The netrin receptor DCC is required in the pubertal organization of mesocortical dopamine circuitry
Open accessAbstract
Netrins are guidance cues involved in neural connectivity. We have shown that the netrin-1 receptor DCC (deleted in colorectal cancer) is involved in the functional organization of the mesocorticolimbic dopamine (DA) system. Adult mice with a heterozygous loss-of-function mutation in dcc exhibit changes in indexes of DA function, including DA-related behaviors. These phenotypes are only observed after puberty, a critical period in the maturation of the mesocortical DA projection. Here, we examined whether dcc heterozygous mice exhibit structural changes in medial prefrontal cortex (mPFC) DA synaptic connectivity, before and after puberty. Stereological counts of tyrosine-hydroxylase (TH)-positive varicosities were increased in the cingulate 1 and prelimbic regions of the pregenual mPFC. dcc heterozygous mice also exhibited alterations in the size, complexity, and dendritic spine density of mPFC layer V pyramidal neuron basilar dendritic arbors. Remarkably, these presynaptic and postsynaptic partner phenotypes were not observed in juvenile mice, suggesting that DCC selectively influences the extensive branching and synaptic differentiation that occurs in the maturing mPFC DA circuit at puberty. Immunolabeling experiments in wild-type mice demonstrated that DCC is segregated to TH-positive fibers innervating the nucleus accumbens, with only scarce DCC labeling in mPFC TH-positive fibers. Netrin had an inverted target expression pattern. Thus, DCC-mediated netrin-1 signaling may influence the formation/maintenance of mesocorticolimbic DA topography. In support of this, we report that dcc heterozygous mice exhibit a twofold increase in the density of mPFC DCC/TH-positive varicosities. Our results implicate DCC-mediated netrin-1 signaling in the establishment of mPFC DA circuitry during puberty.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The dopaminergic innervation of the mPFC in rodent surges during adolescence, hallmarked by massive changes in the organization, shape and density of the dopaminergic fibers.
“The dopaminergic innervation of the mPFC in rodent surges during adolescence hallmarked by massive changes in the organization, shape and density of the dopaminergic fibers [162–164].”
From Development of prefrontal cortex (2022) · cites this paper as [162]
DCC is involved in the organization of dopaminergic circuits within the cortex.
“DCC is involved in the organization of dopaminergic circuits within the cortex [108]”
From Self-domestication in Homo sapiens: Insights from comparative genomics (2017) · cites this paper as [108]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Hong, K., Hinck, L., Nishiyama, M., Poo, M.-M., Tessier‐Lavigne, M., & Stein, E. (1999) · Cell · doi:10.1016/s0092-8674(00)80804-1 · Cited by 684 · see citing works
RetractedThe Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859 · see citing works
The adolescent brain and age-related behavioral manifestations
Spear, L. P. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(00)00014-2 · Cited by 5,433 · see citing works
West, M. J., Slomianka, L., & Gundersen, H. J. G. (1991) · The Anatomical Record · doi:10.1002/ar.1092310411 · Cited by 2,994 · see citing works
The principal features and mechanisms of dopamine modulation in the prefrontal cortex
Seamans, J. K., & Yang, C. R. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.05.006 · Cited by 1,592 · see citing works
Anatomical analysis of afferent projections to the medial prefrontal cortex in the rat
Hoover, W. B., & Vertes, R. P. (2007) · Brain Structure and Function · doi:10.1007/s00429-007-0150-4 · Cited by 1,365 · see citing works
Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord
Kennedy, T. E., Serafini, T. A., de la Torre, J. R., & Tessier‐Lavigne, M. (1994) · Cell · doi:10.1016/0092-8674(94)90421-9 · Cited by 1,341 · see citing works
