DNA methylation at the DAT promoter and risk for psychopathology: Intergenerational transmission between school-age youths and their parents in a community sample
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BACKGROUND: The effect of gene polymorphisms and promoter methylation, associated with maladaptive developmental outcomes, vary depending on environmental factors (e.g., parental psychopathology). Most studies have focused on 0- to 5-year-old children, adolescents, or adults, whereas there is dearth of research on school-age youths and pre-adolescents. METHODS: In a sample of 21 families recruited at schools, we addressed parents' psychopathological symptoms (through SCL-90-R); offspring emotional-behavioral functioning (through CBCL-6-18); dopamine transporter gene (DAT1) for epigenetic status of the 5'-untranslated region (UTR) and for genotype, i.e., variable number of tandem repeats polymorphism at the 3'-UTR. Possible associations were explored between bio-genetic and psychological characteristics within the same individual and between triplets of children, mothers, and fathers. RESULTS: DAT methylation of CpG at positions M1, M6, and M7 in mothers was correlated with maternal (phobic) anxiety, whereas in fathers' position M6 was related to paternal depression, anxiety, hostility, psychoticism, and higher Global Severity Index (GSI). No significant correlations were found between maternal and offspring DAT methylation. Significant correlations were found between fathers' methylation at CpG M1 and children's methylation at CpG M6. Linear regressions showed that mothers and fathers' GSI predicted children's methylation at CpG sites M2, M3, and M6, whereas fathers' GSI predicted children's methylation at CpG sites, particularly M1, M2, and M6. Moreover, offspring methylation of DAT at CpG M2 predicted somatic complaint, internalizing and attention problems; methylation of DAT at CpG M6 predicted withdraw. CONCLUSION: This study may have important clinical implication for the prevention and treatment of emotional-behavioral difficulties in children, as it adds to previous knowledge about the role of genetic and environmental factors in predicting psychopathological symptoms within non-clinical populations.
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Paternal but not maternal methylation at three CpG sites were associated with methylation at three, albeit different, CpG sites in children.
“Paternalbut not maternal -methylation at three CpG sites were associated with methylation at three, albeit different, CpG sites in children (Cimino et al., 2017).”
From The applied implications of epigenetics in anxiety, affective and stress-related disorders - A review and synthesis on psychosocial stress, psychotherapy and prevention (2020) · cites this paper as Cimino et al., 2017
Results, Aim 2 reports no significant mother–child DAT methylation correlations and three significant father–child correlations. But those three correlations involve only two paternal CpG sites (M1 and M5) and two child sites (M3 and M6), not three sites in each. (LLM, conf=0.90)
Experimental — accuracy not yet measuredIn 21 families with school-age children, parental psychological distress severity was found to be predictive of methylation status at three CpG sites located in the DAT promoter region in their children.
“In 21 families with school-age children, parental psychological distress severity was found to be predictive of methylation status at three CpG sites located in the dopamine transporter (DAT; chromosomal location 5p15.33)promotor region in their children.”
From The applied implications of epigenetics in anxiety, affective and stress-related disorders - A review and synthesis on psychosocial stress, psychotherapy and prevention (2020) · cites this paper as Cimino et al., 2017
The majority of studies looked at only maternal transmission, four considered both maternal and paternal, and two focused only on fathers.
“The majority of the studies looked at only maternal transmission, but four considered both maternal and paternal [83,94,95,102], and two focused only on fathers [97,104].”
From Biological Embedding of Early-Life Adversity and a Scoping Review of the Evidence for Intergenerational Epigenetic Transmission of Stress and Trauma in Humans (2023) · cites this paper as [102]
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Cites
DNA methylation patterns and epigenetic memory
Bird, A. (2002) · Genes & Development · doi:10.1101/gad.947102 · Cited by 7,124 · see citing works
Role of genotype in the cycle of violence in maltreated children
Caspi, A., McClay, J., Moffitt, T. E., Mill, J., Martin, J., Craig, I. W., Taylor, A., & Poulton, R. (2002) · Science · doi:10.1126/science.1072290 · Cited by 4,842 · see citing works
How many subjects does it take to do a regression analysis
Green, S. B. (1991) · Multivariate Behavioral Research · doi:10.1207/s15327906mbr2603_7 · Cited by 3,916 · cited 1× · see citing works
“Nevertheless, some authors (79) have suggested the usefulness of cross-sectional studies even for assessing causal links between variables, and other authors have suggested that results from relatively small samples are still informative for the programming of assessment protocols and intervention plans (80), paving t…”
BackgroundDopamine, learning and motivation.
