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Cited by 160Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNeural dynamics and brain function

Neurochemical phenotype of corticocortical connections in the macaque monkey: Quantitative analysis of a subset of neurofilament protein‐immunoreactive projection neurons in frontal, parietal, temporal, and cingulate cortices

Hof, Patrick R., Nimchinsky, Esther A., Morrison, John H.·1995·Journal of Comparative Neurology
DOI 10.1002/cne.903620107
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Abstract

The neurochemical characteristics of the neuronal subsets that furnish different types of corticocortical connections have been only partially determined. In recent years, several cytoskeletal proteins have emerged as reliable markers to distinguish subsets of pyramidal neurons in the cerebral cortex of primates. In particular, previous studies using an antibody to nonphosphorylated neurofilament protein (SMI‐32) have revealed a consistent degree of regional and laminar specificity in the distribution of a subpopulation of pyramidal cells in the primate cerebral cortex. The density of neurofilament protein‐immunoreactive neurons was shown to vary across corticocortical pathways in macaque monkeys. In the present study, we have used the antibody SMI‐32 to examine further and to quantify the distribution of a subset of corticocortically projecting neurons in a series of long ipsilateral corticocortical pathways in comparison to short corticocortical, commissural, and limbic connections. The results demonstrate that the long association pathways interconnecting the frontal, parietal, and temporal neocortex have a high representation of neurofilament protein‐enriched pyramidal neurons (45–90%), whereas short corticocortical, callosal, and limbic pathways are characterized by much lower numbers of such neurons (4–35%). These data suggest that different types of corticocortical connections have differential representation of highly specific neuronal subsets that share common neurochemical characteristics, thereby determining regional and laminar cortical patterns of morphological and molecular heterogeneity. These differences in neuronal neurochernical phenotype among corticocortical circuits may have considerable influence on cortical processing and may be directly related to the type of integrative function subserved by each cortical pathway. Finally, it is worth noting that neurofilainent protein‐immunoreactive neurons are dramatically affected in the course of Alzheimer's disease. The present results support the hypothesis that neurofilament protein may be crucially linked to the development of selective neuronal vulnerability and subsequent disruption of corticocortical pathways that lead to the severe impairment of cognitive function commonly observed in age‐related dementing disorders. © Wiley‐Liss, Inc.

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  • Neurofilament proteins NEFL, NEFM and NEFH are frequently enriched in long-range projection neurons.

    “which are frequently enriched in long-range projection neurons14.”

    From An anatomically comprehensive atlas of the adult human brain transcriptome (2012) · cites this paper as [14]

  • These large layer 3 neurons may be a main neuronal type mediating corticocortical connections.

    “And it suggests that these large layer 3 neurons may be a main neuronal type mediating such corticocortical connections, consistent with tracing studies in monkeys (Hof et al., 1995).”

    From Large-Scale Cellular-Resolution Gene Profiling in Human Neocortex Reveals Species-Specific Molecular Signatures (2012) · cites this paper as Hof et al., 1995

  • Certain populations of neurons that provide long corticocortical association projections linking the prefrontal cortex, temporal cortex, and parietal cortex in primates show metabolically costly characteristics, such as highly myelinated, large axons and fast firing properties.

    “In fact, certain populations of neurons that provide long corticocortical association projections linking the prefrontal cortex, temporal cortex, and parietal cortex in primates show metabolically costly characteristics, such as highly myelinated, large axons and fast firing properties (27–30).”

    From Evolution of increased glia–neuron ratios in the human frontal cortex (2006) · cites this paper as [27]

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Authors
Hof, P. R., Nimchinsky, E. A., & Morrison, J. H.
Affiliations
Icahn School of Medicine at Mount Sinai (US)
Corresponding author
Hof, Patrick R.
ORCID
Nimchinsky, Esther A.
Venue
Journal of Comparative Neurology
Publisher
Wiley
Published
1995-11-06
Volume
362
Issue
1
Pages
109-133
ISSN
  • 0021-9967 (ISSN-L)
  • 1096-9861
DOI
10.1002/cne.903620107
OpenAlex
W1986336068
Cited by
159
References
74
Citations by year
2026: 1 · 2024: 6 · 2023: 2 · 2022: 5 · 2021: 5 · 2020: 5 · 2019: 4 · 2018: 1 · 2017: 2 · 2016: 7 · 2015: 6 · 2014: 3 · 2013: 5 · 2012: 5
FWCI
2.53
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 3261 d)
Locations
  • The Journal of Comparative Neurology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Aging (AG-06647)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
corticocortical connections, neurofilament proteins, SMI-32, pyramidal neurons, macaque, frontal cortex, parietal cortex, temporal cortex, cingulate cortex, Alzheimer's disease, neuronal vulnerability
MeSH terms
Animals, Antibody Specificity, Cerebral Cortex, Cytoskeleton, Frontal Lobe, Gyrus Cinguli, Macaca, Macaca fascicularis, Macaca mulatta, Microinjections, Neural Pathways, Parietal Lobe, Phenotype, Temporal Lobe, Neurofilament Proteins, Pyramidal Cells

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