Muscle wasting in cancer cachexia: clinical implications, diagnosis, and emerging treatment strategies

Epidemiology of Sarcopenia among the Elderly in New Mexico

Baumgartner, R. N., Koehler, K. M., Gallagher, D., Romero, L., Heymsfield, S. B., Ross, R. R., Garry, P. J., & Lindeman, R. D. (1998) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009520 · Cited by 4,004 · see citing works

Identification of ubiquitin ligases required for skeletal muscle atrophy.

Bodine, S. C., Latres, E., Baumhueter, S., Lai, V. K.-M., Nunez, L., Clarke, B. A., Poueymirou, W. T., Panaro, F. J., Na, E., Dharmarajan, K., et al. (2001) · Science · doi:10.1126/science.1065874 · Cited by 3,521 · see citing works

Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: A population-based study

Prado, C. M., Lieffers, J. R., McCargar, L. J., Reiman, T., Sawyer, M. B., Martin, L., & Baracos, V. E. (2008) · The Lancet Oncology · doi:10.1016/s1470-2045(08)70153-0 · Cited by 3,238 · see citing works

Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability

Janssen, I., Heymsfield, S. B., & Ross, R. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50216.x · Cited by 3,139 · see citing works

Prognostic effect of weight loss prior tochemotherapy in cancer patients

DeWys, W. D., Begg, C. B., Lavin, P. T., Band, P. R., Bennett, J. M., Bertino, J. R., Cohen, M. H., Douglass, H. O., Engstrom, P. F., Ezdinli, E. Z., et al. (1980) · The American Journal of Medicine · doi:10.1016/s0149-2918(05)80001-3 · Cited by 2,350 · see citing works

Cachexia: a new definition.

Evans, W., Morley, J., Argilés, J., Bales, C., Baracos, V., Guttridge, D., Jatoi, A., Kalantar-zadeh, K., Lochs, H., Mantovani, G., et al. (2008) · Clinical Nutrition · doi:10.1016/j.clnu.2008.06.013 · Cited by 2,341 · see citing works

Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy

Gomes, M. D., Lecker, S. H., Jagoe, R. T., Navon, A., & Goldberg, A. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.251541198 · Cited by 1,774 · see citing works

Consensus definition of sarcopenia, cachexia and pre-cachexia: joint document elaborated by Special Interest Groups (SIG) “cachexia-anorexia in chronic wasting diseases” and “nutrition in geriatrics”

Muscaritoli, M., Anker, S. D., Argilés, J., Aversa, Z., Bauer, J. M., Biolo, G., Boirie, Y., Bosaeus, I., Cederholm, T., Costelli, P., et al. (2010) · Clinical Nutrition · doi:10.1016/j.clnu.2009.12.004 · Cited by 1,732 · see citing works

The Functional Assessment of Chronic Illness Therapy (FACIT) Measurement System: properties, applications, and interpretation.

(2003) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-1-79 · Cited by 1,506 · see citing works

Mechanisms of Cancer Cachexia

Tisdale, M. J. (2009) · Physiological Reviews · doi:10.1152/physrev.00016.2008 · Cited by 1,192 · see citing works

Skeletal muscle hypertrophy and atrophy signaling pathways

Glass, D. J. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2005.04.018 · Cited by 1,106 · see citing works

Sarcopenia as a Determinant of Chemotherapy Toxicity and Time to Tumor Progression in Metastatic Breast Cancer Patients Receiving Capecitabine Treatment

Prado, C. M. M., Baracos, V. E., McCargar, L. J., Reiman, T., Mourtzakis, M., Tonkin, K. S., Mackey, J. R., Koski, S. L., Pituskin, E., & Sawyer, M. B. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-2242 · Cited by 1,103 · see citing works

Sarcopenic obesity: A new category of obesity in the elderly

Zamboni, M., Mazzali, G., Fantin, F., Rossi, A., & Di Francesco, V. (2008) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2007.10.002 · Cited by 953 · see citing works

Sarcopenia

Morley, J. E., Baumgartner, R., Roubenoff, R., Mayer, J., & Nair, K. S. (2001) · Journal of Laboratory and Clinical Medicine · doi:10.1067/mlc.2001.113504 · Cited by 938 · see citing works

Cachexia: pathophysiology and clinical relevance1,2

Morley, J. E., Thomas, D. R., & Wilson, M.-M. G. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.4.735 · Cited by 786 · see citing works

Skeletal muscle loss: cachexia, sarcopenia, and inactivity

Evans, W. J. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.28608a · Cited by 724 · see citing works

Signalling pathways that mediate skeletal muscle hypertrophy and atrophy

Glass, D. J. (2003) · Nature Cell Biology · doi:10.1038/ncb0203-87 · Cited by 694 · see citing works

Body Composition as an Independent Determinant of 5-Fluorouracil–Based Chemotherapy Toxicity

Prado, C. M. M., Baracos, V. E., McCargar, L. J., Mourtzakis, M., Mulder, K. E., Reiman, T., Butts, C. A., Scarfe, A. G., & Sawyer, M. B. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-3067 · Cited by 621 · see citing works

Epidemiology of Sarcopenia

III, L. J. M., Khosla, S., Crowson, C. S., O'Connor, M. K., O'Fallon, W. M., & Riggs, B. L. (2000) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2000.tb04719.x · Cited by 598 · see citing works

Mechanisms of Cancer-Related Fatigue

Ryan, J. L., Carroll, J. K., Ryan, E. P., Mustian, K. M., Fiscella, K. A., & Morrow, G. R. (2007) · The Oncologist · doi:10.1634/theoncologist.12-s1-22 · Cited by 588 · see citing works

Tumour immunity: effector response to tumour and role of the microenvironment

Mantovani, A., Romero, P. J., Palucka, A. K., & Marincola, F. M. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60241-x · Cited by 536 · see citing works

Chemistry and Structural Biology of Androgen Receptor

Gao, W., Bohl, C. E., & Dalton, J. T. (2005) · Chemical Reviews · doi:10.1021/cr020456u · Cited by 527 · see citing works

Body composition in patients with non−small cell lung cancer: a contemporary view of cancer cachexia with the use of computed tomography image analysis

Baracos, V. E., Reiman, T., Mourtzakis, M., Gioulbasanis, I., & Antoun, S. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.28608c · Cited by 496 · see citing works

Low body mass index and sarcopenia associated with dose-limiting toxicity of sorafenib in patients with renal cell carcinoma

Antoun, S., Baracos, V. E., Birdsell, L., Escudier, B. J., & Sawyer, M. B. (2010) · Annals of Oncology · doi:10.1093/annonc/mdp605 · Cited by 420 · see citing works

Standardizing Patient-Reported Outcomes Assessment in Cancer Clinical Trials: A Patient-Reported Outcomes Measurement Information System Initiative

Garcia, S. F., Cella, D., Clauser, S. B., Flynn, K. E., Lad, T., Lai, J.-S., Reeve, B. B., Wilder Smith, A., Stone, A. A., & Weinfurt, K. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2007.12.2341 · Cited by 407 · see citing works

Signaling pathways perturbing muscle mass.

