The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Non‐genomic transgenerational inheritance of disease risk
Abstract
That there is a heritable or familial component of susceptibility to chronic non‐communicable diseases such as type 2 diabetes, obesity and cardiovascular disease is well established, but there is increasing evidence that some elements of such heritability are transmitted non‐genomically and that the processes whereby environmental influences act during early development to shape disease risk in later life can have effects beyond a single generation. Such heritability may operate through epigenetic mechanisms involving regulation of either imprinted or non‐imprinted genes but also through broader mechanisms related to parental physiology or behaviour. We review evidence and potential mechanisms for non‐genomic transgenerational inheritance of ‘lifestyle’ disease and propose that the ‘developmental origins of disease’ phenomenon is a maladaptive consequence of an ancestral mechanism of developmental plasticity that may have had adaptive value in the evolution of generalist species such as Homo sapiens . BioEssays 29: 145–154, 2007. © 2007 Wiley Periodicals, Inc.
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Citations
Cites
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Developmental Plasticity and Evolution
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Epigenetic differences arise during the lifetime of monozygotic twins
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Transposable elements: targets for early nutritional effects on epigenetic gene regulation
Waterland, R. A., & Jirtle, R. L. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.15.5293-5300.2003 · Cited by 2,019 · cited 1×
“Importantly, the level of DNA methylation of the epialleles in the F1 generation, and the resulting phenotype, can be altered by the F0 maternal environment as reflected by dietary manipulation((53,54)) or, for agouti, endocrine exposure.”
BackgroundNongenomic Transmission Across Generations of Maternal Behavior and Stress Responses in the Rat
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A germline-specific class of small RNAs binds mammalian Piwi proteins
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Epigenetic inheritance at the agouti locus in the mouse
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Predictive adaptive responses and human evolution
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Self-citationBuiting, K., Groß, S., Lich, C., Gillessen-Kaesbach, G., El-Maarri, O., & Horsthemke, B. (2003) · The American Journal of Human Genetics · doi:10.1086/367926 · Cited by 372
Cited by
Early Developmental Conditioning of Later Health and Disease: Physiology or Pathophysiology?
Hanson, M. A., & Gluckman, P. D. (2014) · Physiological Reviews · doi:10.1152/physrev.00029.2013 · Cited by 1,188
Self-citationEvolution, the Extended Synthesis
(2010) · The MIT Press eBooks · doi:10.7551/mitpress/9780262513678.001.0001 · Cited by 964
Glucocorticoids, prenatal stress and the programming of disease
Harris, A., & Seckl, J. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.06.007 · Cited by 871
How race becomes biology: Embodiment of social inequality
Gravlee, C. C. (2009) · American Journal of Physical Anthropology · doi:10.1002/ajpa.20983 · Cited by 625
Epigenetic mechanisms that underpin metabolic and cardiovascular diseases
Gluckman, P. D., Hanson, M. A., Buklijas, T., Low, F. M., & Beedle, A. S. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.102 · Cited by 627
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Metadata
- Authors
- Gluckman, P. D., Hanson, M. A., & Beedle, A. S.
- Venue
- BioEssays
- Publisher
- Wiley
- Published
- 2007-01-16
- Volume
- 29
- Issue
- 2
- Pages
- 145-154
- ISSN
- 0265-9247 (ISSN-L)
- 1521-1878
- OpenAlex
- W2155196041
- Cited by
- 380
- References
- 11
- FWCI
- 4.99
- Type
- journal article
- Language
- en
- Open access
- closed
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