The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Body composition and outcome in patients undergoing resection of colorectal liver metastases19
Abstract
Background: Recent evidence suggests that depletion of skeletal muscle mass (sarcopenia) and an increased amount of intra-abdominal fat (central obesity) influence cancer statistics. This study investigated the impact of sarcopenia and central obesity on survival in patients undergoing liver resection for colorectal liver metastases (CLM). Methods: Diagnostic imaging from patients who had hepatic resection for CLM in one centre between 2001 and 2009, and who had assessable perioperative computed tomograms, was analysed retrospectively. Total cross-sectional areas of skeletal muscle and intra-abdominal fat, and their influence on outcome, were analysed. Results: Of the 196 patients included in the study, 38 (19·4 per cent) were classified as having sarcopenia. Five-year disease-free (15 per cent versus 28·5 per cent in patients without sarcopenia; P = 0·002) and overall (20 per cent versus 49·9 per cent respectively; P < 0·001) survival rates were lower for patients with sarcopenia at a median follow-up of 29 (range 1–97) months. Sarcopenia was an independent predictor of worse recurrence-free (hazard ratio (HR) 1·88, 95 per cent confidence interval 1·25 to 2·82; P = 0·002) and overall (HR 2·53, 1·60 to 4·01; P < 0·001) survival. Central obesity was associated with an increased risk of recurrence in men (P = 0·032), but not in women (P = 0·712). Conclusion: Sarcopenia has a negative impact on cancer outcomes following resection of CLM.
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Janssen, I., Heymsfield, S. B., & Ross, R. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50216.x · Cited by 3,139
Mitsiopoulos, N., Baumgartner, R. N., Heymsfield, S. B., Lyons, W., Gallagher, D., & Ross, R. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.85.1.115 · Cited by 1,522
Dodson, S., Baracos, V. E., Jatoi, A., Evans, W. J., Cella, D., Dalton, J. T., & Steiner, M. S. (2011) · Annual Review of Medicine · doi:10.1146/annurev-med-061509-131248 · Cited by 319
Cited by
Impact of Sarcopenia on Outcomes Following Resection of Pancreatic Adenocarcinoma
Peng, P., Hyder, O., Firoozmand, A., Kneuertz, P., Schulick, R. D., Huang, D., Makary, M., Hirose, K., Edil, B., Choti, M. A., et al. (2012) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-012-1923-5 · Cited by 546
van der Werf, A., Langius, J. A. E., de van der Schueren, M. A. E., Nurmohamed, S. A., van der Pant, K. A. M. I., Blauwhoff-Buskermolen, S., & Wierdsma, N. J. (2018) · European Journal of Clinical Nutrition · doi:10.1038/s41430-017-0034-5 · Cited by 295
Impact of quality as well as quantity of skeletal muscle on outcomes after liver transplantation
Hamaguchi, Y., Kaido, T., Okumura, S., Fujimoto, Y., Ogawa, K., Mori, A., Hammad, A., Tamai, Y., Inagaki, N., & Uemoto, S. (2014) · Liver Transplantation · doi:10.1002/lt.23970 · Cited by 242
van Vugt, J. L. A., Levolger, S., Gharbharan, A., Koek, M., Niessen, W. J., Burger, J. W. A., Willemsen, S. P., de Bruin, R. W. F., & IJzermans, J. N. M. (2017) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12158 · Cited by 217
Self-citationvan Vugt, J. L. A., Alferink, L. J. M., Buettner, S., Gaspersz, M. P., Bot, D., Darwish Murad, S., Feshtali, S., van Ooijen, P. M. A., Polak, W. G., Porte, R. J., et al. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2017.11.030 · Cited by 208
Self-citationOzola Zalite, I., Zykus, R., Francisco Gonzalez, M., Saygili, F., Pukitis, A., Gaujoux, S., Charnley, R. M., & Lyadov, V. (2015) · Pancreatology · doi:10.1016/j.pan.2014.11.006 · Cited by 174
Sjøblom, B., Grønberg, B. H., Wentzel-Larsen, T., Baracos, V. E., Hjermstad, M. J., Aass, N., Bremnes, R. M., Fløtten, Ø., Bye, A., & Jordhøy, M. (2016) · Clinical Nutrition · doi:10.1016/j.clnu.2016.03.010 · Cited by 143
Martin, L., Hopkins, J., Malietzis, G., Jenkins, J. T., Sawyer, M. B., Brisebois, R., MacLean, A., Nelson, G., Gramlich, L., & Baracos, V. E. (2018) · Annals of Surgical Oncology · doi:10.1245/s10434-018-6652-x · Cited by 139
Systematic review and meta-analysis of lean mass and mortality: Rationale and study description
Cheung, C.-L., Lee, G. K.-Y., Au, P. C.-M., Li, G. H.-Y., Chan, M., Li, H.-L., Cheung, B. M.-Y., Wong, I. C.-K., Lee, V. H.-F., Mok, J., et al. (2021) · Osteoporosis and Sarcopenia · doi:10.1016/j.afos.2021.01.001 · Cited by 18
Xun, X., Wang, R., Cheng, Q., & Gao, P. (2026) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2026.106132 · Cited by 5
Metadata
- Authors
- van Vledder, M. G., Levolger, S., Ayez, N., Verhoef, C., Tran, T. C. K., & IJzermans, J. N. M.
- Venue
- British Journal of Surgery
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-01-13
- Volume
- 99
- Issue
- 4
- Pages
- 550-557
- ISSN
- 0007-1323 (ISSN-L)
- 1365-2168
- OpenAlex
- W2090991937
- Cited by
- 462
- References
- 4
- FWCI
- 17.93
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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