Sternberger, L. A., & Sternberger, N. H. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.19.6126 · Cited by 1,158 · see citing works
Phenotype of mice lacking functional Deleted in colorectal cancer (Dec) gene
Fazeli, A., Dickinson, S., Hermiston, M. L., Tighe, R., Steen, R. G., Small, C. G., Stoeckli, E. T., Keino‐Masu, K., Masu, M., Rayburn, H., et al. (1997) · Nature · doi:10.1038/386796a0 · Cited by 778 · see citing works
Robinson, T. E., & Kolb, B. E. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00576.x · Cited by 726 · see citing works
Self-citationA method for vibratome sectioning of Golgi–Cox stained whole rat brain
Gibb, R. L., & Kolb, B. E. (1998) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(97)00163-5 · Cited by 618 · see citing works
Self-citationcAMP-Dependent Growth Cone Guidance by Netrin-1
Ming, G., Song, H., Berninger, B., Holt, C. E., Tessier‐Lavigne, M., & Poo, M.-M. (1997) · Neuron · doi:10.1016/s0896-6273(00)80414-6 · Cited by 560 · see citing works
Development of the dopaminergic innervation in the prefrontal cortex of the rat
Kalsbeek, A., Voorn, P., Buijs, R. M., Pool, C. W., & Uylings, H. B. M. (1988) · Journal of Comparative Neurology · doi:10.1002/cne.902690105 · Cited by 545 · see citing works
Voorn, P., Kalsbeek, A., Jorritsma‐Byham, B., & Groenewegen, H. J. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90041-3 · Cited by 503 · see citing works
Lodge, D. J., Behrens, M. M., & Grace, A. A. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5419-08.2009 · Cited by 488 · see citing works
Cyclic AMP/GMP-dependent modulation of Ca2+ channels sets the polarity of nerve growth-cone turning
Nishiyama, M., Hoshino, A., Tsai, L., Henley, J. R., Goshima, Y., Tessier‐Lavigne, M., Poo, M.-M., & Hong, K. (2003) · Nature · doi:10.1038/nature01751 · Cited by 387 · see citing works
Davey, C. G., Yücel, M., & Allen, N. B. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.04.016 · Cited by 377 · see citing works
Feil, J., Sheppard, D., Fitzgerald, P. B., Yücel, M., Lubman, D. I., & Bradshaw, J. L. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.03.001 · Cited by 342 · see citing works
Regional and laminar density of the dopamine innervation in adult rat cerebral cortex
Descarries, L., Lemay, B., Doucet, G., & Berger, B. (1987) · Neuroscience · doi:10.1016/0306-4522(87)90038-8 · Cited by 341 · see citing works
Rosenberg, D. R., & Lewis, D. A. (1995) · Journal of Comparative Neurology · doi:10.1002/cne.903580306 · Cited by 319 · see citing works
Dopamine, the prefrontal cortex and schizophrenia
Knable, M. B., & Weinberger, D. R. (1997) · Journal of Psychopharmacology · doi:10.1177/026988119701100205 · Cited by 304 · see citing works
Dent, E. W., Barnes, A. M., Tang, F., & Kalil, K. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4963-03.2004 · Cited by 290 · see citing works
Glia Promote Local Synaptogenesis Through UNC-6 (Netrin) Signaling in C. elegans
Colón-Ramos, D., Margeta, M. A., & Shen, K. (2007) · Science · doi:10.1126/science.1143762 · Cited by 284 · see citing works
Berger, B., Tassin, J., Blanc, G., Doyennette‐Moyne, M., & Thierry, A. M. (1974) · Brain Research · doi:10.1016/0006-8993(74)90948-2 · Cited by 278 · see citing works
van Eden, C. G., Hoorneman, E. M. D., Buijs, R. M., Matthijssen, M. A. H., Geffard, M., & Uylings, H. B. M. (1987) · Neuroscience · doi:10.1016/0306-4522(87)92964-2 · Cited by 272 · see citing works
Electrical Activity Modulates Growth Cone Guidance by Diffusible Factors
Ming, G., Henley, J. R., Tessier‐Lavigne, M., Song, H., & Poo, M.-M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00217-3 · Cited by 270 · see citing works
Benes, F. M. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.10.1014 · Cited by 268 · see citing works
Tan, H.-Y., Callicott, J. H., & Weinberger, D. R. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhm069 · Cited by 266 · see citing works
Pirot, S., Godbout, R., Mantz, J., Tassin, J., Glowinski, J., & Thierry, A. M. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90362-6 · Cited by 237 · see citing works
