Cited by 751Cannabis and Cannabinoid ResearchNeuroscience and Neuropharmacology ResearchReceptor Mechanisms and Signaling

Distribution of cannabinoid receptors in the central and peripheral nervous system

Mackie, K.·2005·Handbook of Experimental Pharmacology

Abstract

CB1 cannabinoid receptors appear to mediate most, if not all of the psychoactive effects of delta-9-tetrahydrocannabinol and related compounds. This G protein-coupled receptor has a characteristic distribution in the nervous system: It is particularly enriched in cortex, hippocampus, amygdala, basal ganglia outflow tracts, and cerebellum--a distribution that corresponds to the most prominent behavioral effects of cannabis. In addition, this distribution helps to predict neurological and psychological maladies for which manipulation of the endocannabinoid system might be beneficial. CB1 receptors are primarily expressed on neurons, where most of the receptors are found on axons and synaptic terminals, emphasizing the important role of this receptor in modulating neurotransmission at specific synapses. While our knowledge of CB1 localization in the nervous system has advanced tremendously over the past 15 years, there is still more to learn. Particularly pressing is the need for (1) detailed anatomical studies of brain regions important in the therapeutic actions of drugs that modify the endocannabinoid system and (2) the determination of the localization of the enzymes that synthesize, degrade, and transport the endocannabinoids.

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Crossref · 10.1007/3-540-26573-2_10

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  • CB1R is the most densely expressed ECB receptor in the brain and is present at high levels in corticolimbic regions mediating anxiety, including the mPFC, hippocampus, and BLA.

    “CB1R is the most densely expressed in the brain and is present at high levels in corticolimbic regions mediating anxiety, including the medial prefrontal cortex (mPFC) and hippocampus, as well as the BLA [11,14]”

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Authors
Mackie, K.
Affiliations
University of Washington (US)
Corresponding author
Mackie, K.
Venue
Handbook of Experimental Pharmacology
Published
2005-12-23
Issue
168
Pages
299-325
OpenAlex
W2149183149
Cited by
744
References
103
Citations by year
2026: 28 · 2025: 38 · 2024: 47 · 2023: 56 · 2022: 59 · 2021: 69 · 2020: 48 · 2019: 52 · 2018: 40 · 2017: 37 · 2016: 33 · 2015: 31 · 2014: 26 · 2013: 27 · 2012: 32
FWCI
26.30
Type
book chapter
Language
en
Open access
closed
Locations
  • Springer eBooks (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Drug Abuse (DA00286, DA11322, R01DA011322, K02DA000286)
Topics
  • Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords
CB1 receptor, cannabinoid receptors, endocannabinoid system, delta-9-tetrahydrocannabinol, G protein-coupled receptors, receptor distribution, central nervous system, peripheral nervous system, hippocampus, amygdala, cerebellum, basal ganglia, neurotransmission
MeSH terms
Animals, Autoradiography, Central Nervous System, Humans, Immunohistochemistry, In Situ Hybridization, Peripheral Nervous System, Receptor, Cannabinoid, CB1, Receptor, Cannabinoid, CB2

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