Marijuana and cannabinoid regulation of brain reward circuits
Open accessAbstract
The reward circuitry of the brain consists of neurons that synaptically connect a wide variety of nuclei. Of these brain regions, the ventral tegmental area (VTA) and the nucleus accumbens (NAc) play central roles in the processing of rewarding environmental stimuli and in drug addiction. The psychoactive properties of marijuana are mediated by the active constituent, Delta(9)-THC, interacting primarily with CB1 cannabinoid receptors in a large number of brain areas. However, it is the activation of these receptors located within the central brain reward circuits that is thought to play an important role in sustaining the self-administration of marijuana in humans, and in mediating the anxiolytic and pleasurable effects of the drug. Here we describe the cellular circuitry of the VTA and the NAc, define the sites within these areas at which cannabinoids alter synaptic processes, and discuss the relevance of these actions to the regulation of reinforcement and reward. In addition, we compare the effects of Delta(9)-THC with those of other commonly abused drugs on these reward circuits, and we discuss the roles that endogenous cannabinoids may play within these brain pathways, and their possible involvement in regulating ongoing brain function, independently of marijuana consumption. We conclude that, whereas Delta(9)-THC alters the activity of these central reward pathways in a manner that is consistent with other abused drugs, the cellular mechanism through which this occurs is likely different, relying upon the combined regulation of several afferent pathways to the VTA.
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The actions of cannabinoids in the VTA may be more complex than those of opiates, but appear to involve disinhibitory mechanisms to activate dopamine neurons.
“The actions of cannabinoids in the VTA may be more complex than those of opiates, but appear to involve disinhibitory mechanisms to activate dopamine neurons (Lupica et al., 2004; Gardner, 2005).”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Lupica et al., 2004
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Cites
Structure of a cannabinoid receptor and functional expression of the cloned cDNA
Matsuda, L. A., Lolait, S. J., Brownstein, M. J., Young, A. C., & Bonner, T. I. (1990) · Nature · doi:10.1038/346561a0 · Cited by 5,011 · see citing works
Di Chiara, G., & Imperato, A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5274 · Cited by 4,733 · see citing works
Bardo, M. T., & Hammer, R. P. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90226-e · Cited by 3,229 · see citing works
A psychomotor stimulant theory of addiction.
Wise, R. A., & Bozarth, M. A. (1987) · Psychological Review · doi:10.1037/0033-295x.94.4.469 · Cited by 2,747 · see citing works
Isolation, Structure, and Partial Synthesis of an Active Constituent of Hashish
Gaoni, Y., & Mechoulam, R. (1964) · Journal of the American Chemical Society · doi:10.1021/ja01062a046 · Cited by 2,389 · see citing works
Cannabinoid receptor localization in brain.
Herkenham, M., Lynn, A. B., Little, M. D., Johnson, M. R., Melvin, L. S., de Costa, B. R., & Rice, K. C. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.5.1932 · Cited by 2,321 · see citing works
Herkenham, M., Lynn, A., Johnson, M., Melvin, L., de Costa, B., & Rice, K. (1991) · The Journal of Neuroscience · doi:10.1523/jneurosci.11-02-00563.1991 · Cited by 2,159 · see citing works
SR141716A, a potent and selective antagonist of the brain cannabinoid receptor
Rinaldi, M. L., Barth, F., Héaulme, M., Shire, D. J., Calandra, B., Congy, C., Martinez, S., Maruani, J., Neliat, G., Caput, D., et al. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00773-x · Cited by 1,751 · see citing works
Opioids excite dopamine neurons by hyperpolarization of local interneurons
Johnson, S., & North, R. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-02-00483.1992 · Cited by 1,637 · see citing works
Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses
Wilson, R. I., & Nicoll, R. A. (2001) · Nature · doi:10.1038/35069076 · Cited by 1,607 · see citing works
Role of Endogenous Cannabinoids in Synaptic Signaling
Freund, T. F., Katona, I., & Piomelli, D. (2003) · Physiological Reviews · doi:10.1152/physrev.00004.2003 · Cited by 1,567 · see citing works
Pharmacology of cannabinoid CB1 and CB2 receptors
Pertwee, R. G. (1997) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(97)82001-3 · Cited by 1,489 · see citing works