Development of the noradrenergic innervation of neocortex
Levitt, P., & Moore, R. Y. (1979) · Brain Research · doi:10.1016/0006-8993(79)90287-7 · Cited by 214 · see citing works
Smiley, J. F., & Goldman-Rakic, P. S. (1993) · Cerebral Cortex · doi:10.1093/cercor/3.3.223 · Cited by 211 · see citing works
Excitation of rat prefrontal cortical neurons by dopamine: An in vitro electrophysiological study
Penit-Soria, J., Audinat, É., & Crépel, F. (1987) · Brain Research · doi:10.1016/0006-8993(87)90509-9 · Cited by 205 · see citing works
Axonal sprouting following lesions of the rat substantia nigra
Finkelstein, D. I., Stanić, D., Parish, C. L., Tomas, D., Dickson, K. A., & Horne, M. K. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00009-9 · Cited by 201 · see citing works
Hnasko, T. S., Perez, F. A., Scouras, A. D., Stoll, E. A., Gale, S. D., Luquet, S. H., Phillips, P. E. M., Kremer, E. J., & Palmiter, R. D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603081103 · Cited by 198 · see citing works
The medial prefrontal cortex as a part of the brain reward system
Tzschentke, T. (2000) · Amino Acids · doi:10.1007/s007260070051 · Cited by 194 · see citing works
Werd, H. J. J. M. V. D., Rajkowska, G., Evers, P., & Uylings, H. B. M. (2010) · Brain Structure and Function · doi:10.1007/s00429-010-0247-z · Cited by 191 · see citing works
Shewan, D. A., Dwivedy, A., Anderson, R. B., et al. (2002) · Nature Neuroscience · doi:10.1038/nn919 · Cited by 190 · see citing works
Mutations in DCC Cause Congenital Mirror Movements
Srour, M., Rivière, J., Pham, J. M. T., Dubé, M., Girard, S., Morin, S., Dion, P. A., Asselin, G., Rochefort, D. L., Hince, P., et al. (2010) · Science · doi:10.1126/science.1186463 · Cited by 183 · see citing works
Fallon, J. H., & Loughlin, S. E. (1932) · Cerebral cortex · doi:10.1007/978-1-4615-6616-8_2 · Cited by 165 · see citing works
Hof, P. R., Nimchinsky, E. A., & Morrison, J. H. (1995) · Journal of Comparative Neurology · doi:10.1002/cne.903620107 · Cited by 159 · see citing works
Sesack, S. R. (1998) · Cerebral Cortex · doi:10.1093/cercor/8.7.614 · Cited by 149 · see citing works
Bouchard, J., Moore, S. W., Tritsch, N. X., Roux, P. P., Shekarabi, M., Barker, P. A., & Kennedy, T. E. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4934-03.2004 · Cited by 137 · see citing works
Vezina, P., Blanc, G., Glowinski, J., & Tassin, J. (1991) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1991.tb00036.x · Cited by 135 · see citing works
Brake, W. G., Sullivan, R. M., & Gratton, A. P. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-14-05538.2000 · Cited by 131 · see citing works
Tang, F., & Kalil, K. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0871-05.2005 · Cited by 127 · see citing works
Doherty, M. D., & Gratton, A. P. (1996) · Brain Research · doi:10.1016/0006-8993(95)01557-4 · Cited by 120 · see citing works
Miner, L. H., Schroeter, S., Blakely, R., & Sesack, S. R. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10898 · Cited by 112 · see citing works
Manitt, C., Nikolakopoulou, A. M., Almario, D. R., Nguyen, S. A., & Cohen‐Cory, S. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0947-09.2009 · Cited by 111 · see citing works
Self-citationMeyer, U., & Feldon, J. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1504-9 · Cited by 109 · see citing works
Slopsema, J. S., van der Gugten, J., & de Bruin, J. P. C. (1982) · Brain Research · doi:10.1016/0006-8993(82)90970-2 · Cited by 104 · see citing works
Soluble adenylyl cyclase is required for netrin-1 signaling in nerve growth cones
Wu, K., Zippin, J. H., Huron, D. R., Kamenetsky, M., Hengst, U., Buck, J., Levin, L. R., & Jaffrey, S. R. (2006) · Nature Neuroscience · doi:10.1038/nn1767 · Cited by 99 · see citing works
Ventura, R., Alcaro, A., Cabib, S., Conversi, D., Mandolesi, L., & Puglisi‐Allegra, S. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300300 · Cited by 98 · see citing works
