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Buried alive: How osteoblasts become osteocytes
Open accessAbstract
During osteogenesis, osteoblasts lay down osteoid and transform into osteocytes embedded in mineralized bone matrix. Despite the fact that osteocytes are the most abundant cellular component of bone, little is known about the process of osteoblast‐to‐osteocyte transformation. What is known is that osteoblasts undergo a number of changes during this transformation, yet retain their connections to preosteoblasts and osteocytes. This review explores the osteoblast‐to‐osteocyte transformation during intramembranous ossification from both morphological and molecular perspectives. We investigate how these data support five schemes that describe how an osteoblast could become entrapped in the bone matrix (in mammals) and suggest one of the five scenarios that best fits as a model. Those osteoblasts on the bone surface that are destined for burial and destined to become osteocytes slow down matrix production compared to neighbouring osteoblasts, which continue to produce bone matrix. That is, cells that continue to produce matrix actively bury cells producing less or no new bone matrix (passive burial). We summarize which morphological and molecular changes could be used as characters (or markers) to follow the transformation process. Developmental Dynamics 235:176–190, 2006. © 2005 Wiley‐Liss, Inc.
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“Osteocytes, which comprise 90–95% of the total bone cells, are the most abundant and long-lived cells, with a lifespan of up to 25 years [54].”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [54]
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“In this process, four recognizable stages have been proposed: osteoid-osteocyte, preosteocyte, young osteocyte, and mature osteocyte [54].”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [54]
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Metadata
- Authors
- Franz‐Odendaal, T. A., Hall, B. K., & Witten, P. E.
- Affiliations
- Dalhousie University (CA)
- Corresponding author
- Franz‐Odendaal, Tamara A.
- Witten, P. Eckhard
- Venue
- Developmental Dynamics
- Publisher
- Wiley
- Published
- 2005-10-28
- Volume
- 235
- Issue
- 1
- Pages
- 176-190
- ISSN
- 1058-8388 (ISSN-L)
- 1097-0177
- OpenAlex
- W2032394856
- Cited by
- 795
- References
- 165
- Citations by year
- 2026: 25 · 2025: 29 · 2024: 30 · 2023: 48 · 2022: 41 · 2021: 68 · 2020: 55 · 2019: 58 · 2018: 38 · 2017: 53 · 2016: 38 · 2015: 45 · 2014: 33 · 2013: 48 · 2012: 41
- FWCI
- 1.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Developmental Dynamics (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Natural Sciences and Engineering Research Council of Canada
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Alkaline Phosphatase Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Bone and Dental Protein Studies
- Keywords
- osteocytes, osteoblasts, intramembranous ossification, bone formation, bone matrix mineralization, osteoblast markers
- MeSH terms
- Animals, Bone and Bones, Cell Differentiation, Humans, Models, Biological, Osteoblasts, Osteocytes, Osteogenesis
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