Bisogno, T., Hanuš, L., PETROCELLIS, L. D., Tchilibon, S., Ponde, D. E., Brandi, I., Moriello, A. S., Davis, J. B., Mechoulam, R., & Marzo, V. D. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704327 · Cited by 1,315 · see citing works
Endocannabinoid Signaling in the Brain
Wilson, R. I., & Nicoll, R. A. (2002) · Science · doi:10.1126/science.1063545 · Cited by 1,260 · see citing works
Specificity in the projection patterns of accumbal core and shell in the rat
Heimer, L., Zahm, D. S., Churchill, L., Kalivas, P. W., & Wohltmann, C. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90202-y · Cited by 1,219 · see citing works
Drugs of Abuse and Stress Trigger a Common Synaptic Adaptation in Dopamine Neurons
Saal, D., Dong, Y., Bonci, A., & Malenka, R. C. (2003) · Neuron · doi:10.1016/s0896-6273(03)00021-7 · Cited by 1,147 · see citing works
Tanda, G., Pontieri, F. E., & Chiara, G. D. (1997) · Science · doi:10.1126/science.276.5321.2048 · Cited by 1,079 · see citing works
Inhibitory control of neostriatal projection neurons by GABAergic interneurons
Koós, T. Z., & Tepper, J. M. (1999) · Nature Neuroscience · doi:10.1038/8138 · Cited by 851 · see citing works
Addictive Drugs and Brain Stimulation Reward
Wise, R. A. (1996) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.19.030196.001535 · Cited by 792 · see citing works
Postsynaptic endocannabinoid release is critical to long-term depression in the striatum
Gerdeman, G. L., Ronesi, J. A., & Lovinger, D. M. (2002) · Nature Neuroscience · doi:10.1038/nn832 · Cited by 767 · see citing works
Gonon, F. G. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90307-7 · Cited by 676 · see citing works
Modulation of transmitter release via presynaptic cannabinoid receptors
Schlicker, E., & Kathmann, M. (2001) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01805-8 · Cited by 671 · see citing works
Endogenous cannabinoids mediate long-term synaptic depression in the nucleus accumbens
Robbe, D., Köpf, M., Rémaury, A., Bockaert, J., & Manzoni, O. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122149199 · Cited by 631 · see citing works
Localization of cannabinoid receptor mRNA in rat brain
Matsuda, L. A., Bonner, T. I., & Lolait, S. J. (1993) · Journal of Comparative Neurology · doi:10.1002/cne.903270406 · Cited by 631 · see citing works
Thomas, M. J., Beurrier, C., Bonci, A., & Malenka, R. C. (2001) · Nature Neuroscience · doi:10.1038/nn757 · Cited by 629 · see citing works
Retrograde signaling in the regulation of synaptic transmission: focus on endocannabinoids
Alger, B. E. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00080-1 · Cited by 599 · see citing works
McBride, W. J., Murphy, J. M., & Ikemoto, S. (1999) · Behavioural Brain Research · doi:10.1016/s0166-4328(99)00022-4 · Cited by 574 · see citing works
Cannabinoids inhibit N- and P/Q-type calcium channels in cultured rat hippocampal neurons
Twitchell, W., Brown, S., & Mackie, K. (1997) · Journal of Neurophysiology · doi:10.1152/jn.1997.78.1.43 · Cited by 544 · see citing works
Evidence for a New G Protein-Coupled Cannabinoid Receptor in Mouse Brain
Breivogel, C. S., Griffin, G., Marzo, V. D., & Martin, B. R. (2001) · Molecular Pharmacology · doi:10.1124/mol.60.1.155 · Cited by 537 · see citing works
Zahm, D. S. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(99)00065-2 · Cited by 487 · see citing works
It could be habit forming: drugs of abuse and striatal synaptic plasticity
Gerdeman, G. L., Partridge, J. G., Lupica, C. R., & Lovinger, D. M. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00065-1 · Cited by 480 · see citing works
Self-citationHuestis, M. A., Gorelick, D. A., Heishman, S. J., Preston, K. L., Nelson, R. A., Moolchan, E. T., & Frank, R. A. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.4.322 · Cited by 479 · see citing works
Melis, M., Pistis, M., Perra, S., Muntoni, A. L., Pillolla, G., & Gessa, G. L. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4503-03.2004 · Cited by 478 · see citing works
Mechoulam, R., Fride, E., & Marzo, V. D. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00649-9 · Cited by 431 · see citing works
Hájos, N., Ledent, C. A., & Freund, T. F. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00287-1 · Cited by 420 · see citing works
Burst Firing in Dopamine Neurons Induced by N -Methyl-D-aspartate: Role of Electrogenic Sodium Pump
Johnson, S. W., Seutin, V., & North, R. A. (1992) · Science · doi:10.1126/science.1329209 · Cited by 419 · see citing works
Mechanisms of Cannabinoid Inhibition of GABAASynaptic Transmission in the Hippocampus