Wise, R. A. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1406 · Cited by 3,379 · cited 1× · see citing works
“Dopamine is an important neurotransmitter playing a key role in many functions, including implicit and incentive learning, motivation (28), goal- and reward-seeking (29), aggression (30), and cognitive–behavioral processes functional in exploration (31), in novelty- and sensation-seeking (32) as well as in affiliative…”
BackgroundDNA methylation: roles in mammalian development
Smith, Z. D., & Meissner, A. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3354 · Cited by 3,045 · see citing works
Goodman, S. H., & Gotlib, I. H. (1999) · Psychological Review · doi:10.1037/0033-295x.106.3.458 · Cited by 2,493 · see citing works
Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A
Brunner, H. G., Nelen, M., Breakefield, X. O., Ropers, H. H., & van Oost, B. A. (1993) · Science · doi:10.1126/science.8211186 · Cited by 1,644 · see citing works
Socioeconomic status and the brain: mechanistic insights from human and animal research
Hackman, D. A., Farah, M. J., & Meaney, M. J. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2897 · Cited by 1,409 · see citing works
Socioeconomic Status, Parenting, and Child Development
(2014) · doi:10.4324/9781410607027 · Cited by 1,339 · see citing works
Gene-environment interplay and psychopathology: multiple varieties but real effects
Rutter, M., Moffitt, T. E., & Caspi, A. (2006) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2005.01557.x · Cited by 1,058 · see citing works
Pathways from Childhood to Adult Life*
Rutter, M. L. (1989) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1989.tb00768.x · Cited by 865 · see citing works
Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR
Vandenbergh, D. J., Persico, A. M., Hawkins, A. L., Griffin, C. A., Li, X., Jabs, E. W., & Uhl, G. R. (1992) · Genomics · doi:10.1016/s0888-7543(05)80138-7 · Cited by 708 · see citing works
Laviola, G., Macrı̀, S., Morley-Fletcher, S., & Adriani, W. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(03)00006-x · Cited by 621 · see citing works
Self-citationDrug addiction: bad habits add up
Robbins, T. W., & Everitt, B. J. (1999) · Nature · doi:10.1038/19208 · Cited by 599 · see citing works
Epigenetics: The Science of Change
Weinhold, B. (2006) · Environmental Health Perspectives · doi:10.1289/ehp.114-a160 · Cited by 575 · see citing works
Gene-Environment Interplay in Relation to Emotional and Behavioral Disturbance
Rutter, M. L., & Silberg, J. L. (2002) · Annual Review of Psychology · doi:10.1146/annurev.psych.53.100901.135223 · Cited by 459 · see citing works
Frank, M. J., Doll, B. B., Oas-Terpstra, J., & Moreno, F. (2009) · Nature Neuroscience · doi:10.1038/nn.2342 · Cited by 452 · see citing works
Dopaminergic reward system: a short integrative review
Arias-Carrión, Ó., Stamelou, M., Murillo‐Rodríguez, E., Menéndez‐González, M., & Pöppel, E. (2010) · International Archives of Medicine · doi:10.1186/1755-7682-3-24 · Cited by 413 · see citing works
Neural and behavioral substrates of mood and mood regulation
Davidson, R. J., Lewis, D. A., Alloy, L. B., Amaral, D. G., Bush, G., Cohen, J. D., Drevets, W. C., Farah, M. J., Kagan, J., McClelland, J. L., et al. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01458-0 · Cited by 411 · see citing works
Forbes, E. E., Brown, S. M., Kimak, M., Ferrell, R. E., Manuck, S. B., & Hariri, A. R. (2009) · Molecular Psychiatry · doi:10.1038/sj.mp.4002086 · Cited by 408 · see citing works
Stress and development: Behavioral and biological consequences
Bremner, J., & Vermetten, E. (2001) · Development and Psychopathology · doi:10.1017/s0954579401003042 · Cited by 405 · see citing works
Epigenetic regulatory functions of DNA modifications: 5-methylcytosine and beyond
Breiling, A., & Lyko, F. (2015) · Epigenetics & Chromatin · doi:10.1186/s13072-015-0016-6 · Cited by 353 · see citing works