Glass, D. J. (2010) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e32833862df · Cited by 359 · see citing works

Randomized Comparison of Megestrol Acetate Versus Dexamethasone Versus Fluoxymesterone for the Treatment of Cancer Anorexia/Cachexia

Loprinzi, C. L., Kugler, J. W., Sloan, J. A., Mailliard, J. A., Krook, J. E., Wilwerding, M. B., Rowland, K. M., Camoriano, J. K., Novotny, P. J., & Christensen, B. J. (1999) · Journal of Clinical Oncology · doi:10.1200/jco.1999.17.10.3299 · Cited by 341 · see citing works

Thalidomide in the treatment of cancer cachexia: a randomised placebo controlled trial

Gordon, J., Trebble, T. M., Ellis, R. D., Duncan, H. D., Johns, T., & Goggin, P. M. (2005) · Gut · doi:10.1136/gut.2004.047563 · Cited by 322 · see citing works

ABC of palliative care: Anorexia, cachexia, and nutrition

Bruera, E. D. (1997) · BMJ · doi:10.1136/bmj.315.7117.1219 · Cited by 312 · see citing works

Nutrition support in clinical practice: review of published data and recommendations for future research directions. Summary of a conference sponsored by the National Institutes of Health, American Society for Parenteral and Enteral Nutrition, and American Society for Clinical Nutrition.

Klein, S., Kinney, J., Jeejeebhoy, K., Alpers, D., Hellerstein, M., Murray, M. J., & Twomey, P. (1997) · American Journal of Clinical Nutrition · doi:10.1177/0148607197021003133 · Cited by 306 · see citing works

Drug Insight: testosterone and selective androgen receptor modulators as anabolic therapies for chronic illness and aging

Bhasin, S., Calof, O. M., Storer, T. W., Lee, M. L., Mazer, N. A., Jasuja, R., Montori, V. M., Gao, W., & Dalton, J. T. (2006) · Nature Clinical Practice Endocrinology &#38 Metabolism · doi:10.1038/ncpendmet0120 · Cited by 300 · see citing works

Sarcopenia in elderly men and women

Castillo, E. M., Goodman-Gruen, D., Kritz-Silverstein, D., Morton, D. J., Wingard, D. L., & Barrett-Connor, E. (2003) · American Journal of Preventive Medicine · doi:10.1016/s0749-3797(03)00197-1 · Cited by 290 · see citing works

The emerging role of computerized tomography in assessing cancer cachexia

Prado, C. M. M., Birdsell, L., & Baracos, V. E. (2009) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0b013e328331124a · Cited by 275 · see citing works

Cachexia: prevalence and impact in medicine

Tan, B. H. L., & Fearon, K. C. H. (2008) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e328300ecc1 · Cited by 266 · see citing works

Nutrition support in clinical practice: review of published data and recommendations for future research directions. Summary of a conference sponsored by the National Institutes of Health, American Society for Parenteral and Enteral Nutrition, and American Society for Clinical Nutrition

Klein, S., Kinney, J., Jeejeebhoy, K. N., Alpers, D., Hellerstein, M. K., Murray, M. J., & Twomey, P. L. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/66.3.683 · Cited by 256 · see citing works

Prevention and treatment of cancer cachexia: new insights into an old problem.

Muscaritoli, M., Bossola, M., Aversa, Z., Bellantone, R., & Fanelli, F. R. (2006) · European Journal of Cancer · doi:10.1016/j.ejca.2005.07.026 · Cited by 248 · see citing works

Randomized Phase III Clinical Trial of Five Different Arms of Treatment in 332 Patients with Cancer Cachexia

Mantovani, G., Macciò, A., Madeddu, C., Serpe, R., Massa, E., Dessì, M., Panzone, F., & Contu, P. (2010) · The Oncologist · doi:10.1634/theoncologist.2009-0153 · Cited by 231 · see citing works

Phase III evaluation of four doses of megestrol acetate as therapy for patients with cancer anorexia and/or cachexia.

Loprinzi, C. L., Michalak, J. C., Schaid, D. J., Mailliard, J. A., Athmann, L. M., Goldberg, R. M., Tschetter, L. K., Hatfield, A. K., & Morton, R. F. (1993) · Journal of Clinical Oncology · doi:10.1200/jco.1993.11.4.762 · Cited by 223 · see citing works

Anabolic-Androgenic Steroid Therapy in the Treatment of Chronic Diseases

Basaria, S. S. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.11.5108 · Cited by 223 · see citing works

Expanding the therapeutic use of androgens via selective androgen receptor modulators (SARMs)

Gao, W., & Dalton, J. T. (2007) · Drug Discovery Today · doi:10.1016/j.drudis.2007.01.003 · Cited by 216 · see citing works

Understanding and Managing Cancer Cachexia

Macdonald, N., Easson, A. M., Mazurak, V. C., Dunn, G. P., & Baracos, V. E. (2003) · Journal of the American College of Surgeons · doi:10.1016/s1072-7515(03)00382-x · Cited by 207 · see citing works

Nonsteroidal Selective Androgen Receptor Modulators (SARMs): Dissociating the Anabolic and Androgenic Activities of the Androgen Receptor for Therapeutic Benefit

Mohler, M. L., Bohl, C. E., Jones, A. J., Coss, C. C., Narayanan, R., He, Y., Hwang, D., Dalton, J. T., & Miller, D. D. (2009) · Journal of Medicinal Chemistry · doi:10.1021/jm900280m · Cited by 206 · see citing works

Re-validation and Shortening of the Functional Assessmentof Anorexia/Cachexia Therapy (FAACT) Questionnaire

Ribaudo, J. M., Cella, D. F., Hahn, E. A., Lloyd, S. R., Tchekmedyian, N. S., Roenn, J. V., & Leslie, W. T. (2000) · Quality of Life Research · doi:10.1023/a:1016670403148 · Cited by 205 · see citing works

Pentoxifylline for treatment of cancer anorexia and cachexia? A randomized, double-blind, placebo-controlled trial.

Goldberg, R. M., Loprinzi, C. L., Mailliard, J. A., O'Fallon, J. R., Krook, J. E., Ghosh, C., Hestorff, R., Chong, S. F., Reuter, N. F., & Shanahan, T. G. (1995) · Journal of Clinical Oncology · doi:10.1200/jco.1995.13.11.2856 · Cited by 184 · see citing works

Molecular mechanisms involved in muscle wasting in cancer and ageing: cachexia versus sarcopenia

Argilés, J. M. A., Busquets, S., Felipe, A., & López-Soriano, F. J. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.10.003 · Cited by 177 · see citing works

Cancer-Associated Cachexia and Underlying Biological Mechanisms

Baracos, V. E. (2006) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.26.061505.111151 · Cited by 176 · see citing works

Selective androgen receptor modulators in preclinical and clinical development

Narayanan, R., Mohler, M. L., Bohl, C. E., Miller, D. D., & Dalton, J. T. (2008) · Nuclear Receptor Signaling · doi:10.1621/nrs.06010 · Cited by 159 · see citing works

The ubiquitin-proteasome pathway as a therapeutic target for muscle wasting.