Hoffman, A. F., & Lupica, C. R. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-07-02470.2000 · Cited by 401 · see citing works
Self-citationBeing stoned: a review of self‐reported cannabis effects
Green, B., Kavanagh, D. J., & Young, R. M. (2003) · Drug and Alcohol Review · doi:10.1080/09595230310001613976 · Cited by 390 · see citing works
Electrophysiological Characterization of GABAergic Neurons in the Ventral Tegmental Area
Steffensen, S. C., Svingos, A. L., Pickel, V. M., & Henriksen, S. J. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-19-08003.1998 · Cited by 388 · see citing works
Neuropharmacological Mechanisms of Drug Reward: Beyond Dopamine in the Nucleus Accumbens
Bardo, M. T. (1998) · Critical Reviews in Neurobiology · doi:10.1615/critrevneurobiol.v12.i1-2.30 · Cited by 383 · see citing works
Cannabinoids excite dopamine neurons in the ventral tegmentum and substantia nigra
French, E. D., Dillon, K. A., & Wu, X. (1997) · Neuroreport · doi:10.1097/00001756-199702100-00014 · Cited by 374 · see citing works
Cannabinoids activate mesolimbic dopamine neurons by an action on cannabinoid CB1 receptors
Gessa, G., Melis, M., Muntoni, A., & Diana, M. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)01442-8 · Cited by 370 · see citing works
Robbe, D., Alonso, G., Duchamp, F., Bockaert, J., & Manzoni, O. J. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-01-00109.2001 · Cited by 367 · see citing works
Tanda, G., Munzar, P., & Goldberg, S. R. (2000) · Nature Neuroscience · doi:10.1038/80577 · Cited by 347 · see citing works
Chen, J., Paredes, W. M., Li, J., Smith, D. M., Lowinson, J. H., & Gardner, E. L. (1990) · Psychopharmacology · doi:10.1007/bf02245916 · Cited by 329 · see citing works
GABA-containing neurons in the ventral tegmental area project to the nucleus accumbens in rat brain
Bockstaele, E. J. V., & Pickel, V. M. (1995) · Brain Research · doi:10.1016/0006-8993(95)00334-m · Cited by 328 · see citing works
Rewarding Actions of Phencyclidine and Related Drugs in Nucleus Accumbens Shell and Frontal Cortex
Carlezon, & Wise, R. A. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-09-03112.1996 · Cited by 327 · see citing works
Tanda, G., & Goldberg, S. R. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1485-z · Cited by 280 · see citing works
Szabó, B., Siemes, S., & Wallmichrath, I. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02041.x · Cited by 277 · see citing works
Brain reward circuitry: Four circuit elements “wired” in apparent series
Wise, R. A., & Bozarth, M. A. (1984) · Brain Research Bulletin · doi:10.1016/0361-9230(84)90190-4 · Cited by 252 · see citing works
Cannabinoid Transmission and Reward-Related Events
Gardner, E. L., & Vorel, S. R. (1998) · Neurobiology of Disease · doi:10.1006/nbdi.1998.0219 · Cited by 247 · see citing works
Plenz, D. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00196-6 · Cited by 242 · see citing works
Cannabinoid receptors in microglia of the central nervous system: immune functional relevance
Cabral, G. A., & Marciano‐Cabral, F. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.0405216 · Cited by 240 · see citing works
French, E. D. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00278-4 · Cited by 236 · see citing works
Walaas, I., & Fonnum, F. (1980) · Neuroscience · doi:10.1016/0306-4522(80)90071-8 · Cited by 235 · see citing works
Afferent modulation of dopamine neuron firing patterns
Kitai, S. T., Shepard, P. D., Callaway, J. C., & Scroggs, R. S. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)00040-9 · Cited by 234 · see citing works
Cannabinoids, hippocampal function and memory
Hampson, R. E., & Deadwyler, S. A. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00294-5 · Cited by 221 · see citing works
Synaptic inputs to GABAA and GABAB receptors originate from discrete afferent neurons
Sugita, S., Johnson, S. W., & North, R. A. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90518-c · Cited by 220 · see citing works
A single in-vivo exposure to Δ9THC blocks endocannabinoid-mediated synaptic plasticity
Mato, S., Chevaleyre, V., Robbe, D., Pazos, Á., Castillo, P. E., & Manzoni, O. J. (2004) · Nature Neuroscience · doi:10.1038/nn1251 · Cited by 220 · see citing works
Cannabinoid Receptors and Modulation of Cyclic AMP Accumulation in the Rat Brain
Bidaut‐Russell, M., Devane, W. A., & Howlett, A. C. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb08815.x · Cited by 208 · see citing works
Brain mechanisms of drug reward and euphoria.
