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Cited by 380

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

Non‐genomic transgenerational inheritance of disease risk

Gluckman, Peter D., Hanson, Mark A., Beedle, Alan S.·2007·BioEssays
DOI 10.1002/bies.20522
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Abstract

That there is a heritable or familial component of susceptibility to chronic non‐communicable diseases such as type 2 diabetes, obesity and cardiovascular disease is well established, but there is increasing evidence that some elements of such heritability are transmitted non‐genomically and that the processes whereby environmental influences act during early development to shape disease risk in later life can have effects beyond a single generation. Such heritability may operate through epigenetic mechanisms involving regulation of either imprinted or non‐imprinted genes but also through broader mechanisms related to parental physiology or behaviour. We review evidence and potential mechanisms for non‐genomic transgenerational inheritance of ‘lifestyle’ disease and propose that the ‘developmental origins of disease’ phenomenon is a maladaptive consequence of an ancestral mechanism of developmental plasticity that may have had adaptive value in the evolution of generalist species such as Homo sapiens . BioEssays 29: 145–154, 2007. © 2007 Wiley Periodicals, Inc.

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Metadata

Authors
Gluckman, P. D., Hanson, M. A., & Beedle, A. S.
Venue
BioEssays
Publisher
Wiley
Published
2007-01-16
Volume
29
Issue
2
Pages
145-154
ISSN
  • 0265-9247 (ISSN-L)
  • 1521-1878
DOI
10.1002/bies.20522
OpenAlex
W2155196041
Cited by
380
References
11
FWCI
4.99
Type
journal article
Language
en
Open access
closed

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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