Tisdale, M. J. (2005) · PubMed · Cited by 145 · see citing works

A multicenter, phase II study of infliximab plus gemcitabine in pancreatic cancer cachexia.

Wiedenmann, B., Malfertheiner, P., Friess, H., Ritch, P. S., Arseneau, J. C., Mantovani, G., Caprioni, F., Cutsem, E. V., Richel, D. J., DeWitte, M., et al. (2008) · PubMed · Cited by 144 · see citing works

Pathogenesis of cancer cachexia.

Tisdale, M. J. (2004) · PubMed · Cited by 140 · see citing works

The experience of cancer cachexia: A qualitative study of advanced cancer patients and their family members

Reid, J., McKenna, H., Fitzsimons, D., & McCance, T. (2008) · International Journal of Nursing Studies · doi:10.1016/j.ijnurstu.2008.10.012 · Cited by 140 · see citing works

Phase II nonrandomized study of the efficacy and safety of COX-2 inhibitor celecoxib on patients with cancer cachexia

Mantovani, G., Macciò, A., Madeddu, C., Serpe, R., Antoni, G., Massa, E., Dessì, M., & Panzone, F. (2009) · Journal of Molecular Medicine · doi:10.1007/s00109-009-0547-z · Cited by 135 · see citing works

Proteasome proteolytic activity in skeletal muscle is increased in patients with sepsis

Klaude, M., Fredriksson, K., Tjäder, I., Hammarqvist, F., Ahlman, B. H. J., Rooyackers, O., & Wernerman, J. (2007) · Clinical Science · doi:10.1042/cs20060265 · Cited by 126 · see citing works

Olive oil, other seasoning fats, and the risk of colorectal carcinoma

Braga, C., Vecchia, C. L., Franceschi, S., Negri, E., Parpinel, M. T., Decarli, A., Giacosa, A., & Trichopoulos, D. (1998) · Cancer · doi:10.1002/(sici)1097-0142(19980201)82:3 · Cited by 126 · see citing works

Appendicular lean tissue mass and the prevalence of sarcopenia among healthy women

Tank[oacute], L. B., Movsesyan, L., Mouritzen, U., Christiansen, C., & Svendsen, O. L. (2002) · Metabolism · doi:10.1053/meta.2002.28960 · Cited by 121 · see citing works

Excess Mortality Following Vertebral Fracture

Melton, L. J. (2000) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2000.tb02658.x · Cited by 112 · see citing works

The impact of hypogonadism and autonomic dysfunction on fatigue, emotional function, and sexual desire in male patients with advanced cancer: A pilot study

Strasser, F., Palmer, J. L., Schover, L. R., Yusuf, S. W., Pisters, K., Vassilopoulou‐Sellin, R., DeGracia, B., Willey, J. S., & Bruera, E. (2006) · Cancer · doi:10.1002/cncr.22339 · Cited by 112 · see citing works

Regulation of Protein Catabolism by Muscle-Specific and Cytokine-Inducible Ubiquitin Ligase E3α-II during Cancer Cachexia

Kwak, K. S., Zhou, X., Solomon, V., Baracos, V. E., Davis, J. G., Bannon, A. W., Boyle, W. J., Lacey, D. L., & Han, H. Q. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-2102 · Cited by 111 · see citing works

Pharmacokinetics and Pharmacodynamics of Nonsteroidal Androgen Receptor Ligands

Gao, W., Kim, J., & Dalton, J. T. (2006) · Pharmaceutical Research · doi:10.1007/s11095-006-9024-3 · Cited by 109 · see citing works

Cognitive and mood disturbance as causes and symptoms of fatigue in cancer patients

Valentine, A. D., & Meyers, C. A. (2001) · Cancer · doi:10.1002/1097-0142(20010915)92:6+ · Cited by 106 · see citing works

Cancer cachexia

Gordon, J., Green, S. R., & Goggin, P. M. (2005) · QJM · doi:10.1093/qjmed/hci127 · Cited by 105 · see citing works

An exploration of the experience of cancer cachexia: what patients and their families want from healthcare professionals

Reid, J., McKenna, H., Fitzsimons, D., & CANCE, T. V. M. (2009) · European Journal of Cancer Care · doi:10.1111/j.1365-2354.2009.01124.x · Cited by 103 · see citing works

Oesophageal cancer and cachexia: the effect of short‐term treatment with thalidomide on weight loss and lean body mass

Khan, Z. H., Simpson, E. J., COLE, A. T., Holt, M., Macdonald, I. A., Pye, D., Austin, A., & Freeman, J. G. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01457.x · Cited by 98 · see citing works

Adult malnutrition: simple assessment techniques for use in emergencies

Ferro-Luzzi, A., & James, W. P. T. (1996) · British Journal Of Nutrition · doi:10.1079/bjn19960105 · Cited by 92 · see citing works

Pharmacodynamic hormonal effects of anamorelin, a novel oral ghrelin mimetic and growth hormone secretagogue in healthy volunteers

Garcia, J. M., & Polvino, W. J. (2009) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2008.12.003 · Cited by 89 · see citing works

Cancer cachexia: medical management

Mantovani, G., & Madeddu, C. (2009) · Supportive Care in Cancer · doi:10.1007/s00520-009-0722-3 · Cited by 81 · see citing works

Body composition in French women 75+ years of age: The EPIDOS study

Gillette-Guyonnet, S. (2003) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00198-7 · Cited by 73 · see citing works

MAFbx/Atrogin-1 expression is a poor index of muscle proteolysis

Attaix, D., & Baracos, V. E. (2010) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e328338b9a6 · Cited by 67 · see citing works

Cancer Anorexia-Cachexia Syndrome

McClement, S. (2005) · Journal of Wound Ostomy and Continence Nursing · doi:10.1097/00152192-200507000-00012 · Cited by 67 · see citing works

Body Composition in Cancer Cachexia

Fearon, K. C. H., & Preston, T. (1990) · Transfusion Medicine and Hemotherapy · doi:10.1159/000222558 · Cited by 67 · see citing works

A phase II randomized, placebo-controlled, double-blind study of the efficacy and safety of RC-1291 (RC) for the treatment of cancer cachexia

Garcia, J. M., Boccia, R. V., Graham, C., Kumor, K. M., & Polvino, W. J. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2007.25.18_suppl.9133 · Cited by 52 · see citing works

Update on emerging drugs for cancer cachexia

Murphy, K. T., & Lynch, G. S. (2009) · Expert Opinion on Emerging Drugs · doi:10.1517/14728210903369351 · Cited by 48 · see citing works

Nonsteroidal Selective Androgen Receptor Modulator Ostarine ™ in Cancer Cachexia

Zilbermint, M. F., & Dobs, A. S. (2009) · Future Oncology · doi:10.2217/fon.09.106 · Cited by 45 · see citing works

Therapeutic potential of the SARMs: revisiting the androgen receptor for drug discovery

Segal, S., Narayanan, R., & Dalton, J. T. (2006) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.15.4.377 · Cited by 43 · see citing works

Cancer-induced cachexia: a guide for the oncologist.

