Can Large Language Models Aid Caregivers of Pediatric Cancer Patients in Information Seeking? A Cross‐Sectional Investigation
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Abstract
Purpose: Caregivers in pediatric oncology need accurate and understandable information about their child's condition, treatment, and side effects. This study assesses the performance of publicly accessible large language model (LLM)‐supported tools in providing valuable and reliable information to caregivers of children with cancer. Methods: In this cross‐sectional study, we evaluated the performance of the four LLM‐supported tools—ChatGPT (GPT‐4), Google Bard (Gemini Pro), Microsoft Bing Chat, and Google SGE—against a set of frequently asked questions (FAQs) derived from the Children's Oncology Group Family Handbook and expert input (In total, 26 FAQs and 104 generated responses). Five pediatric oncology experts assessed the generated LLM responses using measures including accuracy, clarity, inclusivity, completeness, clinical utility, and overall rating. Additionally, the content quality was evaluated including readability, AI disclosure, source credibility, resource matching, and content originality. We used descriptive analysis and statistical tests including Shapiro–Wilk, Levene's, Kruskal–Wallis H ‐tests, and Dunn's post hoc tests for pairwise comparisons. Results: ChatGPT shows high overall performance when evaluated by the experts. Bard also performed well, especially in accuracy and clarity of the responses, whereas Bing Chat and Google SGE had lower overall scores. Regarding the disclosure of responses being generated by AI, it was observed less frequently in ChatGPT responses, which may have affected the clarity of responses, whereas Bard maintained a balance between AI disclosure and response clarity. Google SGE generated the most readable responses whereas ChatGPT answered with the most complexity. LLM tools varied significantly ( p < 0.001) across all expert evaluations except inclusivity. Through our thematic analysis of expert free‐text comments, emotional tone and empathy emerged as a unique theme with mixed feedback on expectations from AI to be empathetic. Conclusion: LLM‐supported tools can enhance caregivers' knowledge of pediatric oncology. Each model has unique strengths and areas for improvement, indicating the need for careful selection based on specific clinical contexts. Further research is required to explore their application in other medical specialties and patient demographics, assessing broader applicability and long‐term impacts.
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LLMs have the potential to provide real-time, individually customized, and up-to-date medical information, with concomitant risks and benefits, to allow for informed, complex, and empathic decision-making among caregivers for oncology patients.
“Of particular interest is the potential of LLMs as providers of real-time, individually customized, and up-to-date medical information, with their concomitant risks and benefits, to allow for informed, complex, and empathic decision-making among caregivers for oncology patients [30].”
From Empathic AI for Patient-Centered Cancer Care: A Scoping Review of Patient Navigation, Support, and Clinical Practice (2026) · cites this paper as [30]
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- Authors
- Sezgin, E., Jackson, D. I., Kocaballi, A. B., Bibart, M., Zupanec, S., Landier, W., Audino, A., Ranalli, M., & Skeens, M.
- Affiliations
- The Abigail Wexner Research Institute at Nationwide Children's Hospital Columbus Ohio USA
- Nationwide Children's Hospital (US)
- Macquarie University (AU)
- Hospital for Sick Children (CA)
- University of Alabama at Birmingham (US)
- ORCID
- Venue
- Cancer Medicine
- Publisher
- Wiley
- Published
- 2025-01
- Volume
- 14
- Issue
- 1
- Pages
- e70554-e70554
- ISSN
- 2045-7634 (ISSN-L)
- PMC
- PMC11705392
- OpenAlex
- W4406147515
- Cited by
- 30
- References
- 68
- Citations by year
- 2026: 19 · 2025: 10 · 2024: 1
- FWCI
- 6.98
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cancer Medicine (publishedVersion, cc-by)
- medRxiv (acceptedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Health Informatics › Artificial Intelligence in Healthcare and Education
- Health Sciences › Health Professions › General Health Professions › Health Literacy and Information Accessibility
- Physical Sciences › Computer Science › Information Systems › Information Retrieval and Search Behavior
- Keywords
- large language models, childhood cancer, ChatGPT, Google Bard, Bing Chat, AI-generated health information, information accuracy, AI disclosure, readability, frequently asked questions
- MeSH terms
- Child, Cross-Sectional Studies, Female, Humans, Language, Male, Neoplasms, Caregivers, Information Seeking Behavior
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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