Cited by 795Bone Metabolism and DiseasesAlkaline Phosphatase Research StudiesBone and Dental Protein Studies

The DOI matches its Crossref record; 164 of the 165 references it cites were found in a registry or an index.

Buried alive: How osteoblasts become osteocytes

Open access

Franz‐Odendaal, Tamara A., Hall, Brian K., Witten, P. Eckhard·2006·Developmental Dynamics

DOI 10.1002/dvdy.20603

Open this paper in CoChat — free account Open PDF

Abstract

During osteogenesis, osteoblasts lay down osteoid and transform into osteocytes embedded in mineralized bone matrix. Despite the fact that osteocytes are the most abundant cellular component of bone, little is known about the process of osteoblast‐to‐osteocyte transformation. What is known is that osteoblasts undergo a number of changes during this transformation, yet retain their connections to preosteoblasts and osteocytes. This review explores the osteoblast‐to‐osteocyte transformation during intramembranous ossification from both morphological and molecular perspectives. We investigate how these data support five schemes that describe how an osteoblast could become entrapped in the bone matrix (in mammals) and suggest one of the five scenarios that best fits as a model. Those osteoblasts on the bone surface that are destined for burial and destined to become osteocytes slow down matrix production compared to neighbouring osteoblasts, which continue to produce bone matrix. That is, cells that continue to produce matrix actively bury cells producing less or no new bone matrix (passive burial). We summarize which morphological and molecular changes could be used as characters (or markers) to follow the transformation process. Developmental Dynamics 235:176–190, 2006. © 2005 Wiley‐Liss, Inc.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1002/dvdy.20603

