Cited by 194Neurogenesis and neuroplasticity mechanismsStress Responses and CortisolMemory and Neural Mechanisms

Early-life stress mediated modulation of adult neurogenesis and behavior

Korosi, A., Naninck, E.F.G., Oomen, C.A., Schouten, M., Krugers, H., Fitzsimons, C., Lucassen, P.J.·2012·Behavioural Brain Research

Abstract

Early life is a period of unique sensitivity during which experience can confer enduring effects on brain structure and function. During early perinatal life the quality of the surrounding environment and experiences, in particular the parent-child relationship, is associated with emotional and cognitive development later in life. For instance, adverse early-life experience is correlated with an increased vulnerability to develop psychopathologies and aging-related cognitive decline. These are thought to be mediated by acute and long-lasting effects on the, at that time still developing, stress-neuroendocrine and cognitive systems. Adult hippocampal neurogenesis is involved in learning and memory while both regulation of the stress response as well as early-life stress is known to permanently reduce neurogenesis, and to be implicated in these functional deficits. In order to increase our understanding of the influence of the perinatal environment on the long-lasting programming of neurogenesis, we here discuss immediate and lasting effects of various adverse early-life experiences on hippocampal neurogenesis and the associated behavioral alterations. Considering the persistence of these effects, the underlying molecular mechanisms, with focus on the potential epigenetic mechanisms will be discussed as well. Finally, special attention will be paid to the prominent sex differences in early-life stress-induced alterations in neurogenesis.

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Crossref · 10.1016/j.bbr.2011.07.037

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Authors
Korosi, A., Naninck, E. F. G., Oomen, C. A., Schouten, M., Krugers, H., Fitzsimons, C., & Lucassen, P. J.
Affiliations
  • University of Amsterdam (NL)
  • University of Cambridge (GB)
Venue
Behavioural Brain Research
Publisher
Elsevier BV
Published
2012-02
Volume
227
Issue
2
Pages
400-409
ISSN
0166-4328 (ISSN-L)
OpenAlex
W2081272350
Cited by
194
References
159
Citations by year
2026: 5 · 2025: 8 · 2024: 8 · 2023: 6 · 2022: 7 · 2021: 13 · 2020: 16 · 2019: 12 · 2018: 15 · 2017: 17 · 2016: 13 · 2015: 26 · 2014: 19 · 2013: 17 · 2012: 10
FWCI
1.29
Type
journal article
Language
en
Open access
closed
Locations
  • Behavioural Brain Research (publishedVersion)
  • PubMed (publishedVersion)
  • UvA-DARE (University of Amsterdam) (publishedVersion)
  • UvA-DARE (University of Amsterdam) (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
early life stress, adult hippocampal neurogenesis, perinatal environment, parent-child relationship, stress response, epigenetic mechanisms, sex differences, behavioral alterations, learning and memory, psychopathology, cognitive decline, brain development
MeSH terms
Animals, Behavior, Animal, Hippocampus, Maternal Deprivation, Neuronal Plasticity, Stress, Psychological, Neurogenesis

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