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Cited by 281

The DOI matches its Crossref record; 144 of the 144 references it cites were found in a registry or an index.

The role of taurine in diabetes and the development of diabetic complications

Hansen, Svend Høime·2001·Diabetes/Metabolism Research and Reviews
DOI 10.1002/dmrr.229
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Abstract

The ubiquitously found β‐amino acid taurine has several physiological functions, e.g. in bile acid formation, as an osmolyte by cell volume regulation, in the heart, in the retina, in the formation of N‐chlorotaurine by reaction with hypochlorous acid in leucocytes, and possibly for intracellular scavenging of carbonyl groups. Some animals, such as the cat and the C57BL/6 mouse, have disturbances in taurine homeostasis. The C57BL/6 mouse strain is widely used in diabetic and atherosclerotic animal models. In diabetes, the high extracellular levels of glucose disturb the cellular osmoregulation and sorbitol is formed intracellularly due to the intracellular polyol pathway, which is suspected to be one of the key processes in the development of diabetic late complications and associated cellular dysfunctions. Intracellular accumulation of sorbitol is most likely to cause depletion of other intracellular compounds including osmolytes such as myo‐inositol and taurine. When considering the clinical complications in diabetes, several links can be established between altered taurine metabolism and the development of cellular dysfunctions in diabetes which cause the clinical complications observed in diabetes, e.g. retinopathy, neuropathy, nephropathy, cardiomyopathy, platelet aggregation, endothelial dysfunction and atherosclerosis. Possible therapeutic perspectives could be a supplementation with taurine and other osmolytes and low‐molecular compounds, perhaps in a combinational therapy with aldose reductase inhibitors. Copyright © 2001 John Wiley & Sons, Ltd.

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Metadata

Authors
Hansen, S. H.
Venue
Diabetes/Metabolism Research and Reviews
Publisher
Wiley
Published
2001-09
Volume
17
Issue
5
Pages
330-346
ISSN
  • 1520-7552 (ISSN-L)
  • 1520-7560
DOI
10.1002/dmrr.229
OpenAlex
W1976065525
Cited by
281
References
144
FWCI
2.69
Type
journal article
Language
en
Open access
closed

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