Cites

164 of 164 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.
Lacey, D. L., Timms, E., Tan, H.-L., Kelley, M. J., Dunstan, C. R., Burgess, T., Elliott, R., Colombero, A., Elliott, G., Scully, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81569-x · Cited by 5,439
Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation
Ducy, P., Zhang, R., Geoffroy, V., Ridall, A. L., & Karsenty, G. (1997) · Cell · doi:10.1016/s0092-8674(00)80257-3 · Cited by 4,246
Cbfa1, a Candidate Gene for Cleidocranial Dysplasia Syndrome, Is Essential for Osteoblast Differentiation and Bone Development
Otto, F., Thornell, A., Crompton, T., Denzel, A., Gilmour, K. C., Rosewell, I. R., Stamp, G., Beddington, R. S. P., Mundlos, S., Olsen, B. R., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80259-7 · Cited by 2,813
Birth and Death of Bone Cells: Basic Regulatory Mechanisms and Implications for the Pathogenesis and Treatment of Osteoporosis
Manolagas, S. C. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.2.0395 · Cited by 2,639
A Textbook of Histology
Bloom, W., & Fawcett, D. W. (1962) · Cited by 2,210
Handbuch der Mikroskopischen Anatomie des Menschen
Möllendorff, W. V., & Bargmann, W. (1958) · Springer eBooks · doi:10.1007/978-3-662-30619-2 · Cited by 1,515
Principles of Bone Biology
Compston, J. E. (1997) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1997.2431019.x · Cited by 1,383
Birth and Death of Bone Cells: Basic Regulatory Mechanisms and Implications for the Pathogenesis and Treatment of Osteoporosis
Manolagas, S. C. (2000) · Endocrine Reviews · doi:10.1210/er.21.2.115 · Cited by 1,318
Identity of Osteoclastogenesis Inhibitory Factor (OCIF) and Osteoprotegerin (OPG): A Mechanism by which OPG/OCIF Inhibits Osteoclastogenesis in Vitro1
Yasuda, H., Shima, N., Nakagawa, N., Mochizuki, S.-I., Yano, K., Fujise, N., Sato, Y., Goto, M., Yamaguchi, K., Kuriyama, M., et al. (1998) · Endocrinology · doi:10.1210/endo.139.3.5837 · Cited by 1,201
The Osteoblast: A Sophisticated Fibroblast under Central Surveillance
Ducy, P. F., Schinke, T., & Karsenty, G. (2000) · Science · doi:10.1126/science.289.5484.1501 · Cited by 1,137
Osteocyte control of bone formation via sclerostin, a novel BMP antagonist
Winkler, D. G., Sutherland, M. K., Geoghegan, J. C., Yu, C., Hayes, T., Skonier, J. E., Shpektor, D., Jonas, M., Kovacevich, B. R., Staehling‐Hampton, K., et al. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg599 · Cited by 1,114
Molecular Mechanisms Mediating Proliferation/Differentiation Interrelationships During Progressive Development of the Osteoblast Phenotype
Stein, G. S., & Lian, J. B. (1993) · Endocrine Reviews · doi:10.1210/edrv-14-4-424 · Cited by 1,058
The vertebrate body
Romer, A. S. (1971) · Andalas University Repository (Andalas University) · Cited by 981
Identification and Characterization of a Novel Protein, Periostin, with Restricted Expression to Periosteum and Periodontal Ligament and Increased Expression by Transforming Growth Factor β
Horiuchi, K., Amizuka, N., Takeshita, S., Takamatsu, H., Katsuura, M., Ozawa, H., Toyama, Y., Bonewald, L. F., & Kudō, A. (1999) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1999.14.7.1239 · Cited by 975
Chemistry and Biology of Mineralized Tissues
(2008) · KARGER eBooks · doi:10.1159/isbn.978-3-8055-8625-2 · Cited by 912
Glucocorticoids Act Directly on Osteoblasts and Osteocytes to Induce Their Apoptosis and Reduce Bone Formation and Strength
O’Brien, C. A., Jia, D., Plotkin, L. I., Bellido, T., Powers, C. C., Stewart, S. A., Manolagas, S. C., & Weinstein, R. S. (2003) · Endocrinology · doi:10.1210/en.2003-0990 · Cited by 771
Expression and localization of the two small proteoglycans biglycan and decorin in developing human skeletal and non-skeletal tissues.
Bianco, P., Fisher, L. W., Young, M. F., Termine, J. D., & Robey, P. G. (1990) · Journal of Histochemistry & Cytochemistry · doi:10.1177/38.11.2212616 · Cited by 667
Osteoblast Programmed Cell Death (Apoptosis): Modulation by Growth Factors and Cytokines
Jilka, R. L., Weinstein, R. S., Bellido, T., Parfitt, A. M., & Manolagas, S. C. (1998) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1998.13.5.793 · Cited by 578 · cited 2×
“…(2) transform into inactive osteoblasts and become bone-lining cells, (3) undergo programmed cell death (apoptosis), or in some situations (4) transdifferentiate into cells that deposit chondroid or chondroid bone (Manolagas, 2000; Noble et al., 1997; Jilka et al., 1998; Li et al., 2004).”
Background
Osteoblasts synthesize and respond to transforming growth factor-type beta (TGF-beta) in vitro.
Robey, P. G., Young, M. F., Flanders, K. C., Roche, N. S., Kondaiah, P., Reddi, A. H., Termine, J. D., Sporn, M. B., & Roberts, A. B. (1987) · The Journal of Cell Biology · doi:10.1083/jcb.105.1.457 · Cited by 550
Cartilage-inducing factor-A. Apparent identity to transforming growth factor-beta.
Seyedin, S. M., Thompson, A. Y., Bentz, H., Rosen, D. M., McPherson, J. M., Conti, A., Siegel, N. R., Galluppi, G. R., & Piez, K. A. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)38436-3 · Cited by 521
High Bone Mass in Mice Expressing a Mutant LRP5 Gene
Babij, P., Zhao, W., Small, C. G., Kharode, Y. P., Yaworsky, P. J., Bouxsein, M., Reddy, P. S., Bodine, P. V. N., Robinson, J. A., Bhat, B. M., et al. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.6.960 · Cited by 496
Osteocytes, strain detection, bone modeling and remodeling
Lanyon, L. E. (1993) · Calcified Tissue International · doi:10.1007/bf01673415 · Cited by 439
The many adaptations of bone
Currey, J. D. (2003) · Journal of Biomechanics · doi:10.1016/s0021-9290(03)00124-6 · Cited by 439
Transcriptional mechanisms in osteoblast differentiation and bone formation
Nakashima, K., & Crombrugghe, B. D. (2003) · Trends in Genetics · doi:10.1016/s0168-9525(03)00176-8 · Cited by 433
Mean wall thickness of trabecular bone packets in the human iliac crest: Changes with age
Lips, P. T. A. M., Courpron, P., & Meunier, P. J. (1978) · Calcified Tissue International · doi:10.1007/bf02013227 · Cited by 414
