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Cited by 532

The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.

Chemotherapy-associated hepatotoxicity and surgery for colorectal liver metastases

Zorzi, D, Laurent, A, Pawlik, T M, Lauwers, G Y, Vauthey, J-N, Abdalla, E K·2007·British Journal of Surgery
DOI 10.1002/bjs.5719
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Abstract

Background: Preoperative systemic chemotherapy is increasingly used in patients who undergo hepatic resection for colorectal liver metastases (CLM). Although chemotherapy-related hepatic injury has been reported, the incidence and the effect of such injury on patient outcome remain ill defined. Methods: A systematic review of relevant studies published before May 2006 was performed. Studies that reported on liver injury associated with preoperative chemotherapy for CLM were identified and data on chemotherapy-specific liver injury and patient outcome following hepatic resection were synthesized and tabulated. Results: Hepatic steatosis, a mild manifestation of non-alcoholic fatty liver disease (NAFLD), may occur after treatment with 5-fluorouracil and is associated with increased postoperative morbidity. Non-alcoholic steatohepatitis, a serious complication of NAFLD that includes inflammation and hepatocyte damage, can occur after treatment with irinotecan, especially in obese patients. Irinotecan-associated steatohepatitis can affect hepatic reserve and increase morbidity and mortality after hepatectomy. Hepatic sinusoidal obstruction syndrome can occur in patients treated with oxaliplatin, but does not appear to be associated with an increased risk of perioperative death. Conclusion: Preoperative chemotherapy for CLM induces regimen-specific hepatic changes that can affect patient outcome. Both response rate and toxicity should be considered when selecting preoperative chemotherapy in patients with CLM.

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Metadata

Authors
Zorzi, D., Laurent, A., Pawlik, T. M., Lauwers, G. Y., Vauthey, J.-N., & Abdalla, E. K.
Venue
British Journal of Surgery
Publisher
Oxford University Press (OUP)
Published
2007-02-22
Volume
94
Issue
3
Pages
274-286
ISSN
  • 0007-1323 (ISSN-L)
  • 1365-2168
DOI
10.1002/bjs.5719
OpenAlex
W2139738991
Cited by
532
References
75
FWCI
18.56
Type
journal article
Language
en
Open access
closed

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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