Cited by 277Motor Control and AdaptationVestibular and auditory disordersMemory and Neural Mechanisms

Cerebellar Output Channels

Middleton, Frank A., Strick, Peter L.·1997·International Review of Neurobiology

Abstract

The cerebellum has long been regarded as involved in the control of movement, in part through its connections with the cerebral cortex. These connections were thought to combine inputs from widespread regions of the cerebral cortex and "funnel" them into the motor system at the level of the primary motor cortex. Retrograde transneuronal transport of herpes simplex virus type I has recently been used to identify areas of the cerebral cortex that are "directly" influenced by the output of the cerebellum. Results suggest that cerebellar output projects via the thalamus to multiple cortical areas, including premotor and prefrontal cortex, as well as the primary motor cortex. In addition, the projections to different cortical areas appear to originate from distinct regions of the deep cerebellar nuclei. These observations have led to the proposal that cerebellar output is composed of a number of separate "output channels." Evidence from functional imaging studies in humans and single neuron recording studies in monkeys suggests that individual output channels are concerned with different aspects of motor or cognitive behavior.

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Crossref · 10.1016/s0074-7742(08)60347-5

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66 of 66 references verified0 citation errors · 0 not checkable

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  • Ascending cerebellar fibers innervate motor cortices via caudal fastigial nuclei, interpositus nuclei, and dorsal dentate nuclei.

    “Ascending cerebellar fibers innervate motor cortices via caudal fastigial nuclei, interpositus nuclei, and dorsal segments of dentate nuclei [193].”

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Authors
Middleton, F. A., & Strick, P. L.
Affiliations
  • United States Department of Veterans Affairs (US)
  • State University of New York (US)
Venue
International Review of Neurobiology
Publisher
Elsevier
Published
1997
Volume
41
Pages
61-82
ISSN
0074-7742 (ISSN-L)
OpenAlex
W1603824339
Cited by
277
References
66
Citations by year
2026: 1 · 2025: 3 · 2024: 6 · 2023: 7 · 2022: 7 · 2021: 9 · 2020: 7 · 2019: 10 · 2018: 9 · 2017: 13 · 2016: 7 · 2015: 8 · 2014: 10 · 2013: 6 · 2012: 5
FWCI
14.77
Type
book chapter
Language
en
Open access
closed
Locations
  • International review of neurobiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Mental Health (MH11262, F31MH011262)
  • National Institute of Neurological Disorders and Stroke (NS-24328, R01NS024328)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
  • Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
cerebellar cortex, deep cerebellar nuclei, thalamocortical connections, primary motor cortex, premotor cortex, prefrontal cortex, herpes simplex virus type 1, motor control, cognitive behavior
MeSH terms
Animals, Brain Mapping, Cerebellum, Humans, Magnetic Resonance Imaging, Motor Cortex, Neural Pathways, Neurons, Primates, Prefrontal Cortex

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