Leptin stimulates human osteoblastic cell proliferation, de novo collagen synthesis, and mineralization: Impact on differentiation markers, apoptosis, and osteoclastic signaling
Gordeladze, J. O., Drevon, C. A., Syversen, U., & Reseland, J. E. (2002) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10156 · Cited by 411
Function of osteocytes in bone
Aarden, E. M., Nijweide, P. J., & Burger, E. H. (1994) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240550304 · Cited by 410
Divide, accumulate, differentiate: cell condensation in skeletal development revisited
Hall, B. K., & Miyake, T. (1995) · The International Journal of Developmental Biology · doi:10.1387/ijdb.8901191 · Cited by 388
Self-citation
Bones and cartilage : developmental and evolutionary skeletal biology
Hall, B. (2015) · Choice Reviews Online · doi:10.5860/choice.43-4649 · Cited by 381
Bone matrix RGD glycoproteins: Immunolocalization and interaction with human primary osteoblastic bone cells in vitro
Grzesik, W. J., & Robey, P. G. (1994) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650090408 · Cited by 369
Cellular expression of bone‐related proteins during in vitro osteogenesis in rat bone marrow stromal cell cultures
Malaval, L., Modrowski, D., Gupta, A., & Aubin, J. E. (1994) · Journal of Cellular Physiology · doi:10.1002/jcp.1041580322 · Cited by 369
Nitric Oxide Synthase Expression in Bone Cells
Fox, S. W., & Chow, J. W. M. (1998) · Bone · doi:10.1016/s8756-3282(98)00070-2 · Cited by 320
WHY DOES BONE MATRIX CONTAIN NON‐COLLAGENOUS PROTEINS? THE POSSIBLE ROLES OF OSTEOCALCIN, OSTEONECTIN, OSTEOPONTIN AND BONE SIALOPROTEIN IN BONE MINERALISATION AND RESORPTION
Roach, H. I. (1994) · Cell Biology International · doi:10.1006/cbir.1994.1088 · Cited by 311
The osteocyte
Tate, M. L. K., Adamson, J., Tami, A., & Bauer, T. W. (2003) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(03)00241-3 · Cited by 310
CELL PROLIFERATION AND SPECIALIZATION DURING ENDOCHONDRAL OSTEOGENESIS IN YOUNG RATS
Young, R. W. (1962) · The Journal of Cell Biology · doi:10.1083/jcb.14.3.357 · Cited by 308
Characterization and cloning of the E11 antigen, a marker expressed by Rat Osteoblasts and Osteocytes
Wetterwald, A., Hofstetter, W., Cecchini, M. G., Lanske, B., Wagner, C., Fleisch, H. A., & Atkinson, M. J. (1996) · Bone · doi:10.1016/8756-3282(95)00457-2 · Cited by 303
CELL DIVISION IN ENDOCHONDRAL OSSIFICATION
Kember, N. F. (1960) · Journal of Bone and Joint Surgery - British Volume · doi:10.1302/0301-620x.42b4.824 · Cited by 270
THE FINE STRUCTURE OF BONE CELLS
Dudley, H. R., & Spiro, D. (1961) · The Journal of Cell Biology · doi:10.1083/jcb.11.3.627 · Cited by 264
Cellular and Molecular Biology of Bone
(1993) · Elsevier eBooks · doi:10.1016/c2009-0-02411-8 · Cited by 253
Bone microstructure and developmental plasticity in birds and other dinosaurs
Starck, J. M., & Chinsamy, A. (2002) · Journal of Morphology · doi:10.1002/jmor.10029 · Cited by 252
Major transitions in vertebrate evolution
(2008) · Choice Reviews Online · doi:10.5860/choice.45-4992 · Cited by 239
BONE REMODELLING DYNAMICS
Frost, H. M., & STRAATSMA, C. R. (1964) · Plastic & Reconstructive Surgery · doi:10.1097/00006534-196402000-00013 · Cited by 236
Mean wall thickness and formation periods of trabecular bone packets in corticosteroid-induced osteoporosis
Dempster, D. W., ARLOT, M. E., & Meunier, P. J. (1983) · Calcified Tissue International · doi:10.1007/bf02405069 · Cited by 236
Strain-derived canalicular fluid flow regulates osteoclast activity in a remodelling osteon—a proposal
Burger, E. H., Klein‐Nulend, J., & Smit, T. H. (2003) · Journal of Biomechanics · doi:10.1016/s0021-9290(03)00126-x · Cited by 236
Sox2 induction by FGF and FGFR2 activating mutations inhibits Wnt signaling and osteoblast differentiation
Mansukhani, A., Ambrosetti, D. C., Holmes, G., Cornivelli, L., & Basilico, C. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200409182 · Cited by 234
Identification of apoptotic changes in osteocytes in normal and pathological human bone
Noble, B. S., Stevens, H., Loveridge, N., & Reeve, J. (1997) · Bone · doi:10.1016/s8756-3282(96)00365-1 · Cited by 230
A gain-of-function mutation of Fgfr2c demonstrates the roles of this receptor variant in osteogenesis
Eswarakumar, V. P., Horowitz, M. C., Locklin, R. M., Morriss‐Kay, G. M., & Lonai, P. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405031101 · Cited by 224
Dentin matrix protein 1 expression during osteoblastic differentiation, generation of an osteocyte GFP-transgene
Kalajzić, I., Braut, A., Guo, D., Jiang, X., Kronenberg, M. S., Mina, M., Harris, M. A., Harris, S. E., & Rowe, D. W. (2004) · Bone · doi:10.1016/j.bone.2004.03.006 · Cited by 220
The Skeletal Tissues
Jee, W. S. S. (1983) · doi:10.1007/978-1-349-06859-3_6 · Cited by 218
Differentiation of osteoblasts and formation of mineralized bone in vitro
Tenenbaum, H. C., & Heersche, J. N. M. (1982) · Calcified Tissue International · doi:10.1007/bf02411212 · Cited by 217
Developmental expression of 44-kDa bone phosphoprotein (osteopontin) and bone γ-carboxyglutamic acid (Gla)-containing protein (osteocalcin) in calcifying tissues of rat
Mark, M. P., Butler, W. T., Prince, C. W., Finkelman, R. D., & Ruch, J. (1988) · Differentiation · doi:10.1111/j.1432-0436.1988.tb00804.x · Cited by 216
Matrix Proteins and Mineralization: An Overview
Boskey, A. L. (1996) · Connective Tissue Research · doi:10.3109/03008209609029212 · Cited by 216
Establishment of an Osteoid Preosteocyte-like Cell MLO-A5 That Spontaneously Mineralizes in Culture
Kato, Y., Boskey, A. L., Spevak, L., Dallas, M., Hori, M., & Bonewald, L. F. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.9.1622 · Cited by 207
Developmental Expression of Osteopontin (OPN) mRNA in Rat Tissues: Evidence for a Role for OPN in Bone Formation and Resorption
Chen, J., Singh, K., Mukherjee, B. B., & Sodek, J. (1993) · Matrix · doi:10.1016/s0934-8832(11)80070-3 · Cited by 205
In Vivo Osteocyte Death
Frost, H. M. (1960) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-196042010-00011 · Cited by 193
CELL POPULATION KINETICS OF AN OSTEOGENIC TISSUE · I