Gullett, N. P., Rossi, P. J., Kucuk, O., & Johnstone, P. A. S. (2009) · PubMed · Cited by 39 · see citing works

Pharmacological options for advanced cancer patients with loss of appetite and weight

Behl, D., & Jatoi, A. (2007) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.8.8.1085 · Cited by 34 · see citing works

A phase III randomized study comparing the effects of oxandrolone (Ox) and megestrol acetate (Meg) on lean body mass (LBM), weight (wt) and quality of life (QOL) in patients with solid tumors and weight loss receiving chemotherapy

Lesser, G. J., Case, D., Ottery, F. D., McQuellon, R. P., Choksi, J. K., Sanders, G., Rosdhal, R., & Shaw, E. G. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2008.26.15_suppl.9513 · Cited by 21 · see citing works

Megestrol Acetate Use for Weight Gain Should Be Carefully Considered

Evans, W. J. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2734 · Cited by 21 · see citing works

Ostarine increases lean body mass and improves physical performance in healthy elderly subjects: Implications for cancer cachexia patients

Evans, W. J., Smith, M. R., Morley, J. E., Barnette, K. G., Rodriguez, D., Steiner, M. S., & Dalton, J. T. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2007.25.18_suppl.9119 · Cited by 19 · see citing works

Nos expériences cliniques avec un nouvel alcaloyde extrait du Colchicum autumnale

Gf, G. (2009) · Oncologia · doi:10.1159/000223715 · Cited by 13 · see citing works

Molecular signatures characterize early stage breast cancer arising in young women and have prognostic and therapeutic implications independent of ER status

Anders, C. K., Hsu, S. D., Acharya, C. R., Zhang, Y., Wang, Y., Foekens, J. A., Marcom, P. K., Marks, J. R., Nevins, J. R., Potti, A., et al. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2007.25.18_suppl.522 · Cited by 5 · see citing works

Megestrol Acetate Oral Suspension

Porche, D. J. (2021) · doi:10.31003/uspnf_m48054_01_01 · Cited by 2 · see citing works

Untitled work

Wajchenberg (2000) · doi:10.1002/(sici)1097-0142(20000215)88:4

Age-related and disease-related muscle loss: The effect of diabetes, obesity, and other diseases

Kalyani, R. R., Corriere, M., & Ferrucci, L. (2014) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(14)70034-8 · Cited by 1,102 · see citing works

Understanding the mechanisms and treatment options in cancer cachexia

Fearon, K. C. H., Arends, J., & Baracos, V. E. (2012) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2012.209 · Cited by 937 · see citing works

Sarcopenia is associated with postoperative infection and delayed recovery from colorectal cancer resection surgery

Lieffers, J. R. L., Bathe, O. F., Fassbender, K., Winget, M., & Baracos, V. E. (2012) · British Journal of Cancer · doi:10.1038/bjc.2012.350 · Cited by 816 · see citing works

Dietary protein intake and human health

Wu, G. (2016) · Food & Function · doi:10.1039/c5fo01530h · Cited by 748 · see citing works

Impact of Sarcopenia on Outcomes Following Resection of Pancreatic Adenocarcinoma

Peng, P., Hyder, O., Firoozmand, A., Kneuertz, P., Schulick, R. D., Huang, D., Makary, M., Hirose, K., Edil, B., Choti, M. A., et al. (2012) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-012-1923-5 · Cited by 546 · see citing works

Sarcopenia is an Independent Predictor of Severe Postoperative Complications and Long-Term Survival After Radical Gastrectomy for Gastric Cancer

Zhuang, C., Huang, D., Pang, W., Zhou, C.-J., Wang, S.-L., Lou, N., Ma, L., Yu, Z., & Shen, X. (2016) · Medicine · doi:10.1097/md.0000000000003164 · Cited by 468 · see citing works

Body composition and outcome in patients undergoing resection of colorectal liver metastases19

van Vledder, M. G., Levolger, S., Ayez, N., Verhoef, C. K., Tran, T. C. K., & IJzermans, J. N. M. (2012) · British journal of surgery · doi:10.1002/bjs.7823 · Cited by 462 · see citing works

Cancer cachexia, mechanism and treatment

Aoyagi, T., Terracina, K. P., Raza, A., Matsubara, H., & Takabe, K. (2015) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v7.i4.17 · Cited by 439 · see citing works

Correlation between Oxidative Stress, Nutrition, and Cancer Initiation

Saha, S. K., Lee, S. B., Won, J., Choi, H. Y., Kim, K., Yang, G., Dayem, A. A., & Cho, S. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071544 · Cited by 399 · see citing works

Sarcopenia is a Negative Prognostic Factor After Curative Resection of Colorectal Cancer

Miyamoto, Y., Baba, Y., Sakamoto, Y., Ohuchi, M., Tokunaga, R., Kurashige, J., Hiyoshi, Y., Iwagami, S., Yoshida, N., Yoshida, M., et al. (2015) · Annals of Surgical Oncology · doi:10.1245/s10434-014-4281-6 · Cited by 362 · see citing works

Early Events in Sexual Transmission of HIV and SIV and Opportunities for Interventions

Haase, A. T. (2010) · Annual Review of Medicine · doi:10.1146/annurev-med-080709-124959 · Cited by 322 · see citing works

Neuromuscular electrical stimulation for muscle weakness in adults with advanced disease

Jones, S. E., Man, W. D., Gao, W., Higginson, I. J., Wilcock, A., & Maddocks, M. M. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009419.pub3 · Cited by 293 · see citing works

Sarcopenia and Inflammatory Bowel Disease: A Systematic Review

Ryan, É. J., McNicholas, D. P., Creavin, B., Kelly, M. E., Walsh, T., & Beddy, D. (2018) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izy212 · Cited by 251 · see citing works

Body Composition Tools for Assessment of Adult Malnutrition at the Bedside

Earthman, C. P. (2015) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607115595227 · Cited by 238 · see citing works

Cancer cachexia: Diagnosis, assessment, and treatment

Sadeghi, M. A., Keshavarz‐Fathi, M., Baracos, V. E., Arends, J., Mahmoudi, M., & Rezaei, N. (2018) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2018.05.006 · Cited by 212 · see citing works

Both high level pressure support ventilation and controlled mechanical ventilation induce diaphragm dysfunction and atrophy

Hudson, M. B., Smuder, A. J., Nelson, W. B., Bruells, C. S., Levine, S., & Powers, S. K. (2012) · Critical Care Medicine · doi:10.1097/ccm.0b013e31823c8cc9 · Cited by 206 · see citing works

Acylated and unacylated ghrelin impair skeletal muscle atrophy in mice

Porporato, P. E., Filigheddu, N., Reano, S., Ferrara, M., Angelino, E., Gnocchi, V. F., Prodam, F., Ronchi, G., Fagoonee, S., Fornaro, M., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci39920 · Cited by 190 · see citing works

