Cited by 77Birth, Development, and HealthMaternal Mental Health During Pregnancy and PostpartumPrenatal Substance Exposure Effects

Extending the developmental origins of disease model: Impact of preconception stress exposure on offspring neurodevelopment

Open access
Keenan, Kate, Hipwell, Alison E., Class, Quetzal A., Mbayiwa, Kimberley·2018·Developmental Psychobiology

Abstract

The concept of the developmental origins of health and disease via prenatal programming has informed many etiologic models of health and development. Extensive experimental research in non‐human animal models has revealed the impact of in utero exposure to stress on fetal development and neurodevelopment later in life. Stress exposure, however, is unlikely to occur de novo following conception, and pregnancy health is not independent of the health of the system prior to conception. For these reasons, the preconception period is emerging as an important new focus for research on adverse birth outcomes and offspring neurodevelopment. In this review, we summarize the existing evidence for the role of preconception stress exposure on pregnancy health and offspring neurodevelopment across species and discuss the implications of this model for addressing health disparities in obstetrics and offspring outcomes.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1002/dev.21773

Cites

117 of 117 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 1

  1. Blaxter M (2010). Health (key concepts). Cambridge: Polity Press.

Cited by

Sorted by citations

Authors
Keenan, K., Hipwell, A. E., Class, Q. A., & Mbayiwa, K.
Affiliations
  • University of Chicago (US)
  • University of Pittsburgh (US)
  • University of Illinois Chicago (US)
Corresponding author
Keenan, Kate
Venue
Developmental Psychobiology
Publisher
Wiley
Published
2018-08-24
Volume
60
Issue
7
Pages
753-764
ISSN
  • 0012-1630 (ISSN-L)
  • 1098-2302
OpenAlex
W2888220586
Cited by
77
References
117
Citations by year
2026: 3 · 2025: 11 · 2024: 12 · 2023: 12 · 2022: 13 · 2021: 5 · 2020: 14 · 2019: 7
FWCI
1.24
Type
journal article
Language
en
Open access
Locations
  • Developmental Psychobiology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
NIH Office of the Director (UG3 OD023244)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
Keywords
developmental origins of health and disease, prenatal programming, offspring neurodevelopment, maternal health during pregnancy, adverse birth outcomes, maternal stress
MeSH terms
Adolescent, Adult, Animals, Child, Female, Humans, Human Development, Models, Biological, Pregnancy, Prenatal Exposure Delayed Effects, Stress, Psychological, Fetal Development, Young Adult, Neurodevelopmental Disorders

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review