Wise, R. A., & Bozarth, M. A. (1985) · PubMed · Cited by 206 · see citing works
Hájos, N., & Freund, T. F. (2002) · Neuropharmacology · doi:10.1016/s0028-3908(02)00157-0 · Cited by 198 · see citing works
Marijuana's interaction with brain reward systems: Update 1991
Gardner, E. L., & Lowinson, J. H. (1991) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(91)90365-9 · Cited by 197 · see citing works
Harvey, J., & Lacey, M. G. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-14-05271.1997 · Cited by 196 · see citing works
Hoffman, A. F., & Lupica, C. R. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.85.1.72 · Cited by 194 · see citing works
Self-citationHoffman, A. F., Oz, M., Caulder, T., & Lupica, C. R. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-12-04815.2003 · Cited by 193 · see citing works
Self-citationSullivan, J. (2000) · Learning & Memory · doi:10.1101/lm.7.3.132 · Cited by 173 · see citing works
Henry, D. J., & Chavkin, C. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)11289-9 · Cited by 172 · see citing works
A subset of ventral tegmental area neurons is inhibited by dopamine, 5-hydroxytryptamine and opioids
Cameron, D., Wessendorf, M. W., & Williams, J. T. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00444-7 · Cited by 163 · see citing works
Increase in meso-prefrontal dopaminergic activity after stimulation of CB1 receptors by cannabinoids
Diana, M., Melis, M., & Gessa, G. L. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00292.x · Cited by 152 · see citing works
Ton, J. M. N. C., Gerhardt, G. A., Friedemann, M., Etgen, A. M., Rose, G., Sharpless, N. S., & Gardner, E. L. (1988) · Brain Research · doi:10.1016/0006-8993(88)90749-4 · Cited by 140 · see citing works
Addictive potential of cannabinoids: the underlying neurobiology
Gardner, E. L. (2002) · Chemistry and Physics of Lipids · doi:10.1016/s0009-3084(02)00162-7 · Cited by 137 · see citing works
Increase in meso‐prefrontal dopaminergic activity after stimulation of CB1 receptors by cannabinoids
Diana, M., Melis, M., & Gessa, G. L. (1998) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1998.00292.x · Cited by 129 · see citing works
μ-Opioid Receptors Modulate NMDA Receptor-Mediated Responses in Nucleus Accumbens Neurons
Martin, G. E., Nie, Z., & Siggins, G. R. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-01-00011.1997 · Cited by 127 · see citing works
Nicola, S. M., & Malenka, R. C. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.79.4.1768 · Cited by 123 · see citing works
Carlezon, W. A., Wise, R. A., & Carlezon, W. A. (1996) · Psychopharmacology · doi:10.1007/s002130050151 · Cited by 119 · see citing works
Wu, X., & French, E. D. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(99)00140-9 · Cited by 116 · see citing works
Increased Opioid Inhibition of GABA Release in Nucleus Accumbens during Morphine Withdrawal
Chieng, B. C. H., & Williams, J. T. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-17-07033.1998 · Cited by 112 · see citing works
Cannabinoids inhibit GABAergic synaptic transmission in mice nucleus accumbens
Manzoni, O. J., & Bockaert, J. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)00723-3 · Cited by 103 · see citing works
Chen, J., Marmur, R., Pulles, A., Paredes, W. M., & Gardner, E. L. (1993) · Brain Research · doi:10.1016/0006-8993(93)90298-2 · Cited by 93 · see citing works
Hoffman, A. F., Riegel, A. C., & Lupica, C. R. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02773.x · Cited by 80 · see citing works
Self-citationCheer, J. F., Marsden, C. A., Kendall, D. A., & Mason, R. J. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00241-4 · Cited by 77 · see citing works
Chou, Y.-H., Halldin, C., & Farde, L. (2000) · Synapse · doi:10.1002/1098-2396(200011)38:2 · Cited by 57 · see citing works
Ongali, B., Ase, A. R., H�bert, C., Amdiss, F., & Reader, T. A. (2000) · Synapse · doi:10.1002/(sici)1098-2396(200007)37:1 · Cited by 21 · see citing works
The effects of delta-9-THC on mechanisms of learning and memory.
Deadwyler, S. A., Heyser, C. J., Michaelis, R. C., & Hampson, R. E. (1990) · PubMed · Cited by 14 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- WU, X. & FRENCH, E.D. (2000). Effects of chronic delta9-tetra- hydrocannabinol on rat midbrain dopamine neurons: an electrop- hysiological assessment (in process citation). Neuropharmacology, 39, 391-398.
Cited by
Sorted by citations
The Endocannabinoid System as an Emerging Target of Pharmacotherapy
Pacher, P., Bátkai, S., & Kunos, G. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.3.2 · Cited by 2,077 · see citing works
Ikemoto, S. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.05.004 · Cited by 1,477 · see citing works
Tzschentke, T. M. (2007) · Addiction Biology · doi:10.1111/j.1369-1600.2007.00070.x · Cited by 1,336 · see citing works
ENDOCANNABINOID-MEDIATED SYNAPTIC PLASTICITY IN THE CNS
Chevaleyre, V., Takahashi, K. A., & Castillo, P. E. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112834 · Cited by 779 · see citing works
Adult ADHD and comorbid disorders: clinical implications of a dimensional approach
