Developing nervous tissue induces formation of blood-brain barrier characteristics in invading endothelial cells: A study using quail-chick transplantation chimeras
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The classic tissue transplantation chick-quail experiment suggested nearly 40 years ago that BBB characteristics are not intrinsic to brain endothelium, but rather acquired and shaped in the neural environment during early CNS development.
“The classic tissue transplantation chick-quail experiment (559) suggested nearly 40 yr ago that the BBB characteristics are not intrinsic to brain endothelium, but rather acquired and shaped in the neural environment during early CNS development.”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [559]
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- Authors
- Stewart, P. A., & Wiley, M. J.
- Affiliations
- University of Toronto (CA)
- Corresponding author
- Stewart, P.A.
- Venue
- Developmental Biology
- Publisher
- Elsevier BV
- Published
- 1981-05
- Volume
- 84
- Issue
- 1
- Pages
- 183-192
- ISSN
- 0012-1606 (ISSN-L)
- OpenAlex
- W2005447528
- Cited by
- 684
- References
- 2
- Citations by year
- 2026: 10 · 2025: 6 · 2024: 14 · 2023: 16 · 2022: 17 · 2021: 11 · 2020: 13 · 2019: 15 · 2018: 13 · 2017: 10 · 2016: 8 · 2015: 21 · 2014: 22 · 2013: 15 · 2012: 11
- FWCI
- 1.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- blood-brain barrier, endothelial cells, neural induction, quail-chick chimeras, coelomic cavity, vascularization, endothelial differentiation
- MeSH terms
- Animals, Brain, Cell Differentiation, Cerebrovascular Circulation, Chick Embryo, Chimera, Coturnix, Endothelium, Nerve Tissue, Transplantation, Heterologous
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