Cited by 482Nerve injury and regenerationNeuroinflammation and Neurodegeneration MechanismsTryptophan and brain disorders

Brain-derived neurotrophic factor: a bridge between inflammation and neuroplasticity

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Calabrese, Francesca, Rossetti, Andrea C., Racagni, Giorgio, Gass, Peter, Riva, Marco A., Molteni, Raffaella·2014·Frontiers in Cellular Neuroscience

Abstract

Cytokines are key regulatory mediators involved in the host response to immunological challenges, but also play a critical role in the communication between the immune and the central nervous system. For this, their expression in both systems is under a tight regulatory control. However, pathological conditions may lead to an overproduction of pro-inflammatory cytokines that may have a detrimental impact on central nervous system. In particular, they may damage neuronal structure and function leading to deficits of neuroplasticity, the ability of nervous system to perceive, respond and adapt to external or internal stimuli. In search of the mechanisms by which pro-inflammatory cytokines may affect this crucial brain capability, we will discuss one of the most interesting hypotheses: the involvement of the neurotrophin brain-derived neurotrophic factor (BDNF), which represents one of the major mediators of neuroplasticity.

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Authors
Calabrese, F., Rossetti, A. C., Racagni, G., Gass, P., Riva, M. A., & Molteni, R.
Affiliations
  • University of Milan (IT)
  • Heidelberg University (DE)
Corresponding author
Molteni, Raffaella
Venue
Frontiers in Cellular Neuroscience
Published
2014-12-22
Volume
8
Pages
430-430
ISSN
1662-5102 (ISSN-L)
OpenAlex
W2093694233
Cited by
482
References
98
Citations by year
2026: 22 · 2025: 36 · 2024: 36 · 2023: 33 · 2022: 53 · 2021: 55 · 2020: 55 · 2019: 52 · 2018: 38 · 2017: 50 · 2016: 30 · 2015: 22
FWCI
3.88
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
brain-derived neurotrophic factor, neuroplasticity, inflammation, inflammatory cytokines, neurotrophins, neuroinflammation, neuronal injury

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