Organization of postsynaptic density proteins and glutamate receptors in axodendritic and dendrodendritic synapses of the rat olfactory bulb
Abstract
Glutamate neurotransmission in the olfactory bulb involves both axodendritic synapses and dendrodendritic reciprocal synapses and possibly also extrasynaptic receptors. By using a sensitive immunogold procedure, we have investigated the organization of two synaptic scaffolding molecules, PSD‐95 and PSD‐93, as well as N‐methyl‐D‐aspartate (NMDA) and α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐proprionic acid (AMPA) receptors, at these heterogeneous glutamate signaling sites. Immunolabeling for PSD‐95 and PSD‐93 was present in all major types of putative glutamatergic synapse, suggesting that these proteins are essential components of the synaptic signaling apparatus. The linear density and the subsynaptic distribution of PSD‐95/PSD‐93 gold particles did not differ significantly between axodendritic and dendrodendritic synapses. Antibodies recognizing NMDA and AMPA receptor subunits also labeled asymmetric synapses throughout the olfactory bulb. Immunolabeling for the AMPA receptor subunits GluR2/3 was similar in all types of synapse. In contrast, immunogold signals for the NR1 subunit of NMDA receptors varied significantly among different synapse populations, with olfactory nerve synapses in the glomerular layer showing the lowest labeling intensity. Although the lateral dendrites of mitral and tufted cells have been reported to respond to glutamate, they did not display significant plasma membrane labeling for the NR1 subunit or for PSD‐95, suggesting that the physiological effects of glutamate at these sites are mediated by NMDA autoreceptors that are not clustered and occur only at a low density on the dendritic surface. Our quantitative analysis of olfactory bulb synapses indicates that the density of NMDA receptors is not determined by the complement of PSD‐95/PSD‐93. The latter molecules appear to be expressed in an all‐or‐none fashion and may form a standard lattice common to different types of glutamatergic synapse. J. Comp. Neurol. 463:237–248, 2003. © 2003 Wiley‐Liss, Inc.
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The number of AMPA receptors scales positively with the size of synapses.
“The number of AMPA receptors scales positively with the size of synapses (37)”
From Synaptic evidence for the efficacy of spaced learning (2012) · cites this paper as [37]
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Synaptic evidence for the efficacy of spaced learning
Kramár, E. A., Babayan, A. H., Gavin, C. F., Cox, C. D., Jafari, M., Gall, C. M., Rumbaugh, G., & Lynch, G. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1120700109 · Cited by 192 · see citing works
- Authors
- Sassoé‐Pognetto, M., Utvik, J. K., Camoletto, P., Watanabe, M., Stephenson, F. A., Bredt, D. S., & Ottersen, O. P.
- Affiliations
- University of Turin (IT)
- University of Oslo (NO)
- Hokkaido University (JP)
- University of London (GB)
- University of California, San Francisco (US)
- Corresponding author
- Sassoé‐Pognetto, Marco
- Venue
- Journal of Comparative Neurology
- Publisher
- Wiley
- Published
- 2003-06-16
- Volume
- 463
- Issue
- 3
- Pages
- 237-248
- ISSN
- 0021-9967 (ISSN-L)
- 1096-9861
- OpenAlex
- W2056817409
- Cited by
- 45
- References
- 72
- Citations by year
- 2023: 1 · 2020: 3 · 2018: 4 · 2017: 1 · 2015: 1 · 2014: 3 · 2013: 3 · 2012: 1
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Comparative Neurology (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
- Funders
- Compagnia di San Paolo
- Fondazione Cavalieri Ottolenghi
- Italian M.I.U.R.
- National Institutes of Health
- American Heart Association
- Christopher Reeves Paralysis
- Norwegian Research Council
- EU Biomed (QLG3-CT-2001-02089)
- COST (European Cooperation in the Field of Scientific and Technical Research)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Keywords
- postsynaptic density, PSD-95, PSD-93, glutamate receptors, NMDA receptor, AMPA receptors, axodendritic synapses, dendrodendritic synapses, reciprocal synapses, olfactory bulb, mitral cells, tufted cells, glomerular layer, synaptic scaffolding, extrasynaptic receptors, immunogold labeling
- MeSH terms
- Disks Large Homolog 4 Protein, Animals, Axons, Dendrites, Immunohistochemistry, Membrane Proteins, Nerve Tissue Proteins, Olfactory Bulb, Synapses, Microscopy, Immunoelectron, Rats, Wistar, Receptors, Glutamate, Intracellular Signaling Peptides and Proteins, Rats
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