COGNITION-CHILDHOOD MALTREATMENT INTERACTIONS IN THE PREDICTION OF ANTIDEPRESSANT OUTCOMES IN MAJOR DEPRESSIVE DISORDER PATIENTS: RESULTS FROM THE iSPOT-D TRIAL: Research Article: Cognition and Childhood Maltreatment in MDD

Miller, Shefali; McTeague, Lisa M.; Gyurak, Anett; Patenaude, Brian; Williams, Leanne M.; Grieve, Stuart M.; Korgaonkar, Mayuresh S.; Etkin, Amit

doi:10.1002/da.22368

Cited by 74Child Abuse and TraumaTreatment of Major DepressionNeural and Behavioral Psychology Studies

COGNITION-CHILDHOOD MALTREATMENT INTERACTIONS IN THE PREDICTION OF ANTIDEPRESSANT OUTCOMES IN MAJOR DEPRESSIVE DISORDER PATIENTS: RESULTS FROM THE iSPOT-D TRIAL: Research Article: Cognition and Childhood Maltreatment in MDD

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Miller, Shefali, McTeague, Lisa M., Gyurak, Anett, Patenaude, Brian, Williams, Leanne M., Grieve, Stuart M., Korgaonkar, Mayuresh S., Etkin, Amit·2015·Depression and Anxiety

DOI 10.1002/da.22368PMC PMC4841677

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Abstract

BACKGROUND: Childhood maltreatment (CM) history has been associated with poor treatment response in major depressive disorder (MDD), but the mechanisms underlying this relationship remain opaque. Dysfunction in the neural circuits for executive cognition is a putative neurobiological consequence of CM that may contribute importantly to adverse clinical outcomes. We used behavioral and neuroimaging measures of executive functioning to assess their contribution to the relationship between CM and antidepressant response in MDD patients. METHODS: Ninety eight medication-free MDD outpatients participating in the International Study to Predict Optimized Treatment in Depression were assessed at baseline on behavioral neurocognitive measures and functional magnetic resonance imaging during tasks probing working memory (continuous performance task, CPT) and inhibition (Go/No-go). Seventy seven patients completed 8 weeks of antidepressant treatment. Baseline behavioral and neuroimaging measures were assessed in relation to CM (history of childhood physical, sexual, and/or emotional abuse) and posttreatment depression outcomes. RESULTS: Patients with maltreatment exhibited decreased modulation of right dorsolateral prefrontal cortex (DLPFC) activity during working memory updating on the CPT, and a corresponding impairment in CPT behavioral performance outside the scanner. No between-group differences were found for imaging or behavior on the Go/No-go test of inhibition. Greater DLPFC activity during CPT significantly predicted posttreatment symptom improvement in patients without maltreatment, whereas the relationship between DLPFC activity and symptom change was nonsignificant, and in the opposite direction, in patients with maltreatment. CONCLUSIONS: The effect of CM on prefrontal circuitry involved in executive function is a potential predictor of antidepressant outcomes.

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Increased pretreatment dlPFC reactivity was predictive of future clinical improvement but only in people without a history of childhood abuse.
“The need for such exploration was emphasized by a recent study showing that increased pretreatment dlPFC reactivity was predictive of future clinical improvement but only in people without a history of childhood abuse (Miller et al. 2015).”
From Cognitive neuropsychological theory of antidepressant action: a modern-day approach to depression and its treatment (2021) · cites this paper as Miller et al. 2015

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Index
Selvaraj, S., Brambilla, P., & Soares, J. C. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.022
Preface
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Authors: Miller, S., McTeague, L. M., Gyurak, A., Patenaude, B., Williams, L. M., Grieve, S. M., Korgaonkar, M. S., & Etkin, A.
Affiliations: VA Palo Alto Health Care System (US)
The University of Sydney (AU)
Corresponding author: Etkin, Amit
ORCID: Miller, Shefali
McTeague, Lisa M.
Gyurak, Anett
Williams, Leanne M.
Grieve, Stuart M.
Korgaonkar, Mayuresh S.
Etkin, Amit
Venue: Depression and Anxiety
Publisher: Hindawi Limited
Published: 2015-04-27
Volume: 32
Issue: 8
Pages: 594-604
ISSN: 1091-4269 (ISSN-L)
DOI: 10.1002/da.22368
PMC: PMC4841677
OpenAlex: W1857184706
Cited by: 74
References: 56
Citations by year: 2026: 2 · 2025: 2 · 2024: 5 · 2023: 6 · 2022: 2 · 2021: 25 · 2020: 7 · 2019: 5 · 2018: 9 · 2017: 4 · 2016: 5 · 2015: 2
FWCI: 8.28
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 127 d)
Locations: Depression and Anxiety (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Brain Resource, Inc.
Topics: Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: child abuse, major depressive disorder, antidepressant response, executive function, working memory, dorsolateral prefrontal cortex, inhibition, continuous performance test, go/no-go task, treatment outcome prediction
MeSH terms: Adult, Depressive Disorder, Major, Major Depressive Disorder, Female, Follow-Up Studies, Humans, Inhibition, Psychological, Magnetic Resonance Imaging, Male, Memory, Short-Term, Middle Aged, Biomarkers, Randomized Controlled Trials as Topic, Outcome Assessment, Health Care, Selective Serotonin Reuptake Inhibitors, Prefrontal Cortex, Adult Survivors of Child Abuse, Young Adult, Executive Function

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COGNITION-CHILDHOOD MALTREATMENT INTERACTIONS IN THE PREDICTION OF ANTIDEPRESSANT OUTCOMES IN MAJOR DEPRESSIVE DISORDER PATIENTS: RESULTS FROM THE iSPOT-D TRIAL: Research Article: Cognition and Childhood Maltreatment in MDD

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