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Cited by 69Diet and metabolism studiesMuscle metabolism and nutritionDietary Effects on Health

Enhanced weight loss with protein‐enriched meal replacements in subjects with the metabolic syndrome

Flechtner‐Mors, Marion, Boehm, Bernhard O., Wittmann, Regina, Thoma, Ulrike, Ditschuneit, Herwig H.·2010·Diabetes/Metabolism Research and Reviews
DOI 10.1002/dmrr.1097
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Abstract

Background The objective of this study was to investigate the effects of a protein-rich diet in comparison with a conventional protein diet on weight loss, weight maintenance, and body composition in subjects with the metabolic syndrome. Methods Obese subjects received instructions for an energy-restricted diet with a calorie deficit of 500 kcal/day and were randomly assigned to either high-protein (1.34 g/kg body weight) or conventional protein (0.8 g/kg body weight) diets for 12 months. Protein-enriched meal replacements were used to enrich one arm of the diet with protein throughout the study. In all, 67% of the participants completed the 1-year study. Results Subjects following the high-protein diet lost more body weight and more fat mass compared with those on the conventional protein diet, whereas the loss of fat-free mass was similar in both diet groups. Biochemical parameters associated with the metabolic syndrome improved in both diet groups. Improvements were modestly greater in subjects with the high-protein diet. After 12 months of treatment, 64.5% of the subjects in the high-protein diet group and 34.8% of the subjects in the conventional diet group no longer met three or more of the criteria for having the metabolic syndrome. Conclusions Individuals with the metabolic syndrome achieved significant weight loss while preserving fat-free mass when treated with an energy-restricted, high-protein diet that included nutrient-dense meal replacements, as compared with t…

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  • In a study of individuals with metabolic syndrome (n = 110; baseline triglycerides = 179 mg/dL), after 12 months on a high-protein (1.34 g/kg body weight) weight-loss diet versus a conventional weight-loss diet (0.8 g/kg body weight of protein), those on the high-protein diet had greater weight loss (9 kg vs 6.4 kg).

    “In a study of individuals with metabolic syndrome (n = 110; baseline triglycerides = 179 mg/dL), after 12 months on a high-protein (1.34 g/kg body weight) weight-loss diet (500-calorie deficit per day) versus a conventional weight-loss diet (0.8 g/kg body weight of protein), those on the high-protein diet had greater weight loss (9 kg) than the conventional diet (6.4 kg).”

    From 2021 ACC Expert Consensus Decision Pathway on the Management of ASCVD Risk Reduction in Patients With Persistent Hypertriglyceridemia (2021) · cites this paper as [68]

  • Those on the high-protein diet had a 35% reduction in triglycerides versus a nonsignificant 5% reduction in the conventional diet group.

    “In addition, those on the high-protein diet had a 35% reduction in triglycerides versus a nonsignificant 5% reduction in the conventional diet group (68).”

    From 2021 ACC Expert Consensus Decision Pathway on the Management of ASCVD Risk Reduction in Patients With Persistent Hypertriglyceridemia (2021) · cites this paper as [68]

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Authors
Flechtner‐Mors, M., Boehm, B. O., Wittmann, R., Thoma, U., & Ditschuneit, H. H.
Affiliations
Universität Ulm (DE)
Corresponding author
Flechtner‐Mors, Marion
ORCID
Venue
Diabetes/Metabolism Research and Reviews
Publisher
Wiley
Published
2010-06-27
Volume
26
Issue
5
Pages
393-405
ISSN
  • 1520-7552 (ISSN-L)
  • 1520-7560
DOI
10.1002/dmrr.1097
OpenAlex
W2048404102
Cited by
69
References
14
Citations by year
2026: 3 · 2025: 6 · 2024: 7 · 2023: 3 · 2022: 2 · 2021: 5 · 2020: 2 · 2019: 2 · 2018: 5 · 2017: 4 · 2016: 2 · 2015: 5 · 2014: 7 · 2013: 4 · 2012: 8
FWCI
3.46
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Diabetes/Metabolism Research and Reviews (publishedVersion)
  • PubMed (publishedVersion)
Funders
Universität Ulm
Topics
  • Health Sciences › Medicine › Physiology › Diet and metabolism studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Physiology › Dietary Effects on Health
Keywords
metabolic syndrome, weight loss, high-protein diet, hypocaloric diet, obesity, fat loss, fat-free mass, body composition, weight maintenance
MeSH terms
Adult, Aged, Body Composition, Energy Intake, Diet, Reducing, Dietary Proteins, Female, Humans, Male, Middle Aged, Obesity, Weight Loss, Metabolic Syndrome

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