Differential Outgrowth of Axons and their Branches Is Regulated by Localized Calcium Transients
Hutchins, B. I., & Kalil, K. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4548-07.2008 · Cited by 90 · see citing works
Williams, M. E., Wu, S. C.-Y., McKenna, W. L., & Hinck, L. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-36-11279.2003 · Cited by 82 · see citing works
Xu, B., Goldman, J. S., Rymar, V. V., Forget, C., Lo, P., Bull, S.-J., Vereker, E., Barker, P. A., Trudeau, L., Sadikot, A. F., et al. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.05.025 · Cited by 81 · see citing works
Wang, H.-D., & Deutch, A. Y. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301521 · Cited by 80 · see citing works
Flores, C., Manitt, C., Rodaros, D., Thompson, K. M., Rajabi, H., Luk, K. C., Tritsch, N. X., Sadikot, A. F., Stewart, J., & Kennedy, T. E. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001607 · Cited by 79 · see citing works
Self-citationOsborne, P. B., Halliday, G. M., Cooper, H. M., & Keast, J. R. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.11.043 · Cited by 77 · see citing works
Self-citationPeri-Pubertal Emergence of UNC-5 Homologue Expression by Dopamine Neurons in Rodents
Manitt, C., Labelle‐Dumais, C., Eng, C., Grant, A., Mimee, A., Stroh, T., & Flores, C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011463 · Cited by 72 · see citing works
Self-citationParish, C. L., Stanić, D., Drago, J., Borrelli, E., Finkelstein, D. I., & Horne, M. K. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02132.x · Cited by 67 · see citing works
Kalsbeek, A., Matthijssen, M. A. H., & Uylings, H. B. M. (1989) · Experimental Brain Research · doi:10.1007/bf00228899 · Cited by 66 · see citing works
Grant, A., Hoops, D., Labelle‐Dumais, C., Prévost, M., Rajabi, H., Kolb, B. E., Stewart, J., Arvanitogiannis, A., & Flores, C. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05888.x · Cited by 65 · see citing works
Self-citationRole of netrin-1 in the organization and function of the mesocorticolimbic dopamine system
Flores, C. (2011) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.100171 · Cited by 64 · see citing works
Self-citationBouchard, J., Horn, K. E., Stroh, T., & Kennedy, T. E. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05609.x · Cited by 61 · see citing works
Self-citationPrefrontal cortical up states are synchronized with ventral tegmental area activity
Peters, Y. M., Barnhardt, N. E., & O’Donnell, P. (2004) · Synapse · doi:10.1002/syn.20015 · Cited by 55 · see citing works
Cowan, R. L., Sesack, S. R., Bockstaele, E. J. V., Branchereau, P., Chan, J., & Pickel, V. M. (1994) · Synapse · doi:10.1002/syn.890170206 · Cited by 54 · see citing works
Hm, C., Armes, P., Britto, J., et al. (1995) · PubMed · Cited by 53 · see citing works
Moore, S. W., & Kennedy, T. E. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5419-05.2006 · Cited by 52 · see citing works
Interhemispheric Regulation of the Medial Prefrontal Cortical Glutamate Stress Response in Rats
Lupinsky, D., Moquin, L., & Gratton, A. P. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1187-10.2010 · Cited by 49 · see citing works
Lim, Y.-S., Mallapur, S., Kao, G., Ren, X., & Wadsworth, W. G. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-16-07048.1999 · Cited by 46 · see citing works
Minabe, Y., Matsuno, K., & Ashby, C. R. (1999) · Synapse · doi:10.1002/(sici)1098-2396(199908)33:2 · Cited by 40 · see citing works
Hong, K., Hinck, L., Nishiyama, M., et al. (2022) · Cell · doi:10.1016/j.cell.2022.12.019 · Cited by 39 · see citing works
Regulation of netrin-1 receptors by amphetamine in the adult brain
Yetnikoff, L., Labelle‐Dumais, C., & Flores, C. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.09.069 · Cited by 38 · see citing works
Self-citationKalsbeek, A., de Bruin, J. P. C., Feenstra, M. G. P., Matthijssen, M. A. H., & Uylings, H. B. M. (1988) · Brain Research · doi:10.1016/0006-8993(88)90201-6 · Cited by 37 · see citing works
