Assessing cell and organ senescence biomarkers

de Jesus, Bruno Bernardes; Blasco, Maria A.

doi:10.1161/circresaha.111.247866

Cited by 187Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model OrganismsSirtuins and Resveratrol in Medicine

Assessing cell and organ senescence biomarkers

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de Jesus, Bruno Bernardes, Blasco, Maria A.·2012·Circulation Research

DOI 10.1161/circresaha.111.247866PMC PMC4824275

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Abstract

A major goal in cancer and aging research is to discriminate the biochemical modifications that happen locally that could account for the healthiness or malignancy of tissues. Senescence is one general antiproliferative cellular process that acts as a strong barrier for cancer progression, playing a crucial role in aging. Here, we focus on the current methods to assess cellular senescence, discriminating the advantages and disadvantages of several senescence biomarkers.

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p16INK4A and p21CIP1 expression and SAβgal activity were used as markers of senescent cells.
“Expression of p16INK4A and p21CIP1 were both used as markers of senescent cells, as was SAβgal activity [50,51].”
From Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease (2019) · cites this paper as [51]
Senescent cells are recognized by markers including p16INK4A and increased lysosome β-galactosidase activity, although these markers are neither fully sensitive nor specific and no gold-standard biomarker of cellular senescence has been established.
“Senescent cells are recognized by specific markers, including cyclin-dependent kinase inhibitor 2A (commonly known as p16INK4A) and increased lysosome β-galactosidase activity, although these markers are neither fully sensitive nor specific and, despite intense research, no gold-standard biomarker of cellular senescence has been established90.”
From Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty (2018) · cites this paper as [90]
Common markers used to identify senescent cells in histological sections are senescence associated beta-galactosidase expression, the cyclin inhibitor p16/INK or the DNA damage response protein gamma-H2AX, but these techniques are rarely combined.
“To identify senescent cells in histological section by immunocytochemistry or immunofluorescence, the most common markers used are senescence associated  galactosidase (SA  gal) expression, the cyclin inhibitor p16/INK or the DNA damage response protein  H2AX however these techniques are rarely combined [55].”
From Senescence of T Lymphocytes: Implications for Enhancing Human Immunity (2016) · cites this paper as [55]

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Authors: de Jesus, B. B., & Blasco, M. A.
Affiliations: From the Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre (CNIO), Madrid, Spain.
Venue: Circulation Research
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2012-06-22
Volume: 111
Issue: 1
Pages: 97-109
ISSN: 0009-7330 (ISSN-L)
1524-4571
DOI: 10.1161/circresaha.111.247866
PMC: PMC4824275
OpenAlex: W2097942030
Semantic Scholar: 24ec5011ed34912ebf7a84c15c5320f843b3b0be
Cited by: 187
References: 220
Citations by year: 2026: 7 · 2025: 15 · 2024: 20 · 2023: 11 · 2022: 7 · 2021: 20 · 2020: 17 · 2019: 12 · 2018: 17 · 2017: 17 · 2016: 19 · 2015: 8 · 2014: 6 · 2013: 9 · 2012: 2
FWCI: 0.86
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Circulation Research (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Topics: Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Keywords: cellular senescence, senescence biomarkers, aging, tumor progression
MeSH terms: Aging, Animals, Genetic Markers, Genotype, Humans, Oncogenes, Phenotype, Biomarkers, Telomere, Cellular Senescence, Telomere Shortening

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