Owen, M. E. (1963) · The Journal of Cell Biology · doi:10.1083/jcb.19.1.19 · Cited by 191
The structure of bone tissues and the cellular control of their deposition.
Marotti, G. (1997) · PubMed · Cited by 185
Features of mono‐ and multinucleated bone resorbing cells of the zebrafish Danio rerio and their contribution to skeletal development, remodeling, and growth
Witten, P. E., Hansen, A., & Hall, B. K. (2001) · Journal of Morphology · doi:10.1002/jmor.1065 · Cited by 180
Self-citation
The Loss of Smad3 Results in a Lower Rate of Bone Formation and Osteopenia Through Dysregulation of Osteoblast Differentiation and Apoptosis
Borton, A. J., Frederick, J. P., Datto, M., Wang, X.-F., & Weinstein, R. S. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.10.1754 · Cited by 179
Expression and function of periostin‐isoforms in bone
Litvin, J., Selim, A., Montgomery, M. O., Lehmann, K., Rico, M. C., Devlin, H., Bednarik, D. P., & Safadi, F. F. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20115 · Cited by 178
Enhanced expression of type I receptors for bone morphogenetic proteins during bone formation
Ishidou, Y., Kitajima, I., Obama, H., Maruyama, I., Murata, F., Imamura, T., Yamada, N., ten Dijke, P., Miyazono, K., & Sakou, T. (1995) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650101107 · Cited by 172
Positive and negative immunoselection for enrichment of two classes of osteoprogenitor cells.
Turksen, K., & Aubin, J. E. (1991) · The Journal of Cell Biology · doi:10.1083/jcb.114.2.373 · Cited by 170
Minireview: Transcriptional Regulation in Development of Bone
Kobayashi, T., & Kronenberg, H. M. (2004) · Endocrinology · doi:10.1210/en.2004-1343 · Cited by 164
In VivoDistribution of Parathyroid Hormone Receptors in Bone: Evidence that a Predominant Osseous Target Cell Is Not the Mature Osteoblast*
Rouleau, M. F., Mitchell, J., & Goltzman, D. (1988) · Endocrinology · doi:10.1210/endo-123-1-187 · Cited by 159
Chondroid bone, secondary cartilage, and metaplasia
Beresford, W. A. (1981) · Medical Entomology and Zoology · Cited by 156
In situ hybridization of bone matrix proteins in undecalcified adult rat bone sections.
Ikeda, T., Nomura, S., Yamaguchi, A., Suda, T., & Yoshiki, S. (1992) · Journal of Histochemistry & Cytochemistry · doi:10.1177/40.8.1619274 · Cited by 154
Osteocyte Differentiation in the Tibia of Newborn Rabbit: An Ultrastructural Study of the Formation of Cytoplasmic Processes
Palumbo, C., Palazzini, S., Zaffe, D., & Marotti, G. (1990) · Cells Tissues Organs · doi:10.1159/000146907 · Cited by 151
Compressed vertebrae in Atlantic salmon Salmo salar: evidence for metaplastic chondrogenesis as a skeletogenic response late in ontogeny
Witten, P. E., Gil-Martens, L., Hall, B. K., Huysseune, A., & Obach, A. (2005) · Diseases of Aquatic Organisms · doi:10.3354/dao064237 · Cited by 150
Self-citation
OSTEOBLASTIC CELL LINEAGE
Aubin, J. E., Turksen, K., & Heersche, J. N. M. (1993) · Elsevier eBooks · doi:10.1016/b978-0-08-092500-4.50005-x · Cited by 149
Molecular ontogeny of the skeleton
Eames, B. F., Fuente, L. D. L., & Helms, J. A. (2003) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.10016 · Cited by 148
Chondroid Bone, Secondary Cartilage and Metaplasia
Bcresford, W. A. (1981) · The American Journal of Surgical Pathology · doi:10.1097/00000478-198106000-00012 · Cited by 147
A three-dimensional ultrastructural study of osteoid-osteocytes in the tibia of chick embryos
Palumbo, C. (1986) · Cell and Tissue Research · doi:10.1007/bf00219008 · Cited by 142
Seasonal changes in the lower jaw skeleton in male Atlantic salmon (Salmo salar L.): remodelling and regression of the kype after spawning
Witten, P. E., & Hall, B. K. (2003) · Journal of Anatomy · doi:10.1046/j.1469-7580.2003.00239.x · Cited by 140
Self-citation
The accumulation of whole body skeletal mass in third- and fourth-grade children: Effects of age, gender, ethnicity, and body composition
Nelson, D. A., Simpson, P. M., Johnson, C. C., Barondess, D. A., & Kleerekoper, M. (1997) · Bone · doi:10.1016/s8756-3282(96)00312-2 · Cited by 138
Trans-differentiation of hypertrophic chondrocytes into cells capable of producing a mineralized bone matrix
Roach, H. I. (1992) · Bone and Mineral · doi:10.1016/0169-6009(92)90840-a · Cited by 136
Mean wall thickness and formation periods of trabecular bone packets in idiopathic osteoporosis
Darby, A. J., & Meunier, P. J. (1981) · Calcified Tissue International · doi:10.1007/bf02409438 · Cited by 136
Submicroscopic structure and functional aspects of the osteocyte.
BAUD, C. A. (1968) · PubMed · Cited by 135
Cellular patterns of insulin-like growth factor system gene expression in murine chondrogenesis and osteogenesis
Wang, E., Wang, J., Chin, E. W. M., Zhou, J., & Bondy, C. A. (1995) · Endocrinology · doi:10.1210/endo.136.6.7750499 · Cited by 135
CD44 expression in human bone: A novel marker of osteocytic differentiation
Hughes, D. E., Salter, D. M., & Simpson, R. J. (1994) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650090106 · Cited by 134
Osteocytic osteolysis observed in rats to which parathyroid hormone was continuously administered
Tazawa, K., Hoshi, K., Kawamoto, S., Tanaka, M., Ejiri, S., & Ozawa, H. (2004) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-004-0519-x · Cited by 124
Immunohistochemical distribution of collagens types IV, V, and VI and of pro-collagens types I and III in human alveolar bone and dentine.
Becker, J. C., Schuppan, D., Benzian, H., Bals, T., Hahn, E. G., Cantaluppi, C., & Reichart, P. A. (1986) · Journal of Histochemistry & Cytochemistry · doi:10.1177/34.11.3772076 · Cited by 121
The development of the periodontium: The origin of alveolar bone
Tencate, A. R., & Mills, C. (1972) · The Anatomical Record · doi:10.1002/ar.1091730106 · Cited by 120
Relationships between cellular condensation, preosteoblast formation and epithelial-mesenchymal interactions in initiation of osteogenesis
Dunlop, L.-L. T., & Hall, B. K. (1995) · The International Journal of Developmental Biology · doi:10.1387/ijdb.7545414 · Cited by 118
Self-citation
Matrix extracellular phosphoglycoprotein (MEPE) is highly expressed in osteocytes in human bone