Muramatsu, R., Nakahara, S., Ichikawa, J., Watanabe, K., Matsuki, N., & Koyama, R. (2009) · Brain · doi:10.1093/brain/awp266 · Cited by 37 · see citing works
Flow cytometric analysis and isolation of permeabilized dopamine nerve terminals from rat striatum
Wolf, M., & Kapatos, G. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-01-00106.1989 · Cited by 35 · see citing works
Seaman, C., Anderson, R. B., Emery, B., et al. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00350-1 · Cited by 32 · see citing works
Soluble Adenylyl Cyclase Is Not Required for Axon Guidance to Netrin-1
Moore, S. W., Sun, K. L. W., Xie, F., Barker, P. A., Conti, M., & Kennedy, T. E. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0547-08.2008 · Cited by 32 · see citing works
Wang, H. D., Stanwood, G. D., Grandy, D. K., & Deutch, A. Y. (2009) · Brain Research · doi:10.1016/j.brainres.2009.09.008 · Cited by 31 · see citing works
Yetnikoff, L., Almey, A., Arvanitogiannis, A., & Flores, C. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2312-6 · Cited by 30 · see citing works
Self-citationPost‐pubertal emergence of a dopamine phenotype in netrin‐1 receptor‐deficient mice
Grant, A., Speed, Z., Labelle‐Dumais, C., & Flores, C. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06919.x · Cited by 29 · see citing works
Self-citationGraded expression of netrin-1 by specific neuronal subtypes in the adult mammalian striatum
Shatzmiller, R., Goldman, J. S., Simard‐Émond, L., Rymar, V. V., Manitt, C., Sadikot, A. F., & Kennedy, T. E. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.09.031 · Cited by 26 · see citing works
Self-citationHorne, M. K., Lee, J., Chen, F., Lanning, K. M., Tomas, D., & Lawrence, A. J. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05534.x · Cited by 25 · see citing works
Shi, M., Guo, C., Dai, J., & Ding, Y. (2008) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2008.07.023 · Cited by 23 · see citing works
Berger, B., Verney, C., Gay, M., & Vigny, A. (1983) · Progress in brain research · doi:10.1016/s0079-6123(08)60028-x · Cited by 21 · see citing works
Reneman, L., de Bruin, K. M., Lavalaye, J., Gunning, W. B., & Booij, J. (2001) · Synapse · doi:10.1002/1098-2396(20010301)39:3 · Cited by 16 · see citing works
SCHMOLESKY, M. T., Wang, Y., Creel, D. J., & Leventhal, A. G. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20001113)427:2 · Cited by 13 · see citing works
Flores, C., Bhardwaj, S. K., Labelle‐Dumais, C., & Srivastava, L. K. (2008) · Synapse · doi:10.1002/syn.20584 · Cited by 10 · see citing works
Self-citationBenes (1996) · doi:10.1002/(sici)1098-2396(199608)23:4
Flagged first, then by citations
Cited by
Sorted by citations
<scp>N</scp> icotine and the adolescent brain
Yuan, M., Cross, S. J., Loughlin, S. E., & Leslie, F. M. (2015) · The Journal of Physiology · doi:10.1113/jp270492 · Cited by 582 · see citing works
Development of prefrontal cortex
Kolk, S. M., & Rakic, P. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01137-9 · Cited by 378 · see citing works
Parallel maturation of goal-directed behavior and dopaminergic systems during adolescence
Naneix, F., Marchand, A. R., Di Scala, G., Pape, J.-R., & Coutureau, E. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.3080-12.2012 · Cited by 209 · see citing works
Self-domestication in Homo sapiens: Insights from comparative genomics
Theofanopoulou, C., Gastaldon, S., O’Rourke, T., Samuels, B. D., Messner, A., Martins, P. T., Delogu, F., Alamri, S., & Boeckx, C. (2017) · PLOS ONE · doi:10.1371/journal.pone.0185306 · Cited by 174 · see citing works
Torres-Berrío, A., Lopez, J. P., Bagot, R. C., Nouel, D., Dal Bo, G., Cuesta, S., Zhu, L., Manitt, C., Eng, C., Cooper, H. M., et al. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.08.017 · Cited by 153 · see citing works
Self-citationMesocorticolimbic Dopamine Pathways Across Adolescence: Diversity in Development
Reynolds, L. M., & Flores, C. (2021) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.735625 · Cited by 137 · see citing works
