Autonomic regulation in fragile X syndrome
Open accessAbstract
Autonomic reactivity was studied in individuals with fragile X syndrome (FXS), a genetic disorder partially characterized by abnormal social behavior. Relative to age‐matched controls, the FXS group had faster baseline heart rate and lower amplitude respiratory sinus arrhythmia (RSA). In contrast to the typically developing controls, there was a decrease in RSA with age within the FXS group. Moreover, within the FXS group heart rate did not slow with age. The FXS group also responded with an atypical increase in RSA to the social challenge, while the control group reduced RSA. In a subset of the FXS group, the autonomic profile did not change following 2 months and 1 year of lithium treatment. The observed indices of atypical autonomic regulation, consistent with the Polyvagal Theory, may contribute to the deficits in social behavior and social communication observed in FXS. © 2011 Wiley Periodicals, Inc. Dev Psychobiol 53:785–795, 2011.
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Higher arousal in ASD and related conditions at later stages of development has been reported using a variety of indices, including tonic pupil size, respiratory sinus arrhythmia, baseline heart rate and galvanic skin response.
“Higher arousal in ASD and related conditions at later stages of development has been reported using a variety of indices, including tonic pupil size40, respiratory sinus arrhythmia, baseline heart rate41 and galvanic skin response42 – but has not to our knowledge been researched at the very early stages of development studied here.”
From Shorter spontaneous fixation durations in infants with later emerging autism (2015) · cites this paper as [41]
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Research works printed but not linked: 1
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Shorter spontaneous fixation durations in infants with later emerging autism
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Self-citation
- Authors
- Heilman, K. J., Harden, E. R., Zageris, D. M., Berry‐Kravis, E., & Porges, S. W.
- Affiliations
- University of Illinois Chicago (US)
- Rush University Medical Center (US)
- Corresponding author
- Porges, Stephen W.
- Venue
- Developmental Psychobiology
- Publisher
- Wiley
- Published
- 2011-05-05
- Volume
- 53
- Issue
- 8
- Pages
- 785-795
- ISSN
- 0012-1630 (ISSN-L)
- 1098-2302
- PMC
- PMC3206129
- OpenAlex
- W2122313235
- Cited by
- 42
- References
- 49
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 6 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 6 · 2017: 2 · 2016: 1 · 2015: 4 · 2014: 4 · 2013: 4 · 2012: 5
- FWCI
- 2.86
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Developmental Psychobiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD053570, HD 53570)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Keywords
- fragile X syndrome, autonomic regulation, respiratory sinus arrhythmia, heart rate, social behavior, social communication, lithium therapy, polyvagal theory, autonomic reactivity, age differences
- MeSH terms
- Adolescent, Age Factors, Arrhythmia, Sinus, Autonomic Nervous System, Child, Fragile X Syndrome, Heart Rate, Humans, Male, Motor Activity, Social Behavior, Stress, Psychological, Case-Control Studies, Lithium Compounds, Monitoring, Ambulatory, Young Adult, Respiratory Rate
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