitors

Goldberg, D. R., Lombaert, S. D., Aiello, R. J., Bourassa, P., Barucci, N., Zhang, Q., Paralkar, V. M., Valentine, J. J., & Zavadoski, W. J. (2016) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2016.01.064 · Cited by 18 · see citing works

EphrinA5 Signaling Is Required for the Distinctive Targeting of Raphe Serotonin Neurons in the Forebrain

Teng, T., Gaillard, A., Muzerelle, A., & Gaspar, P. (2017) · eNeuro · doi:10.1523/eneuro.0327-16.2017 · Cited by 18 · see citing works

Neural cell-types and circuits linking thermoregulation and social behavior

Rogers, J. F., Vandendoren, M., Prather, J. F., Landen, J. G., Bedford, N. L., & Nelson, A. C. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105667 · Cited by 20 · see citing works

Brain Serotonin Signaling Does Not Determine Sexual Preference in Male Mice

Angoa‐Pérez, M., Herrera‐Mundo, N., Kane, M. J., Sykes, C. E., Anneken, J. H., Francescutti, D. M., & Kuhn, D. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0118603 · Cited by 17 · see citing works

Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival

Muzerelle, A., Soiza‐Reilly, M., Hainer, C., Ruet, P.-L., Lesch, K., Bäder, M., Alenina, N. V., Scotto‐Lomassese, S., & Gaspar, P. (2021) · Scientific Reports · doi:10.1038/s41598-021-84368-6 · Cited by 16 · see citing works

Central serotonergic neuron deficiency in a mouse model of Zellweger syndrome

Rahim, R. S., Meedeniya, A. C. B., & Crane, D. I. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.05.034 · Cited by 14 · see citing works

Enteric and serological distribution of serotonin and its precursor tryptophan in perinatal low and normal weight piglets

Willemen, S., Che, L., Dewilde, S., van Hauwaert, M.-L., Vos, M. D., Huygelen, V., Fransén, E., Tambuyzer, B. R., Casteleyn, C. R., Cruchten, S. J. M. V., et al. (2014) · animal · doi:10.1017/s1751731114000317 · Cited by 14 · see citing works

Monoaminergic levels at the forebrain and diencephalon signal for the occurrence of mutualistic and conspecific engagement in client reef fish

de Abreu, M. S., Messias, J. P. M., Thörnqvist, P., Winberg, S., & Soares, M. C. (2018) · Scientific Reports · doi:10.1038/s41598-018-25513-6 · Cited by 12 · see citing works

Fgf3 is crucial for the generation of monoaminergic cerebrospinal fluid contacting cells in zebrafish

Reuter, I., Jäckels, J., Kneitz, S., Kuper, J., Lesch, K., & Lillesaar, C. (2019) · Biology Open · doi:10.1242/bio.040683 · Cited by 10 · see citing works

The Association Between Prenatal Exposure to Antidepressants and Autism: Some Research and Public Health Aspects

Kapra, O., Rotem, R. S., & Gross, R. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.555740 · Cited by 10 · see citing works

Central serotonin and autoresuscitation capability in mammalian neonates

Erickson, J. T. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.113162 · Cited by 8 · see citing works

Plasticity of thalamocortical axons is regulated by serotonin levels modulated by preterm birth

Sinclair-Wilson, A., Lawrence, A. R., Férézou, I., Cartonnet, H., Mailhes‐Hamon, C., Garel, S., & Lokmane, L. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2301644120 · Cited by 7 · see citing works

Effects of serta and sertb knockout on aggression in zebrafish (Danio rerio)

Tea, M., Pan, Y. K., Lister, J. G. R., Perry, S. F., & Gilmour, K. M. (2024) · Journal of Comparative Physiology A · doi:10.1007/s00359-024-01693-7 · Cited by 6 · see citing works

Serotonin’s fundamental role in early social development: Socio-affective communication through ultrasonic vocalizations, maternal affiliation, and the bidirectional nature of mother-infant interactions

Wang, T., & Wöhr, M. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106747 · Cited by 2 · see citing works

Hormonal Imbalance as a Prognostic Factor of Physical Development of Children with Intellectual Disability

Smirnova, O. V., Ovcharenko, E. S., & Каспаров, Э. В. (2024) · Children · doi:10.3390/children11080913 · Cited by 1 · see citing works

The effects of paroxetine-induced transient apoptosis and brain remodeling on social behavior in developing zebrafishPreprint

Sato, T., Saito, K., Oyu, T., Tsuda, S., Kurisaki, T., Kajihara, T., & Nagashima, M. (2023) · Research Square · doi:10.21203/rs.3.rs-3565434/v1 · Cited by 1 · see citing works

Paroxetine-induced transient apoptosis with delayed neurogenesis triggers brain-preferential regeneration in developing zebrafish

Sato, T., Saito, K., Oyu, T., Yamaguchi, K., Osawa, M., Shiko, Y., Kawasaki, Y., Kurisaki, T., Tsuda, S., Kajihara, T., et al. (2026) · PLoS ONE · doi:10.1101/2023.11.10.566506

Does prenatal exposure to antidepressants cause autism? - literature review

Marczyńska, Z., Grabowska, P., Olesińska, N., Bolla, P., Senat, H., Senat, A., & Madej, A. (2024) · Journal of Education Health and Sport · doi:10.12775/jehs.2024.57.003

olf413 an octopamine biogenesis pathway gene is required for axon growth and pathfinding during embryonic nervous system development in Drosophila melanogaster

Ramya, R., Venkatesh, C. R., & Shyamala, B. V. (2024) · BMC Research Notes · doi:10.1186/s13104-024-06700-3

Physiopathologie et développement de stratégies thérapeutiques dans le cadre de pathologies neurodéveloppementales : investigation des fonctions sensori-motrices à la naissance dans des modèles murins pour les syndromes de Prader Willi et Schaaf Yang

Prato, L. C. D. (2019) · doi:10.70675/dd91f911z64bbz44d4z84b6ze6b58dbec750

BindingDB Entry 50047047: Discovery of spirocyclic proline tryptophan hydroxylase-1 inhibitors.

BindingDB (2017) · UC San Diego · doi:10.7270/q2wd42dj

AR Highlights

Jensen, E. C. (2012) · The Anatomical Record · doi:10.1002/ar.22406

Postnatal Growth Defects in Mice with Constitutive Depletion of Central Serotonin

Narboux‐Nême, N., Angenard, G., Mosienko, V., Klempin, F., Pitychoutis, P. M., Deneris, E. S., Bäder, M., Bruno Giros, A., Alenina, N. V., & Gaspar, P. (2012) · ACS Chemical Neuroscience · doi:10.1021/cn300165x · Cited by 80 · see citing works

The developmental role of serotonin : lessons from new genetic models targeting serotonin production or storage

Gaspar, P. (2009) · Frontiers in Neuroscience · doi:10.3389/conf.neuro.01.2009.16.050

Impacts of Brain Serotonin Deficiency following Tph2 Inactivation on Development and Raphe Neuron Serotonergic Specification

Gutknecht, L., Araragi, N., Merker, S., Waider, J., Sommerlandt, F. M. J., Mlinar, B., Baccini, G., Mayer, U., Proft, F., Hamon, M., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043157 · Cited by 101 · see citing works

Role of Production and Degradation of Serotonin During Development

Nakamura, K., & Hasegawa, H. (2009) · The Open Neuroscience Journal · doi:10.2174/1874082000903010035 · Cited by 1 · see citing works