Yamada, T., Matsukawa, N., Matsumoto, M., Morimoto, S., Ogihara, T., Ochi, T., Yoshikawa, H., Nampei, A., Hashimoto, J., Hayashida, K., et al. (2004) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-003-0468-9 · Cited by 116
The Mature Osteoblast Phenotype Is Characterized by Extensive Plasticity
Liu, F., Malaval, L., & Aubin, J. E. (1997) · Experimental Cell Research · doi:10.1006/excr.1997.3501 · Cited by 115
Bone sialoprotein (BSP) secretion and osteoblast differentiation: relationship to bromodeoxyuridine incorporation, alkaline phosphatase, and matrix deposition.
Bianco, P., Riminucci, M., BONUCCI, E., Termine, J. D., & Robey, P. G. (1993) · Journal of Histochemistry & Cytochemistry · doi:10.1177/41.2.8419458 · Cited by 113
Localization of the expression of types I, III, and IV collagen, TGF-β1 and c-fos genes in developing human calvarial bones
Sandberg, M., Autio‐Harmainen, H., & VUORIO, E. I. (1988) · Developmental Biology · doi:10.1016/0012-1606(88)90438-1 · Cited by 112
Expression of mRNA for IL1 beta, IL6 and TGF beta 1 in developing human bone and cartilage.
Dodds, R. A., Merry, K., Littlewood, A. J., & Gowen, M. (1994) · Journal of Histochemistry & Cytochemistry · doi:10.1177/42.6.8189035 · Cited by 110
Structure-function relationships in the osteocyte.
Marotti, G., Canè, V., Palazzini, S., & Palumbo, C. (1990) · IRIS UNIMORE (University of Modena and Reggio Emilia) · Cited by 108
Cbfa1 in bone development
Komori, T., & Kishimoto, T. (1998) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(98)80123-8 · Cited by 107
Osteoblasts and osteoclasts in adult human osteophyte tissue express the mRNAs for insulin-like growth factors I and II and the type 1 IGF receptor
Middleton, J., Arnott, N., Walsh, S., & Beresford, J. N. (1995) · Bone · doi:10.1016/8756-3282(94)00040-9 · Cited by 104
Enzyme histochemical characteristics of osteoblasts and mononucleated osteoclasts in a teleost fish with acellular bone ( Oreochromis niloticus , Cichlidae)
Witten, P. E. (1997) · Cell and Tissue Research · doi:10.1007/s004410050782 · Cited by 103
Self-citation
Chemistry and Biology of Mineralized Tissues
Landis, W. J. (2005) · Cited by 100
Bone histomorphometry
Gallagher, P. (1995) · Annals of the Rheumatic Diseases · doi:10.1136/ard.54.1.24 · Cited by 100
Characterization of endosteal bone‐lining cells from fatty marrow bone sites in adult beagles
Miller, S. C., Bowman, B. M., Smith, J. M., & Jee, W. S. S. (1980) · The Anatomical Record · doi:10.1002/ar.1091980204 · Cited by 98
In situ hybridization studies suggest a role for the basic region‐leucine zipper protein hXBP‐1 in exocrine gland and skeletal development during mouse embryogenesis
CLAUSS, I. M., Gravallese, E. M., Darling, J. M., Shapiro, F. E., Glimcher, M. J., & Glimcher, L. H. (1993) · Developmental Dynamics · doi:10.1002/aja.1001970207 · Cited by 97
Biochemical and histological studies on various bone cell preparations
Nijweide, P. J., van der Plas, A., & Scherft, J. P. (1981) · Calcified Tissue International · doi:10.1007/bf02409485 · Cited by 96
In situ localization of PTH/PTHrP receptor mRNA in the bone of fetal and young rats
Lee, K., Deeds, J. D., Bond, A., Jüppner, H., Abou‐Samra, A., & Segre, G. V. (1993) · Bone · doi:10.1016/8756-3282(93)90162-4 · Cited by 94
Individual osteoblasts in the developing calvaria express different gene repertoires
Candeliere, G. A., Liu, F., & Aubin, J. E. (2001) · Bone · doi:10.1016/s8756-3282(01)00410-0 · Cited by 94
Annual skeletal changes in the little brown bat, Myotis lucifugus lucifugus, with particular reference to pregnancy and lactation
Kwiecinski, G. G., Krook, L., & Wimsatt, W. A. (1987) · American Journal of Anatomy · doi:10.1002/aja.1001780410 · Cited by 92
A role for cadherins in cellular signaling and differentiation
Knudsen, K. A., Frankowski, C., Johnson, K. R., & Wheelock, M. J. (1998) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(1998)72:30/31+ · Cited by 88
Matrix Metalloproteinases (MMPs) Safeguard Osteoblasts from Apoptosis during Transdifferentiation into Osteocytes: MT1-MMP Maintains Osteocyte Viability
Karsdal, M. A., Andersen, T., Bonewald, L. F., & Christiansen, C. (2004) · DNA and Cell Biology · doi:10.1089/104454904322964751 · Cited by 85
Submicroscopic Structure and Functional Aspects of the Osteocyte*
BAUD, C. A. (1968) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-196801000-00025 · Cited by 81
Differentiation and growth of kype skeletal tissues in anadromous male Atlantic salmon (Salmo salar)
Witten, P. E., & Hall, B. K. (2002) · The International Journal of Developmental Biology · doi:10.1387/ijdb.12216984 · Cited by 79
Self-citation
Immunocytochemical demonstration of extracellular matrix proteins in isolated osteocytes
Aarden, E. M., Wassenaar, A. M., Alblas, M. J., & Nijweide, P. J. (1996) · Histochemistry and Cell Biology · doi:10.1007/bf02473312 · Cited by 78
Immunolocalization of collagen types I and III, tenascin, and fibronectin in intramembranous bone.
Carter, D. H., Sloan, P., & Aaron, J. E. (1991) · Journal of Histochemistry & Cytochemistry · doi:10.1177/39.5.1707904 · Cited by 78
Regional variation of insulin-like growth factor-I gene expression in mature rat bone and cartilage
Lazowski, D.-A., Fraher, L. J., Hodsman, A. B., Steer, B. M., Modrowski, D., & Han, V. K. M. (1994) · Bone · doi:10.1016/8756-3282(94)90282-8 · Cited by 76
ADP-ribosylation of p53 tumor suppressor protein: Mutant but not wild-type p53 is modified
Węsierska‐Gądek, J., Bugajska-Schretter, A., & Cerni, C. (1996) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(199607)62:1 · Cited by 76
Immunohistochemical localization of osteonectin in developing human and calf bone using monoclonal antibodies
Bianco, P., Silvestrini, G., Termine, J. D., & BONUCCI, E. (1988) · Calcified Tissue International · doi:10.1007/bf02571313 · Cited by 72
Static and dynamic osteogenesis: two different types of bone formation
Ferretti, M., Palumbo, C., Contri, M. B., & Marotti, G. (2002) · Anatomy and Embryology · doi:10.1007/s00429-002-0265-6 · Cited by 72