Katzman, M. A., Bilkey, T. S., Chokka, P. R., Fallu, A., & Klassen, L. J. (2017) · BMC Psychiatry · doi:10.1186/s12888-017-1463-3 · Cited by 732 · see citing works
Lopez‐Quintero, C., Cobos, J. P. D. L., Hasin, D. S., Okuda, M., Wang, S., Grant, B. F., & Blanco, C. (2010) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2010.11.004 · Cited by 702 · see citing works
Pierce, R. C., & Kumaresan, V. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.04.016 · Cited by 913 · see citing works
CANNABINOID RECEPTORS AS THERAPEUTIC TARGETS
Mackie, K. (2005) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.46.120604.141254 · Cited by 508 · see citing works
Δ9-Tetrahydrocannabinol Induces Dopamine Release in the Human Striatum
Bossong, M., van Berckel, B. N., Boellaard, R., Zuurman, L., Schuit, R., Windhorst, A., van Gerven, J. V., Ramsey, N., Lammertsma, A., & Kahn, R. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.138 · Cited by 262 · see citing works
Endocannabinoid signaling system and brain reward: emphasis on dopamine
GARDNER, E. (2005) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2005.01.032 · Cited by 387 · see citing works
Hull, E. M., & Rodrı́guez–Manzo, G. (2009) · Elsevier eBooks · doi:10.1016/b978-008088783-8.00001-2 · Cited by 371 · see citing works
One Is Not Enough: Understanding and Modeling Polysubstance Use
Crummy, E. A., O’Neal, T. J., Baskin, B. M., & Ferguson, S. M. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00569 · Cited by 351 · see citing works
Blurred Boundaries: The Therapeutics and Politics of Medical Marijuana
Bostwick, J. M. (2012) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2011.10.003 · Cited by 261 · see citing works
Lupica, C. R., & Riegel, A. C. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.03.016 · Cited by 256 · see citing works
Self-citationGilman, J. M., Kuster, J. K., Lee, S., Lee, M. J., Kim, B. W., Makris, N., van der Kouwe, A., Blood, A. J., & Breiter, H. C. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.4745-13.2014 · Cited by 250 · see citing works
The endocannabinoid system in brain reward processes
Solinas, M., Goldberg, S. R., & Piomelli, D. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.130 · Cited by 243 · see citing works
Rademacher, D. J., Meier, S. E., Shi, L., Vanessa Ho, W.-S., Jarrahian, A., & Hillard, C. J. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.06.012 · Cited by 233 · see citing works
Price, D. A., Martinez, A. A., Seillier, A., Koek, W., Acosta, Y. P. V., Fernández, E., Strong, R., Lutz, B., Marsicano, G., Roberts, J. L., et al. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06764.x · Cited by 231 · see citing works
The endocannabinoid system: emotion, learning and addiction
Moreira, F. A., & Lutz, B. (2008) · Addiction Biology · doi:10.1111/j.1369-1600.2008.00104.x · Cited by 222 · see citing works
Endocannabinoids in the regulation of appetite and body weight
Kirkham, T. C. (2005) · Behavioural Pharmacology · doi:10.1097/00008877-200509000-00004 · Cited by 220 · see citing works
Lack of CB1 Cannabinoid Receptor Impairs Cocaine Self-Administration
Sòria, G., Mendizábal, V. E., Touriño, C., Robledo, P., Ledent, C. A., Parmentier, M., Maldonado, R. J., & Valverde, O. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300707 · Cited by 214 · see citing works
A new control center for dopaminergic systems: pulling the VTA by the tail
Bourdy, R., & Barrot, M. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.06.007 · Cited by 208 · see citing works
The Role of cannabinoids in neuroanatomic alterations in cannabis users.
Lorenzetti, V., Solowij, N., & Yücel, M. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.11.013 · Cited by 208 · see citing works
“Hannerz and Hindmarsh, 1983 (66) 12 (8) 12 (8) 26 26 10 — — — — — — — — — —”
BackgroundInfluentialRabin, R. A., & George, T. P. (2015) · American Journal on Addictions · doi:10.1111/ajad.12186 · Cited by 206 · see citing works
Progress in brain cannabinoid CB2 receptor research: From genes to behavior
Jordan, C. J., & Xi, Z. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.12.026 · Cited by 197 · see citing works
Hill, M. N., & Gorzalka, B. B. (2005) · Behavioural Pharmacology · doi:10.1097/00008877-200509000-00006 · Cited by 193 · see citing works
Mátyás, F., Urbán, G. M., Watanabe, M., Mackie, K., Zimmer, A., Freund, T. F., & Katona, I. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.05.028 · Cited by 187 · see citing works
Dopamine release is heterogeneous within microenvironments of the rat nucleus accumbens
Wightman, R. M., Heien, M. L., Wassum, K. M., Sombers, L. A., Aragona, B. J., Khan, A. S., Ariansen, J. L., Cheer, J. F., Phillips, P. E. M., & Carelli, R. M. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05772.x · Cited by 179 · see citing works
Chronic effects of cannabis use on the human reward system: An fMRI study
van Hell, H. H., Vink, M., Ossewaarde, L., Jager, G., Kahn, R. S., & Ramsey, N. F. (2010) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2009.11.010 · Cited by 175 · see citing works