Psychometric properties of the Italian version of the SCL-90-R: A study on a large community sample
Prunas, A., Sarno, I., Preti, E., Madeddu, F., & Perugini, M. (2011) · European Psychiatry · doi:10.1016/j.eurpsy.2010.12.006 · Cited by 344 · see citing works
Мала, Э. (2016) · Wiley eBooks · doi:10.1002/9781119125556 · Cited by 344 · see citing works
VanNess, S., Owens, M. J., & Kilts, C. D. (2005) · BMC Genetics · doi:10.1186/1471-2156-6-55 · Cited by 306 · see citing works
Escalated aggressive behavior: Dopamine, serotonin and GABA
de Almeida, R. M. M., Ferrari, P. F., Parmigiani, S., & Miczek, K. A. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.10.004 · Cited by 303 · see citing works
Gene-Environment Interaction in Psychological Traits and Disorders
Dick, D. M. (2011) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-032210-104518 · Cited by 291 · see citing works
A Multiple‐Levels‐of‐Analysis Perspective on Resilience
Cicchetti, D., & Blender, J. A. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1376.029 · Cited by 233 · see citing works
Childhood abuse is associated with methylation of multiple loci in adult DNA
Suderman, M., Borghol, N., Pappas, J. J., Pinto Pereira, S. M., Pembrey, M., Hertzman, C., Power, C., & Szyf, M. (2014) · BMC Medical Genomics · doi:10.1186/1755-8794-7-13 · Cited by 193 · see citing works
Koenen, K. C., Uddin, M., Chang, S.-C., Aiello, A. E., Wildman, D. E., Goldmann, E., & Galea, S. (2011) · Depression and Anxiety · doi:10.1002/da.20825 · Cited by 174 · see citing works
Neurobiological mechanisms of social attachment and pair bonding
Johnson, Z. V., & Young, L. J. (2015) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2015.01.009 · Cited by 169 · see citing works
Frigerio, A., Cattaneo, C., Cataldo, M. G., Schiatti, A., Molteni, M., & Battaglia, M. (2004) · European Journal of Psychological Assessment · doi:10.1027/1015-5759.20.2.124 · Cited by 169 · see citing works
Multilevel perspectives on pathways to resilient functioning
Cicchetti, D., & Curtis, W. J. (2007) · Development and Psychopathology · doi:10.1017/s0954579407000314 · Cited by 156 · see citing works
Influence of paternal preconception exposures on their offspring: through epigenetics to phenotype.
Day, J., Savani, S., Krempley, B. D., Nguyen, M. H., & Kitlinska, J. B. (2016) · Europe PMC (PubMed Central) · Cited by 155 · see citing works
Biomarkers in the Diagnosis of ADHD – Promising Directions
Faraone, S., Bonvicini, C., & Scassellati, C. (2014) · Current Psychiatry Reports · doi:10.1007/s11920-014-0497-1 · Cited by 139 · see citing works
The Concept of Development in Developmental Psychopathology
Sroufe, L. A. (2009) · Child Development Perspectives · doi:10.1111/j.1750-8606.2009.00103.x · Cited by 132 · see citing works
Neural Correlates of Reward Processing in Depressed and Healthy Preschool-Age Children
Belden, A. C., Irvin, K., Hajcak, G., Kappenman, E. S., Kelly, D., Karlow, S. L., Luby, J. L., & Barch, D. M. (2016) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2016.09.503 · Cited by 131 · see citing works
Perroud, N., Zewdie, S., Stenz, L., Adouan, W., Bavamian, S., Prada, P., Nicastro, R., Hasler, R., Nallet, A., Piguet, C., et al. (2016) · Depression and Anxiety · doi:10.1002/da.22406 · Cited by 120 · see citing works
Early life protein restriction alters dopamine circuitry
Vucetic, Z., Totoki, K., Schoch, H., Whitaker, K. W., Hill‐Smith, T. E., Lucki, I., & Reyes, T. M. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.04.010 · Cited by 119 · see citing works
The early‐life social environment and DNA methylation
Moshe Szyf, A. (2012) · Clinical Genetics · doi:10.1111/j.1399-0004.2012.01843.x · Cited by 119 · see citing works
Toward an integration of family systems and developmental psychopathology approaches
Davies, P. T., & Cicchetti, D. (2004) · Development and Psychopathology · doi:10.1017/s0954579404004626 · Cited by 116 · see citing works
Interparental agreement on child behavior problems.
