Yoga for cancer survivors with chemotherapy-induced peripheral neuropathy: Health-related quality of life outcomes
Open accessAbstract
BACKGROUND: Yoga is a meditative movement therapy focused on mind-body awareness. The impact of yoga on health-related quality of life (HRQOL) outcomes in patients with chemotherapy-induced peripheral neuropathy (CIPN) is unclear. METHODS: We conducted a pilot randomized wait-list controlled trial of 8 weeks of yoga (n = 21) versus wait-list control (n = 20) for CIPN in 41 breast and gynecological cancer survivors with persistent moderate to severe CIPN. HRQOL endpoints were Hospital Anxiety and Depression Scale (HADS), Brief Fatigue Inventory (BFI), and Insomnia Severity Index (ISI). The Treatment Expectancy Scale (TES) was administered at baseline. We estimated mean changes and 95% confidence intervals (CIs) from baseline to weeks 8 and 12 and compared arms using constrained linear mixed models. RESULTS: At week 8, HADS anxiety scores decreased -1.61 (-2.75, -0.46) in the yoga arm and -0.32 (-1.38, 0.75) points in the wait-list control arm (p = 0.099). At week 12, HADS anxiety scores decreased -1.42 (-2.57, -0.28) in yoga compared to an increase of 0.46 (-0.60, 1.53) in wait-list control (p = 0.017). There were no significant differences in HADS depression, BFI, or ISI scores between yoga and wait-list control. Baseline TES was significantly higher in yoga than in wait-list control (14.9 vs. 12.7, p = 0.019). TES was not associated with HADS anxiety reduction and HADS anxiety reduction was not associated with CIPN pain reduction. CONCLUSIONS: Yoga may reduce anxiety in patients with CIPN. Future studies are needed to confirm these findings. CLINICAL TRIAL REGISTRATION NUMBER: ClinicalTrials.gov Identifier: NCT03292328.
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Yoga may reduce feeling in patients with chemotherapy-induced peripheral neuropathy.
“Zhi et al. note that yoga may reduce feeling in patients with chemotherapy-induced peripheral neuropathy [100].”
From The Effect of Vinyasa Yoga Practice on the Well-Being of Breast-Cancer Patients during COVID-19 Pandemic (2023) · cites this paper as [100]
The Discussion reports a possible reduction in anxiety among patients with chemotherapy-induced peripheral neuropathy, not a reduction in feeling or sensation. A search for sensory outcomes, including numbness and tingling, found no passage in our copy saying that yoga reduces feeling. (LLM, conf=0.76)
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Zok, A., Matecka, M., Zapala, J., Izycki, D., & Baum, E. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20043770 · Cited by 12 · see citing works
“note that yoga may reduce feeling in patients with chemotherapy-induced peripheral neuropathy [100].”
Background
- Authors
- Zhi, W. I., Baser, R. E., Zhi, L. M., Talukder, D., Li, Q. S., Paul, T., Patterson, C., Piulson, L., Seluzicki, C., Galantino, M. L., & Bao, T.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Manhattan High School (US)
- University of the Witwatersrand (ZA)
- Corresponding author
- Bao, Ting
- ORCID
- Venue
- Cancer Medicine
- Publisher
- Wiley
- Published
- 2021-07-02
- Volume
- 10
- Issue
- 16
- Pages
- 5456-5465
- ISSN
- 2045-7634 (ISSN-L)
- PMC
- PMC8366077
- OpenAlex
- W3176673920
- Cited by
- 33
- References
- 45
- Citations by year
- 2026: 8 · 2025: 6 · 2024: 8 · 2023: 8 · 2022: 3
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cancer Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Cancer Institute (P30 CA008748)
- Topics
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Oncology › Cancer Treatment and Pharmacology
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Keywords
- yoga, chemotherapy-induced peripheral neuropathy, cancer survivors, health-related quality of life, anxiety, depression, fatigue, insomnia, breast cancer, gynecologic cancer, mind-body interventions, treatment expectancy
- MeSH terms
- Cancer Survivors, Adult, Aged, Antineoplastic Agents, Anxiety, Fatigue, Female, Humans, Male, Middle Aged, Neoplasms, Peripheral Nervous System Diseases, Quality of Life, Yoga, Treatment Outcome, Self Report
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