Modification of Ti6AL4V surfaces using collagen I, III, and fibronectin. II. Influence on osteoblast responses
Bierbaum, S., Hempel, U., Geissler, U., Hanke, T., Scharnweber, D., Wenzel, K. ‐., & Worch, H. (2003) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.10084 · Cited by 71
Ultrastructure of the osteogenesis of acellular vertebral bone in the Japanese medaka, Oryzias latipes (teleostei, cyprinidontidae)
Ekanayake, S., & Hall, B. K. (1988) · American Journal of Anatomy · doi:10.1002/aja.1001820305 · Cited by 69
Self-citation
The Response of Articular Cartilage to the In Vivo Replacement of Synovial Fluid with Saline
JOHNSON, R. G., Herbert, M. A., Wright, S., OFFIERSKI, C. M., KELLAM, J., Goodman, S. B., & Bobechko, W. P. (1983) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-198304000-00038 · Cited by 68
How osteoblasts become osteocytes: a decreasing matrix forming process.
Nefussi, J.-R., Sautier, J., Nicolas, V., & Forest, N. (1991) · PubMed · Cited by 67
Transdifferentiation of hypertrophic chondrocytes into osteoblasts in murine fetal metatarsal bones, induced by co-cultured cerebrum
Thesingh, C. W., Groot, C. G., & Wassenaar, A. M. (1991) · Bone and Mineral · doi:10.1016/0169-6009(91)90119-k · Cited by 67
Extracellular Bone Acidic Glycoprotein-75 Defines Condensed Mesenchyme Regions to be Mineralized and Localizes with Bone Sialoprotein during Intramembranous Bone Formation
Gorski, J. P., Wang, A., Lovitch, D., Law, D., Powell, K. A., & Midura, R. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312408200 · Cited by 67
Histochemical evidence of the initial chondrogenesis and osteogenesis in the periosteum of a rib fractured model: Implications of osteocyte involvement in periosteal chondrogenesis
Li, M., Amizuka, N., Oda, K., Tokunaga, K., Ito, T., Takeuchi, K., Takagi, R., & Maeda, T. (2004) · Microscopy Research and Technique · doi:10.1002/jemt.20088 · Cited by 66
Bones and Cartilage
Hall, B. K. 1. (2015) · Elsevier eBooks · doi:10.1016/c2013-0-00143-0 · Cited by 66
Self-citation
Immunohistochemical investigations on the differentiation marker protein E11 in rat calvaria, calvaria cell culture and the osteoblastic cell line ROS 17/2.8
Schulze, E., Witt, M., Kasper, M., Löwik, C. W. G. M., & Funk, R. H. W. (1999) · Histochemistry and Cell Biology · doi:10.1007/s004180050334 · Cited by 63
Temporal variation of c‐fos proto‐oncogene expression during osteoblast differentiation and osteogenesis in developing rat bone
Machwate, M., Jullienne, A., Moukhtar, M. S., & Marie, P. J. (1995) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240570108 · Cited by 63
The ossification process of the developing antler in the white-tailed deer (Odocoileus virginianus)
Banks, W. J. (1974) · Calcified Tissue International · doi:10.1007/bf02060300 · Cited by 63
The development of acellularity of the vertebral bone of the Japanese medaka, Oryzias latipes (Teleostei; Cyprinidontidae)
Ekanayake, S., & Hall, B. K. (1987) · Journal of Morphology · doi:10.1002/jmor.1051930304 · Cited by 61
Self-citation
Untersuchungen zur vergleichenden anatomie der wirbelthiere,
Gegenbaur, C. (1864) · W. Engelmann eBooks · doi:10.5962/bhl.title.83728 · Cited by 59
In VivoDemonstration of Cell Types in Bone That Harbor Epidermal Growth Factor Receptors*
Martineau‐Doizé, B., Lai, W. H., Warshawsky, H., & Bergeron, J. J. M. (1988) · Endocrinology · doi:10.1210/endo-123-2-841 · Cited by 58
Effects of Hibernation on Interradicular Alveolar Bone
Haller, A. C., & Zimny, M. L. (1977) · Journal of Dental Research · doi:10.1177/00220345770560122601 · Cited by 58
Gonadotropin-Releasing Hormone Stimulates Luteinizing Hormone Secretion By Extracellular Calcium-Dependent and -Independent Mechanisms*
Chang, J. P., Stojilković, S. S., Graeter, J. S., & Catt, K. J. (1988) · Endocrinology · doi:10.1210/endo-123-1-87 · Cited by 54
The effects of cold‐stress, hibernation, and prolonged inactivity on bone dynamics in the golden hamster, Mesocricetus auratus
Steinberg, B., Singh, I., & Mitchell, O. G. (1981) · Journal of Morphology · doi:10.1002/jmor.1051670105 · Cited by 52
Transient Chondrogenic Phase in the Intramembranous Pathway During Normal Skeletal Development
Nah, H., Pacifici, M., Gerstenfeld, L. C., ADAMS, S. L., & Kirsch, T. (2000) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2000.15.3.522 · Cited by 50
Comparison of the distribution patterns of tenascin and alkaline phosphatase in developing teeth, cartilage, and bone of rats and mice
Väkevä, L. H., Mackie, E. J., Kantomaa, T., & Thesleff, I. (1990) · The Anatomical Record · doi:10.1002/ar.1092280111 · Cited by 50
Bone resorption and bone remodelling in juvenile carp, Cyprinus carpio L.
Witten, P. E., Villwock, W., Peters, N., & Hall, B. K. (2000) · Journal of Applied Ichthyology · doi:10.1046/j.1439-0426.2000.00233.x · Cited by 49
Self-citation
Histophysiology of cartilage, bone, and joints
Ham, A. W., & Cormack, D. H. (1979) · Medical Entomology and Zoology · Cited by 48
Age-Related Reduction in Bone Matrix Protein mRNA Expression in Rat Bone Tissues: Application of Histomorphometry to In Situ Hybridization
Ikeda, T., Nagai, Y., Yamaguchi, A., Yokose, S., & Yoshiki, S. (1995) · Bone · doi:10.1016/8756-3282(95)80006-c · Cited by 47
General Histology of Bone
Pritchard, J. J. (1972) · Elsevier eBooks · doi:10.1016/b978-0-12-119201-3.50008-1 · Cited by 47
CD44 Expression in Fetal Rat Bone:In Vivoandin VitroAnalysis
Jamal, H. H., & Aubin, J. E. (1996) · Experimental Cell Research · doi:10.1006/excr.1996.0103 · Cited by 46
Stützgewebe und Skelettsystem
Knese, K.-H. (1979) · Handbuch der mikroskopischen Anatomie des Menschen · doi:10.1007/978-3-662-01148-5 · Cited by 45
Aggrecan core protein is expressed in membranous bone of the chick embryo. Molecular and biomechanical studies of normal and nanomelia embryos.
Wong, M., Lawton, T. A., Goetinck, P. F., Kuhn, J. L., Goldstein, S. A., & Bonadio, J. F. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42806-2 · Cited by 44
Localization of types I, II and X collagen and osteocalcin in intramembranous, endochondral and chondroid bone of rats