CT-assessed sarcopenia is a predictive factor for both long-term and short-term outcomes in gastrointestinal oncology patients: a systematic review and meta-analysis

Su, H., Ruan, J., Chen, T., Lin, E., & Shi, L. (2019) · Cancer Imaging · doi:10.1186/s40644-019-0270-0 · Cited by 179 · see citing works

Skeletal muscle atrophy: Potential therapeutic agents and their mechanisms of action

Dutt, V., Gupta, S. K., Dabur, R., Injeti, E. R., & Mittal, A. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.05.010 · Cited by 174 · see citing works

Cancer cachexia: malignant inflammation, tumorkines, and metabolic mayhem

Tsoli, M., & Robertson, G. R. (2012) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2012.10.006 · Cited by 170 · see citing works

Intramyocellular lipid droplets increase with progression of cachexia in cancer patients

Stephens, N. A., Skipworth, R. J. E., MacDonald, A. J., Greig, C. A., Ross, J. A., & Fearon, K. C. H. (2011) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1007/s13539-011-0030-x · Cited by 154 · see citing works

Negative Impact of Skeletal Muscle Loss after Systemic Chemotherapy in Patients with Unresectable Colorectal Cancer

Miyamoto, Y., Baba, Y., Sakamoto, Y., Ohuchi, M., Tokunaga, R., Kurashige, J., Hiyoshi, Y., Iwagami, S., Yoshida, N., Watanabe, M., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0129742 · Cited by 146 · see citing works

Prognostic and clinical impact of sarcopenia in esophageal squamous cell carcinoma

Harada, K., Ida, S., Baba, Y., Ishimoto, T., Kosumi, K., Tokunaga, R., Izumi, D., Ohuchi, M., Nakamura, K., Kiyozumi, Y., et al. (2015) · Diseases of the Esophagus · doi:10.1111/dote.12381 · Cited by 136 · see citing works

Two faces of drug therapy in cancer: drug-related lean tissue loss and its adverse consequences to survival and toxicity

Prado, C. M. M., Antoun, S., Sawyer, M. B., & Baracos, V. E. (2011) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e3283455d45 · Cited by 136 · see citing works

Decreased Skeletal Muscle Mass is Associated with an Increased Risk of Mortality after Radical Nephrectomy for Localized Renal Cell Cancer

Psutka, S. P., Boorjian, S. A., Moynagh, M. R., Schmit, G. D., Costello, B. A., Thompson, R. H., Stewart‐Merrill, S. B., Lohse, C. M., Cheville, J. C., Leibovich, B. C., et al. (2015) · The Journal of Urology · doi:10.1016/j.juro.2015.08.072 · Cited by 135 · see citing works

STAT3 promotes IFNγ/TNFα‐induced muscle wasting in an NF‐κB‐dependent and IL‐6‐independent manner

Ma, J. F., Sánchez, B. J., Hall, D. T., Tremblay, A. K., Marco, S. D., & Gallouzi, I. (2017) · EMBO Molecular Medicine · doi:10.15252/emmm.201607052 · Cited by 135 · see citing works

The Association Between Diabetes Mellitus and Risk of Sarcopenia: Accumulated Evidences From Observational Studies

Qiao, Y.-S., Chai, Y.-H., Gong, H.-J., Zhuldyz, Z., Stehouwer, C. D. A., Zhou, J.-B., & Simó, R. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.782391 · Cited by 132 · see citing works

Weight Change and Survival after Breast Cancer in the After Breast Cancer Pooling Project

Caan, B. J., Kwan, M. L., Shu, X. O., Pierce, J. P., Patterson, R. E., Nechuta, S., Poole, E. M., Kroenke, C. H., Weltzien, E. K., Flatt, S. W., et al. (2012) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-12-0306 · Cited by 131 · see citing works

Nutrition intervention approaches to reduce malnutrition in oncology patients: a systematic review

Lee, J. L. C., Leong, L. P., & Lim, S. L. (2015) · Supportive Care in Cancer · doi:10.1007/s00520-015-2958-4 · Cited by 129 · see citing works

Prognostic significance of CT-determined sarcopenia in patients with advanced gastric cancer

Lee, J. S., Kim, Y. S., Kim, E. Y., & Jin, W. (2018) · PLoS ONE · doi:10.1371/journal.pone.0202700 · Cited by 127 · see citing works

Are there any benefits of exercise training in cancer cachexia?

Argilés, J. M. A., Busquets, S., López-Soriano, F. J., Costelli, P., & Penna, F. (2012) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1007/s13539-012-0067-5 · Cited by 123 · see citing works

Cachexia-associated adipose tissue morphological rearrangement in gastrointestinal cancer patients

Júnior, M. L. B., Henriques, F. D. S., das Neves, R. X., Oliván, M., de Matos‐Neto, E. M., de Alcântara, P. S. M., Maximiano, L. F., Otoch, J. P., Alves, M. J., & Seelaender, M. C. L. (2015) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12037 · Cited by 117 · see citing works

Anamorelin HCl (ONO‐7643), a novel ghrelin receptor agonist, for the treatment of cancer anorexia‐cachexia syndrome: preclinical profile

Pietra, C., Takeda, Y., Tazawa-Ogata, N., Minami, M., Xia, Y., Duus, E. M., & Northrup, R. (2014) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1007/s13539-014-0159-5 · Cited by 115 · see citing works

A 96-well culture platform enables longitudinal analyses of engineered human skeletal muscle microtissue strength

Afshar, M. E., Abraha, H. Y., Bakooshli, M. A., Davoudi, S., Thavandiran, N., Tung, K., Ahn, H., Ginsberg, H. J., Zandstra, P. W., & Gilbert, P. M. (2020) · Scientific Reports · doi:10.1038/s41598-020-62837-8 · Cited by 109 · see citing works

Metabolic interplays between the tumour and the host shape the tumour macroenvironment

Altea‐Manzano, P., Decker-Farrell, A. R., Janowitz, T., & Erez, A. (2025) · Nature reviews. Cancer · doi:10.1038/s41568-024-00786-4 · Cited by 127 · see citing works

Understanding the Role of Exercise in Cancer Cachexia Therapy

Hardee, J. P., Counts, B. R., & Carson, J. A. (2017) · American Journal of Lifestyle Medicine · doi:10.1177/1559827617725283 · Cited by 108 · see citing works

Thalidomide for managing cancer cachexia

Reid, J., Mills, M. E., Cantwell, M. M., Cardwell, C. R., Murray, L., & Donnelly, M. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008664.pub2 · Cited by 109 · see citing works

Dexamethasone-induced autophagy mediates muscle atrophy through mitochondrial clearance

Troncoso, R., Paredes, F., Parra, V., Gatica, D., Vásquez-Trincado, C., Quiroga, C., Bravo, R., López‐Crisosto, C., Rodriguez, A. E., Oyarzún, A. P., et al. (2014) · Cell Cycle · doi:10.4161/cc.29272 · Cited by 108 · see citing works

Skeletal muscle anabolism is a side effect of therapy with the MEK inhibitor: selumetinib in patients with cholangiocarcinoma

