Early-life stress mediated modulation of adult neurogenesis and behavior
Abstract
Early life is a period of unique sensitivity during which experience can confer enduring effects on brain structure and function. During early perinatal life the quality of the surrounding environment and experiences, in particular the parent-child relationship, is associated with emotional and cognitive development later in life. For instance, adverse early-life experience is correlated with an increased vulnerability to develop psychopathologies and aging-related cognitive decline. These are thought to be mediated by acute and long-lasting effects on the, at that time still developing, stress-neuroendocrine and cognitive systems. Adult hippocampal neurogenesis is involved in learning and memory while both regulation of the stress response as well as early-life stress is known to permanently reduce neurogenesis, and to be implicated in these functional deficits. In order to increase our understanding of the influence of the perinatal environment on the long-lasting programming of neurogenesis, we here discuss immediate and lasting effects of various adverse early-life experiences on hippocampal neurogenesis and the associated behavioral alterations. Considering the persistence of these effects, the underlying molecular mechanisms, with focus on the potential epigenetic mechanisms will be discussed as well. Finally, special attention will be paid to the prominent sex differences in early-life stress-induced alterations in neurogenesis.
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Maternal separation stress reduced adult neurogenesis in the rat hippocampus in previous work.
“Previous work showed maternal separation stress reduced adult neurogenesis in the rat hippocampus (37; 62–64), although other studies failed to show this (65).”
From Perineuronal nets, inhibitory interneurons and anxiety-related ventral hippocampal neuronal oscillations are altered by early life adversity (2019) · cites this paper as [64]
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- Authors
- Korosi, A., Naninck, E. F. G., Oomen, C. A., Schouten, M., Krugers, H., Fitzsimons, C., & Lucassen, P. J.
- Affiliations
- University of Amsterdam (NL)
- University of Cambridge (GB)
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 227
- Issue
- 2
- Pages
- 400-409
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W2081272350
- Semantic Scholar
- d35355a2bc143b9e2dde957004fb4094f18347d7
- Cited by
- 194
- References
- 159
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 8 · 2023: 6 · 2022: 7 · 2021: 13 · 2020: 16 · 2019: 12 · 2018: 15 · 2017: 17 · 2016: 13 · 2015: 26 · 2014: 19 · 2013: 17 · 2012: 10
- FWCI
- 1.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- UvA-DARE (University of Amsterdam) (publishedVersion)
- UvA-DARE (University of Amsterdam) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- early life stress, adult hippocampal neurogenesis, perinatal environment, parent-child relationship, stress response, epigenetic mechanisms, sex differences, behavioral alterations, learning and memory, psychopathology, cognitive decline, brain development
- MeSH terms
- Animals, Behavior, Animal, Hippocampus, Maternal Deprivation, Neuronal Plasticity, Stress, Psychological, Neurogenesis
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