PILOT STUDY OF THE CLINICAL AND COGNITIVE EFFECTS OF HIGH-FREQUENCY MAGNETIC SEIZURE THERAPY IN MAJOR DEPRESSIVE DISORDER: Research Article: MST in Depression
Open accessAbstract
BACKGROUND: Electroconvulsive therapy (ECT) is a very commonly used treatment for patients with severe and treatment-resistant depression. Although effective, this treatment is complicated by a number of side effects including cognitive impairment motivating attempts to develop treatment alternatives. Magnetic seizure therapy (MST) is a brain stimulation technique using a high-powered transcranial magnetic stimulation device to produce therapeutic seizures. Preliminary research suggests that MST has antidepressant activity in the absence of cognitive side effects. The aim of this study was therefore to investigate the therapeutic efficacy and cognitive profile of MST provided at high frequency (100 Hz) and potentially longer stimulation trains and longer treatment courses than have been previously investigated. METHODS: Thirteen patients participated in an open-label clinical trial of up to 18 treatment sessions with 100-Hz MST. Assessments of depression severity and cognitive functioning were performed before and after treatment. RESULTS: Of the 13 patients who completed the study, five met clinical response criteria at study end. There was an overall group reduction in depression severity and no evidence of any impairment of orientation, memory, or other elements of cognition after MST treatment. The major limitation of the study was its lack of sham control. CONCLUSIONS: In conclusion, MST shows antidepressant efficacy without apparent cognitive side effects. However, substantial research is required to understand the optimal conditions for stimulation and to compare MST to established treatments including ECT.
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Magnetic seizure therapy studies have most commonly used high-frequency 100 Hz stimulation, while earlier studies used medium-frequency ranges between 40 and 60 Hz.
“The MST studies have most commonly used high-frequency 100 Hz stimulation; 17,18,24 however, earlier studies of MST were conducted with medium-frequency ranges between 40 and 60 Hz.25,26”
From Magnetic seizure therapy is efficacious and well tolerated for treatment-resistant bipolar depression: An open-label clinical trial (2020) · cites this paper as [24]
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- Authors
- Fitzgerald, P. B., Hoy, K. E., Herring, S. E., Clinton, A. M., Downey, G., & Daskalakis, Z. J.
- Affiliations
- The Alfred Hospital (AU)
- Centre for Addiction and Mental Health (CA)
- Corresponding author
- Fitzgerald, Paul B.
- Venue
- Depression and Anxiety
- Publisher
- Wiley
- Published
- 2012-10-18
- Volume
- 30
- Issue
- 2
- Pages
- 129-136
- ISSN
- 1091-4269 (ISSN-L)
- OpenAlex
- W2161407094
- Cited by
- 88
- References
- 49
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 6 · 2023: 6 · 2022: 2 · 2021: 9 · 2020: 12 · 2019: 5 · 2018: 7 · 2017: 6 · 2016: 6 · 2015: 11 · 2014: 8 · 2013: 2
- FWCI
- 4.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Depression and Anxiety (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Health and Medical Research Council (NHMRC)
- NHMRC Training Fellowship
- Canadian Institutes of Health Research (CIHR)
- beyondblue: the national depression initiative
- National Alliance for Research on Schizophrenia and Depression (NARSAD)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- magnetic seizure therapy, major depressive disorder, treatment-resistant depression, antidepressant efficacy, cognitive side effects, transcranial magnetic stimulation, high-frequency stimulation, electroconvulsive therapy, memory, orientation
- MeSH terms
- Adult, Major Depressive Disorder, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Pilot Projects, Seizures, Severity of Illness Index, Treatment Outcome, Transcranial Magnetic Stimulation
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