A novel cytoarchitectonic area induced experimentally within the primate visual cortex.
Open accessAbstract
The cerebral cortex is divisible into a number of cytoarchitectonic areas, but developmental mechanisms that regulate their number and size remain unknown. Here we provide evidence that reducing the population of selected thalamic fibers projecting into the primary visual cortex (area 17) of monkeys during midgestation induces the formation of a novel cytoarchitectonic area situated along the border of and embedded within area 17. This region, termed area X, differs cytoarchitectonically from both area 17 and the adjacent secondary visual cortex (area 18). We propose that an aberrant combination of thalamic and cortical connections acting on a portion of prospective area 17 deprived of its normal thalamic input may result in formation of a hybrid cortex. Our results support the protomap hypothesis of cortical parcellation and suggest how during evolution new cytoarchitectonic regions may arise by cell-cell interactions that depend on a unique combination of intrinsic properties of cortical neurons and afferent fibers.
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- Authors
- Rakic, P., Suñer, I., & Williams, R. W.
- Affiliations
- Yale University (US)
- Section of Neuroanatomy, Yale University School of Medicine, New Haven, CT 06510.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1991-03-15
- Volume
- 88
- Issue
- 6
- Pages
- 2083-2087
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC51173
- OpenAlex
- W2008264702
- Cited by
- 208
- References
- 24
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 2 · 2023: 9 · 2022: 5 · 2021: 5 · 2020: 4 · 2019: 5 · 2018: 5 · 2017: 4 · 2016: 5 · 2015: 7 · 2014: 5 · 2013: 9 · 2012: 9
- FWCI
- 6.32
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- cytoarchitectonic areas, primary visual cortex, area 17, secondary visual cortex, thalamic afferents, cortical parcellation, cortical development, cell-cell interactions, monkey visual cortex
- MeSH terms
- Animals, Computer Graphics, Fetus, Macaca mulatta, Neurons, Reference Values, Retina, Visual Cortex
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