Two brain sites for cannabinoid reward
Zangen, A., Solinas, M., Ikemoto, S., Goldberg, S. R., & Wise, R. A. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3554-05.2006 · Cited by 174 · see citing works
Receptor-independent actions of cannabinoids on cell membranes: Focus on endocannabinoids
Öz, M. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.09.009 · Cited by 164 · see citing works
Cannabinoid–Dopamine Interaction in the Pathophysiology and Treatment of CNS Disorders
Fernández‐Ruíz, J., Hernández, M., & Ramos, J. A. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00144.x · Cited by 163 · see citing works
Gómez, E. S., Matias, I., Rueda‐Orozco, P. E., Cisneros, M., Petrosino, S., Navarro, L., Marzo, V. D., & Prospero-Garcia, O. E. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707313 · Cited by 158 · see citing works
Ji, S., Zhang, Y., Cleemput, J. V., Jiang, W., Liao, M., Li, L., Wan, Q., Backstrom, J. R., & Zhang, X. (2006) · Nature Medicine · doi:10.1038/nm1349 · Cited by 156 · see citing works
A role for cannabinoid CB1 receptors in mood and anxiety disorders
Witkin, J. M., Tzavara, E. T., & Nomikos, G. G. (2005) · Behavioural Pharmacology · doi:10.1097/00008877-200509000-00005 · Cited by 156 · see citing works
The endocannabinoid system and psychiatric disorders
Parolaro, D., Realini, N., Viganò, D., Guidali, C., & Rubino, T. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.03.018 · Cited by 150 · see citing works
Microbiota‐gut‐brain axis as a regulator of reward processes
García‐Cabrerizo, R., Carbia, C., O’Riordan, K. J., Schellekens, H., & Cryan, J. F. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15284 · Cited by 147 · see citing works
Deficits in striatal dopamine release in cannabis dependence
van de Giessen, E., Weinstein, J. J., Cassidy, C., Haney, M., Dong, Z., Ghazzaoui, R., Ojeil, N., Kegeles, L. S., Xu, X., Vadhan, N. P., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.21 · Cited by 136 · see citing works
Self-administration of cannabinoids by experimental animals and human marijuana smokers
Justinová, Z., Goldberg, S. R., Heishman, S. J., & Tanda, G. (2005) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2005.01.026 · Cited by 137 · see citing works
Cannabis and the developing brain: Insights from behavior
Trezza, V., Cuomo, V., & Vanderschuren, L. J. M. J. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.01.058 · Cited by 131 · see citing works
López‐Moreno, J. A., González‐Cuevas, G., Moreno, G., & Navarro, M. A. (2008) · Addiction Biology · doi:10.1111/j.1369-1600.2008.00105.x · Cited by 131 · see citing works
Cannabinoid mechanism in reinstatement of heroin‐seeking after a long period of abstinence in rats
Fattore, L., Spano, M. S., Cossu, G., Deiana, S., & Fratta, W. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02607.x · Cited by 128 · see citing works
The Endocannabinoid System and Cannabidiol's Promise for the Treatment of Substance Use Disorder
Chye, Y., Christensen, E., Solowij, N., & Yücel, M. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00063 · Cited by 128 · see citing works
Bruijnzeel, A. W., & Gold, M. S. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2005.01.007 · Cited by 125 · see citing works
Aracil-Fernández, A., Trigo, J. M., García‐Gutiérrez, M. S., Ortega-Álvaro, A., Ternianov, A., Navarro, D., Robledo, P., Berbel, P. J., Maldonado, R. J., & Manzanares, J. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.22 · Cited by 119 · see citing works
Smith, T. H., Sim‐Selley, L. J., & Selley, D. E. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00777.x · Cited by 117 · see citing works
Xi, Z., Spiller, K. J., Pak, A. C., Gilbert, J. G., Dillon, C., Li, X., Peng, X., & Gardner, E. L. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301552 · Cited by 115 · see citing works
Cannabinoid self-administration increases dopamine release in the nucleus accumbens
Fadda, P., Scherma, M., Spano, M. S., Salis, P., Melis, V., Fattore, L., & Fratta, W. (2006) · Neuroreport · doi:10.1097/01.wnr.0000236853.40221.8e · Cited by 114 · see citing works
Mechanisms of CB1 receptor signaling: endocannabinoid modulation of synaptic strength
Mackie, K. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803273 · Cited by 114 · see citing works
Haney, M. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301243 · Cited by 113 · see citing works
Mateo, Y., Johnson, K. A., Covey, D. P., Atwood, B. K., Wang, H., Zhang, S., Gildish, I., Cachope, R., Bellocchio, L., Guzmán, M., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.11.012 · Cited by 108 · see citing works
Molecular mechanisms of maternal cannabis and cigarette use on human neurodevelopment
Morris, C. V., DiNieri, J. A., Szutorisz, H., & Hurd, Y. L. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07884.x · Cited by 111 · see citing works
Huestis, M. A., Mazzoni, I. E., & Rabin, O. (2011) · Sports Medicine · doi:10.2165/11591430-000000000-00000 · Cited by 110 · see citing works
Orío, L., Edwards, S., George, O., Parsons, L. H., & Koob, G. F. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0563-09.2009 · Cited by 109 · see citing works