Prado, C. M. M., Bekaii‐Saab, T., Doyle, L. A., Shrestha, S., Ghosh, S., Baracos, V. E., & Sawyer, M. B. (2012) · British Journal of Cancer · doi:10.1038/bjc.2012.144 · Cited by 105 · see citing works

Prognostic Significance of Sarcopenia in Patients with Esophagogastric Junction Cancer or Upper Gastric Cancer

Kudou, K., Saeki, H., Nakashima, Y., Edahiro, K., Korehisa, S., Taniguchi, D., Tsutsumi, R., Nishimura, S., Nakaji, Y., Akiyama, S., et al. (2017) · Annals of Surgical Oncology · doi:10.1245/s10434-017-5811-9 · Cited by 104 · see citing works

Sarcopenia as Prognostic Factor in Lung Cancer Patients: A Systematic Review and Meta-analysis

Büntzel, J., Heinz, J., Bleckmann, A., Bauer‐Büntzel, C., Röver, C., Bohnenberger, H., Saha, S., Hinterthaner, M., Baraki, H., Kutschka, I., et al. (2019) · Anticancer Research · doi:10.21873/anticanres.13640 · Cited by 105 · see citing works

Sarcopenia is an independent prognostic factor in male patients with diffuse large B-cell lymphoma

Nakamura, N., Hara, T., Shibata, Y., Matsumoto, T., Nakamura, H., Ninomiya, S., Kito, Y., Kitagawa, J., Kanemura, N., Goto, N., et al. (2015) · Annals of Hematology · doi:10.1007/s00277-015-2499-4 · Cited by 99 · see citing works

Influence of eicosapentaenoic acid supplementation on lean body mass in cancer cachexia

Murphy, R. A., Yeung, E., Mazurak, V. C., & Mourtzakis, M. (2011) · British Journal of Cancer · doi:10.1038/bjc.2011.391 · Cited by 99 · see citing works

Prognostic Significance of Sarcopenia With Inflammation in Patients With Head and Neck Cancer Who Underwent Definitive Chemoradiotherapy

Cho, Y., Kim, J. W., Keum, K. C., Lee, C. G., Jeung, H., & Lee, I. J. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00457 · Cited by 99 · see citing works

Prevalence and Mechanisms of Skeletal Muscle Atrophy in Metabolic Conditions

Jun, L., Robinson, M., Geetha, T., Broderick, T. L., & Babu, J. R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032973 · Cited by 101 · see citing works

One-year prevalence, comorbidities and cost of cachexia-related inpatient admissions in the USA

Arthur, S. T., Noone, J., Roy, D., Blanchette, C., & Doren, B. A. V. (2014) · Drugs in Context · doi:10.7573/dic.212265 · Cited by 98 · see citing works

Sarcopenia predicts 1-year mortality in elderly patients undergoing curative gastrectomy for gastric cancer: a prospective study

Huang, D., Chen, X., Chen, X., Wang, S.-L., Shen, X., Chen, X.-L., Yu, Z., & Zhuang, C. (2016) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-016-2230-4 · Cited by 97 · see citing works

Efficacy of β-hydroxy-β-methylbutyrate supplementation in elderly and clinical populations

Fitschen, P. J., Wilson, G. J., Wilson, J. M., & Wilund, K. R. (2013) · Nutrition · doi:10.1016/j.nut.2012.05.005 · Cited by 97 · see citing works

Silibinin-Mediated Metabolic Reprogramming Attenuates Pancreatic Cancer-Induced Cachexia and Tumor Growth

Shukla, S. K., Dasgupta, A., Mehla, K., Gunda, V., Vernucci, E., Souchek, J., Goode, G., King, R., Mishra, A., Rai, I., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.5843 · Cited by 96 · see citing works

Omega-3 fatty acids and protein metabolism

Girolamo, F. G. D., Situlin, R., Mazzucco, S., Valentini, R., Toigo, G., & Biolo, G. (2014) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000032 · Cited by 97 · see citing works

Inducible nitric oxide synthase (iNOS) in muscle wasting syndrome, sarcopenia, and cachexia

Hall, D. T., Ma, J. F., Marco, S. D., & Gallouzi, I. (2011) · Aging · doi:10.18632/aging.100358 · Cited by 95 · see citing works

Exercise for cancer cachexia in adults

Grande, A. J., Silva, V., Riera, R., Medeiros, A., Vitoriano, S., Peccin, M. S., & Maddocks, M. M. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010804.pub2 · Cited by 92 · see citing works

Neuromuscular electrical stimulation for muscle weakness in adults with advanced disease

Maddocks, M. M., Gao, W., Higginson, I. J., & Wilcock, A. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009419.pub2 · Cited by 91 · see citing works

Impact of Sarcopenia on Outcomes Following Intra-arterial Therapy of Hepatic Malignancies

Dodson, R. M., Firoozmand, A., Hyder, O. N., Tacher, V., Cosgrove, D., Bhagat, N., Herman, J. M., Wolfgang, C. L., Geschwind, J.-F. H., Kamel, I. R., et al. (2013) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-013-2348-5 · Cited by 87 · see citing works

Circulating protein synthesis rates reveal skeletal muscle proteome dynamics

Shankaran, M., King, C. L., Angel, T. E., Holmes, W. E., Li, K. W., Colangelo, M., Price, J. C., Turner, S., Bell, C., Hamilton, K. L., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci79639 · Cited by 86 · see citing works

Sarcopenia and sarcopenic obesity: do they predict inferior oncologic outcomes after gastrointestinal cancer surgery?

Mei, K. L., Batsis, J. A., Mills, J. B., & Holubar, S. D. (2016) · Perioperative Medicine · doi:10.1186/s13741-016-0052-1 · Cited by 84 · see citing works

Modeling the energetic cost of cancer as a result of altered energy metabolism: implications for cachexia

Friesen, D. E., Baracos, V. E., & Tuszyński, J. A. (2015) · Theoretical Biology and Medical Modelling · doi:10.1186/s12976-015-0015-0 · Cited by 84 · see citing works

Sarcopenia as a Novel Preoperative Prognostic Predictor for Survival in Patients with Bladder Cancer Undergoing Radical Cystectomy

Hirasawa, Y., Nakashima, J., Yunaiyama, D., Sugihara, T., Gondo, T., Nakagami, Y., Horiguchi, Y., Ohno, Y., Namiki, K., Ohori, M., et al. (2016) · Annals of Surgical Oncology · doi:10.1245/s10434-016-5606-4 · Cited by 85 · see citing works

Exercise in cancer prevention and anticancer therapy: Efficacy, molecular mechanisms and clinical information

Zhu, C., Ma, H., He, A., Li, Y., He, C., & Xia, Y. (2022) · Cancer Letters · doi:10.1016/j.canlet.2022.215814 · Cited by 80 · see citing works

Concurrent evolution of cancer cachexia and heart failure: bilateral effects exist

Kazemi-Bajestani, S., Becher, H., Fassbender, K., Chu, Q., & Baracos, V. (2014) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1007/s13539-014-0137-y · Cited by 74 · see citing works

