Changing distribution of monoaminergic markers in the developing human cerebral cortex with special emphasis on the serotonin transporter
Abstract
This article reviews the current knowledge of the early onset of the monoaminergic innervation in the developing cerebral cortex in humans and of changes in the distribution of tyrosine hydroxylase (TH) immunoreactivity in different neuronal populations of the developing telencephalon. The early genesis of the central monoaminergic neurons in mammals has led to postulations of a trophic role of monoamines in brain morphogenesis—especially in the cerebral cortex. The developmental effects of amines can be linked to the transient expression of different molecules linked to dopamine or serotonin neurotransmission. We present novel data on the immunocytochemistry of the vesicular monoamine transporter (VMAT2) and of the high‐affinity serotonin transporter (SERT) in human fetuses. SERT is a marker of the serotoninergic axons and allows visualization of the serotonin afferents of the raphe in the human telencephalon. In addition, during a restricted time period corresponding to 12–14 postovulatory weeks, we found SERT‐immunolabeled fibers in the rostral and caudal limbs of the internal capsule that do not correspond to serotoninergic fibers, but do coincide with the calbindin D28k‐labeled thalamocortical fiber tracts. The present observations are correlated with findings in rodents, in which a transient expression of SERT is visible in the thalamocortical axons during early postnatal life. The function of this transporter has been shown to be important for the fine‐tuning of cortical sensory maps during the critical period of development of these maps. Although the present observation does not allow ascertainment of which neurons transiently express SERT, it lends support to the notion that serotonin and serotonin uptake could have important developmental roles, during the formation of brain connections in humans, as they have in rodents. Anat Rec 267:87–93, 2002. © 2002 Wiley‐Liss, Inc.
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Serotonergic projections from the dorsal and medial Raphe nuclei are among the first to emerge and arrive in the PFC around E16/E17 in rodents and postnatal weeks 10-13 in humans.
“The brain matures from the brainstem to the more frontal cortical regions, and it is therefore not surprising that serotonergic projections from both the dorsal as well as the medial Raphe nuclei (DRN, MRN respectively) are among the first to emerge and are set towards cortical regions where they arrive in the PFC around E16/E17 in rodent and week postnatal 10–13 in humans [113–116].”
From Development of prefrontal cortex (2022) · cites this paper as [113]
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- Authors
- Verney, C., Lebrand, C., & Gaspar, P.
- Affiliations
- Inserm (FR)
- Corresponding author
- Verney, Catherine
- ORCID
- Lebrand, Cécile
- Venue
- The Anatomical Record
- Publisher
- Wiley
- Published
- 2002-04-23
- Volume
- 267
- Issue
- 2
- Pages
- 87-93
- ISSN
- 0003-276X (ISSN-L)
- 1097-0185
- OpenAlex
- W2043939919
- Cited by
- 119
- References
- 53
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 8 · 2023: 3 · 2021: 4 · 2020: 4 · 2019: 6 · 2018: 6 · 2017: 7 · 2016: 2 · 2015: 3 · 2014: 6 · 2013: 5 · 2012: 3
- FWCI
- 0.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Anatomical Record (publishedVersion)
- PubMed (publishedVersion)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- serotonin transporter, vesicular monoamine transporter 2, tyrosine hydroxylase, human fetal brain development, cortical development, telencephalon, raphe nuclei, calbindin-D28k, brain morphogenesis, monoaminergic innervation, critical period
- MeSH terms
- Animals, Biological Transport, Carrier Proteins, Cerebral Cortex, Embryonic and Fetal Development, Gestational Age, Humans, Membrane Glycoproteins, Nerve Tissue Proteins, Neuropeptides, Serotonin, Tyrosine 3-Monooxygenase, Biomarkers, Membrane Transport Proteins, Serotonin Plasma Membrane Transport Proteins, Vesicular Biogenic Amine Transport Proteins, Vesicular Monoamine Transport Proteins
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