Foll, B. L., Forget, B., Aubin, H., & Goldberg, S. R. (2008) · Addiction Biology · doi:10.1111/j.1369-1600.2008.00113.x · Cited by 106 · see citing works
Dual Roles of Dopamine in Food and Drug Seeking: The Drive-Reward Paradox
Wise, R. A. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.09.001 · Cited by 95 · see citing works
Cocaine-Induced Endocannabinoid Mobilization in the Ventral Tegmental Area
Wang, H., Treadway, T., Covey, D. P., Cheer, J. F., & Lupica, C. R. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.08.041 · Cited by 95 · see citing works
Self-citationChanges in endocannabinoid levels in a rat model of behavioural sensitization to morphine
Viganò, D., Valenti, M., Cascio, M. G., Marzo, V. D., Parolaro, D., & Rubino, T. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03645.x · Cited by 97 · see citing works
CB1 receptor agonist and heroin, but not cocaine, reinstate cannabinoid‐seeking behaviour in the rat
Spano, M. S., Fattore, L., Cossu, G., Deiana, S., Fadda, P., & Fratta, W. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705932 · Cited by 95 · see citing works
Fan, N., Yang, H., Zhang, J., & Chen, C. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06489.x · Cited by 93 · see citing works
The role of CB1 receptors in psychostimulant addiction
Wiskerke, J., Pattij, T., Schoffelmeer, A. N. M., & Vries, T. J. D. (2008) · Addiction Biology · doi:10.1111/j.1369-1600.2008.00109.x · Cited by 91 · see citing works
Cannabinoid receptor stimulation increases motivation for nicotine and nicotine seeking
Gamaleddin, I., Wertheim, C. E., Zhu, A. Z. X., Coen, K. M., Vemuri, K. V., Makryannis, A., Goldberg, S. R., & Foll, B. L. (2011) · Addiction Biology · doi:10.1111/j.1369-1600.2011.00314.x · Cited by 92 · see citing works
Tao, R., Li, C., Jaffe, A. E., Shin, J. H., Deep‐Soboslay, A., Yamin, R., Weinberger, D. R., Hyde, T. M., & Kleinman, J. E. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0832-8 · Cited by 88 · see citing works
Zhai, H., Li, Y., Wang, X., & Lü, L. (2007) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-007-9240-3 · Cited by 91 · see citing works
Fattore, L., Viganò, D., Fadda, P., Rubino, T., Fratta, W., & Parolaro, D. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05470.x · Cited by 89 · see citing works
Luchicchi, A., Lecca, S., Carta, S., Pillolla, G., Muntoni, A. L., Yaşar, S., Goldberg, S. R., & Pistis, M. (2010) · Addiction Biology · doi:10.1111/j.1369-1600.2010.00222.x · Cited by 86 · see citing works
Kolb, B. E., Gorny, G., Limebeer, C. L., & Parker, L. A. (2006) · Synapse · doi:10.1002/syn.20313 · Cited by 84 · see citing works
Katzman, M., & Sternat, T. (2016) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s111818 · Cited by 83 · see citing works
Caillé, S., & Parsons, L. H. (2003) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2003.02961.x · Cited by 80 · see citing works
Colizzi, M., Weltens, N., McGuire, P. K., Lythgoe, D. J., Williams, S., Oudenhove, L. V., & Bhattacharyya, S. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0374-8 · Cited by 74 · see citing works
Li, X., Hoffman, A. F., Peng, X., Lupica, C. R., Gardner, E. L., & Xi, Z. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1432-0 · Cited by 74 · see citing works
Self-citationRole of the endocannabinoid system in vertebrates: Emphasis on the zebrafish model
Oltrabella, F., Melgoza, A., Nguyen, B., & Guo, S. (2017) · Development Growth & Differentiation · doi:10.1111/dgd.12351 · Cited by 72 · see citing works
Cannabinoid CB1 and CB2 receptor mechanisms underlie cannabis reward and aversion in rats
Spiller, K. J., Bi, G., He, Y., Galaj, E., Gardner, E. L., & Xi, Z. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14625 · Cited by 67 · see citing works
Basic neuroanatomy and neuropharmacology of cannabinoids
Breivogel, C. S., & Sim‐Selley, L. J. (2009) · International Review of Psychiatry · doi:10.1080/09540260902782760 · Cited by 66 · see citing works
Linsenbardt, D. N., & Boehm, S. L. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.08.007 · Cited by 66 · see citing works
Mason, N. L., Theunissen, E. L., Hutten, N. R. P. W., Tse, D. H. Y., Toennes, S. W., Stiers, P. L. J., & Ramaekers, J. G. (2018) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2018.12.003 · Cited by 64 · see citing works
Han, X., He, Y., Bi, G., Zhang, H., Song, R., Liu, Q., Egan, J. M., Gardner, E. L., Li, J., & Xi, Z. (2017) · Scientific Reports · doi:10.1038/s41598-017-12399-z · Cited by 66 · see citing works
Potential of Cannabinoid Receptor Ligands as Treatment for Substance Use Disorders
Galaj, E., & Xi, Z. (2019) · CNS Drugs · doi:10.1007/s40263-019-00664-w · Cited by 65 · see citing works
Role of the endocannabinoid system in MDMA intracerebral self‐administration in rats
Braida, D., & Sala, M. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704825 · Cited by 63 · see citing works
A Brain on Cannabinoids: The Role of Dopamine Release in Reward Seeking and AddictionPreprint
Peters, K. Z., Oleson, E. B., & Cheer, J. F. (2020) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a039305 · Cited by 61 · see citing works