Christensen, A., Margolin, G., & Sullaway, M. E. (1992) · Psychological Assessment · doi:10.1037/1040-3590.4.4.419 · Cited by 102 · see citing works
Finegersh, A., Rompala, G. R., Martin, D. I. K., & Homanics, G. E. (2015) · Alcohol · doi:10.1016/j.alcohol.2015.02.008 · Cited by 98 · see citing works
Eaton, N. R., Krueger, R. F., & Oltmanns, T. F. (2011) · Psychology and Aging · doi:10.1037/a0024406 · Cited by 97 · see citing works
Waddington, Dynamic Systems, and Epigenetics
Tronick, E., & Hunter, R. G. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00107 · Cited by 96 · see citing works
Roth, T. L. (2013) · Development and Psychopathology · doi:10.1017/s0954579413000618 · Cited by 95 · see citing works
Xu, Y., Chen, X.-T., Luo, M., Tang, Y., Zhang, G., Wu, D., Yang, B., Ruan, D., & Wang, H.-L. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.03.006 · Cited by 92 · see citing works
Hay, D. F., Pawlby, S. J., Sharp, D., Schmücker, G., Mills, A., Allen, H., & Kumar, R. (1999) · Journal of Child Psychology and Psychiatry · doi:10.1111/1469-7610.00541 · Cited by 90 · see citing works
Plaß-Christl, A., Haller, A.-C., Otto, C., Barkmann, C., Wiegand‐Grefe, S., Hölling, H., Schulte‐Markwort, M., Ravens‐Sieberer, U., & Klasen, F. (2017) · PLoS ONE · doi:10.1371/journal.pone.0180410 · Cited by 90 · see citing works
Early life socioeconomic factors and genomic DNA methylation in mid-life
Tehranifar, P., Wu, H., Fan, X., Flom, J. D., Ferris, J. S., Cho, Y. H., González, K., Santella, R. M., & Terry, M. B. (2012) · Epigenetics · doi:10.4161/epi.22989 · Cited by 89 · see citing works
Hannigan, L. J., Walaker, N., Waszczuk, M. A., McAdams, T. A., & Eley, T. C. (2016) · Psychopathology Review · doi:10.5127/pr.038315 · Cited by 89 · see citing works
DNA methylation changes in schizophrenia and bipolar disorder
Connor, C., & Akbarian, S. (2008) · Epigenetics · doi:10.4161/epi.3.2.5938 · Cited by 84 · see citing works
DNA Methylation Analysis of the Angiotensin Converting Enzyme (ACE) Gene in Major Depression
Zill, P., Baghai, T. C., Schüle, C., Born, C., Früstück, C., Büttner, A., Eisenmenger, W., Bedarida, G., Rupprecht, R., Möller, H., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040479 · Cited by 82 · see citing works
Shumay, E., Fowler, J. S., & Volkow, N. D. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011067 · Cited by 78 · see citing works
Camardese, G., Giuda, D. D., Nicola, M. D., Cocciolillo, F., Giordano, A., Janiri, L., & Guglielmo, R. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.12.006 · Cited by 72 · see citing works
Lahey, B. B., Rathouz, P. J., Lee, S. S., Chronis-Tuscano, A., Pelham, W. E., Waldman, I. D., & Cook, E. H. (2011) · Journal of Abnormal Psychology · doi:10.1037/a0021133 · Cited by 63 · see citing works
Attention Deficit Hyperactivity Disorder in the Light of the Epigenetic Paradigm
Schuch, V., Utsumi, D. A., Costa, T. V. M. M., Kulikowski, L. D., & Muszkat, M. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00126 · Cited by 60 · see citing works
van der Zwaluw, C. S., Engels, R. C. M. E., Buitelaar, J. K., Verkes, R. J., Franke, B., & Scholte, R. H. J. (2009) · Pharmacogenomics · doi:10.2217/pgs.09.24 · Cited by 57 · see citing works
Li, L., Bao, Y., He, S., Wang, G., Guan, Y., Ma, D., Wang, P., Huang, X., Tao, S., Zhang, D., et al. (2016) · Medicine · doi:10.1097/md.0000000000003074 · Cited by 57 · see citing works
What is a functional genetic polymorphism? Defining classes of functionality
