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Cited by 405

The DOI matches its Crossref record; 90 of the 90 references it cites were found in a registry or an index.

PML nuclear bodies: dynamic sensors of DNA damage and cellular stress

Dellaire, Graham, Bazett‐Jones, David P.·2004·BioEssays
DOI 10.1002/bies.20089
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Abstract

Promyelocytic leukaemia nuclear bodies (PML NBs) are generally present in all mammalian cells, and their integrity correlates with normal differentiation of promyelocytes. Mice that lack PML NBs have impaired immune function, exhibit chromosome instability and are sensitive to carcinogens. Although their direct role in nuclear activity is unclear, PML NBs are implicated in the regulation of transcription, apoptosis, tumour suppression and the anti‐viral response. An emerging view is that they represent sites where multi‐subunit complexes form and where post‐translational modification of regulatory factors, such as p53, occurs in response to cellular stress. Following DNA damage, several repair factors transit through PML NBs in a temporally regulated manner implicating these bodies in DNA repair. We propose that PML NBs are dynamic sensors of cellular stress, which rapidly disassemble following DNA damage into large supramolecular complexes, dispersing associated repair factors to sites of damage. The dramatically increased total surface area available would enhance interactions between PML‐associated factors regulating DNA repair and apoptosis. BioEssays 26:963–977, 2004. © 2004 Wiley Periodicals, Inc.

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Metadata

Authors
Dellaire, G., & Bazett‐Jones, D. P.
Venue
BioEssays
Publisher
Wiley
Published
2004-08-17
Volume
26
Issue
9
Pages
963-977
ISSN
  • 0265-9247 (ISSN-L)
  • 1521-1878
DOI
10.1002/bies.20089
OpenAlex
W2111072547
Cited by
405
References
90
FWCI
1.32
Type
journal article
Language
en
Open access
closed

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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