Age-varying time trends in cannabis- and alcohol-related risk perceptions 2002–2019
Waddell, J. T. (2021) · Addictive Behaviors · doi:10.1016/j.addbeh.2021.107091 · Cited by 61 · see citing works
Oh, S., Jang, H. J., Ko, S. K., Ko, Y., & Park, S. B. (2010) · Journal of Combinatorial Chemistry · doi:10.1021/cc100044w · Cited by 60 · see citing works
Vlachou, S., & Panagis, G. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113199990433 · Cited by 60 · see citing works
Sami, M., Rabiner, E., & Bhattacharyya, S. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.03.011 · Cited by 68 · see citing works
Justinová, Z., Ferré, S., Redhi, G. H., Mascia, P., Stroik, J., Quarta, D., Yaşar, S., Müller, C. E., Franco, R., & Goldberg, S. R. (2010) · Addiction Biology · doi:10.1111/j.1369-1600.2010.00258.x · Cited by 59 · see citing works
Central nervous system effects of haloperidol on THC in healthy male volunteers
Liem-Moolenaar, M., Beek, E. T. T., de Kam, M. L., Franson, K. L., Kahn, R. S., Hijman, R., Touw, D. J., & van Gerven, J. (2010) · Journal of Psychopharmacology · doi:10.1177/0269881109358200 · Cited by 59 · see citing works
Bossong, M., Jansma, J., Bhattacharyya, S., & Ramsey, N. (2014) · Progress in Neuro-psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.11.017 · Cited by 58 · see citing works
Canseco-Alba, A., Schanz, N., Sanabria, B., Zhao, J., Lin, Z., Liu, Q., & Onaivi, E. S. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.11.043 · Cited by 59 · see citing works
Interactions between the cannabinoid and dopaminergic systems: Evidence from animal studies
Khoury, M. E., Gorgievski, V., Moutsimilli, L., Bruno Giros, A., & Tzavara, E. T. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.12.005 · Cited by 58 · see citing works
Mason, N. L., Theunissen, E. L., Hutten, N. R. P. W., Tse, D. H. Y., Toennes, S. W., Jansen, J. F. A., Stiers, P. L. J., & Ramaekers, J. G. (2019) · Addiction Biology · doi:10.1111/adb.12870 · Cited by 58 · see citing works
Synaptic Targets of 9-Tetrahydrocannabinol in the Central Nervous SystemPreprint
Hoffman, A. F., & Lupica, C. R. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a012237 · Cited by 58 · see citing works
Self-citationEpigenetic and Proteomic Expression Changes Promoted by Eating Addictive-Like Behavior
Mancino, S., Burokas, A., Cuesta, J., Gutiérrez‐Martos, M., Martín‐García, E., Pucci, M., Falconi, A., D’Addario, C., Maccarrone, M., & Maldonado, R. J. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.129 · Cited by 57 · see citing works
Wegener, N., Kuhnert, S., Thüns, A., Roese, R., & Koch, M. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1148-1 · Cited by 57 · see citing works
Markou, A., Paterson, N. E., & Semenova, S. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1316.061 · Cited by 56 · see citing works
Cannabinoids as hippocampal network administrators
Lupica, C. R., Hu, Y., Devinsky, O., & Hoffman, A. F. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.04.003 · Cited by 55 · see citing works
Self-citationGinovart, N., Tournier, B. B., Sallanon, M. M., Steimer, T. J., Ibanez, V., & Millet, P. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.91 · Cited by 56 · see citing works
Butovsky, E., Juknat, A., Elbaz, J., Shabat-Simon, M., Eilam, R., Zangen, A., Altstein, M., & Vogel, Z. (2006) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2006.01.008 · Cited by 52 · see citing works
Thiemann, G., VANDERSTELT, M., Petrosino, S., Molleman, A., Marzo, V. D., & Hasenöhrl, R. U. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.09.022 · Cited by 51 · see citing works
Luca, M. A. D., Valentini, V., Bimpisidis, Z., Cacciapaglia, F., Caboni, P., & Chiara, G. D. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00140 · Cited by 51 · see citing works
Animal models of cannabinoid reward
Panlilio, L. V., Justinová, Z., & Goldberg, S. R. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00775.x · Cited by 49 · see citing works
- Authors
- Lupica, C. R., Riegel, A. C., & Hoffman, A. F.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Lupica, Carl R
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 2004-09
- Volume
- 143
- Issue
- 2
- Pages
- 227-234
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- PMC
- PMC1575338
- OpenAlex
- W1993599253
- Cited by
- 289
- References
- 85
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 10 · 2023: 10 · 2022: 17 · 2021: 15 · 2020: 16 · 2019: 12 · 2018: 13 · 2017: 14 · 2016: 12 · 2015: 17 · 2014: 13 · 2013: 6 · 2012: 13
- FWCI
- 1.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Pharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- cannabis, delta-9-tetrahydrocannabinol, CB1 receptor, brain reward circuits, ventral tegmental area, nucleus accumbens, drug addiction, self-administration, synaptic regulation, endocannabinoids, reinforcement, psychoactive effects
- MeSH terms
- Animals, Brain, Cannabinoids, Humans, National Institutes of Health (U.S.), Reward, United States
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