Extending the developmental origins of disease model: Impact of preconception stress exposure on offspring neurodevelopment
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The concept of the developmental origins of health and disease via prenatal programming has informed many etiologic models of health and development. Extensive experimental research in non‐human animal models has revealed the impact of in utero exposure to stress on fetal development and neurodevelopment later in life. Stress exposure, however, is unlikely to occur de novo following conception, and pregnancy health is not independent of the health of the system prior to conception. For these reasons, the preconception period is emerging as an important new focus for research on adverse birth outcomes and offspring neurodevelopment. In this review, we summarize the existing evidence for the role of preconception stress exposure on pregnancy health and offspring neurodevelopment across species and discuss the implications of this model for addressing health disparities in obstetrics and offspring outcomes.
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Preliminary evidence suggests that exposure to stress preconception could also be transmitted across generations.
“Excitingly, there is also some preliminary evidence that exposure to stress preconception could also be transmitted across generations [59].”
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- Authors
- Keenan, K., Hipwell, A. E., Class, Q. A., & Mbayiwa, K.
- Affiliations
- University of Chicago (US)
- University of Pittsburgh (US)
- University of Illinois Chicago (US)
- Corresponding author
- Keenan, Kate
- Venue
- Developmental Psychobiology
- Publisher
- Wiley
- Published
- 2018-08-24
- Volume
- 60
- Issue
- 7
- Pages
- 753-764
- ISSN
- 0012-1630 (ISSN-L)
- 1098-2302
- PMC
- PMC6342272
- OpenAlex
- W2888220586
- Cited by
- 77
- References
- 117
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 12 · 2023: 12 · 2022: 13 · 2021: 5 · 2020: 14 · 2019: 7
- FWCI
- 1.24
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Developmental Psychobiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH Office of the Director (UG3 OD023244)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Keywords
- developmental origins of health and disease, prenatal programming, offspring neurodevelopment, maternal health during pregnancy, adverse birth outcomes, maternal stress
- MeSH terms
- Adolescent, Adult, Animals, Child, Female, Humans, Human Development, Models, Biological, Pregnancy, Prenatal Exposure Delayed Effects, Stress, Psychological, Fetal Development, Young Adult, Neurodevelopmental Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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