Albert, P. R. (2011) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.110137 · Cited by 56 · see citing works
Ding, K.-J., Yang, J.-Z., Reynolds, G., Chen, B., Shao, J., Liu, R.-X., Qian, Q., Liu, H., Yang, R.-X., Wen, J.-F., et al. (2017) · World Journal of Biological Psychiatry · doi:10.1080/15622975.2016.1224928 · Cited by 55 · see citing works
Adriani, W., Romano, E., Pucci, M., Pascale, E., Cerniglia, L., Cimino, S., Tambelli, R., Curatolo, P., Granstrem, O., Maccarrone, M., et al. (2017) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-017-1040-9 · Cited by 51 · see citing works
Self-citationCimino, S., Cerniglia, L., Porreca, A., Simonelli, A., Ronconi, L., & Ballarotto, G. (2016) · Frontiers in Psychology · doi:10.3389/fpsyg.2016.00580 · Cited by 49 · see citing works
Self-citationGiana, G., Romano, E., Porfirio, M. C., D’Ambrosio, R., Giovinazzo, S., Troianiello, M., Barlocci, E., Travaglini, D., Granstrem, O., Pascale, E., et al. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.11.008 · Cited by 48 · see citing works
Self-citationLee, S. S., Lahey, B. B., Waldman, I. D., Hulle, C. A. V., Rathouz, P. J., Pelham, W. E., Loney, J., & Cook, E. H. (2006) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30447 · Cited by 47 · see citing works
van der Pol, L. D., Groeneveld, M. G., Endendijk, J. J., van Berkel, S. R., Hallers‐Haalboom, E. T., Bakermans‐Kranenburg, M. J., & Mesman, J. (2016) · Journal of Child and Family Studies · doi:10.1007/s10826-016-0490-x · Cited by 47 · see citing works
the BELLA Study Group, Wlodarczyk, O., Pawils, S., Metzner, F., Kriston, L., Klasen, F., & Ravens‐Sieberer, U. (2017) · Child and Adolescent Psychiatry and Mental Health · doi:10.1186/s13034-017-0149-4 · Cited by 46 · see citing works
Tambelli, R., Cerniglia, L., Cimino, S., & Ballarotto, G. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.01210 · Cited by 44 · see citing works
Self-citationDeveloping needs led child and adolescent mental health services: issues and prospects
Kerfoot, M., Verduyn, C., & Harrington, R. (1999) · European Child & Adolescent Psychiatry · doi:10.1007/s007870050077 · Cited by 44 · see citing works
Cerniglia, L., Cimino, S., Ballarotto, G., Casini, E., Ferrari, A., Carbone, P., & Cersosimo, M. (2015) · Transportation Research Part F Traffic Psychology and Behaviour · doi:10.1016/j.trf.2015.09.002 · Cited by 42 · see citing works
Self-citationŠerý, O., Paclt, I., Drtílková, I., Theiner, P., Kopečková, M., Zvolský, P., & Balcar, V. J. (2015) · Behavioral and Brain Functions · doi:10.1186/s12993-015-0066-8 · Cited by 42 · see citing works
Measuring Anxiety in Children: The Importance of Separate Mother and Father Reports
Jansen, M., Bodden, D. H. M., Muris, P., van Doorn, M. M., & Granic, I. (2017) · Child & Youth Care Forum · doi:10.1007/s10566-017-9402-5 · Cited by 37 · see citing works
Hayden, E. P., Hanna, B., Sheikh, H. I., Laptook, R. S., Kim, J., Singh, S. M., & Klein, D. N. (2013) · Development and Psychopathology · doi:10.1017/s0954579412000971 · Cited by 36 · see citing works
Birnbaum, L. S., & Jung, P. (2011) · Health Affairs · doi:10.1377/hlthaff.2010.1225 · Cited by 35 · see citing works
Childhood adverse life events and parental psychopathology as risk factors for bipolar disorder
Bergink, V., Larsen, J. T., Hillegers, M. H. J., Dahl, S. K., Stevens, H., Mortensen, P. B., Petersen, L. V., & Munk‐Olsen, T. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.201 · Cited by 35 · see citing works
