Brain-derived neurotrophic factor: a bridge between inflammation and neuroplasticity
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Cytokines are key regulatory mediators involved in the host response to immunological challenges, but also play a critical role in the communication between the immune and the central nervous system. For this, their expression in both systems is under a tight regulatory control. However, pathological conditions may lead to an overproduction of pro-inflammatory cytokines that may have a detrimental impact on central nervous system. In particular, they may damage neuronal structure and function leading to deficits of neuroplasticity, the ability of nervous system to perceive, respond and adapt to external or internal stimuli. In search of the mechanisms by which pro-inflammatory cytokines may affect this crucial brain capability, we will discuss one of the most interesting hypotheses: the involvement of the neurotrophin brain-derived neurotrophic factor (BDNF), which represents one of the major mediators of neuroplasticity.
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Inflammatory cytokines can decrease expression of BDNF, thereby altering neuroplasticity.
“For example, inflammatory cytokines can alter neuroplasticity by decreasing expression of the brain-derived neuroprotective hormone BDNF (Calabrese et al., 2014).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Calabrese et al., 2014
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“Moreover, a large body of evidence has demonstrated that the negative impact of inflammation on neurogenesis might be triggered through pro-inflammatory cytokine-induced reductions in BDNF expression/signaling (Calabrese et al., 2014).”
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- Authors
- Calabrese, F., Rossetti, A. C., Racagni, G., Gass, P., Riva, M. A., & Molteni, R.
- Affiliations
- University of Milan (IT)
- Heidelberg University (DE)
- Corresponding author
- Molteni, Raffaella
- Venue
- Frontiers in Cellular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2014-12-22
- Volume
- 8
- Pages
- 430-430
- ISSN
- 1662-5102 (ISSN-L)
- PMC
- PMC4273623
- OpenAlex
- W2093694233
- Cited by
- 482
- References
- 98
- Citations by year
- 2026: 22 · 2025: 36 · 2024: 36 · 2023: 33 · 2022: 53 · 2021: 55 · 2020: 55 · 2019: 52 · 2018: 38 · 2017: 50 · 2016: 30 · 2015: 22
- FWCI
- 3.88
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- brain-derived neurotrophic factor, neuroplasticity, inflammation, inflammatory cytokines, neurotrophins, neuroinflammation, neuronal injury
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