Cited by 331Adipokines, Inflammation, and Metabolic DiseasesDietary Effects on HealthLipoproteins and Cardiovascular Health

Energy Restriction and Weight Loss on Very-Low-Fat Diets Reduce C-Reactive Protein Concentrations in Obese, Healthy Women

Heilbronn, L. K., Noakes, M., Clifton, P. M.·2001·Arteriosclerosis, Thrombosis, and Vascular Biology

Abstract

Abstract —C-reactive protein (CRP) is an inflammatory-response protein that is a strong, independent predictor of cardiovascular mortality. CRP is positively associated with body mass index (BMI). In this study, we investigated the effects of dynamic weight loss on CRP in 83 healthy, obese women (mean BMI, 33.8±0.4 kg/m 2 ; range, 28.2 to 43.8 kg/m 2 ). Subjects were placed on very-low-fat, energy-restricted diets (5700 kJ, 15% fat) for 12 weeks. Weight, waist and hip circumferences, plasma lipids, glucose, and CRP were measured at baseline and after 12 weeks. CRP was positively associated with BMI ( r =0.281, P =0.01) and waist circumference ( r =0.278, P =0.01) but was not related to other atherosclerosis risk factors. BMI was significantly different between groups split above or below the median for CRP (34.8±0.6 kg/m 2 vs 33.0±0.5 kg/m 2 , P =0.02). After 12 weeks, weight loss was 7.9±0.3 kg. CRP was significantly decreased by 26% ( P <0.001), and a correlation was observed between weight loss and the change in CRP ( r =0.309, P =0.005). The variance in the change in CRP was partly explained by initial CRP (13.6%), energy intake (5.4%), and percentage weight loss (4.6%, P =0.001). This study confirms recent observations that BMI is associated with CRP, a marker for low-grade systemic inflammation. Furthermore, we observed that CRP was lowered in proportion to weight loss.

Integrity signals

Registry

Crossref · 10.1161/01.atv.21.6.968

Cites

18 of 18 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Heilbronn, L. K., Noakes, M., & Clifton, P. M.
Affiliations
Commonwealth Scientific and Industrial Research Organisation (AU)
Venue
Arteriosclerosis, Thrombosis, and Vascular Biology
Published
2001-06
Volume
21
Issue
6
Pages
968-970
ISSN
  • 1079-5642 (ISSN-L)
  • 1524-4636
OpenAlex
W2163805110
Cited by
331
References
18
Citations by year
2026: 1 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 3 · 2021: 7 · 2020: 4 · 2019: 7 · 2018: 4 · 2017: 8 · 2016: 7 · 2015: 11 · 2014: 11 · 2013: 12 · 2012: 17
FWCI
19.59
Type
journal article
Language
en
Open access
closed
Locations
  • Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
  • PubMed (publishedVersion)
  • Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Physiology › Dietary Effects on Health
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Keywords
C-reactive protein, very low-fat diet, caloric restriction, weight loss, obesity, body mass index, waist circumference, low-grade inflammation, cardiovascular risk
MeSH terms
Body Constitution, C-Reactive Protein, Energy Intake, Female, Humans, Middle Aged, Obesity, Weight Loss, Body Mass Index, Diet, Fat-Restricted

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review