Torrone, D., Kuriakose, J., Moors, K., Jiang, H., Niedzwiecki, M., Perera, F., & Rl, M. (2012) · Clinical Epigenetics · doi:10.1186/1868-7083-4-3 · Cited by 33 · see citing works
Thissen, A. J. A. M., Bralten, J., Rommelse, N., Arias-Vásquez, A., Greven, C., Heslenfeld, D., Luman, M., Oosterlaan, J., Hoekstra, P., Hartman, C., et al. (2015) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32290 · Cited by 29 · see citing works
Planning and Analysis of Clinical Studies
Gonnella, C., & Pierre, M. D. (1971) · Physical Therapy · doi:10.1093/ptj/51.11.1261b · Cited by 26 · see citing works
Auerbach, J. G., Zilberman‐Hayun, Y., Atzaba‐Poria, N., & Berger, A. (2016) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-016-0230-0 · Cited by 23 · see citing works
Strober, M. A., Peris, T. S., & Steiger, H. (2014) · International Journal of Eating Disorders · doi:10.1002/eat.22322 · Cited by 20 · see citing works
Clark, W. R., & GRUNSTEIN, M. M. (2004) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195178005.001.0001 · Cited by 18 · see citing works
How nonclinical are community samples?
Thurston, I. B., Curley, J., Fields, S. A., Kamboukos, D. M., Rojas, A., & Phares, V. (2008) · Journal of Community Psychology · doi:10.1002/jcop.20223 · Cited by 16 · see citing works
Zhang, S., Jiang, W., Tang, X., Xu, Q., wang, J., Gui, R., Zhang, X., & Liu, S. (2015) · Europe PMC (PubMed Central) · Cited by 10 · see citing works
The Development of Emotion Regulation and Dysregulation
King, B. H. (1993) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199311000-00039 · Cited by 7 · see citing works
Genetics and epigenetics in family context: Introduction to the special section.
Beach, S. R. H., & Whisman, M. A. (2013) · Journal of Family Psychology · doi:10.1037/a0031484 · Cited by 4 · see citing works
Dunn, E. C., Soare, T. W., Simpkin, A. J., Suderman, M. J., Raffeld, M. R., Smith, A. D. A. C., & Relton, C. L. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.02.632 · Cited by 1 · see citing works
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- Authors
- Cimino, S., Cerniglia, L., Ballarotto, G., Marzilli, E., Pascale, E., D’Addario, C., Adriani, W., & Tambelli, R.
- Affiliations
- Sapienza University of Rome (IT)
- UniNettuno University (IT)
- University of Teramo (IT)
- Istituto Superiore di Sanità (IT)
- Corresponding author
- Cimino, Silvia
- Adriani, Walter
- ORCID
- Venue
- Frontiers in Psychiatry
- Publisher
- Frontiers Media SA
- Published
- 2018-01-10
- Volume
- 8
- Pages
- 303-303
- ISSN
- 1664-0640 (ISSN-L)
- PMC
- PMC5767582
- OpenAlex
- W2783828966
- Cited by
- 48
- References
- 86
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 18 · 2022: 4 · 2021: 5 · 2020: 12 · 2019: 3
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Frontiers in Psychiatry (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion, cc-by-nc-nd)
- UniTERAMO Research Catalog (University of Teramo) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- DNA methylation, dopamine transporter gene, DAT1, promoter methylation, intergenerational transmission, parent-offspring transmission, psychopathology, emotional and behavioral problems, elementary school students, maternal anxiety, paternal depression, epigenetics, variable number tandem repeats, 5' untranslated region, internalizing problems, attention deficits, withdrawal
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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