Mizoguchi, I., Takahashi, I., Sasano, Y., Kagayama, M., Kuboki, Y., & Mitani, H. (1997) · Anatomy and Embryology · doi:10.1007/s004290050098 · Cited by 44
Paradoxical effect of 1.25 dihydroxycholecalciferol on osteoblastic and osteoclastic activity in the skeleton of the eelAnguilla anguilla L
Lopez, É., Intyre, I. M., Martelly, E., Lallier, F., & Vidal, B. (1980) · Calcified Tissue International · doi:10.1007/bf02408525 · Cited by 43
Secondary chondrocyte-derived Ihh stimulates proliferation of periosteal cells during chick development
Buxton, P., Hall, B. K., Archer, C. W., & Francis‐West, P. H. (2003) · Development · doi:10.1242/dev.00610 · Cited by 41
Self-citation
The E11 osteoblastic lineage marker is differentially expressed during fracture healing
Hadjiargyrou, M., Rightmire, E. P., Ando, T., & Lombardo, F. (2001) · Bone · doi:10.1016/s8756-3282(01)00489-6 · Cited by 40
Immunohistochemical Localization of Type I Collagen, Fibronectin and Tenascin C During Embryonic Osteogenesis in the Dentary of Mandibles and Tibias in Rats
Sasano, Y., Li, H.-C., Zhu, J.-X., Imanaka‐Yoshida, K., Mizoguchi, I., & Kagayama, M. (2000) · The Histochemical Journal · doi:10.1023/a:1026720003564 · Cited by 39
Electron Microscopy of the Early Stages of Osteogenesis
Hancox, N. M., & Boothroyd, B. (1965) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-196500400-00017 · Cited by 38
Structural changes of the periosteocytic area inVipera aspis (L.) (Ophidia, viperidae) bone tissue in various physiological conditions
Alcobendas, M., BAUD, C. A., & Castanet, J. (1991) · Calcified Tissue International · doi:10.1007/bf02555903 · Cited by 38
Differentiative ability of the tibial periosteum from the embryonic chick
Scott‐Savage, P., & Hall, B. K. (1980) · Cells Tissues Organs · doi:10.1159/000145174 · Cited by 37
Self-citation
Mechanisms of chondrogenesis and osteogenesis in fins
Witten, P. E., & Huysseune, A. (2006) · Ghent University Academic Bibliography (Ghent University) · Cited by 37
Self-citation
Long-term organ culture of embryonic chick femora: A system for investigating bone and cartilage formation at an intermediate level of organization
Roach, H. I. (1990) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650050113 · Cited by 35
Histological identification of osteocytes in the allegedly acellular bone of the sea breams Acanthopagrus australis, Pagrus auratus and Rhabdosargus sarba (Sparidae, Perciformes, Teleostei)
Hughes, D. R., Bassett, J. R., & Moffat, L. (1994) · Anatomy and Embryology · doi:10.1007/bf00193413 · Cited by 35
Ectopic ossicles associated with metacercariae of Apophallus brevis (Trematoda) in yellow perch, Perca ftavescens (Teleostei): development and identification of hone and chondroid bone
Taylor, L. H., Hall, B. K., Miyake, T., & Cone, D. K. (1994) · Anatomy and Embryology · doi:10.1007/bf00185844 · Cited by 35
Self-citation
Changes in expression of alpha 1 type 1 collagen and osteocalcin mRNA in osteoblasts and odontoblasts at different stages of maturity as shown by in situ hybridization.
Heersche, J. N. M., Reimers, S., Wrana, J. L., Waye, M. M. Y., & Gupta, A. (1992) · PubMed · Cited by 35
Gene expression and immunohistochemical localization of decorin and biglycan in association with early bone formation in the developing mandible.
Kamiya, N., Shigemasa, K., & Takagi, M. (2001) · Journal of Oral Science · doi:10.2334/josnusd.43.179 · Cited by 34
Development of the chick olfactory nerve
Vermeer, P. D., & Silverman, A. (1999) · Developmental Dynamics · doi:10.1002/(sici)1097-0177(199904)214:4 · Cited by 33
Temporal and spatial patterns of cbfal expression during embryonic development in the teleost, Oryzias latipes
Inohaya, K., & Kudō, A. (2000) · Development Genes and Evolution · doi:10.1007/s004270000094 · Cited by 32
Lifetime of the osteoblast in mouse periodontium
McCulloch, C., & Heersche, J. N. M. (1988) · The Anatomical Record · doi:10.1002/ar.1092220204 · Cited by 32
Age, time since menopause, and body parameters as determinants of female spinal bone mass: A mathematical model
Trevisan, C. L., Ortolani, S., Bianchi, M. L., Caraceni, M. P., Ulivieri, F. M., Gandolini, G., & Polli, E. E. (1991) · Calcified Tissue International · doi:10.1007/bf02555894 · Cited by 30
Activation of osteoclasts and the repopulation of bone surfaces following hibernation in the bat, Myotis lucifugus
Doty, S. B., & Nunez, E. A. (1985) · The Anatomical Record · doi:10.1002/ar.1092130403 · Cited by 28
The Ratio of Osteocytic Incorporation to Bone Matrix Formation in Femoral Neck Cancellous Bone: An Enhanced Osteoblast Work Rate in the Vicinity of Hip Osteoarthritis
Jordan, G. R., Loveridge, N., Power, J., Clarke, M., Parker, M. J., & REEVE, J. (2003) · Calcified Tissue International · doi:10.1007/s00223-001-2134-3 · Cited by 26
Immunoelectron microscopy of osteonectin and type I collagen in osteoblasts and bone matrix
Romanowski, R. R., Jundt, G., Termine, J. D., von der Mark, K., & Schulz, A. (1990) · Calcified Tissue International · doi:10.1007/bf02554964 · Cited by 20
Acellular teleost bone: primitive or derived, dead or alive?
Witten, P. E., Huysseune, A., Franz‐Odendaal, T. A., Fedak, T. J., Vickaryous, M. K., Cole, A., & Hall, B. K. (2004) · Ghent University Academic Bibliography (Ghent University) · Cited by 16
Self-citation
Carpus und Tarsus
Dollo, L. (1929) · Development Genes and Evolution · doi:10.1007/bf02109665 · Cited by 13
Acellular teleost bone : dead or alive, primitive or derived?
Witten, P. E., Huysseune, A., Franz‐Odendaal, T. A., Fedak, T. J., Vickaryous, M. K., Cole, A. G., & Hall, B. K. (2004) · Ghent University Academic Bibliography (Ghent University) · Cited by 6
Self-citation
Stress-relaxation plates and the remodeling of callus and cortex under the plate in rabbits
张先龙, 鲍琨, & 戴尅戎 (2000) · 中华医学杂志：英文版 · Cited by 4
Stress-relaxation plates and the remodeling of callus and cortex under the plate in rabbits.
Zhang, X., Bao, K., & Dai, K. (2000) · PubMed · Cited by 4
Osteocytic osteolysis in a cretaceous reptile.
Lf, B. (1977) · PubMed · Cited by 4
Biologists abandon Popper at their peril
(2000) · doi:10.1002/(sici)1521-1878(200002)22:2
Self-citation

