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Cited by 131Tactile and Sensory InteractionsMotor Control and AdaptationNeuroscience and Neuropharmacology Research

Afferent and efferent pathways of the vibrissal region of primary motor cortex in the mouse

Porter, Linda L., White, Edward L.·1983·Journal of Comparative Neurology
DOI 10.1002/cne.902140306
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Abstract

The afferent and efferent connections of the vibrissal representation within the mouse primary motor cortex (Msl) were identified by using the retrograde transport of horseradish peroxidase (HRP) and the anterograde transport of tritiated amino acids injected into Msl. Following aldehyde perfusion brains were frozen‐sectioned at 40 μm and reacted for HRP using the 3‐3′ diaminobenzidine‐cobalt chloride technique of Adams (77). Alternate HRP reacted sections were processed for autoradiography. HRP‐filled pyramidal cell somata and concentrations of developed silver grains above background levels were observed in both the vibrissal area of primary somatosensory cortex (SmI) cortex (i.e., the posteromedial barrel subfield; PMBSF cortex) and in the face region of Smll (area 40). In both regions labeled somata occurred predominantly in cortical layers II‐III and V. Autoradiographic label was superimposed over the regions containing labeled soinata but exhibited a less distinct laminar organization. A dense reciprocal projection connected the injection site with the hom‐otopic area in contralateral Msl; somata occurred for the most part in layers III and V. Developed silver grains were uniformly dispersed over the area containing labeled cell bodies. HRP‐labeled pyramidal somata were noted in contralateral PMBSF cortex, but no silver grains occurred in this region. Reciprocal projections linked Msl cortex with the ipsilateral thalamic nuclei: ventralis pars lateralis (VL) and centralis pars lateralis (CL) and with the zona incerta (ZI). Labeled cell bodies and developed silver grains were more dense in VL than in CL. The ipsilateral striatum and thalamic reticular nucleus (NRT) received afferents from the motor cortex but did not project to it. Thus, the vibrissal area of primary motor cortex is connected with a number of cortical and subcortical structures, each of which has been shown to play a role in motor performance. Identification of the afferent and efferent pathways of Msl cortex will now enable further investigation of the ultrastructural and synaptic organization of the vibrissal area of MsI.

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  • The motor pathway is composed of primary and secondary motor cortical areas (MOp and MOs) and the VAL nucleus.

    “The motor pathway is composed of primary and secondary motor cortical areas (MOp and MOs) and the VAL nucleus92,94.”

    From A mesoscale connectome of the mouse brain (2014) · cites this paper as [92]

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Authors
Porter, L. L., & White, E. L.
Affiliations
Boston University (US)
ORCID
White, Edward L.
Venue
Journal of Comparative Neurology
Publisher
Wiley
Published
1983-03
Volume
214
Issue
3
Pages
279-289
ISSN
  • 0021-9967 (ISSN-L)
  • 1096-9861
DOI
10.1002/cne.902140306
OpenAlex
W2034408566
Cited by
131
References
69
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 4 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 3 · 2015: 7 · 2014: 5 · 2013: 7 · 2012: 3
FWCI
4.69
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 7893 d)
Locations
  • The Journal of Comparative Neurology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Science Foundation
  • National Institutes of Health
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
primary motor cortex, afferent pathways, efferent pathways, barrel cortex, somatosensory cortex, pyramidal neurons, reciprocal projections, zona incerta, thalamic nuclei, striatum, thalamic reticular nucleus, mice
MeSH terms
Afferent Pathways, Animals, Brain Mapping, Corpus Striatum, Efferent Pathways, Face, Hair, Male, Motor Cortex, Sense Organs, Somatosensory Cortex, Thalamic Nuclei, Mice

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