Cited by 795Bone Metabolism and DiseasesAlkaline Phosphatase Research StudiesBone and Dental Protein Studies

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Buried alive: How osteoblasts become osteocytes

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Franz‐Odendaal, Tamara A., Hall, Brian K., Witten, P. Eckhard·2006·Developmental Dynamics

DOI 10.1002/dvdy.20603

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Abstract

During osteogenesis, osteoblasts lay down osteoid and transform into osteocytes embedded in mineralized bone matrix. Despite the fact that osteocytes are the most abundant cellular component of bone, little is known about the process of osteoblast‐to‐osteocyte transformation. What is known is that osteoblasts undergo a number of changes during this transformation, yet retain their connections to preosteoblasts and osteocytes. This review explores the osteoblast‐to‐osteocyte transformation during intramembranous ossification from both morphological and molecular perspectives. We investigate how these data support five schemes that describe how an osteoblast could become entrapped in the bone matrix (in mammals) and suggest one of the five scenarios that best fits as a model. Those osteoblasts on the bone surface that are destined for burial and destined to become osteocytes slow down matrix production compared to neighbouring osteoblasts, which continue to produce bone matrix. That is, cells that continue to produce matrix actively bury cells producing less or no new bone matrix (passive burial). We summarize which morphological and molecular changes could be used as characters (or markers) to follow the transformation process. Developmental Dynamics 235:176–190, 2006. © 2005 Wiley‐Liss, Inc.

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Authors: Franz‐Odendaal, T. A., Hall, B. K., & Witten, P. E.
Affiliations: Dalhousie University (CA)
Corresponding author: Franz‐Odendaal, Tamara A.
Witten, P. Eckhard
ORCID: Franz‐Odendaal, Tamara A.
Hall, Brian K.
Witten, P. Eckhard
Venue: Developmental Dynamics
Publisher: Wiley
Published: 2005-10-28
Volume: 235
Issue: 1
Pages: 176-190
ISSN: 1058-8388 (ISSN-L)
1097-0177
DOI: 10.1002/dvdy.20603
OpenAlex: W2032394856
Cited by: 795
References: 165
Citations by year: 2026: 25 · 2025: 29 · 2024: 30 · 2023: 48 · 2022: 41 · 2021: 68 · 2020: 55 · 2019: 58 · 2018: 38 · 2017: 53 · 2016: 38 · 2015: 45 · 2014: 33 · 2013: 48 · 2012: 41
FWCI: 1.56
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Developmental Dynamics (publishedVersion)
PubMed (publishedVersion)
Ghent University Academic Bibliography (Ghent University) (publishedVersion)
Ghent University Academic Bibliography (Ghent University) (submittedVersion)
Funders: Deutsche Forschungsgemeinschaft
Natural Sciences and Engineering Research Council of Canada
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Alkaline Phosphatase Research Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Bone and Dental Protein Studies
Keywords: osteocytes, osteoblasts, intramembranous ossification, bone formation, bone matrix mineralization, osteoblast markers
MeSH terms: Animals, Bone and Bones, Cell Differentiation, Humans, Models, Biological, Osteoblasts, Osteocytes, Osteogenesis

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