Cited by 378Cannabis and Cannabinoid ResearchNeurotransmitter Receptor Influence on BehaviorNeuropeptides and Animal Physiology

Functional interaction between opioid and cannabinoid receptors in drug self-administration.

Open access
Navarro, M., Carrera, M. R. A., Fratta, W., Valverde, O., Cossu, G., Fattore, L., Chowen, J. A., Gómez, R. +5 more·2001·The Journal of Neuroscience

Abstract

The present study was designed to explore the relationship between the cannabinoid and opioid receptors in animal models of opioid-induced reinforcement. The acute administration of SR141716A, a selective central cannabinoid CB1 receptor antagonist, blocked heroin self-administration in rats, as well as morphine-induced place preference and morphine self-administration in mice. Morphine-dependent animals injected with SR141716A exhibited a partial opiate-like withdrawal syndrome that had limited consequences on operant responses for food and induced place aversion. These effects were associated with morphine-induced changes in the expression of CB1 receptor mRNA in specific nuclei of the reward circuit, including dorsal caudate putamen, nucleus accumbens, and septum. Additionally, the opioid antagonist naloxone precipitated a mild cannabinoid-like withdrawal syndrome in cannabinoid-dependent rats and blocked cannabinoid self-administration in mice. Neither SR141716A nor naloxone produced any intrinsic effect on these behavioral models. The present results show the existence of a cross-interaction between opioid and cannabinoid systems in behavioral responses related to addiction and open new strategies for the treatment of opiate dependence.

Integrity signals

Registry

Crossref · 10.1523/jneurosci.21-14-05344.2001

Cites

63 of 63 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Antagonists of opioid receptors reduced discriminative stimulus and reinforcing effects produced by activation of CB1 receptors in preclinical studies.

    “Evidence from pre-clinical studies demonstrates that antagonists of opioid receptors were able to reduce discriminative stimulus and reinforcing effects produced by the activation of CB1 receptors 71, 72.”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Navarro, M., Carrera, M. R. A., Fratta, W., Valverde, O., Cossu, G., Fattore, L., Chowen, J. A., Gómez, R., del Arco, I., Villanúa, M. A., Maldonado, R., Koob, G. F., & de Fonseca, F. R.
Affiliations
  • Scripps Research Institute (US)
  • University of Cagliari (IT)
  • Universitat Pompeu Fabra (ES)
  • Consejo Superior de Investigaciones Científicas (ES)
  • Universidad Complutense de Madrid (ES)
Venue
The Journal of Neuroscience
Published
2001-07-15
Volume
21
Issue
14
Pages
5344-5350
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
OpenAlex
W1699530412
Cited by
378
References
63
Citations by year
2026: 6 · 2025: 10 · 2024: 7 · 2023: 5 · 2022: 13 · 2021: 7 · 2020: 10 · 2019: 5 · 2018: 14 · 2017: 14 · 2016: 11 · 2015: 12 · 2014: 18 · 2013: 18 · 2012: 14
FWCI
14.10
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion)
Funders
  • Sanofi
  • Comunidad de Madrid
  • Universidad Complutense de Madrid
  • Consiglio Nazionale delle Ricerche
  • National Institutes of Health
  • Plan Nacional sobre Drogas
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK 26741, P01DK026741)
Topics
  • Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
opioid-cannabinoid interaction, CB1 receptor, SR141716A, naloxone, heroin self-administration, morphine self-administration, place preference, opioid withdrawal, cannabinoid withdrawal, reward systems, nucleus accumbens, caudate-putamen, septum, addiction, opioid use disorder
MeSH terms
Rimonabant, Animals, Avoidance Learning, Cannabinoids, Caudate Nucleus, Conditioning, Operant, Heroin, Disease Models, Animal, Heroin Dependence, Male, Morphine, Morphine Dependence, Naloxone, Narcotic Antagonists, Nucleus Accumbens, Piperidines, Putamen, Pyrazoles, Receptors, Drug, Receptors, Opioid, RNA, Messenger, Self Administration, Rats, Wistar, Septum of Brain, Receptors, Cannabinoid, Mice, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review