The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Proinflammatory cytokine synthesis in the injured mouse spinal cord: Multiphasic expression pattern and identification of the cell types involved
Abstract
We have studied the spatial and temporal distribution of six proinflammatory cytokines and identified their cellular source in a clinically relevant model of spinal cord injury (SCI). Our findings show that interleukin‐1β (IL‐1β) and tumor necrosis factor (TNF) are rapidly (<5 and 15 minutes, respectively) and transiently expressed in mice following contusion. At 30–45 minutes post SCI, IL‐1β and TNF‐positive cells could already be seen over the entire spinal cord segment analyzed. Multilabeling analyses revealed that microglia and astrocytes were the two major sources of IL‐1β and TNF at these times, suggesting a role for these cytokines in gliosis. Results obtained from SCI mice previously transplanted with green fluorescent protein (GFP)‐expressing hematopoietic stem cells confirmed that neural cells were responsible for the production of IL‐1β and TNF for time points preceding 3 hours. From 3 hours up to 24 hours, IL‐1β, TNF, IL‐6, and leukemia inhibitory factor (LIF) were strongly upregulated within and immediately around the contused area. Colocalization studies revealed that all populations of central nervous system resident cells, including neurons, synthesized cytokines between 3 and 24 hours post SCI. However, work done with SCI‐GFP chimeric mice revealed that at least some infiltrating leukocytes were responsible for cytokine production from 12 hours on. By 2 days post‐SCI, mRNA signal for all the above cytokines had nearly disappeared. Notably, we also observed another wave of expression for IL‐1β and TNF at 14 days. Overall, these results indicate that following SCI, all classes of neural cells initially contribute to the organization of inflammation, whereas recruited immune cells mostly contribute to its maintenance at later time points. J. Comp. Neurol. 500:267–285, 2007. © 2006 Wiley‐Liss, Inc.
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Microglia-specific localisation of a novel calcium binding protein, Iba1
Ito, D., Imai, Y., Ohsawa, K., Nakajima, K., Fukuuchi, Y., & Kohsaka, S. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00040-0 · Cited by 1,476
Imai, Y., Ibata, I., Ito, D., Ohsawa, K., & Kohsaka, S. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.1112 · Cited by 872 · cited 1×
“However, by using the same antibody, Imai and colleagues have previously detected a single 17-kDa band corresponding to Iba1 in proteins extracted from cultured microglia and hematopoietic cells but not from neurons, astrocytes, and fibroblasts (Imai et al., 1996; Ito et al., 1998).”
BackgroundReactive astrogliosis in the neonatal mouse brain and its modulation by cytokines
Balasingam, V, Tejada-Berges, T., Wright, E., Bouckova, R., & Yong, V. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-02-00846.1994 · Cited by 342
Lacroix, S., & Rivest, S. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70020452.x · Cited by 280
Bone marrow-derived cells that populate the adult mouse brain preserve their hematopoietic identity
Vallières, L., & Sawchenko, P. E. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-12-05197.2003 · Cited by 245
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The role of neural stem cells in regulating glial scar formation and repair
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Gatto, N., Dos Santos Souza, C., Shaw, A. C., Bell, S. M., Myszczynska, M. A., Powers, S., Meyer, K., Castelli, L. M., Karyka, E., Mortiboys, H., et al. (2021) · Aging Cell · doi:10.1111/acel.13281 · Cited by 58
Metadata
- Authors
- Pineau, I., & Lacroix, S.
- Venue
- Journal of Comparative Neurology
- Publisher
- Wiley
- Published
- 2006-11-16
- Volume
- 500
- Issue
- 2
- Pages
- 267-285
- ISSN
- 0021-9967 (ISSN-L)
- 1096-9861
- OpenAlex
- W1997507612
- Cited by
- 590
- References
- 5
- FWCI
- 12.29
- Type
- journal article
- Language
- en
- Open access
- closed
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