The importance of protein sources to support muscle anabolism in cancer: An expert group opinion

Ford, K. L., Arends, J., Atherton, P. J., ENGELEN, M. P. K. J., Gonçalves, T. J. M., Laviano, A., Lobo, D. N., Phillips, S. M., Ravasco, P., Deutz, N. E. P., et al. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.11.032 · Cited by 77 · see citing works

IGF-1 and IGFBP-3 in Inflammatory Cachexia

Martı́n, A. I., Priego, T., Moreno‐Rupérez, Á., González‐Hedström, D., Granado, M., & López‐Calderón, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179469 · Cited by 75 · see citing works

Abnormal myofiber morphology and limb dysfunction in claudication

Koutakis, P., Myers, S. A., Cluff, K., Ha, D. M., Haynatzki, G. R., McComb, R. D., Uchida, K., Miserlis, D., Papoutsi, E., Johanning, J. M., et al. (2015) · Journal of Surgical Research · doi:10.1016/j.jss.2015.02.011 · Cited by 75 · see citing works

Skeletal muscle loss is an independent negative prognostic factor in patients with advanced lower rectal cancer treated with neoadjuvant chemoradiotherapy

Takeda, Y., Akiyoshi, T., Matsueda, K., Fukuoka, H., Ogura, A., Miki, H., Hiyoshi, Y., Nagasaki, T., Konishi, T., Fujimoto, Y., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0195406 · Cited by 75 · see citing works

Muscle Atrophy: Present and Future

Cao, R. Y., Li, J., Dai, Q., Li, Q. X., & Yang, J. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-1435-3_29 · Cited by 75 · see citing works

Habitual Myofibrillar Protein Synthesis Is Normal in Patients with Upper GI Cancer Cachexia

MacDonald, A. J., Johns, N., Stephens, N. A., Greig, C. A., Ross, J. A., Small, A. C., Husi, H., Fearon, K. C. H., & Preston, T. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-2004 · Cited by 74 · see citing works

Sarcopenia predicts perioperative adverse events following complex revision surgery for the thoracolumbar spine

Hirase, T., Haghshenas, V., Bratescu, R. A., Dong, D., Kuo, P. H., Rashid, A., Kavuri, V. C., Hanson, D. S., Meyer, B. C., & Marco, R. A. W. (2021) · The Spine Journal · doi:10.1016/j.spinee.2021.02.001 · Cited by 73 · see citing works

MG132-mediated inhibition of the ubiquitin–proteasome pathway ameliorates cancer cachexia

Zhang, L., Tang, H., Kou, Y., Li, R., Zheng, Y., Wang, Q., Zhou, X., & Jin, L. (2013) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-013-1412-6 · Cited by 72 · see citing works

Sarcopenia in gastric cancer: when the loss costs too much

Ongaro, E., Buoro, V., Cinausero, M., Caccialanza, R., Turri, A., Fanotto, V., Basile, D., Vitale, M. G., Ermacora, P., Cardellino, G. G., et al. (2017) · Gastric Cancer · doi:10.1007/s10120-017-0722-9 · Cited by 72 · see citing works

Exercise for cancer cachexia in adults

Grande, A. J., Silva, V., Neto, L. S., Basmage, J. P. T., Peccin, M. S., & Maddocks, M. M. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010804.pub3 · Cited by 71 · see citing works

Association of muscle wasting with mortality risk among adults: A systematic review and meta‐analysis of prospective studies

Zhou, H., Liao, Y., Peng, Z., Liu, F., Wang, Q., & Yang, W. Q. (2023) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13263 · Cited by 70 · see citing works

Selective Androgen Receptor Modulators (SARMs) Negatively Regulate Triple-Negative Breast Cancer Growth and Epithelial:Mesenchymal Stem Cell Signaling

Narayanan, R., Ahn, S., Cheney, M. D., Yepuru, M., Miller, D. D., Steiner, M. S., & Dalton, J. T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103202 · Cited by 71 · see citing works

Altered mitochondrial quality control signaling in muscle of old gastric cancer patients with cachexia

Marzetti, E., Lorenzi, M., Landi, F., Picca, A., Rosa, F., Tanganelli, F., Galli, M., Doglietto, G. B., Pacelli, F., Cesari, M., et al. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.10.003 · Cited by 70 · see citing works

Pathophysiological mechanisms explaining poor clinical outcome of older cancer patients with low skeletal muscle mass

Looijaard, S. M. L. M., Hekkert, M. L. T. L., Wüst, R. C. I., Otten, R. H. J., Meskers, C. G. M., & Maier, A. B. (2020) · Acta Physiologica · doi:10.1111/apha.13516 · Cited by 65 · see citing works

Deciphering the selective androgen receptor modulators paradigm

Zhang, X., & Sui, Z. (2012) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2013.741582 · Cited by 64 · see citing works

Combined effect of aerobic interval training and selenium nanoparticles on expression of IL-15 and IL-10/TNF-α ratio in skeletal muscle of 4T1 breast cancer mice with cachexia

Shamsi, M. M., Chekachak, S., Soudi, S., Quinn, L. S., Ranjbar, K., Chenari, J., Yazdi, M. H., & Mahdavi, M. (2016) · Cytokine · doi:10.1016/j.cyto.2016.11.005 · Cited by 63 · see citing works

Risk factors associated with increased nonrelapse mortality and with poor overall survival in children with chronic graft-versus-host disease

Jacobsohn, D. A., Arora, M., Klein, J. P., Hassebroek, A. M., Flowers, M. E. D., Cutler, C. S., Urbano-Ispizúa, Á., Bolwell, B. J., Antin, J. H., Boyiadzis, M. M., et al. (2011) · Blood · doi:10.1182/blood-2011-04-349068 · Cited by 62 · see citing works

Cancer Cachexia Syndrome: Pathogenesis, Diagnosis, and New Therapeutic Options

Mondello, P., Mian, M., Aloisi, C., Famà, F., Mondello, S., & Pitini, V. V. (2014) · Nutrition and Cancer · doi:10.1080/01635581.2015.976318 · Cited by 61 · see citing works

Activin receptor antagonists for cancer-related anemia and bone disease

Fields, S. Z., Parshad, S., Anne, M., Raftopoulos, H., Alexander, M. J., Sherman, M. L., Laadem, A., Sung, V., & Terpos, E. (2012) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2013.738666 · Cited by 58 · see citing works

Prognostic Value of Scores Based on Malnutrition or Systemic Inflammatory Response in Patients With Metastatic or Recurrent Gastric Cancer

Šachlová, M., Májek, O., & Tuček, Š. (2014) · Nutrition and Cancer · doi:10.1080/01635581.2014.956261 · Cited by 58 · see citing works

Dietary lipids with potential to affect satiety: Mechanisms and evidence

Maher, T., & Clegg, M. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1423277 · Cited by 59 · see citing works

Understanding tumor anabolism and patient catabolism in cancer-associated cachexia.