Self-citationManitt, C., Eng, C., Pokinko, M., Ryan, R. T., Torres-Berrío, A., Lopez, J. P., Yogendran, S. V., Daubaras, M. J. J., Grant, A., Schmidt, E. R. E., et al. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.105 · Cited by 125 · see citing works
Self-citationDevelopment, wiring and function of dopamine neuron subtypes
Garritsen, O., van Battum, E. Y., Grossouw, L. M., & Pasterkamp, R. J. (2023) · Nature reviews. Neuroscience · doi:10.1038/s41583-022-00669-3 · Cited by 128 · see citing works
Early Adolescence is a Critical Period for the Maturation of Inhibitory Behavior
Reynolds, L. M., Yetnikoff, L., Pokinko, M., Wodzinski, M., Epelbaum, J. G., Lambert, L. C., Cossette, M.-P., Arvanitogiannis, A., & Flores, C. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhy247 · Cited by 75 · see citing works
Self-citationAssociation between schizophrenia and genetic variation in DCC: a case–control study
Grant, A., Fathalli, F., Rouleau, G., Joober, R., & Flores, C. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.02.023 · Cited by 53 · see citing works
Self-citationAlkam, T., Mamiya, T., Kimura, N., Yoshida, A., Kihara, D., Tsunoda, Y., Aoyama, Y., Hiramatsu, M., Kim, H.-C., & Nabeshima, T. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4591-z · Cited by 50 · see citing works
Yetnikoff, L., Almey, A., Arvanitogiannis, A., & Flores, C. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2312-6 · Cited by 30 · see citing works
Self-citationAmphetamine disrupts dopamine axon growth in adolescence by a sex-specific mechanism in mice
Reynolds, L. M., Hernandez, G., MacGowan, D., Popescu, C., Nouel, D., Cuesta, S., Burke, S., Savell, K. E., Zhao, J., Restrepo-Lozano, J. M., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39665-1 · Cited by 30 · see citing works
Self-citationAdolescence: a time of transition for the phenotype of dcc heterozygous mice
Yetnikoff, L., Pokinko, M., Arvanitogiannis, A., & Flores, C. (2014) · Psychopharmacology · doi:10.1007/s00213-013-3083-z · Cited by 18 · see citing works
Self-citationAdolescent dopamine development
Reynolds, L. M., & Flores, C. (2021) · Diagnosis, Management and Modeling of Neurodevelopmental Disorders · doi:10.1016/b978-0-12-817988-8.00026-9 · Cited by 10 · see citing works
Self-citationThe scheduling of adolescence with Netrin-1 and UNC5C
Hoops, D., Kyne, R., Salameh, S., MacGowan, D., Avramescu, R. G., Ewing, E., He, A. T., Orsini, T., Durand, A., Popescu, C., et al. (2024) · eLife · doi:10.7554/elife.88261 · Cited by 8 · see citing works
Self-citation
- Authors
- Manitt, C., Mimee, A., Eng, C., Pokinko, M., Stroh, T., Cooper, H. M., Kolb, B., & Flores, C.
- Affiliations
- Douglas Mental Health University Institute (CA)
- Montreal Neurological Institute and Hospital (CA)
- The University of Queensland (AU)
- University of Lethbridge (CA)
- Corresponding author
- Flores, C.
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2011-06-08
- Volume
- 31
- Issue
- 23
- Pages
- 8381-8394
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6623341
- OpenAlex
- W1982830599
- Cited by
- 133
- References
- 89
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 17 · 2023: 14 · 2022: 8 · 2021: 11 · 2020: 7 · 2019: 6 · 2018: 8 · 2017: 14 · 2016: 5 · 2015: 5 · 2014: 10 · 2013: 11 · 2012: 6
- FWCI
- 3.84
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Journal of Neuroscience (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- DCC receptor, netrin-1, mesocortical dopamine system, medial prefrontal cortex, puberty, synaptic connectivity, dendritic spine density, nucleus accumbens, tyrosine hydroxylase, varicosities, axon guidance, dendritic arbor development
- MeSH terms
- DCC Receptor, Analysis of Variance, Animals, Cell Count, Dopamine, Immunohistochemistry, Male, Mice, Transgenic, Nerve Net, Neurons, Receptors, Cell Surface, Synapses, Tyrosine 3-Monooxygenase, Prefrontal Cortex, Tumor Suppressor Proteins, Dendritic Spines, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