Flagged first, then by citations

1 of the 165 references couldn’t be matched to a known paper.

Research works printed but not linked: 20

10.1002/(SICI)1097-4644(1998)72:30/31 <73::AID-JCB11>3.0.CO;2-L · DOI
Bélanger LF, 1977, Histology
Beresford WA, 1993, Patterns of structural and systematic diversity, 9
Boyde A, 1980, Evidence against “osteocytic osteolysis.”, Metab Bone Dis Rel Res, 25, 239
10.1097/00003086-198304000-00036 · DOI
Delling G, 1992, Osteoporose
Gehron Robey P, 1993, Structural and molecular regulation of bone matrix proteins, J Bone Miner Res, 8, S2
Hall BK, 1990, Bonem, 494
Heersche JNM, 1990, Bone, 327
Holtrop ME, 1990, Bone, 1
Huysseune A, 1990, Carbohydrate histochemistry of mature chondroid bone in Astatotilapia elegans. (Teleostei: Cichlidae) with a comparison to acellular bone and cartilage, Ann Sci Natur Zool Paris, 13, 29
Kwiecinski GG, 1985, Bone remodelling and its regulation in Myotis lucifugus, Prog Zool, 30, 45
Meunier FJ, 1989, The acellularisation process in Osteichthyan bone, Fortschr Zool, 35, 443
Ørvig T, 1951, Histological studies of placoderms and fossil elasmobranches: I. The endoskeleton with remarks on the hard tissues of lower vertebrates in general, Arkin Zool, 2, 321
Parfitt AM, 1990, Bone, 351
Semba T, 1966, Observations on the fine structure of chick embryo osteocytes: effects of parathyroid extract, 569
Vickaryous MK, 2005, Fins and limbs
10.1210/en.136.6.2741 · DOI
Windle WF, 1976, Textbook of histology, 561
Witten PE, 2005, Fins and Limbs

Sorted by citations

The amazing osteocyte
Bonewald, L. F. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.320 · Cited by 2,287
Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells
Florencio-Silva, R., Sasso, G. R. D. S., Sasso-Cerri, E., Simões, M. J., & Cerri, P. S. (2015) · BioMed Research International · doi:10.1155/2015/421746 · Cited by 2,044
Evidence for osteocyte regulation of bone homeostasis through RANKL expression
Nakashima, T., Hayashi, M., Fukunaga, T., Kurata, K., Oh-hora, M., Feng, J. Q., Bonewald, L. F., Kodama, T., Wutz, A., Wagner, E. F., et al. (2011) · Nature Medicine · doi:10.1038/nm.2452 · Cited by 1,778
The Osteocyte: An Endocrine Cell … and More
Dallas, S. L., Prideaux, M., & Bonewald, L. F. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1026 · Cited by 1,042
Scaffold Design for Bone Regeneration
Polo-Corrales, L., Latorre‐Esteves, M., & Ramı́rez-Vick, J. E. (2014) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2014.9127 · Cited by 969

See all 795

Authors: Franz‐Odendaal, T. A., Hall, B. K., & Witten, P. E.
Affiliations: Dalhousie University (CA)
Corresponding author: Franz‐Odendaal, Tamara A.
Witten, P. Eckhard
ORCID: Franz‐Odendaal, Tamara A.
Hall, Brian K.
Witten, P. Eckhard
Venue: Developmental Dynamics
Publisher: Wiley
Published: 2005-10-28
Volume: 235
Issue: 1
Pages: 176-190
ISSN: 1058-8388 (ISSN-L)
1097-0177
DOI: 10.1002/dvdy.20603
OpenAlex: W2032394856
Cited by: 795
References: 165
Citations by year: 2026: 25 · 2025: 29 · 2024: 30 · 2023: 48 · 2022: 41 · 2021: 68 · 2020: 55 · 2019: 58 · 2018: 38 · 2017: 53 · 2016: 38 · 2015: 45 · 2014: 33 · 2013: 48 · 2012: 41
FWCI: 1.56
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Developmental Dynamics (publishedVersion)
PubMed (publishedVersion)
Ghent University Academic Bibliography (Ghent University) (publishedVersion)
Ghent University Academic Bibliography (Ghent University) (submittedVersion)
Funders: Deutsche Forschungsgemeinschaft
Natural Sciences and Engineering Research Council of Canada
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Alkaline Phosphatase Research Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Bone and Dental Protein Studies
Keywords: osteocytes, osteoblasts, intramembranous ossification, bone formation, bone matrix mineralization, osteoblast markers
MeSH terms: Animals, Bone and Bones, Cell Differentiation, Humans, Models, Biological, Osteoblasts, Osteocytes, Osteogenesis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Buried alive: How osteoblasts become osteocytes

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks