The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Biotechnology of flavonoids and other phenylpropanoid‐derived natural products. Part I: Chemical diversity, impacts on plant biology and human health
Abstract
Plant natural products derived from phenylalanine and the phenylpropanoid pathway are impressive in their chemical diversity and are the result of plant evolution, which has selected for the acquisition of large repertoires of pigments, structural and defensive compounds, all derived from a phenylpropanoid backbone via the plant‐specific phenylpropanoid pathway. These compounds are important in plant growth, development and responses to environmental stresses and thus can have large impacts on agricultural productivity. While plant‐based medicines containing phenylpropanoid‐derived active components have long been used by humans, the benefits of specific flavonoids and other phenylpropanoid‐derived compounds to human health and their potential for long‐term health benefits have been only recognized more recently. In this part of the review, we discuss the diversity and biosynthetic origins of phenylpropanoids and particularly of the flavonoid and stilbenoid natural products. We then review data pertaining to the modes of action and biological properties of these compounds, referring on their effects on human health and physiology and their roles as plant defense and antimicrobial compounds. This review continues in Part II discussing the use of biotechnological tools targeting the rational reconstruction of multienzyme pathways in order to modify the production of such compounds in plants and model microbial systems for the benefit of agriculture and forestry.
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Cites
Writing Group for the Women's Health Initiative Investigators (2002) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.288.3.321 · Cited by 15,889
Structure-antioxidant activity relationships of flavonoids and phenolic acids
Rice-Evans, C. A., Miller, N. J., & Paganga, G. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)02227-9 · Cited by 9,085
Advances in flavonoid research since 1992
Harborne, J. B., & Williams, C. A. (2000) · Phytochemistry · doi:10.1016/s0031-9422(00)00235-1 · Cited by 3,956
Antimicrobial properties of tannins
Scalbert, A. (1991) · Phytochemistry · doi:10.1016/0031-9422(91)83426-l · Cited by 2,321
Meta-Analysis of the Effects of Soy Protein Intake on Serum Lipids
Anderson, J. W., Johnstone, B. M., & Cook-Newell, M. E. (1995) · New England Journal of Medicine · doi:10.1056/nejm199508033330502 · Cited by 2,048
Flavonoids: antioxidants or signalling molecules?
Williams, R. J., Spencer, J. P. E., & Rice-Evans, C. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.01.001 · Cited by 2,016
The use of estrogens and progestins and the risk of breast cancer in postmenopausal women.
Colditz, G. A., Hankinson, S. E., Hunter, D. J., Willett, W. C., Manson, J. E., Stampfer, M. J., Hennekens, C., Rosner, B., & Speizer, F. E. (1995) · New England Journal of Medicine · doi:10.1056/nejm199506153322401 · Cited by 1,487
Effect of Hormone Replacement Therapy on Breast Cancer Risk: Estrogen Versus Estrogen Plus Progestin
Ross, R. K. (2000) · Journal of the National Cancer Institute · doi:10.1093/jnci/92.4.328 · Cited by 877
Two Classes of Plant Antibiotics: Phytoalexins versus "Phytoanticipins"
VanEtten, H. D., Mansfield, J. W., Bailey, J. A., & Farmer, E. E. (1994) · The Plant Cell · doi:10.1105/tpc.6.9.1191 · Cited by 710
Biondi, D. M., Rocco, C., & Ruberto, G. (2003) · Journal of Natural Products · doi:10.1021/np020365s · Cited by 89
Cited by
Ma, D., Sun, D., Wang, C., Li, Y., & Guo, T. (2014) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2014.03.024 · Cited by 477
Martens, S., Preuß, A., & Matern, U. (2010) · Phytochemistry · doi:10.1016/j.phytochem.2010.04.016 · Cited by 258
Plant–arthropod interactions: who is the winner?
Stahl, E., Hilfiker, O., & Reymond, P. (2018) · The Plant Journal · doi:10.1111/tpj.13773 · Cited by 164
Antimicrobial Activities of Natural Bioactive Polyphenols
Mandal, M. K., & Domb, A. J. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16060718 · Cited by 141
Ouahabi, S., Daoudi, N. E., Loukili, E. H., Asmae, H., Merzouki, M., Bnouham, M., Challioui, A., Hammouti, B., Fauconnier, M.-L., Rhazi, L., et al. (2024) · Marine Drugs · doi:10.3390/md22060240 · Cited by 37
Metadata
- Authors
- Ververidis, F., Trantas, E., Douglas, C., Vollmer, G., Kretzschmar, G., & Panopoulos, N.
- Venue
- Biotechnology Journal
- Publisher
- Wiley
- Published
- 2007-10
- Volume
- 2
- Issue
- 10
- Pages
- 1214-1234
- ISSN
- 1860-6768 (ISSN-L)
- 1860-7314
- OpenAlex
- W2009046676
- Cited by
- 490
- References
- 10
- FWCI
- 5.03
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Ververidis, F., Trantas, E., Douglas, C., Vollmer, G., Kretzschmar, G., & Panopoulos, N. (2007). Biotechnology of flavonoids and other phenylpropanoid‐derived natural products. Part I: Chemical diversity, impacts on plant biology and human health. Biotechnology Journal. https://doi.org/10.1002/biot.200700084
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