Schcolnik‐Cabrera, A., Chávez-Blanco, A. D., Domínguez-Gómez, G., & Dueñas‐González, A. (2017) · Europe PMC (PubMed Central) · Cited by 54 · see citing works

Exercise for Toxicity Management in Cancer—A Narrative Review

Kleckner, I. R., Dunne, R. F., Asare, M., Cole, C. L., Fleming, F. J., Fung, C., Lin, P., & Mustian, K. M. (2018) · touchREVIEWS in Oncology & Haematology · doi:10.17925/ohr.2018.14.1.28 · Cited by 54 · see citing works

Postdiagnosis Loss of Skeletal Muscle, but Not Adipose Tissue, Is Associated with Shorter Survival of Patients with Advanced Pancreatic Cancer

Babić, A., Rosenthal, M. H., Bamlet, W. R., Takahashi, N., Sugimoto, M., Danai, L. V., Morales‐Oyarvide, V., Khalaf, N. I., Dunne, R. F., Brais, L. K., et al. (2019) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-19-0370 · Cited by 54 · see citing works

Supplemental dietary leucine and the skeletal muscle anabolic response to essential amino acids: Nutrition Reviews©, Vol. ••, No. ••

Pasiakos, S. M., & McClung, J. P. (2011) · Nutrition Reviews · doi:10.1111/j.1753-4887.2011.00420.x · Cited by 53 · see citing works

Body mass index and weight change in relation to triple-negative breast cancer survival

Bao, P., Cai, H., Peng, P., Gu, K., Su, T., Shu, X., & Zheng, Y. F. (2015) · Cancer Causes & Control · doi:10.1007/s10552-015-0700-7 · Cited by 53 · see citing works

Antioxidant supplementation accelerates cachexia development by promoting tumor growth in C26 tumor-bearing mice

Assi, M., Derbré, F., Lefeuvre‐Orfila, L., & Rébillard, A. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.12.019 · Cited by 53 · see citing works

Prognostic significance of sarcopenia and skeletal muscle mass change during preoperative chemoradiotherapy in locally advanced rectal cancer

Chung, E., Lee, H. S., Cho, E., Park, E. J., Baik, S. H., Lee, K. Y., & Kang, J. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2019.03.014 · Cited by 54 · see citing works

Sarcopenia and Systemic Inflammation Response Index Predict Response to Systemic Therapy for Hepatocellular Carcinoma and Are Associated With Immune Cells

Zhao, M., Duan, X., Han, X., Wang, J., Han, G., Mi, L., Shi, J., Li, N., Yin, X., Hou, J., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.854096 · Cited by 52 · see citing works

Impact of cancer anorexia-cachexia syndrome on health-related quality of life and resource utilisation: A systematic review

Tarricone, R., Ricca, G., Wakholi, B. N., & Medina‐Lara, A. (2015) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2015.12.008 · Cited by 51 · see citing works

Pancreatic cancer cell-derived IGFBP-3 contributes to muscle wasting

Huang, X., Huang, Z.-L., Yang, J., Xu, Y., Sun, J., Zheng, Q., Wei, C., Song, W., & Yuan, Z. (2016) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-016-0317-z · Cited by 52 · see citing works

Impact of exercise on cancer: mechanistic perspectives and new insights

Ye, F., Feng, X., Wan, R., Luo, Z., Qu, L., & Wang, Q. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1474770 · Cited by 51 · see citing works

A Novel Preoperative Skeletal Muscle Measure as a Predictor of Postoperative Complications, Long-Term Survival and Tumor Recurrence for Patients with Gastric Cancer After Radical Gastrectomy

Lü, J., Zheng, Z., Li, P., Xie, J., Wang, J.-B., Lin, J., Chen, Q., Cao, L., Lin, M., Tu, R., et al. (2017) · Annals of Surgical Oncology · doi:10.1245/s10434-017-6269-5 · Cited by 50 · see citing works

mTORC1 and the regulation of skeletal muscle anabolism and mass

Adegoke, O. A. J., Abdullahi, A., & Tavajohi‐Fini, P. (2012) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h2012-009 · Cited by 49 · see citing works

Expression of TRAF6 and ubiquitin mRNA in skeletal muscle of gastric cancer patients

Sun, Y., Ye, Z., Qian, Z., Xu, X., & Hu, J. (2012) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/1756-9966-31-81 · Cited by 49 · see citing works

Incorporating sarcopenia and inflammation with radiation therapy in patients with hepatocellular carcinoma treated with nivolumab

Kim, N., Yu, J. I., Park, H. C., Yoo, G. S., Choi, C., Hong, J. Y., Lim, H. Y., Lee, J., Choi, M. S., Lee, J. E., et al. (2020) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-020-02794-3 · Cited by 49 · see citing works

Postoperative development of sarcopenia is a strong predictor of a poor prognosis in patients with adenocarcinoma of the esophagogastric junction and upper gastric cancer

Kudou, K., Saeki, H., Nakashima, Y., Sasaki, S., Jogo, T., Hirose, K., Hu, Q., Tsuda, Y., Kimura, K., Nakanishi, R., et al. (2018) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2018.07.003 · Cited by 48 · see citing works

Role of altered proteostasis network in chronic hypobaric hypoxia induced skeletal muscle atrophy

Agrawal, A., Rathor, R., Kumar, R. S., Suryakumar, G., & Ganju, L. (2018) · PLoS ONE · doi:10.1371/journal.pone.0204283 · Cited by 48 · see citing works

The Influence of Sarcopenia on High-Risk Neuroblastoma

Kawakubo, N., Kinoshita, Y., Souzaki, R., Koga, Y., Oba, U., Ohga, S., & Taguchi, T. (2018) · Journal of Surgical Research · doi:10.1016/j.jss.2018.10.048 · Cited by 48 · see citing works

Cancer cachexia: Contemporary insights into pathobiology, clinical burden, and integrated management approaches

Mahani, A., & Pruthi, D. S. (2026) · IP Journal of Nutrition Metabolism and Health Science · doi:10.18231/j.ijnmhs.41455.1777634744

Cancer-induced muscle wasting: latest findings in prevention and treatment

Aversa, Z., Costelli, P., & Muscaritoli, M. (2017) · Therapeutic Advances in Medical Oncology · doi:10.1177/1758834017698643 · Cited by 212 · see citing works

Cancer-Mediated Muscle Cachexia: Etiology and Clinical Management

Siff, T., Parajuli, P., Razzaque, M., & Atfi, A. (2021) · Trends in endocrinology and metabolism · doi:10.1016/j.tem.2021.03.007 · Cited by 62 · see citing works

Gastric Cancer: A Model to Study Skeletal Muscle Wasting of Cachexia

Bossola, M., Pacelli, F., Rosa, F., Cusumano, G., Tortorelli, A. P., & Doglietto, G. B. (2012) · Springer eBooks · doi:10.1007/978-88-470-2318-5_28 · Cited by 2 · see citing works

Understanding the mechanisms and treatment options in cancer cachexia

Fearon, K. C. H., Arends, J., & Baracos, V. E. (2012) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2012.209 · Cited by 937 · see citing works